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The map label for this gene is uvrC [H]

Identifier: 54295483

GI number: 54295483

Start: 2938692

End: 2940548

Strand: Reverse

Name: uvrC [H]

Synonym: lpl2570

Alternate gene names: 54295483

Gene position: 2940548-2938692 (Counterclockwise)

Preceding gene: 54295484

Following gene: 54295480

Centisome position: 87.89

GC content: 39.42

Gene sequence:

>1857_bases
ATGAATGACTTACAGCTTTCCGCTGAACTCGCTTTATTTTTAACGAAACTCCCAAGTGAACCGGGTATATACCGCATGTT
AGACGAAGAAGGCACCGTTCTATATGTGGGAAAAGCAGCCAATCTAAAAAAAAGAGTCAATAGCTATTTTAGTAAACAAA
ATACAGGAGTTAAGACACGAGCATTGGTAAGCCAAATCAAATCCATAGAAATTTCTGTGACAAGATCGGAGACAGAGGCC
TTATTATTAGAGAGTAATTTAATTAAAGCGTTAAGGCCAAAATATAATGTTTTGTTGCGCGATGATAAATCCTATCCTTA
TATTCATCTATCAAATCATCCAGACTTTCCAAGAGTTGAGTTATACCGAAGTAAAAAGAAGCCTCCCTCCGGTAATTTTT
TTGGCCCCTATCCTGGTGTGGCTGCTGTAAGAGAAACGATAGTCACCATTCAAAAAATATTTAAAATTCGCAATTGCAGA
GACAGCTATTTTAAAGCTCGTTCTCGCCCTTGTTTGCAATATCAAATAAAACGCTGTACTGCGCCTTGCGTTCATTATAT
TTCTCCTGAAAACTACAAATTGTCTGTAGAGGATGCCATAAGATTTTTACAGGGGAAGTGCCAAATAATTCTTGATGAAC
TTGCCGAACGAATGAAAAACGCGGTAAGTCAATTAAATTTCGAAGAAGCTGCTGTTTTGCGTGATCAGATAAAAAATTTG
CGCTTAATTCAAGAACAACAAGGAGTTGTCCAGTTACGTGGTGATGCTGATGTGATCGCAATAGAAGTACGTCCTGGTTT
CGCATGTATTCAGTGTGTGACTATTCGTGAAGGACAAGTACTGAATAGTCAAAGCTTTTTCCCTACAGTGCCTTATGCTG
TATTAGATGAAGAATTGGATGCCAATTCACTTTGGCAGCAGACTTTTGAAGCCTTTATTGGTTTTTATTATTTGGATACA
TCAGAAAGAATTCCGGATTTGATAATTACTAATCAATCAATAACAGAGAGTCGCTCATTAGAGTATATTTTGTCCCAGCG
ACGAGGCAAATCCTGTAAAATTCAAGTCAATCCAAGAGGTGTCAAATCGAGATGGATGGATTTTGCAGTGAACAATTTAC
GAATTTCAGTAGCAGAATATGTCAGCAAACATTCTACGATAAGATCAAGATATCAGGCATTAAGGCAATTGCTTGCGCTT
GATAAAAATATAGAGCGAATGGAGTGTTTTGATATTAGCCATACTCAAGGTGAAGCAACTGTTGCATCTTGTGTTGTATT
TGATACAGAAGGCCCTCGCCCCAGTGAATACAGGCGATTTAACATTGAGGGTATTACTCCAGGGGATGATTACGCAGCAA
TGGAACAGGCAGTTACTCGCCGATTTAAAAGACTGATTGGTGCTCAATTATTGCCAGATGTTTTGATTATTGATGGAGGT
AAAGGCCAGGTTTCTATTGTAAAACGAGTTTTAACCTCTCTGGGTGTGGAAGATATTACTTTATTAGGTGTATCCAAGGG
GCCTTCACGAAAGGCGGGATGGGAGAAATTGATACTGGTTAATGAAAACAGAGAATTTGTTTTGCCAGAGGACTCCAAAG
CGCTTCATCTTTTACAACATATTCGTGATGAAGCGCATCGTTTTGCTATTACTGCCCATCGGAAGAAAAGACAAAAGACA
CGTGTTGAATCCACTCTTGAAAGTATAGAGGGTGTTGGCGCGAAACGACGTCAAGCGTTGCTGCAGCGTTTTGGCGGGTT
GCGAGAGTTGGCTAAAGCGTCACTGGAAGAAATTTGTAAAGTTCAGGGAATCAGCGAGCAGTTGGCAAAGCGAATTTATG
AACATTTTCATCCTTGA

Upstream 100 bases:

>100_bases
TGGGGATTAAAAATGATGTGGAGCTTACTTATTTGGCTATGAAGCACCGCATTATTGAGCACCCCAATGATTTGTCACAA
GATGATTAGATGTTAATTTC

Downstream 100 bases:

>100_bases
GCAAAATTGAAGTTTTGACATAGTTAAAAGGCTCTTACAGCACGGACAGCAGCTGTTTTATTTTTGGCAATGTTTTTAAT
TTCCCCTGTTTTAGAATTAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRVELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKNAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFIGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRGVKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALRQLLAL
DKNIERMECFDISHTQGEATVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIGAQLLPDVLIIDGG
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGAKRRQALLQRFGGLRELAKASLEEICKVQGISEQLAKRIYEHFHP

Sequences:

>Translated_618_residues
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRVELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKNAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFIGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRGVKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALRQLLAL
DKNIERMECFDISHTQGEATVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIGAQLLPDVLIIDGG
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGAKRRQALLQRFGGLRELAKASLEEICKVQGISEQLAKRIYEHFHP
>Mature_618_residues
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRVELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKNAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFIGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRGVKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALRQLLAL
DKNIERMECFDISHTQGEATVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIGAQLLPDVLIIDGG
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGAKRRQALLQRFGGLRELAKASLEEICKVQGISEQLAKRIYEHFHP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=48.6842105263158, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1788037, Length=201, Percent_Identity=29.3532338308458, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 70397; Mature: 70397

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTR
CCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHH
ALVSQIKSIEISVTRSETEALLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRVE
HHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHH
LYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCRDSYFKARSRPCLQYQIKRCT
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHC
APCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKNAVSQLNFEEAAVLRDQIKNL
HHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELD
HHHHHCCCCEEEECCCCEEEEEECCCCEEEEEEEECCCCEECCCCCCCCCCHHHHHCCCC
ANSLWQQTFEAFIGFYYLDTSERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRG
HHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCC
VKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALRQLLALDKNIERMECFDISHTQGEAT
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCE
VASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIGAQLLPDVLIIDGG
EEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQH
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEECCCCCHHHHHHHH
IRDEAHRFAITAHRKKRQKTRVESTLESIEGVGAKRRQALLQRFGGLRELAKASLEEICK
HHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
VQGISEQLAKRIYEHFHP
HCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTR
CCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHH
ALVSQIKSIEISVTRSETEALLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRVE
HHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHH
LYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCRDSYFKARSRPCLQYQIKRCT
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHC
APCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKNAVSQLNFEEAAVLRDQIKNL
HHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELD
HHHHHCCCCEEEECCCCEEEEEECCCCEEEEEEEECCCCEECCCCCCCCCCHHHHHCCCC
ANSLWQQTFEAFIGFYYLDTSERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRG
HHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCC
VKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALRQLLALDKNIERMECFDISHTQGEAT
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCE
VASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIGAQLLPDVLIIDGG
EEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQH
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEECCCCCHHHHHHHH
IRDEAHRFAITAHRKKRQKTRVESTLESIEGVGAKRRQALLQRFGGLRELAKASLEEICK
HHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
VQGISEQLAKRIYEHFHP
HCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA