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The map label for this gene is argG [H]

Identifier: 54293483

GI number: 54293483

Start: 577834

End: 579051

Strand: Direct

Name: argG [H]

Synonym: lpl0532

Alternate gene names: 54293483

Gene position: 577834-579051 (Clockwise)

Preceding gene: 54293482

Following gene: 54293484

Centisome position: 17.27

GC content: 40.64

Gene sequence:

>1218_bases
ATGAAAAAAAATATTAAAAAAATCGCATTGGCTTATTCAGGTGGTTTGGATACTTCCATCATGATCCCTTGGCTTAAAGA
GCATTATGAGCATGCTGAAGTAATCGCTGTGATTTGTGATTTAGGGCAACAGGAAGATCTCGATGCCATAAAAAATAAAG
CGCTAAAAAGCGGCGCTTCCAAAGCGTATGTAGTCGATGTGAAGAATGAGTTTGCCATTCAATATCTTTGGCCTTTGGTA
AAATCAGGTGCTTTATATGAAGATCAATACATTTTGGGCACTATTTCAAGGCCACTAATTGCTCAAAAGCTTGTTGAAAT
TGCTTTGACGGAGCAAGTAAATGCCGTTGCACATGGAGCCACCGGTAAAGGGAATGATCAAGTGCGTTTTGAATATTCGC
TTAAGGCACTTGCACCTCAGCTTGAAATTATTGCTCCCTGGAGAGCTTGGGATATTAAATCAAGACAGGAAGCAATTGTG
TATGCTAAAGCGCATGGCATTGAGGTACCAGTGACTCCCAAAGCGCCTTATTCTAGAGATCATAACATTTGGTATATTTC
TCATGAAGGTGGTGTGCTCGAAGATCCTTCTCAGGAGATGCCTGATGATGTGTTATTAATGACCAGTCCTGTATCGCAGG
CCCCTGATGAAGAGGAAATGATTATTCTTGATTTCAAAAAAGGGGTTCCAGTCGCCTTAAATGAACAAAAACTTTCTCCA
GTGGCTCTCTTAAATTCATTAAATCAAAAGGCAGGCCAGCATGGTATTGGAGTGGCAGACATTGTTGAAAATCGATTAGT
TGGGATGAAGATTCGAGGGATTTATGAAGCACCTGCTGCTGCCGTGCTTTATAAAGCGCATAAACTGCTGGAGAGTTTAT
GTCTCACTCGTTCAACGTTACATTTGAAGCAATCTTTGCAGCAAACTTATGCCAATTTGGTTTATGAAGGAAGATGGTTT
TCACAAACCAAGCAGGCTTTGGATGCATTCATTGATGTAACGCAGCAGCATGTCACGGGTCGTGTTAAGTTAAAGTTATT
CAAAGGAAACATTATCCCTGCCGGTATGCATTCTCCCTATAGCTTGCATCATCCAGCATTAGCTACTTTTGAAGAGGATA
ATGTATACAACCAAAAGGACGCTGAAGGATTCATTAACCTCTTTTCTTTATCCGCTAAAATTTATAGCCAGGTACATCAG
GGGGGGAATTATGACTAA

Upstream 100 bases:

>100_bases
TGCTGGTCGTAAAGCAAGGGAAATTAATTGCAGACTTTAAAACCCAAGAGGTGTCTGACCCTATTTTATATCTACAGCAG
TTTTACCAGGGGGAAATATT

Downstream 100 bases:

>100_bases
TAAAACATGGGGAGGGCGATTTAAGAAATCTTTGGATAGCGGTGTCAACCAGTTTAATGCGTCATTGTCTTTTGATCATG
TGCTTTTTGACCAGGACATT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKKNIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDAIKNKALKSGASKAYVVDVKNEFAIQYLWPLV
KSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGATGKGNDQVRFEYSLKALAPQLEIIAPWRAWDIKSRQEAIV
YAKAHGIEVPVTPKAPYSRDHNIWYISHEGGVLEDPSQEMPDDVLLMTSPVSQAPDEEEMIILDFKKGVPVALNEQKLSP
VALLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTLHLKQSLQQTYANLVYEGRWF
SQTKQALDAFIDVTQQHVTGRVKLKLFKGNIIPAGMHSPYSLHHPALATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQ
GGNYD

Sequences:

>Translated_405_residues
MKKNIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDAIKNKALKSGASKAYVVDVKNEFAIQYLWPLV
KSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGATGKGNDQVRFEYSLKALAPQLEIIAPWRAWDIKSRQEAIV
YAKAHGIEVPVTPKAPYSRDHNIWYISHEGGVLEDPSQEMPDDVLLMTSPVSQAPDEEEMIILDFKKGVPVALNEQKLSP
VALLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTLHLKQSLQQTYANLVYEGRWF
SQTKQALDAFIDVTQQHVTGRVKLKLFKGNIIPAGMHSPYSLHHPALATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQ
GGNYD
>Mature_405_residues
MKKNIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDAIKNKALKSGASKAYVVDVKNEFAIQYLWPLV
KSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGATGKGNDQVRFEYSLKALAPQLEIIAPWRAWDIKSRQEAIV
YAKAHGIEVPVTPKAPYSRDHNIWYISHEGGVLEDPSQEMPDDVLLMTSPVSQAPDEEEMIILDFKKGVPVALNEQKLSP
VALLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTLHLKQSLQQTYANLVYEGRWF
SQTKQALDAFIDVTQQHVTGRVKLKLFKGNIIPAGMHSPYSLHHPALATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQ
GGNYD

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=402, Percent_Identity=44.5273631840796, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI16950633, Length=402, Percent_Identity=44.5273631840796, Blast_Score=333, Evalue=1e-91,
Organism=Escherichia coli, GI1789563, Length=361, Percent_Identity=30.7479224376731, Blast_Score=148, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324514, Length=407, Percent_Identity=37.5921375921376, Blast_Score=269, Evalue=7e-73,
Organism=Drosophila melanogaster, GI21358151, Length=414, Percent_Identity=41.0628019323672, Blast_Score=307, Evalue=8e-84,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 45052; Mature: 45052

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDAIKNKALKSGAS
CCCCCEEEEEEECCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
KAYVVDVKNEFAIQYLWPLVKSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGA
CEEEEECCCCHHHHHHHHHHHCCCEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
TGKGNDQVRFEYSLKALAPQLEIIAPWRAWDIKSRQEAIVYAKAHGIEVPVTPKAPYSRD
CCCCCCEEEEEEEHHHHCCCEEEEECCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCC
HNIWYISHEGGVLEDPSQEMPDDVLLMTSPVSQAPDEEEMIILDFKKGVPVALNEQKLSP
CCEEEEECCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCH
VALLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTL
HHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
HLKQSLQQTYANLVYEGRWFSQTKQALDAFIDVTQQHVTGRVKLKLFKGNIIPAGMHSPY
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEECCCCCCC
SLHHPALATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQGGNYD
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKNIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDAIKNKALKSGAS
CCCCCEEEEEEECCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
KAYVVDVKNEFAIQYLWPLVKSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGA
CEEEEECCCCHHHHHHHHHHHCCCEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
TGKGNDQVRFEYSLKALAPQLEIIAPWRAWDIKSRQEAIVYAKAHGIEVPVTPKAPYSRD
CCCCCCEEEEEEEHHHHCCCEEEEECCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCC
HNIWYISHEGGVLEDPSQEMPDDVLLMTSPVSQAPDEEEMIILDFKKGVPVALNEQKLSP
CCEEEEECCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCH
VALLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTL
HHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
HLKQSLQQTYANLVYEGRWFSQTKQALDAFIDVTQQHVTGRVKLKLFKGNIIPAGMHSPY
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEECCCCCCC
SLHHPALATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQGGNYD
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA