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The map label for this gene is hisI [H]

Identifier: 54294137

GI number: 54294137

Start: 1344301

End: 1344924

Strand: Reverse

Name: hisI [H]

Synonym: lpl1201

Alternate gene names: 54294137

Gene position: 1344924-1344301 (Counterclockwise)

Preceding gene: 54294138

Following gene: 54294133

Centisome position: 40.2

GC content: 37.34

Gene sequence:

>624_bases
ATGAGTGACTTGGACATTAACTCTCTTGATTGGCAAAAAATGAATGGACTATTGCCGGCAATAATCCAAAACGCAGAAAA
TGGTAAAGTATTGATGCTAGGTTATATGAATCAGGAAGCATTAATTGCCACACTAACTACAGGACAATTGACCTTATACA
GCAGAAGTCGGAAAAGACTATGGCGTAAGGGAGAGTCTTCCGGCAATAGTATGGCTCTGCAACATATTAGTGCCGATTGC
GACAATGACAGTCTTTTGATCCAGGTTATTCCTAAAGGTCCCGCTTGTCATTTAGGTTATTCAACCTGCTATCAGCCACA
TAATAATTATACTCTTGGTTTTCTTGATGGTTTGATTGAATTAATTAATGAACGTGCTGAGGAAAAAAATCCAAACAGTT
ATACTGCTCAACTCTTGGATTCTGGTGTGAACCGATGTGCTCAAAAATTAGGAGAAGAGGCGGTAGAAACAGTGATCGCT
GCTGTGAGTAACAATAAAGAAGAACTTATCAACGAAACGTCTGATTTAATTTATCATTTATTAGTGCTTCTCAAAGCTTG
TGAATTAAGTTTTTACGATGTTTTATTGTGTTTACAGGCAAGAGACAGAAGTGTACATACTTAA

Upstream 100 bases:

>100_bases
GTGTCAGTGGGGCTTTGGCAGCAAGCGTTTTTCATGACAAAATACTTGCAATCAATGACATAAAACTAGCATTACAAACA
GAAAATATTGAGGTAAGACT

Downstream 100 bases:

>100_bases
TTGCTTATTCCATAGAAGATCTCTATAACCAGAATCCCCAGTAATTATCAATCAAGACTAGTTAATTTTTTAAACTACTA
TTAAGAAATTAACTTTTCTT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSDLDINSLDWQKMNGLLPAIIQNAENGKVLMLGYMNQEALIATLTTGQLTLYSRSRKRLWRKGESSGNSMALQHISADC
DNDSLLIQVIPKGPACHLGYSTCYQPHNNYTLGFLDGLIELINERAEEKNPNSYTAQLLDSGVNRCAQKLGEEAVETVIA
AVSNNKEELINETSDLIYHLLVLLKACELSFYDVLLCLQARDRSVHT

Sequences:

>Translated_207_residues
MSDLDINSLDWQKMNGLLPAIIQNAENGKVLMLGYMNQEALIATLTTGQLTLYSRSRKRLWRKGESSGNSMALQHISADC
DNDSLLIQVIPKGPACHLGYSTCYQPHNNYTLGFLDGLIELINERAEEKNPNSYTAQLLDSGVNRCAQKLGEEAVETVIA
AVSNNKEELINETSDLIYHLLVLLKACELSFYDVLLCLQARDRSVHT
>Mature_206_residues
SDLDINSLDWQKMNGLLPAIIQNAENGKVLMLGYMNQEALIATLTTGQLTLYSRSRKRLWRKGESSGNSMALQHISADCD
NDSLLIQVIPKGPACHLGYSTCYQPHNNYTLGFLDGLIELINERAEEKNPNSYTAQLLDSGVNRCAQKLGEEAVETVIAA
VSNNKEELINETSDLIYHLLVLLKACELSFYDVLLCLQARDRSVHT

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=193, Percent_Identity=50.259067357513, Blast_Score=192, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319819, Length=167, Percent_Identity=34.7305389221557, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23047; Mature: 22915

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLDINSLDWQKMNGLLPAIIQNAENGKVLMLGYMNQEALIATLTTGQLTLYSRSRKRL
CCCCCCCCCCHHHHHCHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCEEEEHHHHHHHH
WRKGESSGNSMALQHISADCDNDSLLIQVIPKGPACHLGYSTCYQPHNNYTLGFLDGLIE
HHCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHH
LINERAEEKNPNSYTAQLLDSGVNRCAQKLGEEAVETVIAAVSNNKEELINETSDLIYHL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVLLKACELSFYDVLLCLQARDRSVHT
HHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDLDINSLDWQKMNGLLPAIIQNAENGKVLMLGYMNQEALIATLTTGQLTLYSRSRKRL
CCCCCCCCCHHHHHCHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCEEEEHHHHHHHH
WRKGESSGNSMALQHISADCDNDSLLIQVIPKGPACHLGYSTCYQPHNNYTLGFLDGLIE
HHCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHH
LINERAEEKNPNSYTAQLLDSGVNRCAQKLGEEAVETVIAAVSNNKEELINETSDLIYHL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVLLKACELSFYDVLLCLQARDRSVHT
HHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]