| Definition | Legionella pneumophila str. Lens, complete genome. |
|---|---|
| Accession | NC_006369 |
| Length | 3,345,687 |
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The map label for this gene is dfp [H]
Identifier: 54295323
GI number: 54295323
Start: 2738117
End: 2739313
Strand: Reverse
Name: dfp [H]
Synonym: lpl2408
Alternate gene names: 54295323
Gene position: 2739313-2738117 (Counterclockwise)
Preceding gene: 54295327
Following gene: 54295322
Centisome position: 81.88
GC content: 41.27
Gene sequence:
>1197_bases ATGCAAGATTTTATTAATAAAAAAATTCTACTTGGTATTTGTGGAGGCATTGCTGCTTATAAATCTGCTCATCTGGTTAG AGAATTGACTCGTTTGGGGGCTGATGTGAGGGTTGTCATGACTCATTCAGCACAACAGTTCATTAACCCTTTATTGATGC AGGCATTATCAGGCAATGAAGCGAGGATTGATTTATTCGATACTCAAGCTGAACGGGCTATGGGACATATTGAATTAGCC AGATGGGCAGATTATTTGCTCATTGCTCCTGCGTCCGCAAATTGTCTTGCTAAAATGGCTCAAGGTCTTGCTGATGATTT GCTTTCAACATTATACCTCGTTACTGAAACGCCAGTAATTGTTTGTCCTGCCATGAACAGAAGCATGTGGGCACATCCAG CAACCAAGGCAAATTGTGAATTGTTAAAAGAACGAGGCGTGTTTTTTGTCGGGCCTGAAGAAGGCTCCCAGGCTTGTGGG GAACATGGATTGGGAAGAGTCAGCGAGGCGGATCAAATTGTGAATACCTTGCGCTTACTGGATGTGAATCAACTATTGCA TGGCAAACGAATTGTGATTACTGCAGGCCCTACTCGCGAGTCGATTGATCCAGTTCGTTATTTAAGCAATTACAGTTCAG GGAAGATGGGTTTTGCAATGGCTGAAGCTGCTGCTATGGCAGGCGCACAAGTGACATTAATTAGTGGTCCTTGTCATTTA CAAACGTTTTCGGACATCGAGGTCATAAGAGTGGAGTCTGCTCAATCGATGCTGGAAGAAGTGAACAGGCATGTACAACA GGGAGATGTATTTATTGGAACAGCAGCAGTATCAGATTATAAAGTGCTGAATCCTGCTTCGGAAAAAATGAAAAAAAATG AGAATTCTGAACTCACTCTCCAGCTTGTTAGAAATACCGATATTCTTTCTGAAGTAGCTAAAAGTGGTAAAGCTTCCTTT GTTGTTGGGTTTGCAGCTGAAACAACTGATGTGATTTCCTATGCAAAAGAAAAAATGAAAAATAAAAAACTGGATATGAT TATCGCCAATCAGGTAGGTAGGGGAATGGGATTCGAAAGTGATGTAAATCAAGTAACAGTGATTACAAAAAACAAACAAA TAGAGCTGCCATTAACCCATAAAACACGCCTGGCAGGCCAAATTATTGCAATCCTTGCTGCAAGTCTGCAAAATTAG
Upstream 100 bases:
>100_bases TTGCGCTGTATGGGCAACCATCATTTTGTATTCCTTTTATATTCCTTTATTGCGAAGTTTGTGCTTTGATCGGAGTTATT CTTATCAAAAATGGCGAGCC
Downstream 100 bases:
>100_bases GCGCAATAAAACGATTGAGAATTATTATGCATCAAGTTATTCAGTTAAAAATTCTGGATTCAAGGATAGGAGATACCATT TCATTGCCTGCCTATGCCAC
Product: hypothetical protein
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 398; Mature: 398
Protein sequence:
>398_residues MQDFINKKILLGICGGIAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQALSGNEARIDLFDTQAERAMGHIELA RWADYLLIAPASANCLAKMAQGLADDLLSTLYLVTETPVIVCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACG EHGLGRVSEADQIVNTLRLLDVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISGPCHL QTFSDIEVIRVESAQSMLEEVNRHVQQGDVFIGTAAVSDYKVLNPASEKMKKNENSELTLQLVRNTDILSEVAKSGKASF VVGFAAETTDVISYAKEKMKNKKLDMIIANQVGRGMGFESDVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN
Sequences:
>Translated_398_residues MQDFINKKILLGICGGIAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQALSGNEARIDLFDTQAERAMGHIELA RWADYLLIAPASANCLAKMAQGLADDLLSTLYLVTETPVIVCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACG EHGLGRVSEADQIVNTLRLLDVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISGPCHL QTFSDIEVIRVESAQSMLEEVNRHVQQGDVFIGTAAVSDYKVLNPASEKMKKNENSELTLQLVRNTDILSEVAKSGKASF VVGFAAETTDVISYAKEKMKNKKLDMIIANQVGRGMGFESDVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN >Mature_398_residues MQDFINKKILLGICGGIAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQALSGNEARIDLFDTQAERAMGHIELA RWADYLLIAPASANCLAKMAQGLADDLLSTLYLVTETPVIVCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACG EHGLGRVSEADQIVNTLRLLDVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISGPCHL QTFSDIEVIRVESAQSMLEEVNRHVQQGDVFIGTAAVSDYKVLNPASEKMKKNENSELTLQLVRNTDILSEVAKSGKASF VVGFAAETTDVISYAKEKMKNKKLDMIIANQVGRGMGFESDVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=174, Percent_Identity=34.4827586206897, Blast_Score=104, Evalue=1e-22, Organism=Escherichia coli, GI87082301, Length=389, Percent_Identity=49.3573264781491, Blast_Score=333, Evalue=1e-92, Organism=Caenorhabditis elegans, GI17560194, Length=182, Percent_Identity=32.4175824175824, Blast_Score=82, Evalue=5e-16, Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=30.5699481865285, Blast_Score=83, Evalue=7e-17, Organism=Saccharomyces cerevisiae, GI6322925, Length=219, Percent_Identity=24.6575342465753, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24657262, Length=179, Percent_Identity=31.2849162011173, Blast_Score=81, Evalue=1e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 43282; Mature: 43282
Theoretical pI: Translated: 7.00; Mature: 7.00
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 3.8 %Met (Translated Protein) 5.3 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 3.8 %Met (Mature Protein) 5.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQDFINKKILLGICGGIAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQALSGNE CCCHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCC ARIDLFDTQAERAMGHIELARWADYLLIAPASANCLAKMAQGLADDLLSTLYLVTETPVI EEEEEECCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE VCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACGEHGLGRVSEADQIVNTLRLL EECCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHHHHHHHHHH DVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISGPCHL HHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCC QTFSDIEVIRVESAQSMLEEVNRHVQQGDVFIGTAAVSDYKVLNPASEKMKKNENSELTL CCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCHHHHHHCCCCCCEEE QLVRNTDILSEVAKSGKASFVVGFAAETTDVISYAKEKMKNKKLDMIIANQVGRGMGFES EEECCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCC DVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN CCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MQDFINKKILLGICGGIAAYKSAHLVRELTRLGADVRVVMTHSAQQFINPLLMQALSGNE CCCHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCC ARIDLFDTQAERAMGHIELARWADYLLIAPASANCLAKMAQGLADDLLSTLYLVTETPVI EEEEEECCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE VCPAMNRSMWAHPATKANCELLKERGVFFVGPEEGSQACGEHGLGRVSEADQIVNTLRLL EECCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHHHHHHHHHH DVNQLLHGKRIVITAGPTRESIDPVRYLSNYSSGKMGFAMAEAAAMAGAQVTLISGPCHL HHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCC QTFSDIEVIRVESAQSMLEEVNRHVQQGDVFIGTAAVSDYKVLNPASEKMKKNENSELTL CCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCHHHHHHCCCCCCEEE QLVRNTDILSEVAKSGKASFVVGFAAETTDVISYAKEKMKNKKLDMIIANQVGRGMGFES EEECCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCC DVNQVTVITKNKQIELPLTHKTRLAGQIIAILAASLQN CCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10952301 [H]