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The map label for this gene is lon1

Identifier: 55980739

GI number: 55980739

Start: 736488

End: 738875

Strand: Reverse

Name: lon1

Synonym: TTHA0770

Alternate gene names: 55980739

Gene position: 738875-736488 (Counterclockwise)

Preceding gene: 55980740

Following gene: 55980738

Centisome position: 39.94

GC content: 68.22

Gene sequence:

>2388_bases
ATGAAGGACTTTCTGCGCCTAGAACTCCCCGTGCTCCCTCTCCGGAACACCGTGGTCCTCCCCCACACCACCACCGGGGT
GGACGTGGGGCGCCTCAAGAGCAAGCGGGCGGTGGAGGAGGCCCTCTCCGCCGACCGGCTCCTCTTCTTGGTGACCCAGA
AGGACCCGGAGGTGGACGACCCCGCCCCGGAGGACCTTTACGCCGTGGGCACCCTGGCCGTGGTCAAGCAGGCCATGCGC
CTGCCGGACGGCACCCTCCAGGTGATGGTGGAGGCGAGAAGCCGGGCCCGGCTCCTCTCCTACGTGGCCGCCCCTTACCT
CCGGGCCGTGGGCGAGGCCATCCCCGAGCCTCCCCTAAAGGATCCCGAACTCGCCCGGGTCCTGGTGAACGAGGTCCAAG
AGGCCTTTGAGCGCTACCTGCAGAACCACAAGACCCTGCGCCTGGACCGCTACCAGCAGGAGGCGGTCAAGAGCACCCGG
GACCCCGCCATCCTGGCGGACCTCGTGGCCCATCACGCCACCTGGACCCTGGAGGAGAAGCAGACCATCCTGGAGACCCC
GGAGGTGGAGGAGCGCCTGAAGCGGGTGCTGGCCCTGCTCCTCCGCGACCTGGAGCGCTTTGAGCTGGACAAGAAGATCG
CCGCCCGGGTCAAGGAGCAGATGGACCAGAACCAGAGGGAGTACTACCTCCGGGAGCAGATGAAGGCCATCCAGAAAGAG
CTCGGGGGTGGGGAGGACTTCCTCACGGAGATAGAGGAGCTCCGCGAACGCATTGAAAAGAAGGGCATGCCCGAGCCCGT
GAAGGAGAAGGCCCTCAAGGAGCTCAAGCGCCTGGAGCGCATGCAGCCCGGCTCCCCCGAGGCCACGGTGAGCCGCACCT
ACCTGGACTGGCTCCTCGAGGTCCCCTGGACCGAGGCCGACCCCGAGGTGCTGGACATCTCCGTGACCAAGCGGGTCCTG
GACGAAGACCACTACGGCCTCAAGGAGGTGAAGGAGCGCATCCTGGAGTACCTGGCGGTGCGCCAGCTCACCCAGGGGAA
GGAGGTGAAGGGCCACGCCCCCATCCTCTGCTTCGTGGGGCCCCCCGGGGTGGGCAAGACCTCCCTGGGCAAGAGCATCG
CCCGGAGCATGAACCGCCGCTTCCACCGCATCTCCTTGGGCGGGGTGCGGGACGAGGCGGAGATCCGGGGCCACCGCCGC
ACCTACATCGGGGCCCTCCCCGGCAAGATCATCCAGGGGATGAAGCAGGTGGGGGTGGTGAACCCCGTCTTCCTCCTGGA
CGAGATTGACAAGCTCTCCTCCGACTGGCGGGGGGACCCGGCGGCGGCCCTCCTCGAGGTCTTAGACCCCGAGCAGAACC
ACACCTTCACCGACCACTACCTGGACGTGCCCTACGACCTCTCCAAGGTCTTCTTCATCACCACGGCCAACACCCTCTCC
ACCATCCCGAGGCCCCTTCTGGACCGGATGGAGGTCATTGAGATCCCCGGCTACACCCTCCACGAGAAGCGCGCCATCGC
CCGCTACTTCCGCTGGCCCTTCCAGGTGAAGGAGGCGGGGCTTGAAGGGAGGCTGGAGATCACCGACCGGGCCATAGAGC
GCATCGTCCAGGAGTACACCCGGGAGGCCGGGGTGCGCAACCTGGACCGGGAGCTCTCCAAGGTGGCCAGGAAGGCCGCT
AAGGACTACCTGGAAAAGCCCTGGGAAGGGGTCAGGGTGGTGGACGCCGAGGACCTCGAGGCCTACCTGGGCGTCCCCAA
GTACCGCCCCGACCGGGCGGAGAAGGAGCCCCAGGTGGGGGCGGCCCAGGGCCTGGCCTGGACCCCCTACGGGGGCACCC
TCCTCACCATTGAGGCCGTGGCCGTCCCCGGCACGGGCAAGGTGAACCTCACCGGGAACCTGGGGGAGGTCATGAAGGAG
TCGGCCCACGCCGCCCTCACCTACCTCCGGGCCCACCGGGAGGAGTGGGGGCTTCCGGAGGGCTTCCACAAGGACTACGA
TCTCCACATCCACGTCCCCGAGGGCGCCACCCCAAAAGACGGCCCCTCGGCGGGGATCACCATCGCCACCGCCCTGGCGA
GCGCCCTCACGGGCCGCCCGGTGCGCATGGACATCGCCATGACCGGGGAGATCACCCTAAGGGGCAGGGTCCTCCCCATC
GGCGGGGTGAAGGAAAAGCTCCTCGCCGCCCACCAGGCGGGGATCCACCGGGTCATTCTCCCCAAGGAGAACGCCGCCGA
GCTCAAGGAGGTGCCCGAGGAGATCCTCAAGGACCTGGAGATCCACTTCGTGGAGGAGGTGGGCGAGGTCCTGAAGCTCC
TCCTCCTCCCCCCTCCCCCACCCCCGGCGGTCCAGCCGGACCGCCCCCAGCCCGGCGTGGGCGCTTAG

Upstream 100 bases:

>100_bases
AATCCCCTCCGCTGGCGGCCGCGGTCCCCGGCCAAAGCCTGAACGCCCATTGTGCCCCGGGGTGCCTTTGTTTCCTGAAA
GGGGGGTATCATAGGGGCAG

Downstream 100 bases:

>100_bases
GACCATGGCCCGGCTCCGGCTAGGCCTCCTCGGGCTTCTCCTCCTCGCGGCCTTCCTCGCCTGGCGGGCCGCCCCTGAGG
TCTTCTGGACCCTCCCCGCC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 1

Number of amino acids: Translated: 795; Mature: 795

Protein sequence:

>795_residues
MKDFLRLELPVLPLRNTVVLPHTTTGVDVGRLKSKRAVEEALSADRLLFLVTQKDPEVDDPAPEDLYAVGTLAVVKQAMR
LPDGTLQVMVEARSRARLLSYVAAPYLRAVGEAIPEPPLKDPELARVLVNEVQEAFERYLQNHKTLRLDRYQQEAVKSTR
DPAILADLVAHHATWTLEEKQTILETPEVEERLKRVLALLLRDLERFELDKKIAARVKEQMDQNQREYYLREQMKAIQKE
LGGGEDFLTEIEELRERIEKKGMPEPVKEKALKELKRLERMQPGSPEATVSRTYLDWLLEVPWTEADPEVLDISVTKRVL
DEDHYGLKEVKERILEYLAVRQLTQGKEVKGHAPILCFVGPPGVGKTSLGKSIARSMNRRFHRISLGGVRDEAEIRGHRR
TYIGALPGKIIQGMKQVGVVNPVFLLDEIDKLSSDWRGDPAAALLEVLDPEQNHTFTDHYLDVPYDLSKVFFITTANTLS
TIPRPLLDRMEVIEIPGYTLHEKRAIARYFRWPFQVKEAGLEGRLEITDRAIERIVQEYTREAGVRNLDRELSKVARKAA
KDYLEKPWEGVRVVDAEDLEAYLGVPKYRPDRAEKEPQVGAAQGLAWTPYGGTLLTIEAVAVPGTGKVNLTGNLGEVMKE
SAHAALTYLRAHREEWGLPEGFHKDYDLHIHVPEGATPKDGPSAGITIATALASALTGRPVRMDIAMTGEITLRGRVLPI
GGVKEKLLAAHQAGIHRVILPKENAAELKEVPEEILKDLEIHFVEEVGEVLKLLLLPPPPPPAVQPDRPQPGVGA

Sequences:

>Translated_795_residues
MKDFLRLELPVLPLRNTVVLPHTTTGVDVGRLKSKRAVEEALSADRLLFLVTQKDPEVDDPAPEDLYAVGTLAVVKQAMR
LPDGTLQVMVEARSRARLLSYVAAPYLRAVGEAIPEPPLKDPELARVLVNEVQEAFERYLQNHKTLRLDRYQQEAVKSTR
DPAILADLVAHHATWTLEEKQTILETPEVEERLKRVLALLLRDLERFELDKKIAARVKEQMDQNQREYYLREQMKAIQKE
LGGGEDFLTEIEELRERIEKKGMPEPVKEKALKELKRLERMQPGSPEATVSRTYLDWLLEVPWTEADPEVLDISVTKRVL
DEDHYGLKEVKERILEYLAVRQLTQGKEVKGHAPILCFVGPPGVGKTSLGKSIARSMNRRFHRISLGGVRDEAEIRGHRR
TYIGALPGKIIQGMKQVGVVNPVFLLDEIDKLSSDWRGDPAAALLEVLDPEQNHTFTDHYLDVPYDLSKVFFITTANTLS
TIPRPLLDRMEVIEIPGYTLHEKRAIARYFRWPFQVKEAGLEGRLEITDRAIERIVQEYTREAGVRNLDRELSKVARKAA
KDYLEKPWEGVRVVDAEDLEAYLGVPKYRPDRAEKEPQVGAAQGLAWTPYGGTLLTIEAVAVPGTGKVNLTGNLGEVMKE
SAHAALTYLRAHREEWGLPEGFHKDYDLHIHVPEGATPKDGPSAGITIATALASALTGRPVRMDIAMTGEITLRGRVLPI
GGVKEKLLAAHQAGIHRVILPKENAAELKEVPEEILKDLEIHFVEEVGEVLKLLLLPPPPPPAVQPDRPQPGVGA
>Mature_795_residues
MKDFLRLELPVLPLRNTVVLPHTTTGVDVGRLKSKRAVEEALSADRLLFLVTQKDPEVDDPAPEDLYAVGTLAVVKQAMR
LPDGTLQVMVEARSRARLLSYVAAPYLRAVGEAIPEPPLKDPELARVLVNEVQEAFERYLQNHKTLRLDRYQQEAVKSTR
DPAILADLVAHHATWTLEEKQTILETPEVEERLKRVLALLLRDLERFELDKKIAARVKEQMDQNQREYYLREQMKAIQKE
LGGGEDFLTEIEELRERIEKKGMPEPVKEKALKELKRLERMQPGSPEATVSRTYLDWLLEVPWTEADPEVLDISVTKRVL
DEDHYGLKEVKERILEYLAVRQLTQGKEVKGHAPILCFVGPPGVGKTSLGKSIARSMNRRFHRISLGGVRDEAEIRGHRR
TYIGALPGKIIQGMKQVGVVNPVFLLDEIDKLSSDWRGDPAAALLEVLDPEQNHTFTDHYLDVPYDLSKVFFITTANTLS
TIPRPLLDRMEVIEIPGYTLHEKRAIARYFRWPFQVKEAGLEGRLEITDRAIERIVQEYTREAGVRNLDRELSKVARKAA
KDYLEKPWEGVRVVDAEDLEAYLGVPKYRPDRAEKEPQVGAAQGLAWTPYGGTLLTIEAVAVPGTGKVNLTGNLGEVMKE
SAHAALTYLRAHREEWGLPEGFHKDYDLHIHVPEGATPKDGPSAGITIATALASALTGRPVRMDIAMTGEITLRGRVLPI
GGVKEKLLAAHQAGIHRVILPKENAAELKEVPEEILKDLEIHFVEEVGEVLKLLLLPPPPPPAVQPDRPQPGVGA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=829, Percent_Identity=39.686369119421, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI21396489, Length=635, Percent_Identity=44.4094488188976, Blast_Score=527, Evalue=1e-149,
Organism=Escherichia coli, GI1786643, Length=777, Percent_Identity=51.8661518661519, Blast_Score=758, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=661, Percent_Identity=42.9652042360061, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556486, Length=546, Percent_Identity=41.3919413919414, Blast_Score=417, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319449, Length=663, Percent_Identity=42.8355957767722, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI221513036, Length=689, Percent_Identity=44.4121915820029, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24666867, Length=689, Percent_Identity=44.4121915820029, Blast_Score=544, Evalue=1e-155,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON1_THET2 (Q72KS4)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_004393.1
- ProteinModelPortal:   Q72KS4
- STRING:   Q72KS4
- MEROPS:   S16.001
- GeneID:   2775294
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   HTFQDHY
- PhylomeDB:   Q72KS4
- ProtClustDB:   CLSK445340
- BioCyc:   TTHE262724:TT_C0418-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 89313; Mature: 89313

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 683-683 ACT_SITE 726-726

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDFLRLELPVLPLRNTVVLPHTTTGVDVGRLKSKRAVEEALSADRLLFLVTQKDPEVDD
CCCCCEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
PAPEDLYAVGTLAVVKQAMRLPDGTLQVMVEARSRARLLSYVAAPYLRAVGEAIPEPPLK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DPELARVLVNEVQEAFERYLQNHKTLRLDRYQQEAVKSTRDPAILADLVAHHATWTLEEK
CHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEHHH
QTILETPEVEERLKRVLALLLRDLERFELDKKIAARVKEQMDQNQREYYLREQMKAIQKE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LGGGEDFLTEIEELRERIEKKGMPEPVKEKALKELKRLERMQPGSPEATVSRTYLDWLLE
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VPWTEADPEVLDISVTKRVLDEDHYGLKEVKERILEYLAVRQLTQGKEVKGHAPILCFVG
CCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
PPGVGKTSLGKSIARSMNRRFHRISLGGVRDEAEIRGHRRTYIGALPGKIIQGMKQVGVV
CCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCHHHEECCCCHHHHHHHHHHCCC
NPVFLLDEIDKLSSDWRGDPAAALLEVLDPEQNHTFTDHYLDVPYDLSKVFFITTANTLS
CHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECHHHH
TIPRPLLDRMEVIEIPGYTLHEKRAIARYFRWPFQVKEAGLEGRLEITDRAIERIVQEYT
HCCHHHHHHHHEEECCCCCHHHHHHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHHHHHHH
REAGVRNLDRELSKVARKAAKDYLEKPWEGVRVVDAEDLEAYLGVPKYRPDRAEKEPQVG
HHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCC
AAQGLAWTPYGGTLLTIEAVAVPGTGKVNLTGNLGEVMKESAHAALTYLRAHREEWGLPE
HHCCCEECCCCCEEEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFHKDYDLHIHVPEGATPKDGPSAGITIATALASALTGRPVRMDIAMTGEITLRGRVLPI
CCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECEEEEEEEEEEC
GGVKEKLLAAHQAGIHRVILPKENAAELKEVPEEILKDLEIHFVEEVGEVLKLLLLPPPP
CCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PPAVQPDRPQPGVGA
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MKDFLRLELPVLPLRNTVVLPHTTTGVDVGRLKSKRAVEEALSADRLLFLVTQKDPEVDD
CCCCCEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
PAPEDLYAVGTLAVVKQAMRLPDGTLQVMVEARSRARLLSYVAAPYLRAVGEAIPEPPLK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DPELARVLVNEVQEAFERYLQNHKTLRLDRYQQEAVKSTRDPAILADLVAHHATWTLEEK
CHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEHHH
QTILETPEVEERLKRVLALLLRDLERFELDKKIAARVKEQMDQNQREYYLREQMKAIQKE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LGGGEDFLTEIEELRERIEKKGMPEPVKEKALKELKRLERMQPGSPEATVSRTYLDWLLE
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VPWTEADPEVLDISVTKRVLDEDHYGLKEVKERILEYLAVRQLTQGKEVKGHAPILCFVG
CCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
PPGVGKTSLGKSIARSMNRRFHRISLGGVRDEAEIRGHRRTYIGALPGKIIQGMKQVGVV
CCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCHHHEECCCCHHHHHHHHHHCCC
NPVFLLDEIDKLSSDWRGDPAAALLEVLDPEQNHTFTDHYLDVPYDLSKVFFITTANTLS
CHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECHHHH
TIPRPLLDRMEVIEIPGYTLHEKRAIARYFRWPFQVKEAGLEGRLEITDRAIERIVQEYT
HCCHHHHHHHHEEECCCCCHHHHHHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHHHHHHH
REAGVRNLDRELSKVARKAAKDYLEKPWEGVRVVDAEDLEAYLGVPKYRPDRAEKEPQVG
HHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCC
AAQGLAWTPYGGTLLTIEAVAVPGTGKVNLTGNLGEVMKESAHAALTYLRAHREEWGLPE
HHCCCEECCCCCEEEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFHKDYDLHIHVPEGATPKDGPSAGITIATALASALTGRPVRMDIAMTGEITLRGRVLPI
CCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECEEEEEEEEEEC
GGVKEKLLAAHQAGIHRVILPKENAAELKEVPEEILKDLEIHFVEEVGEVLKLLLLPPPP
CCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PPAVQPDRPQPGVGA
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA