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The map label for this gene is dxr [H]

Identifier: 55980825

GI number: 55980825

Start: 817977

End: 819080

Strand: Reverse

Name: dxr [H]

Synonym: TTHA0856

Alternate gene names: 55980825

Gene position: 819080-817977 (Counterclockwise)

Preceding gene: 55980826

Following gene: 55980824

Centisome position: 44.28

GC content: 70.29

Gene sequence:

>1104_bases
ATGAAGCGGGTCGTCGTCCTCGGATCCACGGGTTCCATCGGCCAGCAGGCCCTCGAGGTCTGCCGCCTGAGGGGTTACGA
GGTGGTGGGCCTCGCCGCCGGGAAAAACCTCGAGGCCCTCTCCCGGCAGATCGCCCTCTGGAAGCCCCGCCTGGTGGCGG
CGGAGGAAAGCCTCCACAAGGAGCTCAAGGCCCGCTTCCCCGGGCTTAGGCTCGCCACGGCCGAGGAGGTGGCCGCCCTG
GAGGCGGAGGTGGCCGTGGCCGCCATCCCTGGCCTCGCCGGGCTCGCCCCTACCCGGGCGGCGGTGCGGACCGGGAAGCG
GGTGGCCCTCGCCAACAAGGAGGCCATGGTGGCGGCGGGGCCTCTTTTGTGGCGGGAGGCGGAAGCCCACGGGGCCGAGA
TCCTCCCCGTGGACTCGGAGCACTCCGCCCTCTTCCAAGCCCTCCTCGGGGAGAGGCGGGAGGACGTGGCCGAGCTCATC
CTCACGGCGAGCGGGGGGCCTTTCCTCAGGGAGCCTGAGGACCTCGCCCAGGTGACCCCGGAGATGGCCCTCCGCCACCC
CCGCTGGCGGATGGGCCCCAAGGTCACCGTGGACTCCGCCACCCTCTTCAACAAGGGCCTCGAGGTCCTGGAGGCCAAGG
AGCTCTTCCGCTTCCCCCTGGAGAGGATCAAGGTCCTCATCCATCCCCAGGCCTACGTCCACGGCCTGGTGCGCTTCGTG
GACGGAAGCCTCAAGGCCCAGCTCGGCCCCACGGACATGCGCCTTTTCATCCAGTACGCCCTCACCTACCCCGAGCGGGC
GGAAACCCCCCTGAAGGACCTCCCCATCCCCGGGGTGCTGGAATTCTTAGAGCCCGACCTCAAGCGCTTTCCCGCCCTCG
CCGTGGCCTACGAGGCGGGAAGGCGGGGGGGCTTGGCCCAGGTGGCCGTCTCCGCCGCCGACGAGGTGGCGGTGGAGGCC
TTCCTCCAGGGGAAAATCCCCTTCCCCCGCATCCCCGAGATCCTGGCCCGGGTGCTGGAAGCCACCCCTATAGAGCCTCT
AACATGGGAGAGCCTCTTCGCCGTGGACGCCTGGGCCCGGGAGGAGGCCAAGAGGTGGGCATGA

Upstream 100 bases:

>100_bases
ACTCAGGGAACTTCCTCCCCGGGCACGGAGGCCTTCTGGACCGGATAGACAGCCTCCTCTTCGCCTTCCCCCTCACGTAC
TTCCTGGTGGTGCTCTTCAC

Downstream 100 bases:

>100_bases
GCCTGTTCTGGTTTCTGGTCATCATCGGCGTCAGCGTCTTCGTCCACGAGCTCGGTCACTACCTGGCGGCGAGGCTTCAA
GGGGTACGGGTCAAGGCCTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKRVVVLGSTGSIGQQALEVCRLRGYEVVGLAAGKNLEALSRQIALWKPRLVAAEESLHKELKARFPGLRLATAEEVAAL
EAEVAVAAIPGLAGLAPTRAAVRTGKRVALANKEAMVAAGPLLWREAEAHGAEILPVDSEHSALFQALLGERREDVAELI
LTASGGPFLREPEDLAQVTPEMALRHPRWRMGPKVTVDSATLFNKGLEVLEAKELFRFPLERIKVLIHPQAYVHGLVRFV
DGSLKAQLGPTDMRLFIQYALTYPERAETPLKDLPIPGVLEFLEPDLKRFPALAVAYEAGRRGGLAQVAVSAADEVAVEA
FLQGKIPFPRIPEILARVLEATPIEPLTWESLFAVDAWAREEAKRWA

Sequences:

>Translated_367_residues
MKRVVVLGSTGSIGQQALEVCRLRGYEVVGLAAGKNLEALSRQIALWKPRLVAAEESLHKELKARFPGLRLATAEEVAAL
EAEVAVAAIPGLAGLAPTRAAVRTGKRVALANKEAMVAAGPLLWREAEAHGAEILPVDSEHSALFQALLGERREDVAELI
LTASGGPFLREPEDLAQVTPEMALRHPRWRMGPKVTVDSATLFNKGLEVLEAKELFRFPLERIKVLIHPQAYVHGLVRFV
DGSLKAQLGPTDMRLFIQYALTYPERAETPLKDLPIPGVLEFLEPDLKRFPALAVAYEAGRRGGLAQVAVSAADEVAVEA
FLQGKIPFPRIPEILARVLEATPIEPLTWESLFAVDAWAREEAKRWA
>Mature_367_residues
MKRVVVLGSTGSIGQQALEVCRLRGYEVVGLAAGKNLEALSRQIALWKPRLVAAEESLHKELKARFPGLRLATAEEVAAL
EAEVAVAAIPGLAGLAPTRAAVRTGKRVALANKEAMVAAGPLLWREAEAHGAEILPVDSEHSALFQALLGERREDVAELI
LTASGGPFLREPEDLAQVTPEMALRHPRWRMGPKVTVDSATLFNKGLEVLEAKELFRFPLERIKVLIHPQAYVHGLVRFV
DGSLKAQLGPTDMRLFIQYALTYPERAETPLKDLPIPGVLEFLEPDLKRFPALAVAYEAGRRGGLAQVAVSAADEVAVEA
FLQGKIPFPRIPEILARVLEATPIEPLTWESLFAVDAWAREEAKRWA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=42.4552429667519, Blast_Score=259, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40088; Mature: 40088

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVVLGSTGSIGQQALEVCRLRGYEVVGLAAGKNLEALSRQIALWKPRLVAAEESLHK
CCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHH
ELKARFPGLRLATAEEVAALEAEVAVAAIPGLAGLAPTRAAVRTGKRVALANKEAMVAAG
HHHHHCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEECCCHHEEEC
PLLWREAEAHGAEILPVDSEHSALFQALLGERREDVAELILTASGGPFLREPEDLAQVTP
CHHHHHHHCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCH
EMALRHPRWRMGPKVTVDSATLFNKGLEVLEAKELFRFPLERIKVLIHPQAYVHGLVRFV
HHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHEEECCHHHHHHHHHHH
DGSLKAQLGPTDMRLFIQYALTYPERAETPLKDLPIPGVLEFLEPDLKRFPALAVAYEAG
CCCHHCCCCCHHHHHHHHHHHCCCHHCCCCHHHCCCCHHHHHHCHHHHHCCHHHHHHHHC
RRGGLAQVAVSAADEVAVEAFLQGKIPFPRIPEILARVLEATPIEPLTWESLFAVDAWAR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EEAKRWA
HHHHCCC
>Mature Secondary Structure
MKRVVVLGSTGSIGQQALEVCRLRGYEVVGLAAGKNLEALSRQIALWKPRLVAAEESLHK
CCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHH
ELKARFPGLRLATAEEVAALEAEVAVAAIPGLAGLAPTRAAVRTGKRVALANKEAMVAAG
HHHHHCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEECCCHHEEEC
PLLWREAEAHGAEILPVDSEHSALFQALLGERREDVAELILTASGGPFLREPEDLAQVTP
CHHHHHHHCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCH
EMALRHPRWRMGPKVTVDSATLFNKGLEVLEAKELFRFPLERIKVLIHPQAYVHGLVRFV
HHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHEEECCHHHHHHHHHHH
DGSLKAQLGPTDMRLFIQYALTYPERAETPLKDLPIPGVLEFLEPDLKRFPALAVAYEAG
CCCHHCCCCCHHHHHHHHHHHCCCHHCCCCHHHCCCCHHHHHHCHHHHHCCHHHHHHHHC
RRGGLAQVAVSAADEVAVEAFLQGKIPFPRIPEILARVLEATPIEPLTWESLFAVDAWAR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EEAKRWA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA