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The map label for this gene is tdh [H]

Identifier: 54293686

GI number: 54293686

Start: 839889

End: 840911

Strand: Direct

Name: tdh [H]

Synonym: lpl0739

Alternate gene names: 54293686

Gene position: 839889-840911 (Clockwise)

Preceding gene: 54293685

Following gene: 54293687

Centisome position: 25.1

GC content: 41.94

Gene sequence:

>1023_bases
ATGAAATCATTGGTTAAAGCAAAAAAAGAGCCTGGAATTTGGATGCAGGATATTCCTGTTCCTGAATATGGAGTAAACGA
TGTTTTAATAAAAATTAAAAGGACTGCAATTTGTGGTACAGATATCCATATTTATTCCTGGGATGAATGGGCGCAAGCCA
CAATTCCTGTTCCTATGACCGTAGGGCATGAATTTTATGGTGAAATAGTAGAGGTTGGAAAAGAAGTACAAGGTTTGAAA
GTTGGACAGAGAGTTTCTGGTGAAGGTCATATTACCTGTGGTTTTTGCAGAAATTGTCGTGCCGGCAAGCGTCATTTATG
TCGTAATACCCTGGGGGTGGGGGTGAATCGACCAGGATGCTTTGCTGAGTATCTGGCGCTTCCTGCTACCAATGTCATTG
CTCTCCCTGACAACATTACAGAAGAGCAAGCGGCTATTCTCGATCCTTTTGGAAATGCTGCTCATTGTGCATTGGCATTT
GATGTAGTAGGCGAAGACGTTTTGATTACTGGTGCAGGTCCCATAGGAATAATGGCCGCAGCCATCGTAAGACATATTGG
CGCACGGCATGTTGTTATCACCGATGTTAACGATCATCGATTGGAACTGGCCAGGAAAATGGGTGTCAGCCGAGCGGTTA
ATGTCAAATACCAAAAATTAAGTGATGTGGCTAATGAGTTGGGAATGCTCGAAGGGTTTGATGTTGGTCTGGAAATGTCA
GGGAATCCTATGGCATTAAACGACATGATGAAAGCGATGAATCATGGTGGTCATGTGGCTTTATTAGGTATTCCACCACA
AGAAACCCCGATAGATTGGAACCAGGTTATTTTCAAGGGATTAGTTATTAAGGGTATTTATGGGCGAGAAATGTTTGAAA
CCTGGTATAAGATGATTGCTATGCTACAAAGTGGTTTAAATATTTCCCCTGTTATTACTCATAATTTCCCAGTAGATGAA
TATCAGCACGCATTTCAAATTATGGCATCGGGTCAGTCAGGAAAAGTCATACTGAACTGGTAG

Upstream 100 bases:

>100_bases
TTCTCAGTAATCTGAAACTAAATTACTCTACATTTCACAACCTGATATTTTTAGGGTGAATTGCGAAATGGTGGTATTAC
CTAATTAATGAGGTATGGCA

Downstream 100 bases:

>100_bases
TATTGTTTGATAAAAGGCTGATTATAGAGAGTTGGAGCGATTATGGCGCAGTATATATTCACTATGAATAGAGTGAGCAA
GATTGTTGAGAACCAAAGAT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKSLVKAKKEPGIWMQDIPVPEYGVNDVLIKIKRTAICGTDIHIYSWDEWAQATIPVPMTVGHEFYGEIVEVGKEVQGLK
VGQRVSGEGHITCGFCRNCRAGKRHLCRNTLGVGVNRPGCFAEYLALPATNVIALPDNITEEQAAILDPFGNAAHCALAF
DVVGEDVLITGAGPIGIMAAAIVRHIGARHVVITDVNDHRLELARKMGVSRAVNVKYQKLSDVANELGMLEGFDVGLEMS
GNPMALNDMMKAMNHGGHVALLGIPPQETPIDWNQVIFKGLVIKGIYGREMFETWYKMIAMLQSGLNISPVITHNFPVDE
YQHAFQIMASGQSGKVILNW

Sequences:

>Translated_340_residues
MKSLVKAKKEPGIWMQDIPVPEYGVNDVLIKIKRTAICGTDIHIYSWDEWAQATIPVPMTVGHEFYGEIVEVGKEVQGLK
VGQRVSGEGHITCGFCRNCRAGKRHLCRNTLGVGVNRPGCFAEYLALPATNVIALPDNITEEQAAILDPFGNAAHCALAF
DVVGEDVLITGAGPIGIMAAAIVRHIGARHVVITDVNDHRLELARKMGVSRAVNVKYQKLSDVANELGMLEGFDVGLEMS
GNPMALNDMMKAMNHGGHVALLGIPPQETPIDWNQVIFKGLVIKGIYGREMFETWYKMIAMLQSGLNISPVITHNFPVDE
YQHAFQIMASGQSGKVILNW
>Mature_340_residues
MKSLVKAKKEPGIWMQDIPVPEYGVNDVLIKIKRTAICGTDIHIYSWDEWAQATIPVPMTVGHEFYGEIVEVGKEVQGLK
VGQRVSGEGHITCGFCRNCRAGKRHLCRNTLGVGVNRPGCFAEYLALPATNVIALPDNITEEQAAILDPFGNAAHCALAF
DVVGEDVLITGAGPIGIMAAAIVRHIGARHVVITDVNDHRLELARKMGVSRAVNVKYQKLSDVANELGMLEGFDVGLEMS
GNPMALNDMMKAMNHGGHVALLGIPPQETPIDWNQVIFKGLVIKGIYGREMFETWYKMIAMLQSGLNISPVITHNFPVDE
YQHAFQIMASGQSGKVILNW

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=28.0597014925373, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=24.0540540540541, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=24.1847826086957, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=24.1847826086957, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=24.3243243243243, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=22.972972972973, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=22.2841225626741, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501939, Length=353, Percent_Identity=22.0963172804533, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI71565154, Length=361, Percent_Identity=24.9307479224377, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=70, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=28.6103542234332, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=29.0229885057471, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788073, Length=331, Percent_Identity=26.8882175226586, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082125, Length=370, Percent_Identity=30, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI226510992, Length=269, Percent_Identity=32.7137546468402, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790718, Length=343, Percent_Identity=25.9475218658892, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788407, Length=334, Percent_Identity=26.9461077844311, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786825, Length=368, Percent_Identity=27.445652173913, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081918, Length=265, Percent_Identity=27.1698113207547, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786552, Length=377, Percent_Identity=26.525198938992, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786518, Length=288, Percent_Identity=28.125, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=30.5389221556886, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562878, Length=338, Percent_Identity=29.2899408284024, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71988145, Length=193, Percent_Identity=29.5336787564767, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=280, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=286, Percent_Identity=26.2237762237762, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=327, Percent_Identity=28.7461773700306, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319955, Length=327, Percent_Identity=28.7461773700306, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323099, Length=328, Percent_Identity=29.5731707317073, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=335, Percent_Identity=26.865671641791, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=25.5376344086022, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=262, Percent_Identity=27.8625954198473, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=306, Percent_Identity=27.1241830065359, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=269, Percent_Identity=26.3940520446097, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=262, Percent_Identity=31.2977099236641, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=304, Percent_Identity=25.9868421052632, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=306, Percent_Identity=26.1437908496732, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137530, Length=330, Percent_Identity=27.5757575757576, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=26.3636363636364, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=25.7372654155496, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551930, Length=331, Percent_Identity=26.2839879154079, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550770, Length=331, Percent_Identity=25.6797583081571, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221457811, Length=331, Percent_Identity=25.6797583081571, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37211; Mature: 37211

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLVKAKKEPGIWMQDIPVPEYGVNDVLIKIKRTAICGTDIHIYSWDEWAQATIPVPMT
CCCHHHHCCCCCCEEECCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCEECCCCHH
VGHEFYGEIVEVGKEVQGLKVGQRVSGEGHITCGFCRNCRAGKRHLCRNTLGVGVNRPGC
CCHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEHHHCCCCHHHHHHHHHHHCCCCCCCCH
FAEYLALPATNVIALPDNITEEQAAILDPFGNAAHCALAFDVVGEDVLITGAGPIGIMAA
HHHHHHCCCCCEEECCCCCCHHHHHHHCCCCCCEEHEEEEEECCCCEEEECCCHHHHHHH
AIVRHIGARHVVITDVNDHRLELARKMGVSRAVNVKYQKLSDVANELGMLEGFDVGLEMS
HHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHHCCCCCCCCCEEEC
GNPMALNDMMKAMNHGGHVALLGIPPQETPIDWNQVIFKGLVIKGIYGREMFETWYKMIA
CCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
MLQSGLNISPVITHNFPVDEYQHAFQIMASGQSGKVILNW
HHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MKSLVKAKKEPGIWMQDIPVPEYGVNDVLIKIKRTAICGTDIHIYSWDEWAQATIPVPMT
CCCHHHHCCCCCCEEECCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCEECCCCHH
VGHEFYGEIVEVGKEVQGLKVGQRVSGEGHITCGFCRNCRAGKRHLCRNTLGVGVNRPGC
CCHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEHHHCCCCHHHHHHHHHHHCCCCCCCCH
FAEYLALPATNVIALPDNITEEQAAILDPFGNAAHCALAFDVVGEDVLITGAGPIGIMAA
HHHHHHCCCCCEEECCCCCCHHHHHHHCCCCCCEEHEEEEEECCCCEEEECCCHHHHHHH
AIVRHIGARHVVITDVNDHRLELARKMGVSRAVNVKYQKLSDVANELGMLEGFDVGLEMS
HHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHHCCCCCCCCCEEEC
GNPMALNDMMKAMNHGGHVALLGIPPQETPIDWNQVIFKGLVIKGIYGREMFETWYKMIA
CCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
MLQSGLNISPVITHNFPVDEYQHAFQIMASGQSGKVILNW
HHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA