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The map label for this gene is hemF [H]

Identifier: 54294159

GI number: 54294159

Start: 1364031

End: 1364960

Strand: Reverse

Name: hemF [H]

Synonym: lpl1223

Alternate gene names: 54294159

Gene position: 1364960-1364031 (Counterclockwise)

Preceding gene: 54294174

Following gene: 54294155

Centisome position: 40.8

GC content: 41.18

Gene sequence:

>930_bases
ATGCCAATCTCGAAGACACTTCCTTATAATGCGATAGAACAAATTAAATCTTATCTGCTCCAACTCCAAAATACAATTTG
TGTCTCACTGGAGTCAATTGATGGCCAAACCAAATTCCATGAGGATTCCTGGCAGCGAGCTGCTGGAGGCGGAGGAAAAA
CAAGAATAATGGCGAATGGGAATGTCTTTGAAAAAGCCGGCGTAAATTTTTCACATGTTTCAGGGGAACAATTACCAGCA
TCAGCCAGTGCACATAGAGAAGAATTGGCAGGAAGACATTTCAGCGCATTAGGGGTATCTCTGGTAATTCATCCTCAAAA
CCCCTATGTGCCAACAACACATGCCAATGTTCGGTTTTTTGTCGCTGAAAAGGAGGATTCTGAACCAGTCTGGTGGTTTG
GTGGAGGATTTGATTTAACCCCTTATTATGGATTTATTGAAGACTGTGAGCATTGGCATCAAACGGCATTAAATGCCTGT
TTACCTTTTGGAGAAACGATTTACCCAAAATTCAAGCGTTGGTGCGATGATTATTTTTTTATTAAGCACAGAAATGAAGC
ACGTGGGATTGGCGGCTTATTTTTTGATGATTACAATGAAATCAGCTTTGATCACAGCTTTGAACTCATGCGTAGCATAG
GCGATCATTTTATTCTGGCTTATGAACCCATAGTGGCTCGCCGTAAAGACATCCCTTTTGGCAACAGAGAAAAAGCATTT
CAGAATTACCGCAGAGGCCGTTATGCGGAGTTCAATTTAGTCTATGATCGGGGCACTTTATTTGGTCTTCAATCTGGCGG
AAGGACTGAGTCCATATTGATGTCCCTGCCTCCCATTGTTCATTGGGAATACAATTGGCATCCTGAAAAAGGCAGTAATG
AAGAAAAATTATACACAGATTTTTTACCTGCAAAAGATTGGTTGAAATAG

Upstream 100 bases:

>100_bases
AATAAAAAAATCCTATTTAAACAAAGCAAACATTGTGCCAATATCCAAAAAATGAGAAAATGAAGCACCCAAGCGCTAAT
TCCCTATGCGGAGTCTCATC

Downstream 100 bases:

>100_bases
GAGTAAAACACCAAACTCAAAAATAACTGATGTCCTTCTCCCCTTCCCCTACCTGAAAATTTTGAGAAGCCAGTATACAT
GCAGTAAATGAACACCGCGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGQTKFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSGEQLPA
SASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFIEDCEHWHQTALNAC
LPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAF
QNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSNEEKLYTDFLPAKDWLK

Sequences:

>Translated_309_residues
MPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGQTKFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSGEQLPA
SASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFIEDCEHWHQTALNAC
LPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAF
QNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSNEEKLYTDFLPAKDWLK
>Mature_308_residues
PISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGQTKFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSGEQLPAS
ASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFIEDCEHWHQTALNACL
PFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAFQ
NYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSNEEKLYTDFLPAKDWLK

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=310, Percent_Identity=43.8709677419355, Blast_Score=269, Evalue=2e-72,
Organism=Escherichia coli, GI1788777, Length=295, Percent_Identity=65.0847457627119, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320249, Length=316, Percent_Identity=45.253164556962, Blast_Score=271, Evalue=7e-74,
Organism=Drosophila melanogaster, GI17864388, Length=308, Percent_Identity=48.0519480519481, Blast_Score=279, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35548; Mature: 35417

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGQTKFHEDSWQRAAGGGGKTRIMANG
CCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECC
NVFEKAGVNFSHVSGEQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFF
CEEHHCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCEEEE
VAEKEDSEPVWWFGGGFDLTPYYGFIEDCEHWHQTALNACLPFGETIYPKFKRWCDDYFF
EEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEE
IKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAF
EEECCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEECHHHHHCCCCCCCCHHHHH
QNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSNEEKLYTD
HHHHCCCEEEEEEEEECCEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCCEEHH
FLPAKDWLK
CCCCHHHCC
>Mature Secondary Structure 
PISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGQTKFHEDSWQRAAGGGGKTRIMANG
CCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECC
NVFEKAGVNFSHVSGEQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFF
CEEHHCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCEEEE
VAEKEDSEPVWWFGGGFDLTPYYGFIEDCEHWHQTALNACLPFGETIYPKFKRWCDDYFF
EEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEE
IKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAF
EEECCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEECHHHHHCCCCCCCCHHHHH
QNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSNEEKLYTD
HHHHCCCEEEEEEEEECCEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCCEEHH
FLPAKDWLK
CCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA