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The map label for this gene is kbl [C]

Identifier: 54293685

GI number: 54293685

Start: 838619

End: 839803

Strand: Direct

Name: kbl [C]

Synonym: lpl0738

Alternate gene names: 54293685

Gene position: 838619-839803 (Clockwise)

Preceding gene: 54293679

Following gene: 54293686

Centisome position: 25.07

GC content: 42.19

Gene sequence:

>1185_bases
GTGCTTGAGCGATTCATTAATTATTTACAAAATGAACTTGAAACACTCAAGGCAGACGGATTGTATAAATCAGAGCGAGT
TATTTCCAGCCAACAGCAAGCTGACGTGAAGGTTAACGAAAGAGAAGTCATTAATCTTTGTGCAAATAACTATTTGGGTT
TGGCCAATGATCCTGAACTAATAGCGGAGGGACAGGCTGCGTTAGCCAAGTACGGATATGGCATGGCTTCTGTTCGTTTT
ATTTGTGGAACACAAACTCCGCATAAGCAACTGGAACAAAAAATTAGCCATTTTTTAAGTAAAGAAGACACTATATTGTA
TTCTTCCTGTTTTGATGCCAATACGGGATTATTTGAGACATTATTGACAGAAGAAGATGCCATTATCAGCGATGCCCTGA
ATCATGCGAGTATTATTGATGGAGTCAGGCTGTGTAAGGCTGCACGTTATCGATATGCCAATAATGATATGAAGGCTCTG
GAAGAACAGTTAATTGCAGCGAAAAATGCGAGATTTCGTTTGATTGCAACAGATGGTGTTTTTTCAATGGATGGTATATT
AGCTAACTTGCCAGCAATTTGTGAACTGGCCGACAAGTATGACGCCATGGTGATGGTTGATGATTCTCATGCTGTTGGTT
TCATGGGTAAGACAGGTAGAGGAACACCAGAGCATTTTGGAGTTAGTGATAGAATCGATATCGTAACTGGCACTCTTGGT
AAAGCCTTAGGGGGCGCATCGGGAGGATATACTGCGTCAAATCAAGTTGTCATTGATTGGTTGCGCCAACGATCCAGGCC
TTATCTGTTTTCCAATACATTGGCGCCTGTTATTGCGCATACTTCTTGTGTGGTGCTCGATAAATTGTCCACAAATAACT
CCCTTGCTGAAAAATTAAAGCGCAATAGTCATTATTTCCGTGAAGGAATGACCCAGTTAGGTTTTGAGTTAATCCCGGGT
GAACACCCTATTATTCCTGTCATGTTAGGAGATGCCAGTTTGGCCGGGCGAATCGCTAATCGGTTGCTGGAGTTGGGGGT
CTATGTTGTAGGGTTTTCCTATCCAGTGGTACCCAAAGGTTTAGCTCGCATTCGTACCCAAATGTCTGCGGCTCTTGAAT
TACATCATTTGGATAAAGCCTTGAAGGCGTTTGAAACGGTTGGTAAGGAATTCTCAGTAATCTGA

Upstream 100 bases:

>100_bases
TTAATGTTTGAAAGTGAAATTTTCTTGATAATATCTCATGGTGAGAATGTTTAAAATTTGGTATTATTTACAAATTTATC
CAGAAATACAGGAGATTATA

Downstream 100 bases:

>100_bases
AACTAAATTACTCTACATTTCACAACCTGATATTTTTAGGGTGAATTGCGAAATGGTGGTATTACCTAATTAATGAGGTA
TGGCAATGAAATCATTGGTT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MLERFINYLQNELETLKADGLYKSERVISSQQQADVKVNEREVINLCANNYLGLANDPELIAEGQAALAKYGYGMASVRF
ICGTQTPHKQLEQKISHFLSKEDTILYSSCFDANTGLFETLLTEEDAIISDALNHASIIDGVRLCKAARYRYANNDMKAL
EEQLIAAKNARFRLIATDGVFSMDGILANLPAICELADKYDAMVMVDDSHAVGFMGKTGRGTPEHFGVSDRIDIVTGTLG
KALGGASGGYTASNQVVIDWLRQRSRPYLFSNTLAPVIAHTSCVVLDKLSTNNSLAEKLKRNSHYFREGMTQLGFELIPG
EHPIIPVMLGDASLAGRIANRLLELGVYVVGFSYPVVPKGLARIRTQMSAALELHHLDKALKAFETVGKEFSVI

Sequences:

>Translated_394_residues
MLERFINYLQNELETLKADGLYKSERVISSQQQADVKVNEREVINLCANNYLGLANDPELIAEGQAALAKYGYGMASVRF
ICGTQTPHKQLEQKISHFLSKEDTILYSSCFDANTGLFETLLTEEDAIISDALNHASIIDGVRLCKAARYRYANNDMKAL
EEQLIAAKNARFRLIATDGVFSMDGILANLPAICELADKYDAMVMVDDSHAVGFMGKTGRGTPEHFGVSDRIDIVTGTLG
KALGGASGGYTASNQVVIDWLRQRSRPYLFSNTLAPVIAHTSCVVLDKLSTNNSLAEKLKRNSHYFREGMTQLGFELIPG
EHPIIPVMLGDASLAGRIANRLLELGVYVVGFSYPVVPKGLARIRTQMSAALELHHLDKALKAFETVGKEFSVI
>Mature_394_residues
MLERFINYLQNELETLKADGLYKSERVISSQQQADVKVNEREVINLCANNYLGLANDPELIAEGQAALAKYGYGMASVRF
ICGTQTPHKQLEQKISHFLSKEDTILYSSCFDANTGLFETLLTEEDAIISDALNHASIIDGVRLCKAARYRYANNDMKAL
EEQLIAAKNARFRLIATDGVFSMDGILANLPAICELADKYDAMVMVDDSHAVGFMGKTGRGTPEHFGVSDRIDIVTGTLG
KALGGASGGYTASNQVVIDWLRQRSRPYLFSNTLAPVIAHTSCVVLDKLSTNNSLAEKLKRNSHYFREGMTQLGFELIPG
EHPIIPVMLGDASLAGRIANRLLELGVYVVGFSYPVVPKGLARIRTQMSAALELHHLDKALKAFETVGKEFSVI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=390, Percent_Identity=52.5641025641026, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI284448556, Length=416, Percent_Identity=49.2788461538462, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI83977442, Length=393, Percent_Identity=31.2977099236641, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI83977440, Length=393, Percent_Identity=31.2977099236641, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI83977444, Length=391, Percent_Identity=31.4578005115089, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=34.1530054644809, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=33.1521739130435, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4502025, Length=395, Percent_Identity=29.3670886075949, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI40316939, Length=395, Percent_Identity=29.3670886075949, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI5454084, Length=261, Percent_Identity=30.6513409961686, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=62.72040302267, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=30.3977272727273, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=391, Percent_Identity=55.7544757033248, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=34.0540540540541, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=364, Percent_Identity=32.967032967033, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17560912, Length=364, Percent_Identity=32.967032967033, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71982617, Length=277, Percent_Identity=26.7148014440433, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=277, Percent_Identity=26.7148014440433, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=360, Percent_Identity=31.6666666666667, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320267, Length=374, Percent_Identity=34.4919786096257, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6323954, Length=271, Percent_Identity=28.7822878228782, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=54.8969072164949, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI17137420, Length=359, Percent_Identity=30.6406685236769, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17136286, Length=373, Percent_Identity=31.3672922252011, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24653280, Length=392, Percent_Identity=26.530612244898, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24653276, Length=392, Percent_Identity=26.530612244898, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24653278, Length=392, Percent_Identity=26.530612244898, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43285; Mature: 43285

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERFINYLQNELETLKADGLYKSERVISSQQQADVKVNEREVINLCANNYLGLANDPEL
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHH
IAEGQAALAKYGYGMASVRFICGTQTPHKQLEQKISHFLSKEDTILYSSCFDANTGLFET
HHCCHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHH
LLTEEDAIISDALNHASIIDGVRLCKAARYRYANNDMKALEEQLIAAKNARFRLIATDGV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCC
FSMDGILANLPAICELADKYDAMVMVDDSHAVGFMGKTGRGTPEHFGVSDRIDIVTGTLG
EEHHHHHHCCHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCHHCCCCCCHHEEECHHH
KALGGASGGYTASNQVVIDWLRQRSRPYLFSNTLAPVIAHTSCVVLDKLSTNNSLAEKLK
HHHCCCCCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHCCEEEEECCCCCHHHHHHHH
RNSHYFREGMTQLGFELIPGEHPIIPVMLGDASLAGRIANRLLELGVYVVGFSYPVVPKG
HHHHHHHHHHHHCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCHHH
LARIRTQMSAALELHHLDKALKAFETVGKEFSVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLERFINYLQNELETLKADGLYKSERVISSQQQADVKVNEREVINLCANNYLGLANDPEL
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHH
IAEGQAALAKYGYGMASVRFICGTQTPHKQLEQKISHFLSKEDTILYSSCFDANTGLFET
HHCCHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHH
LLTEEDAIISDALNHASIIDGVRLCKAARYRYANNDMKALEEQLIAAKNARFRLIATDGV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCC
FSMDGILANLPAICELADKYDAMVMVDDSHAVGFMGKTGRGTPEHFGVSDRIDIVTGTLG
EEHHHHHHCCHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCHHCCCCCCHHEEECHHH
KALGGASGGYTASNQVVIDWLRQRSRPYLFSNTLAPVIAHTSCVVLDKLSTNNSLAEKLK
HHHCCCCCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHCCEEEEECCCCCHHHHHHHH
RNSHYFREGMTQLGFELIPGEHPIIPVMLGDASLAGRIANRLLELGVYVVGFSYPVVPKG
HHHHHHHHHHHHCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCHHH
LARIRTQMSAALELHHLDKALKAFETVGKEFSVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]