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The map label for this gene is sdhB [H]

Identifier: 54293526

GI number: 54293526

Start: 623134

End: 623856

Strand: Direct

Name: sdhB [H]

Synonym: lpl0577

Alternate gene names: 54293526

Gene position: 623134-623856 (Clockwise)

Preceding gene: 54293525

Following gene: 54293527

Centisome position: 18.62

GC content: 41.77

Gene sequence:

>723_bases
ATGGCTGATAGTAGAAATGTAATCCTGTCGATTTATCGCTATAATCCTGAGGTGGATGCCAAGCCTTACATGAAAGATTA
TGAGATAGAAATCCCGGCTAAAAGTGATCCCATGTTACTTACCTTGCTTGAGCGCTTGAAAGCTGAGCAAGACCCTTCTA
TTACTTACAGACGGTCATGTCGAGAAGGAGTATGTGGTTCTGACGGTATGAATATCAATGGGACTAATGGATTAGCTTGC
ATTACACATCTTTCACAATTAAAAACAGATAAAATTGTCATTCGTCCTTTGCCAGGTTTTCCAGTAATTCGTGACTTGGC
AGTTGATATGACACAATTTTATCAGCAGTATGAACGCATTGAGCCTTATTTACAGAATGATGAAGTAGCACCTGCTCGAG
AGAGGTTACAATCTCCTGAAGAGCGGGCACAATTGGATGGCTTGTATGAGTGCATTTTATGCGCTTGCTGTACCAGTTCA
TGTCCTTCTTATTGGTGGAATCCTGATAAATTTGTAGGCCCTGCTGGACTTTTACAAGCCAGGCGTTTTTTAGCAGACAG
TCGTGACAAGGCAACGCAACATCGTTTGGATTTATTACAAGATCCTTTCAGTGTATTTCGTTGTCGTACTATTATGAATT
GCACGAATGTATGCCCGAAGGGACTCAATCCAGCGCAAGCGATTGCAAAAATTCGCACGCAAATGTTGACGCAGGAAACG
TAA

Upstream 100 bases:

>100_bases
TGAGGAAGGTGAGGTGATAGATTATCGTCCGGTTAATACCTCACCTAAGTATGTCGAGCCTTTTGAGCCGAAAGAACGCG
TTTACTAATGAGGATATTTT

Downstream 100 bases:

>100_bases
TAAATCAGTCCTTGTTACTCAGAAAGTTTCTGAGTGAACCCTTTGGAGAGAATGATAATGAGCAGTTCTGATCTGCAAAA
AGAATGGGCTTCTTCCTATT

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MADSRNVILSIYRYNPEVDAKPYMKDYEIEIPAKSDPMLLTLLERLKAEQDPSITYRRSCREGVCGSDGMNINGTNGLAC
ITHLSQLKTDKIVIRPLPGFPVIRDLAVDMTQFYQQYERIEPYLQNDEVAPARERLQSPEERAQLDGLYECILCACCTSS
CPSYWWNPDKFVGPAGLLQARRFLADSRDKATQHRLDLLQDPFSVFRCRTIMNCTNVCPKGLNPAQAIAKIRTQMLTQET

Sequences:

>Translated_240_residues
MADSRNVILSIYRYNPEVDAKPYMKDYEIEIPAKSDPMLLTLLERLKAEQDPSITYRRSCREGVCGSDGMNINGTNGLAC
ITHLSQLKTDKIVIRPLPGFPVIRDLAVDMTQFYQQYERIEPYLQNDEVAPARERLQSPEERAQLDGLYECILCACCTSS
CPSYWWNPDKFVGPAGLLQARRFLADSRDKATQHRLDLLQDPFSVFRCRTIMNCTNVCPKGLNPAQAIAKIRTQMLTQET
>Mature_239_residues
ADSRNVILSIYRYNPEVDAKPYMKDYEIEIPAKSDPMLLTLLERLKAEQDPSITYRRSCREGVCGSDGMNINGTNGLACI
THLSQLKTDKIVIRPLPGFPVIRDLAVDMTQFYQQYERIEPYLQNDEVAPARERLQSPEERAQLDGLYECILCACCTSSC
PSYWWNPDKFVGPAGLLQARRFLADSRDKATQHRLDLLQDPFSVFRCRTIMNCTNVCPKGLNPAQAIAKIRTQMLTQET

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=54.7413793103448, Blast_Score=261, Evalue=4e-70,
Organism=Escherichia coli, GI1786943, Length=235, Percent_Identity=65.531914893617, Blast_Score=320, Evalue=5e-89,
Organism=Escherichia coli, GI1790596, Length=235, Percent_Identity=37.4468085106383, Blast_Score=165, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17533915, Length=235, Percent_Identity=48.936170212766, Blast_Score=239, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322987, Length=229, Percent_Identity=51.9650655021834, Blast_Score=255, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17137106, Length=229, Percent_Identity=53.7117903930131, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24643156, Length=227, Percent_Identity=51.9823788546256, Blast_Score=251, Evalue=3e-67,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27347; Mature: 27215

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSRNVILSIYRYNPEVDAKPYMKDYEIEIPAKSDPMLLTLLERLKAEQDPSITYRRSC
CCCCCCEEEEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
REGVCGSDGMNINGTNGLACITHLSQLKTDKIVIRPLPGFPVIRDLAVDMTQFYQQYERI
HCCCCCCCCCEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
EPYLQNDEVAPARERLQSPEERAQLDGLYECILCACCTSSCPSYWWNPDKFVGPAGLLQA
CCHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RRFLADSRDKATQHRLDLLQDPFSVFRCRTIMNCTNVCPKGLNPAQAIAKIRTQMLTQET
HHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADSRNVILSIYRYNPEVDAKPYMKDYEIEIPAKSDPMLLTLLERLKAEQDPSITYRRSC
CCCCCEEEEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
REGVCGSDGMNINGTNGLACITHLSQLKTDKIVIRPLPGFPVIRDLAVDMTQFYQQYERI
HCCCCCCCCCEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
EPYLQNDEVAPARERLQSPEERAQLDGLYECILCACCTSSCPSYWWNPDKFVGPAGLLQA
CCHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RRFLADSRDKATQHRLDLLQDPFSVFRCRTIMNCTNVCPKGLNPAQAIAKIRTQMLTQET
HHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]