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The map label for this gene is lprN [H]

Identifier: 54295351

GI number: 54295351

Start: 2778194

End: 2779756

Strand: Reverse

Name: lprN [H]

Synonym: lpl2436

Alternate gene names: 54295351

Gene position: 2779756-2778194 (Counterclockwise)

Preceding gene: 54295352

Following gene: 54295350

Centisome position: 83.08

GC content: 42.48

Gene sequence:

>1563_bases
CTGGTATACATGTTGAAAATCCTTGTTCTCTTAAGTTGTTTGATTCTAAGCTCCTGTCTGGTCGGGCCAAATTTTAAAGA
GCCTAAAAAAGATGCTGCCAATTATTGGCTTACTTCAAGCCCTGCAATAAAACAATCCGCCTTTCAAAATGCAAATTGGT
GGAAAGTCTTTAATGATCCCACTTTAACCGCATTAATCAATAATGGTTATCATAACAATCTCTCCTTGCAAATCGCAGGA
GTTCGCGTTTTGCAAGCAAGGGCACAGCTTGCTCAATCGGTTGGGGAGCTTTATCCCCAGCAGCAAGCTATGGTAGGAGA
TTATAATTATAATCGAATCGGGGGCAATCAATTACAAGGGCTTCTGCCCCCCGATTTTTTAACAGCCAGTCTTGGATTTT
CCGCAAGCTGGGAACTTGATTTTTGGGGAAAATACCGAAGAGCCATTCAATCTAATGATGCCCTGTTCCTTGCCTCTCTG
GCCGCTTATGATTCCGCATTGGTTACTCTCACGTCAGATATTGCCAGTACTTTTATTAAAATCCGCACCAGCGAAGAATT
AATCAAAGTAACAAAAGCGAATATCCAGGTACAGGCCATGAGTCTTAAAATCGCAAAGAACCGTTATTATGGTGGTCAAA
CCAGTTTACTGGATGTGGAACAAGCAGCAACAGAACTTGCGGAAACCCAAGCAAAACTGCCTCAATACGTCAGTGATCTC
CAACATCAAAAAGATATTTTGGCTGTATTGCTTGGCACCACTCCCGATAAAGTGGATGGCTTGCTCAAAAAAAATAAAGG
GATACCAAAAGCTTCGGCGGTAGTGGAAGTTGGAATTCCCAAAGAGGTGATAGCGCGAAGGCCGGATGTCTATCAAGCCA
GAATGGAGGCTATAGCCCAATCAGCCGCAATTGGCGCCGTGAAGGCTAATCTTTATCCCTCACTTTCATTAGTCGGGACT
TTTGTTTTTGCTTCAAATAATATCGGCAATTCTACCATTAGTGATATATTTAACTGGTCTAATCGCAATATAGTCGCAGG
CCCGTCATTGGCATGGTCTTTATTAAATTATGGTCAAATCACAAATGCGGTACGAGCTCAAGATGCTGCTTTCCAACAAG
CCTTGCTCAATTATCTTAATTTGGTGCTCAAAGTGCAGCAGGAAGTTCAAGACAATATTACGCGCTATGTTGAGGGGCAA
AAAACAGTCTCTTCACTTAAATCAGCCAATGCCTCTGCTATAGAATCAACAAGGCTTGCTTTAGTGCGATATAAGGAAGG
AGAGGCTAATTACACCACTGTATTGAATGCAGAACAGCAACAATTGCGAGTACAAACCTCGCTGGTCAATGCCACAGGTG
AGTTGGCTTTGTCTCTGGTTGGCTTATACCGCTCGCTTGGAGGCGGTTGGCAAATACGAGGCAAGAATGATATTGTTTCA
AATCAAATAAAAAGTGAAATGGCTGCCCGTACTAATTGGGGTAGTTTATTGAAGCAAGAAAATCATTTGCCTCCAGACTC
TAACGGACAACGAATGAAACAACTATATTTACCAACCTGGTGA

Upstream 100 bases:

>100_bases
TTCAATTGAGTATTCATAGATAATATCTAATGATTGATGAACCAATAGTTCAAATCCATCTTCAATCTACATAAGCTGCT
TTTGAACAGATAGGGAAATA

Downstream 100 bases:

>100_bases
TGAGAATGAACTCTCAAAATAAACAAAATTTAGTTAAAACCGTAGCAATTGTATTTTTTGGTATTGTCTTTGTTTATTTA
GTATATGACCATTTTACAAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MVYMLKILVLLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDPTLTALINNGYHNNLSLQIAG
VRVLQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLQGLLPPDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASL
AAYDSALVTLTSDIASTFIKIRTSEELIKVTKANIQVQAMSLKIAKNRYYGGQTSLLDVEQAATELAETQAKLPQYVSDL
QHQKDILAVLLGTTPDKVDGLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQSAAIGAVKANLYPSLSLVGT
FVFASNNIGNSTISDIFNWSNRNIVAGPSLAWSLLNYGQITNAVRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQ
KTVSSLKSANASAIESTRLALVRYKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVS
NQIKSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW

Sequences:

>Translated_520_residues
MVYMLKILVLLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDPTLTALINNGYHNNLSLQIAG
VRVLQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLQGLLPPDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASL
AAYDSALVTLTSDIASTFIKIRTSEELIKVTKANIQVQAMSLKIAKNRYYGGQTSLLDVEQAATELAETQAKLPQYVSDL
QHQKDILAVLLGTTPDKVDGLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQSAAIGAVKANLYPSLSLVGT
FVFASNNIGNSTISDIFNWSNRNIVAGPSLAWSLLNYGQITNAVRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQ
KTVSSLKSANASAIESTRLALVRYKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVS
NQIKSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW
>Mature_520_residues
MVYMLKILVLLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDPTLTALINNGYHNNLSLQIAG
VRVLQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLQGLLPPDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASL
AAYDSALVTLTSDIASTFIKIRTSEELIKVTKANIQVQAMSLKIAKNRYYGGQTSLLDVEQAATELAETQAKLPQYVSDL
QHQKDILAVLLGTTPDKVDGLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQSAAIGAVKANLYPSLSLVGT
FVFASNNIGNSTISDIFNWSNRNIVAGPSLAWSLLNYGQITNAVRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQ
KTVSSLKSANASAIESTRLALVRYKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVS
NQIKSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=472, Percent_Identity=23.9406779661017, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI2367348, Length=493, Percent_Identity=23.7322515212982, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 57167; Mature: 57167

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYMLKILVLLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDP
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCEECCCCHHHHHHHCCCCCEEEECCC
TLTALINNGYHNNLSLQIAGVRVLQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLQG
EEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCCCCCC
LLPPDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASLAAYDSALVTLTSDIASTFIK
CCCHHHHHHHCCCCEEECCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHEE
IRTSEELIKVTKANIQVQAMSLKIAKNRYYGGQTSLLDVEQAATELAETQAKLPQYVSDL
EECHHHHHHHHHCCEEEEEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
QHQKDILAVLLGTTPDKVDGLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQ
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHCEEEECCCHHHHHCCCHHHHHHHHHHHH
SAAIGAVKANLYPSLSLVGTFVFASNNIGNSTISDIFNWSNRNIVAGPSLAWSLLNYGQI
HHHHHHHHHCCCCCHHHHEEEEEECCCCCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHH
TNAVRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQKTVSSLKSANASAIESTRLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHEEE
LVRYKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVS
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHH
NQIKSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW
HHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MVYMLKILVLLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDP
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCEECCCCHHHHHHHCCCCCEEEECCC
TLTALINNGYHNNLSLQIAGVRVLQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLQG
EEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCCCCCC
LLPPDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASLAAYDSALVTLTSDIASTFIK
CCCHHHHHHHCCCCEEECCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHEE
IRTSEELIKVTKANIQVQAMSLKIAKNRYYGGQTSLLDVEQAATELAETQAKLPQYVSDL
EECHHHHHHHHHCCEEEEEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
QHQKDILAVLLGTTPDKVDGLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQ
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHCEEEECCCHHHHHCCCHHHHHHHHHHHH
SAAIGAVKANLYPSLSLVGTFVFASNNIGNSTISDIFNWSNRNIVAGPSLAWSLLNYGQI
HHHHHHHHHCCCCCHHHHEEEEEECCCCCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHH
TNAVRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQKTVSSLKSANASAIESTRLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHEEE
LVRYKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVS
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHH
NQIKSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW
HHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]