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The map label for this gene is mltA [H]

Identifier: 54294891

GI number: 54294891

Start: 2211959

End: 2213149

Strand: Reverse

Name: mltA [H]

Synonym: lpl1970

Alternate gene names: 54294891

Gene position: 2213149-2211959 (Counterclockwise)

Preceding gene: 54294892

Following gene: 54294889

Centisome position: 66.15

GC content: 38.96

Gene sequence:

>1191_bases
ATGAAATCGAAATTAATTTATCTGACAGTAGCCTTGGCTGCAATTATATTAAGCGCAGCAGTGTGGTGGTGGTTGCAATC
TCCCAAGCCAACTTTCAGGCAGGTAAGCTTTAAGCATTTACCTGGGTGGGAGAATGCACAACTTAAAAAATCGTTAGAAA
CTTTTCAAACATCTTGTCGAGCCTTTCTAAAACAAAATCCTGAACGTGTTGTTGGCACAGAGCAGATTGATTTACAGGCA
AAAGATTGGCATCCAGCCTGTCGCGCTGCTTTAAAAATAAATCCTGTTGATGAACAATCATCAAAAGTATTTTTTGAGAA
GTGGTTTGCCCCTGTGGAATTCTATGATGATAAACCAGTAAAAGGTTTATTTACGGGCTATTATATGCCTTTAATTAAAG
GCAGTTATACCAAATCAGAGGAATTTAGTATTCCTATTTATGAACTACCCAGTAACTTAGTGACTGTTGACTTGGGTTTA
TTCCTTCCTAATTTAAAAAATAAGAAAATTATTGGACGAATTGCGGGTAATAAAGTTGTACCATTTTATACTCGAGAGGA
AATTAACAAAGGAGCAATTAAAAACACAGCACGTGTTTTGGTGTGGATCCATAGCCCTGTAGACAGGTTATTTTTAGAAA
TTCAGGGATCAGGAATCATTGAGCTTGAAGATGGCAAACGAATTTTTATAGGCTATGATGGTCAAAATGGTGCCCCCTAT
ACTGCCATTGCTGGAGTATTAATTAAAAAGGGTATTATGACCAAGCACAATGCTTCAATGCAAAGGATTAAAAAGTATCT
GGAAGCTCACCCCAAGCAAATGGATAAAATAATCAATCAAAATAAATCATTTGTTTTTTTCCGCAAGTTGTCATTAGAAG
CGGCTTTGGGTTCACAGGGTGTGGCATTAACACCCGGTTATTCTCTTGCTATTGATAAACAATGGATACCAATGGGAGCG
CCTCTGTGGTTAAACACTACAAGACCAGATAGTAAAAATCCTGACGTCAATAAACCTATGCAACGTTTGATGATAGCTCA
AGATACTGGTGGGGCTATTCGTGGTAAAGTAAGAGGTGATGTATTTTGGGGCGGTGGTGACAAAGCCACTTTGATTGCTG
GCCATATGAAGAACGAGGGGCATTATTGGCTTCTTCTGCCGGCTCATGCATTATCGCGCTTGGCACAGTAG

Upstream 100 bases:

>100_bases
AAAAAAACTATTATAACCGGATGTTTTTTGTAGTAAGATGGACTAATAACAATAATTTTTAGTTGCATTTTTCCCCATCA
CGTGTAAAAATTGACCTCCT

Downstream 100 bases:

>100_bases
AAGTAGGGGCGTAAGTTCTGTCTTTGCAATTTTTTATTTGGCTATTGGGATTCACCAGTCCTGTGACAATGAATCCCCGA
TAGCATTGTAAATCATTTGT

Product: hypothetical protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKSKLIYLTVALAAIILSAAVWWWLQSPKPTFRQVSFKHLPGWENAQLKKSLETFQTSCRAFLKQNPERVVGTEQIDLQA
KDWHPACRAALKINPVDEQSSKVFFEKWFAPVEFYDDKPVKGLFTGYYMPLIKGSYTKSEEFSIPIYELPSNLVTVDLGL
FLPNLKNKKIIGRIAGNKVVPFYTREEINKGAIKNTARVLVWIHSPVDRLFLEIQGSGIIELEDGKRIFIGYDGQNGAPY
TAIAGVLIKKGIMTKHNASMQRIKKYLEAHPKQMDKIINQNKSFVFFRKLSLEAALGSQGVALTPGYSLAIDKQWIPMGA
PLWLNTTRPDSKNPDVNKPMQRLMIAQDTGGAIRGKVRGDVFWGGGDKATLIAGHMKNEGHYWLLLPAHALSRLAQ

Sequences:

>Translated_396_residues
MKSKLIYLTVALAAIILSAAVWWWLQSPKPTFRQVSFKHLPGWENAQLKKSLETFQTSCRAFLKQNPERVVGTEQIDLQA
KDWHPACRAALKINPVDEQSSKVFFEKWFAPVEFYDDKPVKGLFTGYYMPLIKGSYTKSEEFSIPIYELPSNLVTVDLGL
FLPNLKNKKIIGRIAGNKVVPFYTREEINKGAIKNTARVLVWIHSPVDRLFLEIQGSGIIELEDGKRIFIGYDGQNGAPY
TAIAGVLIKKGIMTKHNASMQRIKKYLEAHPKQMDKIINQNKSFVFFRKLSLEAALGSQGVALTPGYSLAIDKQWIPMGA
PLWLNTTRPDSKNPDVNKPMQRLMIAQDTGGAIRGKVRGDVFWGGGDKATLIAGHMKNEGHYWLLLPAHALSRLAQ
>Mature_396_residues
MKSKLIYLTVALAAIILSAAVWWWLQSPKPTFRQVSFKHLPGWENAQLKKSLETFQTSCRAFLKQNPERVVGTEQIDLQA
KDWHPACRAALKINPVDEQSSKVFFEKWFAPVEFYDDKPVKGLFTGYYMPLIKGSYTKSEEFSIPIYELPSNLVTVDLGL
FLPNLKNKKIIGRIAGNKVVPFYTREEINKGAIKNTARVLVWIHSPVDRLFLEIQGSGIIELEDGKRIFIGYDGQNGAPY
TAIAGVLIKKGIMTKHNASMQRIKKYLEAHPKQMDKIINQNKSFVFFRKLSLEAALGSQGVALTPGYSLAIDKQWIPMGA
PLWLNTTRPDSKNPDVNKPMQRLMIAQDTGGAIRGKVRGDVFWGGGDKATLIAGHMKNEGHYWLLLPAHALSRLAQ

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Note=In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=267, Percent_Identity=32.9588014981273, Blast_Score=128, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44567; Mature: 44567

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKLIYLTVALAAIILSAAVWWWLQSPKPTFRQVSFKHLPGWENAQLKKSLETFQTSCR
CCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHCCCCCCCHHHHHHHHHHHHHHH
AFLKQNPERVVGTEQIDLQAKDWHPACRAALKINPVDEQSSKVFFEKWFAPVEFYDDKPV
HHHHCCCCCCCCCEEEEEEECCCCHHHHEEEEECCCCCCHHHHHHHHHCCCEEECCCCCC
KGLFTGYYMPLIKGSYTKSEEFSIPIYELPSNLVTVDLGLFLPNLKNKKIIGRIAGNKVV
CHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCEEEEEEEHCCCCCCCCEEEEEECCCEEE
PFYTREEINKGAIKNTARVLVWIHSPVDRLFLEIQGSGIIELEDGKRIFIGYDGQNGAPY
EEEEHHHCCCCCCCCCEEEEEEEECCCCEEEEEECCCEEEEEECCCEEEEEECCCCCCCH
TAIAGVLIKKGIMTKHNASMQRIKKYLEAHPKQMDKIINQNKSFVFFRKLSLEAALGSQG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCEEEEEEEEHHHHCCCCC
VALTPGYSLAIDKQWIPMGAPLWLNTTRPDSKNPDVNKPMQRLMIAQDTGGAIRGKVRGD
EEECCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHEEEECCCCEEEEEEEEE
VFWGGGDKATLIAGHMKNEGHYWLLLPAHALSRLAQ
EEECCCCCEEEEEEEECCCCCEEEEECHHHHHHHCC
>Mature Secondary Structure
MKSKLIYLTVALAAIILSAAVWWWLQSPKPTFRQVSFKHLPGWENAQLKKSLETFQTSCR
CCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHCCCCCCCHHHHHHHHHHHHHHH
AFLKQNPERVVGTEQIDLQAKDWHPACRAALKINPVDEQSSKVFFEKWFAPVEFYDDKPV
HHHHCCCCCCCCCEEEEEEECCCCHHHHEEEEECCCCCCHHHHHHHHHCCCEEECCCCCC
KGLFTGYYMPLIKGSYTKSEEFSIPIYELPSNLVTVDLGLFLPNLKNKKIIGRIAGNKVV
CHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCEEEEEEEHCCCCCCCCEEEEEECCCEEE
PFYTREEINKGAIKNTARVLVWIHSPVDRLFLEIQGSGIIELEDGKRIFIGYDGQNGAPY
EEEEHHHCCCCCCCCCEEEEEEEECCCCEEEEEECCCEEEEEECCCEEEEEECCCCCCCH
TAIAGVLIKKGIMTKHNASMQRIKKYLEAHPKQMDKIINQNKSFVFFRKLSLEAALGSQG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCEEEEEEEEHHHHCCCCC
VALTPGYSLAIDKQWIPMGAPLWLNTTRPDSKNPDVNKPMQRLMIAQDTGGAIRGKVRGD
EEECCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHEEEECCCCEEEEEEEEE
VFWGGGDKATLIAGHMKNEGHYWLLLPAHALSRLAQ
EEECCCCCEEEEEEEECCCCCEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]