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The map label for this gene is hemE [H]

Identifier: 54294926

GI number: 54294926

Start: 2248174

End: 2249235

Strand: Reverse

Name: hemE [H]

Synonym: lpl2005

Alternate gene names: 54294926

Gene position: 2249235-2248174 (Counterclockwise)

Preceding gene: 54294928

Following gene: 54294924

Centisome position: 67.23

GC content: 40.87

Gene sequence:

>1062_bases
ATGATGTTTGATTTGAACCAATCCCTTTTTCTTCGAGCTTTGAGAAGACAACCTGTAGAGAGAACTCCAATCTGGATTAT
GCGCCAGGCTGGGCGTTATTTGCCTGAATATAGAAAAGTAAGAGAGTATGCTGGTGATTTTTTAAATCTTTGCAAGAATC
CGGAGCTCGCCTGTGAAGTAACCTTGCAACCGTTGCGTCGCTATGCTTTGGATGCAGCTATTTTATTTTCCGATATTTTA
ACAATACCTGATGCTATGGGGCTAGGGCTCTATTTTGCTGAAGGAGAAGGGCCTCGTTTCACAAATCCTTTACAAGATAC
CAAGGCAATTCATACCCTGAAGATTCCTTCCATTCCTGAATCTTTATCCTATGTTTTTGATGCTGCGCGCTTAATCCGCC
AGGAAATGCCTAAAGAATTACCTTTGATCGGATTTTCTGGTAGCCCATGGACTTTAGCTTGTTACATGGTTGAGGGCGGG
AGCAGTAGAGATTTTAAGCGAATTTTAAATTTAATATACACTGAAAAAGAAGCAGCGCACCTGTTATTGAGTAAATTGGC
TGCCTCTGTGACTGCTTATTTAATTGAGCAAATAAAGGCGGGGGTTAATGCGGTTATGATCTTTGATACGTGGGGGGGAG
TTTTAACTCCACAAAATTATAAGGATTTTTCTTTGGCATATATGCATCAAATTGTTCAGCAATTGAAAAAAGAATACCCT
GATATCCCTGTAATTTTATTTACCAAGAATGGTGGGCAATGGTTAGAATGGATGGCAGAAACTGGTTGTGATGCATTAGG
AGTTGACTGGACGTGTGATTTGGCTTCCGCGCGCAAGAGAGTAGGCGGAAAAGTCGCTTTACAAGGAAATCTGGATCCTG
CTGTTTTACTAACTACAAAAAATTGTATACGAAGTGAGGTTGGGAGTGTACTGGCATCTTATGGTTATGGAACAGGGCAT
ATCTTTAATTTGGGTCATGGTATTACTCCGGATGTACCCCCTGAGAATGTTGCAATAATGATTGAGGCGGTACATGAGAT
AAGTCCTCAATATCATTTGTAG

Upstream 100 bases:

>100_bases
GTGTCCTGTTTATATTGTTAAGTATCGATTGCTATTTATACCACTGTATTGATTACCTTAACATGATACTATAAACACTT
TTTATTGTGATAGTGATTAA

Downstream 100 bases:

>100_bases
TTTGTGCGAGGCAAAAATTATTGTTTCAAAATAGTGAAATGCCTCAAGAATAAGACAATCGTAATAGTACACGGGGTATG
CAAATTTTTCTTTTTATAAG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MMFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREYAGDFLNLCKNPELACEVTLQPLRRYALDAAILFSDIL
TIPDAMGLGLYFAEGEGPRFTNPLQDTKAIHTLKIPSIPESLSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGG
SSRDFKRILNLIYTEKEAAHLLLSKLAASVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYP
DIPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTKNCIRSEVGSVLASYGYGTGH
IFNLGHGITPDVPPENVAIMIEAVHEISPQYHL

Sequences:

>Translated_353_residues
MMFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREYAGDFLNLCKNPELACEVTLQPLRRYALDAAILFSDIL
TIPDAMGLGLYFAEGEGPRFTNPLQDTKAIHTLKIPSIPESLSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGG
SSRDFKRILNLIYTEKEAAHLLLSKLAASVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYP
DIPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTKNCIRSEVGSVLASYGYGTGH
IFNLGHGITPDVPPENVAIMIEAVHEISPQYHL
>Mature_353_residues
MMFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREYAGDFLNLCKNPELACEVTLQPLRRYALDAAILFSDIL
TIPDAMGLGLYFAEGEGPRFTNPLQDTKAIHTLKIPSIPESLSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGG
SSRDFKRILNLIYTEKEAAHLLLSKLAASVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYP
DIPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTKNCIRSEVGSVLASYGYGTGH
IFNLGHGITPDVPPENVAIMIEAVHEISPQYHL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=42.4501424501425, Blast_Score=290, Evalue=1e-78,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=63.7393767705383, Blast_Score=469, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6320252, Length=357, Percent_Identity=38.9355742296919, Blast_Score=262, Evalue=7e-71,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=39.4812680115274, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=39.4812680115274, Blast_Score=268, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39485; Mature: 39485

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREYAGDFLNLCKNPELACEV
CEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEE
TLQPLRRYALDAAILFSDILTIPDAMGLGLYFAEGEGPRFTNPLQDTKAIHTLKIPSIPE
EHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCHHHHHCEEEEECCCCCH
SLSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGGSSRDFKRILNLIYTEKEAAH
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHH
LLLSKLAASVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYP
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
DIPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTK
CCCEEEEECCCCHHHHHHHHCCCCCCCCCCEECHHHHHHHCCCEEEEECCCCCEEEEECH
NCIRSEVGSVLASYGYGTGHIFNLGHGITPDVPPENVAIMIEAVHEISPQYHL
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEHHHHHHHCCCCCCC
>Mature Secondary Structure
MMFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREYAGDFLNLCKNPELACEV
CEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEE
TLQPLRRYALDAAILFSDILTIPDAMGLGLYFAEGEGPRFTNPLQDTKAIHTLKIPSIPE
EHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCHHHHHCEEEEECCCCCH
SLSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGGSSRDFKRILNLIYTEKEAAH
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHH
LLLSKLAASVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYP
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
DIPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTK
CCCEEEEECCCCHHHHHHHHCCCCCCCCCCEECHHHHHHHCCCEEEEECCCCCEEEEECH
NCIRSEVGSVLASYGYGTGHIFNLGHGITPDVPPENVAIMIEAVHEISPQYHL
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA