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The map label for this gene is sdhA [H]

Identifier: 54293525

GI number: 54293525

Start: 621352

End: 623121

Strand: Direct

Name: sdhA [H]

Synonym: lpl0576

Alternate gene names: 54293525

Gene position: 621352-623121 (Clockwise)

Preceding gene: 54293524

Following gene: 54293526

Centisome position: 18.57

GC content: 44.75

Gene sequence:

>1770_bases
ATGACAGTGGCACGTAACAGATTTGATGCGGTAATTATAGGAGCTGGCGGTGCAGGAATGCGAGCTGCACTCCAGATGAC
AAATTCTGGTTTAAAAGTAGCGTTGTTATCAAAAGTATTTCCAACCCGCTCACATACTGTGTCGGCTCAAGGTGGTATTA
CAGCTGCTTTGGGAAATGCTGATGAAGACGACTGGCGCTGGCACATGTATGATACCGTGAAAGGTGCTGATTACATTGGT
GATCAGGATTGTATAGAGTATCTATGTAAAACCGGGCCTGAAGCAGTTTATGAACTGGAGCATATGGGGCTACCTTTTTC
ACGAATGGATAATGGAAAAATCTACCAACGTCAGTTTGGTGGCCAGTCAAAACATTTCGGTGGAGAACAAGCGGCCCGTA
CCTGTGCTGCGGCAGATAGAACAGGGCATGCTTTGCTGCACACTCTTTATCAACAGAATTTAAAAGCTAAAACTCATGTA
TTTAGTGAGTGGTATGCTCTCGATCTGGTAAAAAACTCGCAAGGAAGAATTGCAGGTGTTACTGCCATGTGTATGGAGAC
TGGCGAGATTGTATTTTTTCAGACTCGAGTTTGTATTTTGGCGACTGGAGGAGCCGGTAGAATTTTTCAATCTACAACGA
ATGCTTTTATTAATACTGGCGATGGCTTTGGAATGGCACTAAGAGCTGGTATACCTCTTCAAGACATGGAAATGTGGCAA
TTTCATCCAACTGGTATAGCGGGAGCTGGTGTTCTGGTTACGGAGGGTTGTCGAGGTGAAGGTGGTTATTTAATAAACAA
AGATGGTGAGCGTTTTATGGAGCGTTATGCTCCCAGAGTAAAGGACTTGGCTTCCCGGGATGTGGTCGCTCGCGCTATGG
CCTTGGAAATTCGAGCTGGGAAAGGATTTGATCCAAAAGGTGTCGACCATGTTAAGTTAAAGCTTGACCATCTGGGCGCT
GATTTGATTATGTCTCGCTTGCCTGGCATTCGCGAGTTATCAATGAAGTTTGCCGGTGTGGATCCAATCGTTGAGCCGAT
TCCAGTTGTTCCAACTTGCCACTACAGTATGGGAGGAATACCCACCAACATGCATGGCCAGGTTATAACTAAAACTGATG
GCAAAGAGCATGTGGTGGAGGGGTTGTATGCTGTAGGGGAGTGTGCCTGCGTTTCAGTGCATGGTGCCAATCGATTAGGT
GGTAATTCCTTATTGGATTTGGTTGTGTTTGGCCGTGCAGCCGGGATACATGTTGAAGAATTATGGCAATCAAATCAATT
GCCCGATATGTCTTATGTAAGTGAAGACGATGTAGTGGCTTCCCTGGTTCGTTATGAGCGTTGGGAAAACTCAAAGGATG
GTGAAAGCCATGCGGTAATACGAGATGAAATGCAAAGAGTAATGCAGGAAGATTTTGGAGTATTCCGTACCGGTGAGGTA
ATGGCTTCAGGATTGAAACGTTTACAAGCCCTGCGTGATCGATTAGCACATGCTAAACTTGATGATAAAAGTCAAATTTT
TAATACAGAGCGCGTTGAAGCTATGGAATTGGATAATTTAATGGCAACTGCTTATGCAACGGCTTTATCTGCAATTGCGC
GAACTGAAAGCAGAGGAGCGCACAGCAGGGAAGATTATCCAAAACGAGATGATGCAAACTGGATTAAGCACACATTGTAT
TTTGAGGAAGGTGAGGTGATAGATTATCGTCCGGTTAATACCTCACCTAAGTATGTCGAGCCTTTTGAGCCGAAAGAACG
CGTTTACTAA

Upstream 100 bases:

>100_bases
ATGAAATGTACTGTGATACGTTTATCAGTACAGTTATTGGTTGTTTTATGGCTCTTTGGTCAATTTATCTGGGGCCTTAT
GATCATTTGGGGACAATAGC

Downstream 100 bases:

>100_bases
TGAGGATATTTTATGGCTGATAGTAGAAATGTAATCCTGTCGATTTATCGCTATAATCCTGAGGTGGATGCCAAGCCTTA
CATGAAAGATTATGAGATAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MTVARNRFDAVIIGAGGAGMRAALQMTNSGLKVALLSKVFPTRSHTVSAQGGITAALGNADEDDWRWHMYDTVKGADYIG
DQDCIEYLCKTGPEAVYELEHMGLPFSRMDNGKIYQRQFGGQSKHFGGEQAARTCAAADRTGHALLHTLYQQNLKAKTHV
FSEWYALDLVKNSQGRIAGVTAMCMETGEIVFFQTRVCILATGGAGRIFQSTTNAFINTGDGFGMALRAGIPLQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLINKDGERFMERYAPRVKDLASRDVVARAMALEIRAGKGFDPKGVDHVKLKLDHLGA
DLIMSRLPGIRELSMKFAGVDPIVEPIPVVPTCHYSMGGIPTNMHGQVITKTDGKEHVVEGLYAVGECACVSVHGANRLG
GNSLLDLVVFGRAAGIHVEELWQSNQLPDMSYVSEDDVVASLVRYERWENSKDGESHAVIRDEMQRVMQEDFGVFRTGEV
MASGLKRLQALRDRLAHAKLDDKSQIFNTERVEAMELDNLMATAYATALSAIARTESRGAHSREDYPKRDDANWIKHTLY
FEEGEVIDYRPVNTSPKYVEPFEPKERVY

Sequences:

>Translated_589_residues
MTVARNRFDAVIIGAGGAGMRAALQMTNSGLKVALLSKVFPTRSHTVSAQGGITAALGNADEDDWRWHMYDTVKGADYIG
DQDCIEYLCKTGPEAVYELEHMGLPFSRMDNGKIYQRQFGGQSKHFGGEQAARTCAAADRTGHALLHTLYQQNLKAKTHV
FSEWYALDLVKNSQGRIAGVTAMCMETGEIVFFQTRVCILATGGAGRIFQSTTNAFINTGDGFGMALRAGIPLQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLINKDGERFMERYAPRVKDLASRDVVARAMALEIRAGKGFDPKGVDHVKLKLDHLGA
DLIMSRLPGIRELSMKFAGVDPIVEPIPVVPTCHYSMGGIPTNMHGQVITKTDGKEHVVEGLYAVGECACVSVHGANRLG
GNSLLDLVVFGRAAGIHVEELWQSNQLPDMSYVSEDDVVASLVRYERWENSKDGESHAVIRDEMQRVMQEDFGVFRTGEV
MASGLKRLQALRDRLAHAKLDDKSQIFNTERVEAMELDNLMATAYATALSAIARTESRGAHSREDYPKRDDANWIKHTLY
FEEGEVIDYRPVNTSPKYVEPFEPKERVY
>Mature_588_residues
TVARNRFDAVIIGAGGAGMRAALQMTNSGLKVALLSKVFPTRSHTVSAQGGITAALGNADEDDWRWHMYDTVKGADYIGD
QDCIEYLCKTGPEAVYELEHMGLPFSRMDNGKIYQRQFGGQSKHFGGEQAARTCAAADRTGHALLHTLYQQNLKAKTHVF
SEWYALDLVKNSQGRIAGVTAMCMETGEIVFFQTRVCILATGGAGRIFQSTTNAFINTGDGFGMALRAGIPLQDMEMWQF
HPTGIAGAGVLVTEGCRGEGGYLINKDGERFMERYAPRVKDLASRDVVARAMALEIRAGKGFDPKGVDHVKLKLDHLGAD
LIMSRLPGIRELSMKFAGVDPIVEPIPVVPTCHYSMGGIPTNMHGQVITKTDGKEHVVEGLYAVGECACVSVHGANRLGG
NSLLDLVVFGRAAGIHVEELWQSNQLPDMSYVSEDDVVASLVRYERWENSKDGESHAVIRDEMQRVMQEDFGVFRTGEVM
ASGLKRLQALRDRLAHAKLDDKSQIFNTERVEAMELDNLMATAYATALSAIARTESRGAHSREDYPKRDDANWIKHTLYF
EEGEVIDYRPVNTSPKYVEPFEPKERVY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=570, Percent_Identity=52.1052631578947, Blast_Score=570, Evalue=1e-162,
Organism=Escherichia coli, GI1786942, Length=591, Percent_Identity=69.0355329949239, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=41.0434782608696, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1788928, Length=565, Percent_Identity=31.858407079646, Blast_Score=228, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17550100, Length=570, Percent_Identity=51.4035087719298, Blast_Score=554, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17505833, Length=572, Percent_Identity=49.1258741258741, Blast_Score=535, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6322701, Length=561, Percent_Identity=54.1889483065954, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6322416, Length=596, Percent_Identity=52.5167785234899, Blast_Score=582, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6320788, Length=479, Percent_Identity=29.0187891440501, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322511, Length=483, Percent_Identity=24.0165631469979, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=50.8169934640523, Blast_Score=566, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=50.8169934640523, Blast_Score=566, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=50.8169934640523, Blast_Score=566, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=47.6345840130506, Blast_Score=526, Evalue=1e-149,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64971; Mature: 64839

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVARNRFDAVIIGAGGAGMRAALQMTNSGLKVALLSKVFPTRSHTVSAQGGITAALGNA
CCCCCCCCCEEEEECCCCCHHHHHHHCCCCCEEEEHHHHCCCCCCEEECCCCEEEEECCC
DEDDWRWHMYDTVKGADYIGDQDCIEYLCKTGPEAVYELEHMGLPFSRMDNGKIYQRQFG
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHCCCCCEEHHHCC
GQSKHFGGEQAARTCAAADRTGHALLHTLYQQNLKAKTHVFSEWYALDLVKNSQGRIAGV
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCEEHH
TAMCMETGEIVFFQTRVCILATGGAGRIFQSTTNAFINTGDGFGMALRAGIPLQDMEMWQ
HHEECCCCCEEEEEEEEEEEEECCCCCHHHHCCCCEEECCCCCCEEEECCCCCCCCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLINKDGERFMERYAPRVKDLASRDVVARAMALEIRAG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHEEEECC
KGFDPKGVDHVKLKLDHLGADLIMSRLPGIRELSMKFAGVDPIVEPIPVVPTCHYSMGGI
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PTNMHGQVITKTDGKEHVVEGLYAVGECACVSVHGANRLGGNSLLDLVVFGRAAGIHVEE
CCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHH
LWQSNQLPDMSYVSEDDVVASLVRYERWENSKDGESHAVIRDEMQRVMQEDFGVFRTGEV
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECHHH
MASGLKRLQALRDRLAHAKLDDKSQIFNTERVEAMELDNLMATAYATALSAIARTESRGA
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HSREDYPKRDDANWIKHTLYFEEGEVIDYRPVNTSPKYVEPFEPKERVY
CCCCCCCCCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
TVARNRFDAVIIGAGGAGMRAALQMTNSGLKVALLSKVFPTRSHTVSAQGGITAALGNA
CCCCCCCCEEEEECCCCCHHHHHHHCCCCCEEEEHHHHCCCCCCEEECCCCEEEEECCC
DEDDWRWHMYDTVKGADYIGDQDCIEYLCKTGPEAVYELEHMGLPFSRMDNGKIYQRQFG
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHCCCCCEEHHHCC
GQSKHFGGEQAARTCAAADRTGHALLHTLYQQNLKAKTHVFSEWYALDLVKNSQGRIAGV
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCEEHH
TAMCMETGEIVFFQTRVCILATGGAGRIFQSTTNAFINTGDGFGMALRAGIPLQDMEMWQ
HHEECCCCCEEEEEEEEEEEEECCCCCHHHHCCCCEEECCCCCCEEEECCCCCCCCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLINKDGERFMERYAPRVKDLASRDVVARAMALEIRAG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHEEEECC
KGFDPKGVDHVKLKLDHLGADLIMSRLPGIRELSMKFAGVDPIVEPIPVVPTCHYSMGGI
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PTNMHGQVITKTDGKEHVVEGLYAVGECACVSVHGANRLGGNSLLDLVVFGRAAGIHVEE
CCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHH
LWQSNQLPDMSYVSEDDVVASLVRYERWENSKDGESHAVIRDEMQRVMQEDFGVFRTGEV
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECHHH
MASGLKRLQALRDRLAHAKLDDKSQIFNTERVEAMELDNLMATAYATALSAIARTESRGA
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HSREDYPKRDDANWIKHTLYFEEGEVIDYRPVNTSPKYVEPFEPKERVY
CCCCCCCCCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]