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The map label for this gene is ltaA [H]

Identifier: 55980722

GI number: 55980722

Start: 719697

End: 720299

Strand: Reverse

Name: ltaA [H]

Synonym: TTHA0753

Alternate gene names: 55980722

Gene position: 720299-719697 (Counterclockwise)

Preceding gene: 55980723

Following gene: 55980714

Centisome position: 38.94

GC content: 71.31

Gene sequence:

>603_bases
ATGCGCCTCGTGGACCTGAGGAGCGACACCCTCACCCGCCCCACCCCGGCCATGCGCAAGGCCATGGCGGAGGCGGAGGT
GGGGGACGACGCCTACGGCGAAGACCCCACGGTGAACCGCCTCGAGGCCCTGGCGGCGGAAAGGCTCGGGTTTGAACGGG
CCCTCTTCCTGCCCTCGGGCACCATGGCCAACCAGGTGGCCCTCCTCCTCCACCTGCCCAAGGAGCTGGAGGCCGAGGCC
CGGCGTTACCGCAAGCTCCTCGGAGGCGGGTGGCGGCAGGCGGGGGTCTTGGCCGCGGCGGGGATCCTGGCCCTAGAGGA
AGGCCCCAAGCACCTCCGGCGCGACCACGAGATGGCCCGCGCCCTGGCGGAGGGGCTTTTTCGCCTGGGGCTCGCCGTGG
ACCTGGGGGCGGTGGAGACCAACATGGTCTACCTGGAGGTGGAGGACCCCGAGGGCTTTCTCCAGGGTCTAAGGGCCCGG
GGGGTGCTCGCGGGGCGCGTGGGGGGAAGGGTGCGGTTCGTGACCCACCGGGACCTCATGGACGAGGACATCCCCCTTGC
CCTGGAGAGGGTCCAAGACCTCCTTCACTCCAGGCCCAGGTAG

Upstream 100 bases:

>100_bases
GAGAGGGGCGAGGGGGTGCGGGTGGAGGTGGAGGGGGAGGTCTACCTCCTGCCCCGGGCCCTCGCCCAGGCGGTGGGGGT
GGAGCCCTTAGGCTAGGGGC

Downstream 100 bases:

>100_bases
ACCAGGGTGCGGAAGGCGTGCTGGAGCCTGGCCCCAAGCCGGGAGTGGAGGGCCTTCTCCGGCTCCAGGACGGAGAGGAG
GTTCGGGGCCTGGGCGAGGT

Product: L-allo-threonine aldolase

Products: Acetaldehyde; Glycine [C]

Alternate protein names: L-allo-TA; L-allo-threonine acetaldehyde-lyase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MRLVDLRSDTLTRPTPAMRKAMAEAEVGDDAYGEDPTVNRLEALAAERLGFERALFLPSGTMANQVALLLHLPKELEAEA
RRYRKLLGGGWRQAGVLAAAGILALEEGPKHLRRDHEMARALAEGLFRLGLAVDLGAVETNMVYLEVEDPEGFLQGLRAR
GVLAGRVGGRVRFVTHRDLMDEDIPLALERVQDLLHSRPR

Sequences:

>Translated_200_residues
MRLVDLRSDTLTRPTPAMRKAMAEAEVGDDAYGEDPTVNRLEALAAERLGFERALFLPSGTMANQVALLLHLPKELEAEA
RRYRKLLGGGWRQAGVLAAAGILALEEGPKHLRRDHEMARALAEGLFRLGLAVDLGAVETNMVYLEVEDPEGFLQGLRAR
GVLAGRVGGRVRFVTHRDLMDEDIPLALERVQDLLHSRPR
>Mature_200_residues
MRLVDLRSDTLTRPTPAMRKAMAEAEVGDDAYGEDPTVNRLEALAAERLGFERALFLPSGTMANQVALLLHLPKELEAEA
RRYRKLLGGGWRQAGVLAAAGILALEEGPKHLRRDHEMARALAEGLFRLGLAVDLGAVETNMVYLEVEDPEGFLQGLRAR
GVLAGRVGGRVRFVTHRDLMDEDIPLALERVQDLLHSRPR

Specific function: Stereospecifically catalyzes the interconversion of L- allo-threonine and glycine [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=72, Percent_Identity=61.1111111111111, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193206522, Length=108, Percent_Identity=49.0740740740741, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193206520, Length=108, Percent_Identity=49.0740740740741, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193206524, Length=108, Percent_Identity=49.0740740740741, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320789, Length=68, Percent_Identity=51.4705882352941, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355439, Length=70, Percent_Identity=60, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: 4.1.2.5 [C]

Molecular weight: Translated: 22108; Mature: 22108

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVDLRSDTLTRPTPAMRKAMAEAEVGDDAYGEDPTVNRLEALAAERLGFERALFLPSG
CCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHEEECCCC
TMANQVALLLHLPKELEAEARRYRKLLGGGWRQAGVLAAAGILALEEGPKHLRRDHEMAR
CHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ALAEGLFRLGLAVDLGAVETNMVYLEVEDPEGFLQGLRARGVLAGRVGGRVRFVTHRDLM
HHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHCCEEEECCCCEEEEEECCCCC
DEDIPLALERVQDLLHSRPR
CCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLVDLRSDTLTRPTPAMRKAMAEAEVGDDAYGEDPTVNRLEALAAERLGFERALFLPSG
CCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHEEECCCC
TMANQVALLLHLPKELEAEARRYRKLLGGGWRQAGVLAAAGILALEEGPKHLRRDHEMAR
CHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ALAEGLFRLGLAVDLGAVETNMVYLEVEDPEGFLQGLRARGVLAGRVGGRVRFVTHRDLM
HHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHCCEEEECCCCEEEEEECCCCC
DEDIPLALERVQDLLHSRPR
CCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: 1.7

Km value (mM): 2.85 {L-Thr}} 0.24 {DL-erythro-phenylserine}} 0.12 {DL-threo-phenylserine}} 0.22 {L-allo-Thr}} [C]

Substrates: L-Threonine [C]

Specific reaction: L-Threonine <==> Acetaldehyde + Glycine [C]

General reaction: Elimination of an aldehyde, C-C bond cleavage [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171400; 9228760 [H]