Click here to switch to the map view.

The map label for this gene is neuC [H]

Identifier: 54293737

GI number: 54293737

Start: 896481

End: 897614

Strand: Direct

Name: neuC [H]

Synonym: lpl0790

Alternate gene names: 54293737

Gene position: 896481-897614 (Clockwise)

Preceding gene: 54293736

Following gene: 54293738

Centisome position: 26.8

GC content: 39.24

Gene sequence:

>1134_bases
ATGACCAGAAAAATAATTTATGTTACAGGTACTCGTGCCGATTATGGACTGATGCGAGAAGTACTAAAAAGATTACACCA
GTCAGAAGACATTGACTTATCGATTTGTGTCACTGGTATGCATCTTGATGCTTTGTATGGAAATACAGTTAACGAAATTA
AAGCAGATCAGTTCTCAATATGCGGCATTATTCCTGTTGATCTTGCCAATGCCCAGCATAGTTCTATGGCAAAAGCTATC
GGCCATGAACTTTTGGGGTTCACCGATGTATTCGAAAGTGAAACTCCTGATGCCGTTTTATTGCTGGGAGATCGAGGTGA
AATGCTTGCTGCGGCCATAGCAGCGATACATTTAAATATCCCGGTTGTACATCTGCACGGAGGAGAGCGCTCTGGAACTG
TTGATGAAATGGTAAGACATGCGATTTCCAAATTATCTCATTATCATTTTGTCGCAACAGAGGCATCCAAACAACGATTG
ATTAGAATGGGTGAGAAAGAAGAAACCATTTTTCAGGTTGGTGCTCCGGGCTTGGATGAAATCATGCAGTATAAAACGTC
TACACGTGATGTTTTTAATCAACGTTATGGATTTGATCCTGACAAAAAAATCTGCTTATTAATCTACCACCCAGTTGTTC
AAGAAATTGACTCGATTAAAATTCAATTTCAAAGTGTGATTCAGGCAGCACTCGCCACAAATTTACAGATCATTTGCCTT
GAGCCTAATTCCGATTCGGGCGGTCATTTAATTCGAGAAGTGATTCAGGAATACATTGATCATTCTGATGTTAGAATTAT
CAAGCACTTACATCGTCCGGAATTTATTGATTGCCTTGCAAATTCTGATGTGATGCTGGGAAATTCCAGTAGTGGCATCA
TAGAGGCAGCCTCATTTAACCTCAACGTGGTTAATGTTGGAAGCAGGCAAAATTTAAGAGAGCGAAGCGATAATGTCATT
GATGTTGGTATCACTTATGATGCTATTTTGGCCGGTCTAAGAGAAGCGCTAAGCAAACCCAAAATGAAATACTCGAATTG
TTATGGGGATGGGAAAACAAGTGAAAGGTGTTATCAATTGTTAAAAACGATCTCTTTGCATTCACAAATATTGAATAAAT
GCAATGCATACTAA

Upstream 100 bases:

>100_bases
CTGGGATAGCGCCCTCTGAAATATCAAATATTGTAGGCGCTCGATTAAGTATGAATTTGTCTGCGGGTACTACTTTGTTA
TGGGAACATATTGAAGCGTA

Downstream 100 bases:

>100_bases
ATTGAAAATAATAGGATGTGGTGGGCACTGCAAAGTGGTGATTGATGCCTTATCACTGACTCAGCACTCTTTGCAAGTTT
CACTTTGTGATAGCAATAAG

Product: N-acylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTRKIIYVTGTRADYGLMREVLKRLHQSEDIDLSICVTGMHLDALYGNTVNEIKADQFSICGIIPVDLANAQHSSMAKAI
GHELLGFTDVFESETPDAVLLLGDRGEMLAAAIAAIHLNIPVVHLHGGERSGTVDEMVRHAISKLSHYHFVATEASKQRL
IRMGEKEETIFQVGAPGLDEIMQYKTSTRDVFNQRYGFDPDKKICLLIYHPVVQEIDSIKIQFQSVIQAALATNLQIICL
EPNSDSGGHLIREVIQEYIDHSDVRIIKHLHRPEFIDCLANSDVMLGNSSSGIIEAASFNLNVVNVGSRQNLRERSDNVI
DVGITYDAILAGLREALSKPKMKYSNCYGDGKTSERCYQLLKTISLHSQILNKCNAY

Sequences:

>Translated_377_residues
MTRKIIYVTGTRADYGLMREVLKRLHQSEDIDLSICVTGMHLDALYGNTVNEIKADQFSICGIIPVDLANAQHSSMAKAI
GHELLGFTDVFESETPDAVLLLGDRGEMLAAAIAAIHLNIPVVHLHGGERSGTVDEMVRHAISKLSHYHFVATEASKQRL
IRMGEKEETIFQVGAPGLDEIMQYKTSTRDVFNQRYGFDPDKKICLLIYHPVVQEIDSIKIQFQSVIQAALATNLQIICL
EPNSDSGGHLIREVIQEYIDHSDVRIIKHLHRPEFIDCLANSDVMLGNSSSGIIEAASFNLNVVNVGSRQNLRERSDNVI
DVGITYDAILAGLREALSKPKMKYSNCYGDGKTSERCYQLLKTISLHSQILNKCNAY
>Mature_376_residues
TRKIIYVTGTRADYGLMREVLKRLHQSEDIDLSICVTGMHLDALYGNTVNEIKADQFSICGIIPVDLANAQHSSMAKAIG
HELLGFTDVFESETPDAVLLLGDRGEMLAAAIAAIHLNIPVVHLHGGERSGTVDEMVRHAISKLSHYHFVATEASKQRLI
RMGEKEETIFQVGAPGLDEIMQYKTSTRDVFNQRYGFDPDKKICLLIYHPVVQEIDSIKIQFQSVIQAALATNLQIICLE
PNSDSGGHLIREVIQEYIDHSDVRIIKHLHRPEFIDCLANSDVMLGNSSSGIIEAASFNLNVVNVGSRQNLRERSDNVID
VGITYDAILAGLREALSKPKMKYSNCYGDGKTSERCYQLLKTISLHSQILNKCNAY

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=378, Percent_Identity=33.0687830687831, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI298566312, Length=378, Percent_Identity=33.0687830687831, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4885285, Length=378, Percent_Identity=33.0687830687831, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI298566325, Length=333, Percent_Identity=33.6336336336336, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI298566315, Length=324, Percent_Identity=29.320987654321, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI48994967, Length=394, Percent_Identity=26.3959390862944, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 41954; Mature: 41822

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKIIYVTGTRADYGLMREVLKRLHQSEDIDLSICVTGMHLDALYGNTVNEIKADQFSI
CCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEEHHHHCCCHHHHCCCCEEE
CGIIPVDLANAQHSSMAKAIGHELLGFTDVFESETPDAVLLLGDRGEMLAAAIAAIHLNI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHEECC
PVVHLHGGERSGTVDEMVRHAISKLSHYHFVATEASKQRLIRMGEKEETIFQVGAPGLDE
EEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEHHHHHHHHHCCCCHHHEEEECCCCHHH
IMQYKTSTRDVFNQRYGFDPDKKICLLIYHPVVQEIDSIKIQFQSVIQAALATNLQIICL
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
EPNSDSGGHLIREVIQEYIDHSDVRIIKHLHRPEFIDCLANSDVMLGNSSSGIIEAASFN
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCEEECCCCCCEEEEEEEE
LNVVNVGSRQNLRERSDNVIDVGITYDAILAGLREALSKPKMKYSNCYGDGKTSERCYQL
EEEEECCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHH
LKTISLHSQILNKCNAY
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRKIIYVTGTRADYGLMREVLKRLHQSEDIDLSICVTGMHLDALYGNTVNEIKADQFSI
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEEHHHHCCCHHHHCCCCEEE
CGIIPVDLANAQHSSMAKAIGHELLGFTDVFESETPDAVLLLGDRGEMLAAAIAAIHLNI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHEECC
PVVHLHGGERSGTVDEMVRHAISKLSHYHFVATEASKQRLIRMGEKEETIFQVGAPGLDE
EEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEHHHHHHHHHCCCCHHHEEEECCCCHHH
IMQYKTSTRDVFNQRYGFDPDKKICLLIYHPVVQEIDSIKIQFQSVIQAALATNLQIICL
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
EPNSDSGGHLIREVIQEYIDHSDVRIIKHLHRPEFIDCLANSDVMLGNSSSGIIEAASFN
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCEEECCCCCCEEEEEEEE
LNVVNVGSRQNLRERSDNVIDVGITYDAILAGLREALSKPKMKYSNCYGDGKTSERCYQL
EEEEECCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHH
LKTISLHSQILNKCNAY
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]