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The map label for this gene is argH [H]

Identifier: 54293484

GI number: 54293484

Start: 579044

End: 580279

Strand: Direct

Name: argH [H]

Synonym: lpl0533

Alternate gene names: 54293484

Gene position: 579044-580279 (Clockwise)

Preceding gene: 54293483

Following gene: 54293485

Centisome position: 17.31

GC content: 39.64

Gene sequence:

>1236_bases
ATGACTAATAAAACATGGGGAGGGCGATTTAAGAAATCTTTGGATAGCGGTGTCAACCAGTTTAATGCGTCATTGTCTTT
TGATCATGTGCTTTTTGACCAGGACATTAATGGCAGTCAGGTTCATGTGAAGCAATTAGCTAAACAGAAGATTTTAACAG
AAGCTGAATGCCAGGGGATTTATTCTGCTCTTGAAGAAATCAGAACAGAGATAAAACAAGGCCAATATTCATTTAATGAA
CGTGATGAAGAAGACATACATATGTTTATTGAGCAATTGCTGATTCAAAAAATAGGTGATTTGGGTAAGAAATTACACAC
CGGCCGTAGTCGTAATGATCAAGTGGCTTTGGATCTTCGTTTATATACCAGAGATAAAGGCTGTCTGATTAATGAACTTT
TGACAAGGCTTATCGTTTGTCTAGATGATCTAACCAGTAAACATCAACAGGATTTAATGCCAGGCTATACTCATTTACAG
CAAGCCCAACCTGTTGCGTTAGGGGCTTATTTTAACGCGTATCAATGCATGTTTAGCCGAGATAAAAGCAGGCTGGAAGA
TTGGTTTAAACGCATGAATTATTCTCCTTTGGGCGCCGGGGCACTGGCTGGAAGTACCTTGCCTCTTGATAGAGAATGGG
TAGCCGAATCCTTGGGATTTGCAGGGATCATTCCTAATACTCTTGATGCAGTCAGTGACAGAGATTTTGTTATCGAGTTA
TGCAGTGTTGCTGCAATGATTATGATGCATCTCTCCAGATTATGTGAAGATTTGATTCTCTGGTCTACCCAGGAGTTTAA
TTTTGTTACATTGGATGATGCGTTTGCTACAGGCTCTTCATTGATGCCTAACAAAAAAAATCCCGATGTTCCTGAATTGA
TTCGTGGCAAATCAGGACGAGTTTATGGTCATCTAATGGCTATTTTAACAGTAATGAAGGGGTTGCCCCTGGCTTATAAC
AAAGACATGCAGGAGGATAAAGAAGGATTATTTGATACGATTAATACGATAATCGTTTGCCTGCAAATGATAACTCCTTT
TTTGCAAAGTCTGACTTTTAATACCCCGTTAATGAGAACCAAAGCTCAAAGTGGTTACCTTGATGCAACTGCCATTCTGG
AGTCATTAGTGATGAAGGGTATGCCTTTTCGTGATGCGCACCATCAAGTTGGGGCATGGATTGCAGAAGCGATAGAAAAA
CAATGTTCACTGAATGAATTATTAAAAGGAGGCTAA

Upstream 100 bases:

>100_bases
GAAGAGGATAATGTATACAACCAAAAGGACGCTGAAGGATTCATTAACCTCTTTTCTTTATCCGCTAAAATTTATAGCCA
GGTACATCAGGGGGGGAATT

Downstream 100 bases:

>100_bases
GAATGTCTTTTTCCACCTCAACCAATTTGACTCCAATTGAAATGCAAGACGATGACCTTGAAAAAATTCAATCTCAGAAT
AACCCATCTGCAATTAATGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEAECQGIYSALEEIRTEIKQGQYSFNE
RDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLRLYTRDKGCLINELLTRLIVCLDDLTSKHQQDLMPGYTHLQ
QAQPVALGAYFNAYQCMFSRDKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIEL
CSVAAMIMMHLSRLCEDLILWSTQEFNFVTLDDAFATGSSLMPNKKNPDVPELIRGKSGRVYGHLMAILTVMKGLPLAYN
KDMQEDKEGLFDTINTIIVCLQMITPFLQSLTFNTPLMRTKAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEK
QCSLNELLKGG

Sequences:

>Translated_411_residues
MTNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEAECQGIYSALEEIRTEIKQGQYSFNE
RDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLRLYTRDKGCLINELLTRLIVCLDDLTSKHQQDLMPGYTHLQ
QAQPVALGAYFNAYQCMFSRDKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIEL
CSVAAMIMMHLSRLCEDLILWSTQEFNFVTLDDAFATGSSLMPNKKNPDVPELIRGKSGRVYGHLMAILTVMKGLPLAYN
KDMQEDKEGLFDTINTIIVCLQMITPFLQSLTFNTPLMRTKAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEK
QCSLNELLKGG
>Mature_410_residues
TNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEAECQGIYSALEEIRTEIKQGQYSFNER
DEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLRLYTRDKGCLINELLTRLIVCLDDLTSKHQQDLMPGYTHLQQ
AQPVALGAYFNAYQCMFSRDKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIELC
SVAAMIMMHLSRLCEDLILWSTQEFNFVTLDDAFATGSSLMPNKKNPDVPELIRGKSGRVYGHLMAILTVMKGLPLAYNK
DMQEDKEGLFDTINTIIVCLQMITPFLQSLTFNTPLMRTKAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEKQ
CSLNELLKGG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=406, Percent_Identity=44.5812807881773, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI68303542, Length=406, Percent_Identity=44.5812807881773, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI68303549, Length=406, Percent_Identity=42.6108374384236, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI68303547, Length=406, Percent_Identity=42.1182266009852, Blast_Score=306, Evalue=3e-83,
Organism=Escherichia coli, GI1790398, Length=405, Percent_Identity=50.3703703703704, Blast_Score=384, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321806, Length=401, Percent_Identity=45.1371571072319, Blast_Score=334, Evalue=2e-92,
Organism=Drosophila melanogaster, GI221473854, Length=410, Percent_Identity=39.7560975609756, Blast_Score=304, Evalue=8e-83,
Organism=Drosophila melanogaster, GI78706858, Length=410, Percent_Identity=39.7560975609756, Blast_Score=304, Evalue=8e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 46273; Mature: 46142

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEAECQGI
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
YSALEEIRTEIKQGQYSFNERDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLR
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
LYTRDKGCLINELLTRLIVCLDDLTSKHQQDLMPGYTHLQQAQPVALGAYFNAYQCMFSR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
DKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIEL
CHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCHHHHHHH
CSVAAMIMMHLSRLCEDLILWSTQEFNFVTLDDAFATGSSLMPNKKNPDVPELIRGKSGR
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHCCCCCC
VYGHLMAILTVMKGLPLAYNKDMQEDKEGLFDTINTIIVCLQMITPFLQSLTFNTPLMRT
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEKQCSLNELLKGG
HCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
TNKTWGGRFKKSLDSGVNQFNASLSFDHVLFDQDINGSQVHVKQLAKQKILTEAECQGI
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
YSALEEIRTEIKQGQYSFNERDEEDIHMFIEQLLIQKIGDLGKKLHTGRSRNDQVALDLR
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
LYTRDKGCLINELLTRLIVCLDDLTSKHQQDLMPGYTHLQQAQPVALGAYFNAYQCMFSR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
DKSRLEDWFKRMNYSPLGAGALAGSTLPLDREWVAESLGFAGIIPNTLDAVSDRDFVIEL
CHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCHHHHHHH
CSVAAMIMMHLSRLCEDLILWSTQEFNFVTLDDAFATGSSLMPNKKNPDVPELIRGKSGR
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHCCCCCC
VYGHLMAILTVMKGLPLAYNKDMQEDKEGLFDTINTIIVCLQMITPFLQSLTFNTPLMRT
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KAQSGYLDATAILESLVMKGMPFRDAHHQVGAWIAEAIEKQCSLNELLKGG
HCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA