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The map label for this gene is gabT [C]

Identifier: 55980831

GI number: 55980831

Start: 822923

End: 824221

Strand: Reverse

Name: gabT [C]

Synonym: TTHA0862

Alternate gene names: 55980831

Gene position: 824221-822923 (Counterclockwise)

Preceding gene: 55980832

Following gene: 55980830

Centisome position: 44.56

GC content: 70.21

Gene sequence:

>1299_bases
ATGAAGCCCAGCGTCCGCACTCCCCTTCCCGGGCCCAGGGCCCGGGCCCTCCTGGAGCGGGGAGAAAAGGTCCTCTCCCC
CTCCTACGTGCGCCCTTACCCCTTCGTGCCCGCAAGGGGCCAGGGGGCCTTTTTAGAAGACGTGGACGGCAACCTCTTCC
TGGACTTCATGTCCGGCATCGCGGTGAACACCACGGGCTACGCCCACCCCAAGGTGGTGGAGGCGGTCCGGGCCCAGGCG
GAGCGCTTCGCCCACGTCTGCTTCTCCGACTTCACCCACGAGCCCACCCTCTCCCTGGCGGAGCGGCTCGTGGGCAAACT
GGGCGGGGGCTACCGGGTCTTCTTCGGCAACTCGGGCACCGAGGGCGTGGAAGCCGCCATCAAGCTCGTCCGCTACCACA
CCCGGCGCCCCTACCTTTTGGCCTTCACCGGGGCCTTCCACGGCAGGAGCCTCGGCGCCCTCTCCGTCACCGCCAGCAAG
AGCGCCTACCGCCAAGGCTTCGCCCCCTTCCTTCCCGGCGTCGTCCACCTTCCCTTCCCCAACCCCTTCCGCCCCCCCTT
GGGGGCCCGCCCGGAAGAGGTGGGGGATGCGGTGCTGAACCACCTGGAGCACCTCTTCCAGACCGTCCTCCCGCCCGAGG
AGGTGGCCGCTTTGTTCCTCGAGCCCATCCAGGGCGAAGGCGGGTACGTGGTGCCGCCCCCCGGGTTCATCCCCCGGCTG
AAGGAGGTTCTGGACCGCTTCGGCATCCTGCTGGTGGCCGACGAGGTCCAGACCGGGGCGGGGCGCACGGGTCGGTTTTT
CGCCCTGGAACATGAGGGCGTACAGGCGGACGTGTACGTCCTGGCCAAGGGCCTCGCCTCGGGGTACCCCATAAGCGCCG
TCCTCTTCCGGGAAGAGCTGGGAAGCTGGCCCCCTGGGGCCCACGGCACCACCTTCGGCGGCCAGGCGGTGGCGGCCGCG
GCGGCCCACGCCACCCTTGACCTTTTGGAAGGGGGGCTCCAGGAGAACGCCGCCAGGCTTGGGGAGTTCCTCCTTGCGGA
GCTTCGCGCCCTCAAGCGCCGCTTCCCCTTCCTGGGGGACGTGAGGGGCCGGGGCCTGATGATCGGCCTGGACTTCGGCG
ACCCGGACCACCCCCGGCCCGACCTAAGGGACAAGGCGGTGCGCCTCGCCTTTGAGAAAGGGCTCCTCCTCCTCCCCGCC
GGGCCCTCCGCCCTCCGCATCGCCCCACCCCTCGTCCTGACCCAGGAGGAGGCCGCCCTTGGGCTTGAGATCCTGGAGGA
GGTCTTCCGCGCCCTCTAA

Upstream 100 bases:

>100_bases
CGCCTAGGCGCTTCCCGGGCCGGCGGGGGTATAAAAGCCGAGGCCTGGCGCATAAACTCGGGCTAGGATCCGCCTCCTTT
CCCCGGTAGACTGGCCCTGT

Downstream 100 bases:

>100_bases
GGCGAACCCCCCGGCCTCGAGGCCGGGGGGGCCCATCTGGTGGAGCGGCGGGGACTTGAACCCCGGACCTCCCGCTTGCA
AGGCGGGTGCTCTCCCTCTG

Product: 4-aminobutyrate aminotransferase

Products: L-Glutamate; Succinic semialdehyde [C]

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKPSVRTPLPGPRARALLERGEKVLSPSYVRPYPFVPARGQGAFLEDVDGNLFLDFMSGIAVNTTGYAHPKVVEAVRAQA
ERFAHVCFSDFTHEPTLSLAERLVGKLGGGYRVFFGNSGTEGVEAAIKLVRYHTRRPYLLAFTGAFHGRSLGALSVTASK
SAYRQGFAPFLPGVVHLPFPNPFRPPLGARPEEVGDAVLNHLEHLFQTVLPPEEVAALFLEPIQGEGGYVVPPPGFIPRL
KEVLDRFGILLVADEVQTGAGRTGRFFALEHEGVQADVYVLAKGLASGYPISAVLFREELGSWPPGAHGTTFGGQAVAAA
AAHATLDLLEGGLQENAARLGEFLLAELRALKRRFPFLGDVRGRGLMIGLDFGDPDHPRPDLRDKAVRLAFEKGLLLLPA
GPSALRIAPPLVLTQEEAALGLEILEEVFRAL

Sequences:

>Translated_432_residues
MKPSVRTPLPGPRARALLERGEKVLSPSYVRPYPFVPARGQGAFLEDVDGNLFLDFMSGIAVNTTGYAHPKVVEAVRAQA
ERFAHVCFSDFTHEPTLSLAERLVGKLGGGYRVFFGNSGTEGVEAAIKLVRYHTRRPYLLAFTGAFHGRSLGALSVTASK
SAYRQGFAPFLPGVVHLPFPNPFRPPLGARPEEVGDAVLNHLEHLFQTVLPPEEVAALFLEPIQGEGGYVVPPPGFIPRL
KEVLDRFGILLVADEVQTGAGRTGRFFALEHEGVQADVYVLAKGLASGYPISAVLFREELGSWPPGAHGTTFGGQAVAAA
AAHATLDLLEGGLQENAARLGEFLLAELRALKRRFPFLGDVRGRGLMIGLDFGDPDHPRPDLRDKAVRLAFEKGLLLLPA
GPSALRIAPPLVLTQEEAALGLEILEEVFRAL
>Mature_432_residues
MKPSVRTPLPGPRARALLERGEKVLSPSYVRPYPFVPARGQGAFLEDVDGNLFLDFMSGIAVNTTGYAHPKVVEAVRAQA
ERFAHVCFSDFTHEPTLSLAERLVGKLGGGYRVFFGNSGTEGVEAAIKLVRYHTRRPYLLAFTGAFHGRSLGALSVTASK
SAYRQGFAPFLPGVVHLPFPNPFRPPLGARPEEVGDAVLNHLEHLFQTVLPPEEVAALFLEPIQGEGGYVVPPPGFIPRL
KEVLDRFGILLVADEVQTGAGRTGRFFALEHEGVQADVYVLAKGLASGYPISAVLFREELGSWPPGAHGTTFGGQAVAAA
AAHATLDLLEGGLQENAARLGEFLLAELRALKRRFPFLGDVRGRGLMIGLDFGDPDHPRPDLRDKAVRLAFEKGLLLLPA
GPSALRIAPPLVLTQEEAALGLEILEEVFRAL

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=442, Percent_Identity=32.8054298642534, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=30.9090909090909, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=34.5565749235474, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI37574042, Length=415, Percent_Identity=28.6746987951807, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=28.7058823529412, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI226442705, Length=415, Percent_Identity=27.9518072289157, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI226442709, Length=383, Percent_Identity=28.9817232375979, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI188536080, Length=472, Percent_Identity=27.5423728813559, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI38679950, Length=472, Percent_Identity=27.5423728813559, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI38679946, Length=472, Percent_Identity=27.5423728813559, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1789016, Length=424, Percent_Identity=37.5, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=35.7320099255583, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1789759, Length=417, Percent_Identity=35.2517985611511, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1788044, Length=416, Percent_Identity=35.5769230769231, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI145693181, Length=400, Percent_Identity=38.5, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1786991, Length=416, Percent_Identity=31.0096153846154, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786349, Length=322, Percent_Identity=31.055900621118, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=443, Percent_Identity=30.6997742663657, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32564660, Length=425, Percent_Identity=30.8235294117647, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=424, Percent_Identity=30.8962264150943, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=283, Percent_Identity=32.8621908127208, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17541228, Length=474, Percent_Identity=27.8481012658228, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71981843, Length=196, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324432, Length=422, Percent_Identity=33.175355450237, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=31.7241379310345, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321456, Length=474, Percent_Identity=26.7932489451477, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324386, Length=449, Percent_Identity=27.6169265033408, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161085790, Length=449, Percent_Identity=33.8530066815145, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21357415, Length=437, Percent_Identity=32.4942791762014, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI28574759, Length=444, Percent_Identity=33.3333333333333, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI21356575, Length=408, Percent_Identity=30.3921568627451, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI281366494, Length=474, Percent_Identity=24.4725738396624, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24667139, Length=474, Percent_Identity=24.4725738396624, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24667143, Length=474, Percent_Identity=24.4725738396624, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19 [C]

Molecular weight: Translated: 46609; Mature: 46609

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSVRTPLPGPRARALLERGEKVLSPSYVRPYPFVPARGQGAFLEDVDGNLFLDFMSGI
CCCCCCCCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEHHHHCCE
AVNTTGYAHPKVVEAVRAQAERFAHVCFSDFTHEPTLSLAERLVGKLGGGYRVFFGNSGT
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCC
EGVEAAIKLVRYHTRRPYLLAFTGAFHGRSLGALSVTASKSAYRQGFAPFLPGVVHLPFP
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCHHHHHCCCHHHCCCEEECCCC
NPFRPPLGARPEEVGDAVLNHLEHLFQTVLPPEEVAALFLEPIQGEGGYVVPPPGFIPRL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHH
KEVLDRFGILLVADEVQTGAGRTGRFFALEHEGVQADVYVLAKGLASGYPISAVLFREEL
HHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
GSWPPGAHGTTFGGQAVAAAAAHATLDLLEGGLQENAARLGEFLLAELRALKRRFPFLGD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VRGRGLMIGLDFGDPDHPRPDLRDKAVRLAFEKGLLLLPAGPSALRIAPPLVLTQEEAAL
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEECCCEEEECHHHHH
GLEILEEVFRAL
HHHHHHHHHHHC
>Mature Secondary Structure
MKPSVRTPLPGPRARALLERGEKVLSPSYVRPYPFVPARGQGAFLEDVDGNLFLDFMSGI
CCCCCCCCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEHHHHCCE
AVNTTGYAHPKVVEAVRAQAERFAHVCFSDFTHEPTLSLAERLVGKLGGGYRVFFGNSGT
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCC
EGVEAAIKLVRYHTRRPYLLAFTGAFHGRSLGALSVTASKSAYRQGFAPFLPGVVHLPFP
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCHHHHHCCCHHHCCCEEECCCC
NPFRPPLGARPEEVGDAVLNHLEHLFQTVLPPEEVAALFLEPIQGEGGYVVPPPGFIPRL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHH
KEVLDRFGILLVADEVQTGAGRTGRFFALEHEGVQADVYVLAKGLASGYPISAVLFREEL
HHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
GSWPPGAHGTTFGGQAVAAAAAHATLDLLEGGLQENAARLGEFLLAELRALKRRFPFLGD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VRGRGLMIGLDFGDPDHPRPDLRDKAVRLAFEKGLLLLPAGPSALRIAPPLVLTQEEAAL
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEECCCEEEECHHHHH
GLEILEEVFRAL
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-Aminobutanoate; 2-Oxoglutarate [C]

Specific reaction: 4-Aminobutanoate + 2-Oxoglutarate --> L-Glutamate + Succinic semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA