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The map label for this gene is lon [H]

Identifier: 54294746

GI number: 54294746

Start: 2038395

End: 2040845

Strand: Reverse

Name: lon [H]

Synonym: lpl1823

Alternate gene names: 54294746

Gene position: 2040845-2038395 (Counterclockwise)

Preceding gene: 54294747

Following gene: 54294745

Centisome position: 61.0

GC content: 39.53

Gene sequence:

>2451_bases
ATGTCTAATGAAAATGAAATAATATCAAATGAGACTGTGAAATCTTCTGCTTTGCCTGTATTACCATTGAGGGACGTAGT
CGTCTATCCGCATATGGTAATACCTCTCTTTGTTGGGCGTGGCAAGTCAATTAAAGCTCTTGAAGCTGCGATGATTGATA
ATAAACAAATTTTTTTAGTTGCACAGCGTAAATCGGCGCATGATGATCCTGGCCCAGAAGATATCTATCAAGTGGGAACT
GTATCCAGTGTTTTGCAATTGTTAAAGTTACCTGACGGAACTGTAAAAGTTCTTGTTGAAGGTGAGCAGCGTGCACGTGT
CAAGGAGTATGCTCAGGATAAAGGTTACCTCGAAGCGACACTTGAATACATTGAGGAAGTTGGCTCAACAATTCAAGAGC
AAGAAATTGGAATTCTAATGCGGTCCTTGATGTCGCAATTTGAACAATATATAAAGCTTAATAAGAAAATTCCACCAGAA
GTCTTGTCACCATTGGCAGGAATAGAAGAGCCAGGTCGACTGGCAGATACCATTGCCGCACATTTAACGCTTAAAGTAGA
TGATAAGCAAGAGTTGCTTGAAACTATGGATGTAGGAACTCGACTTGAGAAATTAATGGCGGCGATAGAAAATGAAATTG
ATCTGTTACATGTTGAAAAACGTGTAAGAGGTCGAGTCAAACGTCAAATGGAAAAAAGCCAGAGAGAATACTATCTAAAC
GAACAAATCAAAGCTATTCAGAAAGAATTAGGGGAAATGGGTGAGGAAGGCAATGAGATTGAACAATTGGAAAATTCAAT
CAAAAAGGCCGGAATGCCGAAAGAAGCTAAAGAAAAATCATTAGCAGAGTTACATAAATTAAAAATGATGTCTCCCATGT
CTGCTGAAGCAACTGTTATTCGTAATTATCTTGATTGGATGCTGATGGTCCCATGGAAGAAGCGGACCAAAATTCAGTTT
GATTTACTAAAAGCAGAAAAGCTGCTCGATAAGGAGCATCATGGTCTGGAGCAGGTTAAAGAGCGTATCATCGAATATCT
TGCTGTACAACAACGAGTAAAAAGATTGAAAGGACCGATATTGTGTTTAGTAGGCCCTCCGGGAGTAGGTAAAACTTCTC
TTGGACAATCTATCGCCAATGCTACTGGAAGAACTTTCATACGCATCGCTCTGGGTGGGGTAAGAGATGAAGCAGAAATT
CGTGGTCATCGAAGAACATATATAGGTTCCATGCCAGGTAAAATTATCCAAAAATTATGCAAGGCAGGAGTTAAAAATCC
TCTTATCATGCTGGATGAAGTAGATAAGATGGCAATGGATTTTCGTGGTGATCCGGCATCGGCATTACTGGAAGTATTGG
ATCCTGAACAGAACCATACATTTAGTGATCATTACTTGGAAGTTGATTATGACTTGAGTGATGTTATGTTTATTGCAACT
GCCAATTCGCTAGAAATTCCAGCCCCGTTATTGGATAGAATGGAAGTTATTCGCTTGCCTGGATATACTGAGGACGAAAA
AGTCAGTATTGCTGAAAAATATTTGGTTCCCAAACAAATGCTGCTAAATGGTTTAACCAATGAAGAAATCCATATTAGCG
AAGGGGCTATTAGAGATATCATACGTTATTATACTCGAGAGGCTGGAGTACGTAATCTTGAAAGGGATATAGCGAGTATA
TGCAGAAAAGTTGTTAAAGAAATACTCTCAAGCAAAAAAGGAAAAAAAGGAAAAACAATCAGTATAACTGTTAGCAACAT
TACTAAGTATTTGGGCGTTAAAAAGTATCGTTATGGATTAGCTGAGCAATATGATCAGATAGGTCAAGTCACTGGTTTAG
CCTGGACAAGTGTTGGAGGTGAACTTCTGACTATAGAAGCATCCATTATGCCAGGTAAGGGTAAAGTTACTCATACTGGT
CAGCTTGGTGAGGTAATGCAAGAATCTATCCATGCAGCTATGACGGTAGTAAGAAGCCGCGCTAAAGCTTTTGGGTTGCC
AGATGATTTTTATGAGAAACATGATTTTCATGTTCATGTACCAGAAGGTGCAACACCCAAAGATGGCCCAAGCGCTGGTA
TAGGAATGTGCACGGTACTAGTCTCCATAGTAACACAAATCCCAGTTAAGGCAGATGTCGCCATGACCGGTGAAATTACT
CTGCGTGGGCAAGTTTTACCAATTGGAGGATTAAAAGAAAAATTGCTGGCTGCACATCGTGGTGGAATCAAGCATGTCAT
TATCCCCGAGGAGAATGTAAAAGACCTTGAGGAAATCCCTGATAATGTGCTCCGTAAGCTGACAATTCATCCTGTTAACA
CCATTGAACAGGTTTTGGAACTGGCTTTGCAACGCAATCCATGGGTGGAAGAGCCAACAAATATACAACCTGGCACTATA
TTGAATAAAAAATCAAAAAAAATTAAAAATAATGATTTACACGCACATTAA

Upstream 100 bases:

>100_bases
CTCATATTACGAATTGTTCACCAGCACCAATATCTGTATACTCGTAAGAAATAGTATAAGAAACTATAACCAAGAAATTT
TCCTTTGAATAAGGGTCATT

Downstream 100 bases:

>100_bases
TACAGAGTATATTTCTCTTCGTGGCCCGCTACTGGCGGGCTCTGCAAGGATGTACGAACTTGACTGGAGCAGTTGAATCT
GTTTAAATCAGCTCCGGAAT

Product: hypothetical protein

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 816; Mature: 815

Protein sequence:

>816_residues
MSNENEIISNETVKSSALPVLPLRDVVVYPHMVIPLFVGRGKSIKALEAAMIDNKQIFLVAQRKSAHDDPGPEDIYQVGT
VSSVLQLLKLPDGTVKVLVEGEQRARVKEYAQDKGYLEATLEYIEEVGSTIQEQEIGILMRSLMSQFEQYIKLNKKIPPE
VLSPLAGIEEPGRLADTIAAHLTLKVDDKQELLETMDVGTRLEKLMAAIENEIDLLHVEKRVRGRVKRQMEKSQREYYLN
EQIKAIQKELGEMGEEGNEIEQLENSIKKAGMPKEAKEKSLAELHKLKMMSPMSAEATVIRNYLDWMLMVPWKKRTKIQF
DLLKAEKLLDKEHHGLEQVKERIIEYLAVQQRVKRLKGPILCLVGPPGVGKTSLGQSIANATGRTFIRIALGGVRDEAEI
RGHRRTYIGSMPGKIIQKLCKAGVKNPLIMLDEVDKMAMDFRGDPASALLEVLDPEQNHTFSDHYLEVDYDLSDVMFIAT
ANSLEIPAPLLDRMEVIRLPGYTEDEKVSIAEKYLVPKQMLLNGLTNEEIHISEGAIRDIIRYYTREAGVRNLERDIASI
CRKVVKEILSSKKGKKGKTISITVSNITKYLGVKKYRYGLAEQYDQIGQVTGLAWTSVGGELLTIEASIMPGKGKVTHTG
QLGEVMQESIHAAMTVVRSRAKAFGLPDDFYEKHDFHVHVPEGATPKDGPSAGIGMCTVLVSIVTQIPVKADVAMTGEIT
LRGQVLPIGGLKEKLLAAHRGGIKHVIIPEENVKDLEEIPDNVLRKLTIHPVNTIEQVLELALQRNPWVEEPTNIQPGTI
LNKKSKKIKNNDLHAH

Sequences:

>Translated_816_residues
MSNENEIISNETVKSSALPVLPLRDVVVYPHMVIPLFVGRGKSIKALEAAMIDNKQIFLVAQRKSAHDDPGPEDIYQVGT
VSSVLQLLKLPDGTVKVLVEGEQRARVKEYAQDKGYLEATLEYIEEVGSTIQEQEIGILMRSLMSQFEQYIKLNKKIPPE
VLSPLAGIEEPGRLADTIAAHLTLKVDDKQELLETMDVGTRLEKLMAAIENEIDLLHVEKRVRGRVKRQMEKSQREYYLN
EQIKAIQKELGEMGEEGNEIEQLENSIKKAGMPKEAKEKSLAELHKLKMMSPMSAEATVIRNYLDWMLMVPWKKRTKIQF
DLLKAEKLLDKEHHGLEQVKERIIEYLAVQQRVKRLKGPILCLVGPPGVGKTSLGQSIANATGRTFIRIALGGVRDEAEI
RGHRRTYIGSMPGKIIQKLCKAGVKNPLIMLDEVDKMAMDFRGDPASALLEVLDPEQNHTFSDHYLEVDYDLSDVMFIAT
ANSLEIPAPLLDRMEVIRLPGYTEDEKVSIAEKYLVPKQMLLNGLTNEEIHISEGAIRDIIRYYTREAGVRNLERDIASI
CRKVVKEILSSKKGKKGKTISITVSNITKYLGVKKYRYGLAEQYDQIGQVTGLAWTSVGGELLTIEASIMPGKGKVTHTG
QLGEVMQESIHAAMTVVRSRAKAFGLPDDFYEKHDFHVHVPEGATPKDGPSAGIGMCTVLVSIVTQIPVKADVAMTGEIT
LRGQVLPIGGLKEKLLAAHRGGIKHVIIPEENVKDLEEIPDNVLRKLTIHPVNTIEQVLELALQRNPWVEEPTNIQPGTI
LNKKSKKIKNNDLHAH
>Mature_815_residues
SNENEIISNETVKSSALPVLPLRDVVVYPHMVIPLFVGRGKSIKALEAAMIDNKQIFLVAQRKSAHDDPGPEDIYQVGTV
SSVLQLLKLPDGTVKVLVEGEQRARVKEYAQDKGYLEATLEYIEEVGSTIQEQEIGILMRSLMSQFEQYIKLNKKIPPEV
LSPLAGIEEPGRLADTIAAHLTLKVDDKQELLETMDVGTRLEKLMAAIENEIDLLHVEKRVRGRVKRQMEKSQREYYLNE
QIKAIQKELGEMGEEGNEIEQLENSIKKAGMPKEAKEKSLAELHKLKMMSPMSAEATVIRNYLDWMLMVPWKKRTKIQFD
LLKAEKLLDKEHHGLEQVKERIIEYLAVQQRVKRLKGPILCLVGPPGVGKTSLGQSIANATGRTFIRIALGGVRDEAEIR
GHRRTYIGSMPGKIIQKLCKAGVKNPLIMLDEVDKMAMDFRGDPASALLEVLDPEQNHTFSDHYLEVDYDLSDVMFIATA
NSLEIPAPLLDRMEVIRLPGYTEDEKVSIAEKYLVPKQMLLNGLTNEEIHISEGAIRDIIRYYTREAGVRNLERDIASIC
RKVVKEILSSKKGKKGKTISITVSNITKYLGVKKYRYGLAEQYDQIGQVTGLAWTSVGGELLTIEASIMPGKGKVTHTGQ
LGEVMQESIHAAMTVVRSRAKAFGLPDDFYEKHDFHVHVPEGATPKDGPSAGIGMCTVLVSIVTQIPVKADVAMTGEITL
RGQVLPIGGLKEKLLAAHRGGIKHVIIPEENVKDLEEIPDNVLRKLTIHPVNTIEQVLELALQRNPWVEEPTNIQPGTIL
NKKSKKIKNNDLHAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=764, Percent_Identity=40.0523560209424, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=667, Percent_Identity=40.1799100449775, Blast_Score=496, Evalue=1e-140,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=68.8311688311688, Blast_Score=1068, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=660, Percent_Identity=40.3030303030303, Blast_Score=473, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17556486, Length=542, Percent_Identity=41.8819188191882, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=694, Percent_Identity=40.2017291066282, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24666867, Length=629, Percent_Identity=42.6073131955485, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI221513036, Length=629, Percent_Identity=42.6073131955485, Blast_Score=499, Evalue=1e-141,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91214; Mature: 91083

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNENEIISNETVKSSALPVLPLRDVVVYPHMVIPLFVGRGKSIKALEAAMIDNKQIFLV
CCCCCCCCCCCCHHHCCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHCCCCEEEEE
AQRKSAHDDPGPEDIYQVGTVSSVLQLLKLPDGTVKVLVEGEQRARVKEYAQDKGYLEAT
EECCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCHHHHH
LEYIEEVGSTIQEQEIGILMRSLMSQFEQYIKLNKKIPPEVLSPLAGIEEPGRLADTIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHH
HLTLKVDDKQELLETMDVGTRLEKLMAAIENEIDLLHVEKRVRGRVKRQMEKSQREYYLN
HEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQIKAIQKELGEMGEEGNEIEQLENSIKKAGMPKEAKEKSLAELHKLKMMSPMSAEATVI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
RNYLDWMLMVPWKKRTKIQFDLLKAEKLLDKEHHGLEQVKERIIEYLAVQQRVKRLKGPI
HHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCE
LCLVGPPGVGKTSLGQSIANATGRTFIRIALGGVRDEAEIRGHRRTYIGSMPGKIIQKLC
EEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCHHHHCCCCCHHHHHHHH
KAGVKNPLIMLDEVDKMAMDFRGDPASALLEVLDPEQNHTFSDHYLEVDYDLSDVMFIAT
HCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEE
ANSLEIPAPLLDRMEVIRLPGYTEDEKVSIAEKYLVPKQMLLNGLTNEEIHISEGAIRDI
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCCCEEECCHHHHHH
IRYYTREAGVRNLERDIASICRKVVKEILSSKKGKKGKTISITVSNITKYLGVKKYRYGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
AEQYDQIGQVTGLAWTSVGGELLTIEASIMPGKGKVTHTGQLGEVMQESIHAAMTVVRSR
HHHHHHHHHHHCCCHHCCCCEEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHH
AKAFGLPDDFYEKHDFHVHVPEGATPKDGPSAGIGMCTVLVSIVTQIPVKADVAMTGEIT
HHHCCCCHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECEEE
LRGQVLPIGGLKEKLLAAHRGGIKHVIIPEENVKDLEEIPDNVLRKLTIHPVNTIEQVLE
EEEEEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHEECCCHHHHHHHHH
LALQRNPWVEEPTNIQPGTILNKKSKKIKNNDLHAH
HHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SNENEIISNETVKSSALPVLPLRDVVVYPHMVIPLFVGRGKSIKALEAAMIDNKQIFLV
CCCCCCCCCCCHHHCCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHCCCCEEEEE
AQRKSAHDDPGPEDIYQVGTVSSVLQLLKLPDGTVKVLVEGEQRARVKEYAQDKGYLEAT
EECCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCHHHHH
LEYIEEVGSTIQEQEIGILMRSLMSQFEQYIKLNKKIPPEVLSPLAGIEEPGRLADTIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHH
HLTLKVDDKQELLETMDVGTRLEKLMAAIENEIDLLHVEKRVRGRVKRQMEKSQREYYLN
HEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQIKAIQKELGEMGEEGNEIEQLENSIKKAGMPKEAKEKSLAELHKLKMMSPMSAEATVI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
RNYLDWMLMVPWKKRTKIQFDLLKAEKLLDKEHHGLEQVKERIIEYLAVQQRVKRLKGPI
HHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCE
LCLVGPPGVGKTSLGQSIANATGRTFIRIALGGVRDEAEIRGHRRTYIGSMPGKIIQKLC
EEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCHHHHCCCCCHHHHHHHH
KAGVKNPLIMLDEVDKMAMDFRGDPASALLEVLDPEQNHTFSDHYLEVDYDLSDVMFIAT
HCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEE
ANSLEIPAPLLDRMEVIRLPGYTEDEKVSIAEKYLVPKQMLLNGLTNEEIHISEGAIRDI
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCCCEEECCHHHHHH
IRYYTREAGVRNLERDIASICRKVVKEILSSKKGKKGKTISITVSNITKYLGVKKYRYGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
AEQYDQIGQVTGLAWTSVGGELLTIEASIMPGKGKVTHTGQLGEVMQESIHAAMTVVRSR
HHHHHHHHHHHCCCHHCCCCEEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHH
AKAFGLPDDFYEKHDFHVHVPEGATPKDGPSAGIGMCTVLVSIVTQIPVKADVAMTGEIT
HHHCCCCHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECEEE
LRGQVLPIGGLKEKLLAAHRGGIKHVIIPEENVKDLEEIPDNVLRKLTIHPVNTIEQVLE
EEEEEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHEECCCHHHHHHHHH
LALQRNPWVEEPTNIQPGTILNKKSKKIKNNDLHAH
HHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]