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The map label for this gene is ahpC [C]

Identifier: 54295192

GI number: 54295192

Start: 2590262

End: 2590801

Strand: Reverse

Name: ahpC [C]

Synonym: lpl2272

Alternate gene names: 54295192

Gene position: 2590801-2590262 (Counterclockwise)

Preceding gene: 54295194

Following gene: 54295191

Centisome position: 77.44

GC content: 39.81

Gene sequence:

>540_bases
ATGATTACGGTAGGCAACAAATTTCCAGAATTTCAACTTAAAGCAACAGTGGCCAATGATGTAAGTAATGCATTTCAAAT
GATCTCTAATGAAACGTATCAGGGTAAATGGTTAGTCGTATTTTTTTGGCCTAAAGATTTTACCTTTGTCTGCCCTACTG
AAATTGCGGAGTTTGGAAGGCTAAATTCCGAGTTTGCTGATCGAGATGCTCAAATTCTGGGTGGAAGCACAGACAGTGAA
TTTGTACACTTGGCCTGGAGAAATCAGCATCCAGACTTAAACAATTTACCATTTCCCATGCTGGCTGATGTTAAACGAGA
ATTGACAGCAAATTTGGGCATATTGGATGACGAGGAGGGAGTTGCCCAACGTGCGACATTTATTGTAGACCCTCAGGGAA
TTACTCGTTTTGTGATGGTTACGGATTTAAATGTAGGGCGCAATCCAGCTGAAGTATTACGTGTTCTGGATGCTTTACAG
ACCGATGAACTTTGTCCATGTAATTGGAAAAAAGGTGAAGAAACAATTCATATCAAATAA

Upstream 100 bases:

>100_bases
TTTATTTATCGTTTTGATAAAAACAATTGATTTTATTTATTTAGTGATTTCACCTAAATTTAACAATGAAAAGGGTGTTA
ATTTAATGAGGAGAAAACTT

Downstream 100 bases:

>100_bases
ATTAAAAAAAAGAGGCATCAATCATGTTAGAGAATGTTAAAGAAAGTATACCGGAAGTGGCTAAGGACATACGCTTGAAT
TTGACTAAGGTACTTGATCT

Product: hypothetical protein

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MITVGNKFPEFQLKATVANDVSNAFQMISNETYQGKWLVVFFWPKDFTFVCPTEIAEFGRLNSEFADRDAQILGGSTDSE
FVHLAWRNQHPDLNNLPFPMLADVKRELTANLGILDDEEGVAQRATFIVDPQGITRFVMVTDLNVGRNPAEVLRVLDALQ
TDELCPCNWKKGEETIHIK

Sequences:

>Translated_179_residues
MITVGNKFPEFQLKATVANDVSNAFQMISNETYQGKWLVVFFWPKDFTFVCPTEIAEFGRLNSEFADRDAQILGGSTDSE
FVHLAWRNQHPDLNNLPFPMLADVKRELTANLGILDDEEGVAQRATFIVDPQGITRFVMVTDLNVGRNPAEVLRVLDALQ
TDELCPCNWKKGEETIHIK
>Mature_179_residues
MITVGNKFPEFQLKATVANDVSNAFQMISNETYQGKWLVVFFWPKDFTFVCPTEIAEFGRLNSEFADRDAQILGGSTDSE
FVHLAWRNQHPDLNNLPFPMLADVKRELTANLGILDDEEGVAQRATFIVDPQGITRFVMVTDLNVGRNPAEVLRVLDALQ
TDELCPCNWKKGEETIHIK

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=180, Percent_Identity=43.3333333333333, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI4505591, Length=180, Percent_Identity=41.6666666666667, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI32455266, Length=180, Percent_Identity=41.6666666666667, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI32455264, Length=180, Percent_Identity=41.6666666666667, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI5802974, Length=163, Percent_Identity=39.2638036809816, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI32483377, Length=163, Percent_Identity=39.2638036809816, Blast_Score=130, Evalue=6e-31,
Organism=Homo sapiens, GI5453549, Length=163, Percent_Identity=40.4907975460123, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4758638, Length=192, Percent_Identity=32.2916666666667, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI33188454, Length=109, Percent_Identity=39.4495412844037, Blast_Score=81, Evalue=4e-16,
Organism=Escherichia coli, GI1786822, Length=157, Percent_Identity=37.5796178343949, Blast_Score=124, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17554494, Length=178, Percent_Identity=42.1348314606742, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193204376, Length=180, Percent_Identity=40.5555555555556, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32565831, Length=180, Percent_Identity=40.5555555555556, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25153706, Length=193, Percent_Identity=32.1243523316062, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323613, Length=181, Percent_Identity=41.9889502762431, Blast_Score=138, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=41.9889502762431, Blast_Score=138, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319407, Length=186, Percent_Identity=32.258064516129, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17738015, Length=166, Percent_Identity=43.9759036144578, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17157991, Length=163, Percent_Identity=43.558282208589, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24641739, Length=163, Percent_Identity=43.558282208589, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21357347, Length=183, Percent_Identity=35.5191256830601, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24656348, Length=175, Percent_Identity=37.1428571428571, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17864676, Length=175, Percent_Identity=37.1428571428571, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17975518, Length=161, Percent_Identity=36.0248447204969, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24652436, Length=161, Percent_Identity=36.0248447204969, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24652434, Length=161, Percent_Identity=36.0248447204969, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24581278, Length=184, Percent_Identity=29.8913043478261, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20262; Mature: 20262

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVGNKFPEFQLKATVANDVSNAFQMISNETYQGKWLVVFFWPKDFTFVCPTEIAEFGR
CCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEECCHHHHHHCC
LNSEFADRDAQILGGSTDSEFVHLAWRNQHPDLNNLPFPMLADVKRELTANLGILDDEEG
CCCHHHCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCC
VAQRATFIVDPQGITRFVMVTDLNVGRNPAEVLRVLDALQTDELCPCNWKKGEETIHIK
HHHHEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MITVGNKFPEFQLKATVANDVSNAFQMISNETYQGKWLVVFFWPKDFTFVCPTEIAEFGR
CCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEECCHHHHHHCC
LNSEFADRDAQILGGSTDSEFVHLAWRNQHPDLNNLPFPMLADVKRELTANLGILDDEEG
CCCHHHCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCC
VAQRATFIVDPQGITRFVMVTDLNVGRNPAEVLRVLDALQTDELCPCNWKKGEETIHIK
HHHHEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA