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The map label for this gene is proA

Identifier: 54293459

GI number: 54293459

Start: 556038

End: 557669

Strand: Direct

Name: proA

Synonym: lpl0508

Alternate gene names: NA

Gene position: 556038-557669 (Clockwise)

Preceding gene: 54293458

Following gene: 54293461

Centisome position: 16.62

GC content: 39.64

Gene sequence:

>1632_bases
ATGCACCCAAATTATTATTTGTCACCTTTAGCTGTAGCTATAGCATTAGGGATTGCTTCACCTGTAAAGGCAGCCGACCC
GATCCCTTTACAAAAGTCGTCTTTTTCTGAAGTCACACAAAAATTTCAGTTGACTTTGCCTGGTGTTATGAAAGGTGCTG
TAGTTTCAACGAATAGTTTGCAGTTTATAAGACAGCATACTGATGGGAATAAAGTGACGCATGTTCGTATGCAGCAACAA
TATGCCGGGTTTCCAGTTTTTGGTGGTTACGCTATCCTGCACAGTAAGAATGCCACTCCTAGTTTAGCGACGGCAAAATC
TGATGTGAAAATGAATGGTGTGATTTATGATGGGTTGCAAGCAGAATTAGGCCAGCCTAAACCTTCATTTGTGAAAAATG
CTTCTTTGGCATTACAACAATTTAAGGATAAATACGCGAATAAGCAAATTAGTGAAGATCAAGTAACCCCAATGATTTAC
ATTGATGAAAAACATCAAGCTCATTGGGCTTACAAAGTCAGCGTTTTAGTTATCCATGACGATAGAATTCCTGAGCGGCC
AACAGCAATTATTGATGCAGAAACCAATAAGCCTTTTGTCCAATGGGATGATGTAAAAACGGAAAAAGTTCAAGCAAAAG
GGATGGGCTTTGGTGGAAATCGTAAAATTGGTGAATATCAATTTGGCAAGGACTTGCCATTATTAGAAATCACACGTGAT
TCAAGTGTTGAAATGTGCTTTATGGAAAATACCGATGTTAAAGTAGTCGACATGGGGCATAAGTACTATTCAAATAACAA
ACCTATGCAATTTACTTGTAAAGAGACTCCCGATACTCAATCGACTAAAACTTATTATACCGGATATTCGGCTGATGGTT
ATGATAGAGATAATGGAGCTGCTTCTCCTACCAATGACGCATTGTATGCAGGTTATGTCATTAAACACATGTACCATGAT
TGGTATGGGGTGGAGGCATTGACTAAATCAGATGGATCGCCAATGCAATTAGTTATGAGAGTGCATTATGGCCAAGGCTA
TGAAAACGCCTACTGGGACGGCAAACAAATGACCTTTGGTGATGGTGACACCATGATGTATCCTTTGGTTTCTCTAGGTG
TAGGTGGTCATGAAGTCAGCCACGGGTTCACCGAACAACATTCTGGACTTGAATATTTCGGTCAGTCTGGTGGCATGAAT
GAGTCGTTTTCAGATATGGCTGCCCAAGCTGCTGAATATTATTCAGTTGGAAAAAACAGCTGGCAAATCGGCCCGGAAAT
AATGAAAGAAGACAGTGGTTATGATGCATTGCGTTATATGGATAAACCAAGCCGTGATGGTATGTCTATTGATGTAGCTG
ATGATTATTATGGCGGGTTAGATGTTCATTACTCCAGTGGAGTGTATAACCATTTATTCTACATATTAGCCAATCAACCT
AATTGGAATCTTCGTATGGCTTTTGATGTCATGGTGAAAGCCAATATGGATTATTGGACACCTTATTCAACGTTTGATGA
GGGTGGTTGCGGTATGTTGAGTGCTGCCAAAGACCTGGGTTACAATCTGGATGATATTAAAAAGTCATTGAGTGAAGTGA
CTATAAATTATCAATCTTGTTATGTCGATTAA

Upstream 100 bases:

>100_bases
TACGCTAAAAATTAACTGAAAAATTATAGGGGAATATAACAAACCTGGGCACTCCAGGAAGAGTTGCTGTATGAGAATTT
AGTTTAAGGAGTTAGAATCA

Downstream 100 bases:

>100_bases
TTCATTTTATTGATTGATAAAATTTAGCCAGAAGTCGACTGATGACTTCTGGCTTTTCCATATGAATATGGTGTCCACCA
TCTAACCTCTCAATTTTAAT

Product: zinc metalloproteinase precursor

Products: NA

Alternate protein names: PEP1; PRO A [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MHPNYYLSPLAVAIALGIASPVKAADPIPLQKSSFSEVTQKFQLTLPGVMKGAVVSTNSLQFIRQHTDGNKVTHVRMQQQ
YAGFPVFGGYAILHSKNATPSLATAKSDVKMNGVIYDGLQAELGQPKPSFVKNASLALQQFKDKYANKQISEDQVTPMIY
IDEKHQAHWAYKVSVLVIHDDRIPERPTAIIDAETNKPFVQWDDVKTEKVQAKGMGFGGNRKIGEYQFGKDLPLLEITRD
SSVEMCFMENTDVKVVDMGHKYYSNNKPMQFTCKETPDTQSTKTYYTGYSADGYDRDNGAASPTNDALYAGYVIKHMYHD
WYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFGDGDTMMYPLVSLGVGGHEVSHGFTEQHSGLEYFGQSGGMN
ESFSDMAAQAAEYYSVGKNSWQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVADDYYGGLDVHYSSGVYNHLFYILANQP
NWNLRMAFDVMVKANMDYWTPYSTFDEGGCGMLSAAKDLGYNLDDIKKSLSEVTINYQSCYVD

Sequences:

>Translated_543_residues
MHPNYYLSPLAVAIALGIASPVKAADPIPLQKSSFSEVTQKFQLTLPGVMKGAVVSTNSLQFIRQHTDGNKVTHVRMQQQ
YAGFPVFGGYAILHSKNATPSLATAKSDVKMNGVIYDGLQAELGQPKPSFVKNASLALQQFKDKYANKQISEDQVTPMIY
IDEKHQAHWAYKVSVLVIHDDRIPERPTAIIDAETNKPFVQWDDVKTEKVQAKGMGFGGNRKIGEYQFGKDLPLLEITRD
SSVEMCFMENTDVKVVDMGHKYYSNNKPMQFTCKETPDTQSTKTYYTGYSADGYDRDNGAASPTNDALYAGYVIKHMYHD
WYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFGDGDTMMYPLVSLGVGGHEVSHGFTEQHSGLEYFGQSGGMN
ESFSDMAAQAAEYYSVGKNSWQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVADDYYGGLDVHYSSGVYNHLFYILANQP
NWNLRMAFDVMVKANMDYWTPYSTFDEGGCGMLSAAKDLGYNLDDIKKSLSEVTINYQSCYVD
>Mature_543_residues
MHPNYYLSPLAVAIALGIASPVKAADPIPLQKSSFSEVTQKFQLTLPGVMKGAVVSTNSLQFIRQHTDGNKVTHVRMQQQ
YAGFPVFGGYAILHSKNATPSLATAKSDVKMNGVIYDGLQAELGQPKPSFVKNASLALQQFKDKYANKQISEDQVTPMIY
IDEKHQAHWAYKVSVLVIHDDRIPERPTAIIDAETNKPFVQWDDVKTEKVQAKGMGFGGNRKIGEYQFGKDLPLLEITRD
SSVEMCFMENTDVKVVDMGHKYYSNNKPMQFTCKETPDTQSTKTYYTGYSADGYDRDNGAASPTNDALYAGYVIKHMYHD
WYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFGDGDTMMYPLVSLGVGGHEVSHGFTEQHSGLEYFGQSGGMN
ESFSDMAAQAAEYYSVGKNSWQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVADDYYGGLDVHYSSGVYNHLFYILANQP
NWNLRMAFDVMVKANMDYWTPYSTFDEGGCGMLSAAKDLGYNLDDIKKSLSEVTINYQSCYVD

Specific function: Cleaves collagen, gelatin, casein, alpha-1-antitrypsin, and bovine insulin. May play a role in the pathogenesis of legionnaires disease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: NA

Molecular weight: Translated: 60671; Mature: 60671

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPNYYLSPLAVAIALGIASPVKAADPIPLQKSSFSEVTQKFQLTLPGVMKGAVVSTNSL
CCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHEEEECCCHHCCCEEECCCH
QFIRQHTDGNKVTHVRMQQQYAGFPVFGGYAILHSKNATPSLATAKSDVKMNGVIYDGLQ
HHHHCCCCCCEEEEEEEHHHHCCCCEECCEEEEECCCCCCCHHCCCCCCEECCEEECCCH
AELGQPKPSFVKNASLALQQFKDKYANKQISEDQVTPMIYIDEKHQAHWAYKVSVLVIHD
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEEEC
DRIPERPTAIIDAETNKPFVQWDDVKTEKVQAKGMGFGGNRKIGEYQFGKDLPLLEITRD
CCCCCCCCEEEECCCCCCEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECC
SSVEMCFMENTDVKVVDMGHKYYSNNKPMQFTCKETPDTQSTKTYYTGYSADGYDRDNGA
CCEEEEEECCCCEEEEECCCHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCC
ASPTNDALYAGYVIKHMYHDWYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFG
CCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEECCCCCCCCEECCCEEEEC
DGDTMMYPLVSLGVGGHEVSHGFTEQHSGLEYFGQSGGMNESFSDMAAQAAEYYSVGKNS
CCCEEEHHHHHHCCCCHHHCCCCHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
WQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVADDYYGGLDVHYSSGVYNHLFYILANQP
CCCCHHHHCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCEEEEECCCCCEEEEEEEECCC
NWNLRMAFDVMVKANMDYWTPYSTFDEGGCGMLSAAKDLGYNLDDIKKSLSEVTINYQSC
CCCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHEEEEEHEE
YVD
ECC
>Mature Secondary Structure
MHPNYYLSPLAVAIALGIASPVKAADPIPLQKSSFSEVTQKFQLTLPGVMKGAVVSTNSL
CCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHEEEECCCHHCCCEEECCCH
QFIRQHTDGNKVTHVRMQQQYAGFPVFGGYAILHSKNATPSLATAKSDVKMNGVIYDGLQ
HHHHCCCCCCEEEEEEEHHHHCCCCEECCEEEEECCCCCCCHHCCCCCCEECCEEECCCH
AELGQPKPSFVKNASLALQQFKDKYANKQISEDQVTPMIYIDEKHQAHWAYKVSVLVIHD
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEEEC
DRIPERPTAIIDAETNKPFVQWDDVKTEKVQAKGMGFGGNRKIGEYQFGKDLPLLEITRD
CCCCCCCCEEEECCCCCCEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECC
SSVEMCFMENTDVKVVDMGHKYYSNNKPMQFTCKETPDTQSTKTYYTGYSADGYDRDNGA
CCEEEEEECCCCEEEEECCCHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCC
ASPTNDALYAGYVIKHMYHDWYGVEALTKSDGSPMQLVMRVHYGQGYENAYWDGKQMTFG
CCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEECCCCCCCCEECCCEEEEC
DGDTMMYPLVSLGVGGHEVSHGFTEQHSGLEYFGQSGGMNESFSDMAAQAAEYYSVGKNS
CCCEEEHHHHHHCCCCHHHCCCCHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
WQIGPEIMKEDSGYDALRYMDKPSRDGMSIDVADDYYGGLDVHYSSGVYNHLFYILANQP
CCCCHHHHCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCEEEEECCCCCEEEEEEEECCC
NWNLRMAFDVMVKANMDYWTPYSTFDEGGCGMLSAAKDLGYNLDDIKKSLSEVTINYQSC
CCCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHEEEEEHEE
YVD
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110146 [H]