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The map label for this gene is zwf [H]

Identifier: 54293410

GI number: 54293410

Start: 502055

End: 503545

Strand: Direct

Name: zwf [H]

Synonym: lpl0459

Alternate gene names: 54293410

Gene position: 502055-503545 (Clockwise)

Preceding gene: 54293408

Following gene: 54293411

Centisome position: 15.01

GC content: 37.63

Gene sequence:

>1491_bases
ATGCTCTTAAAAGCAGAATCGAAGTATCCTTGTGATTTAATTTTGTTTGGTACGCTGGGTGACTTGTCTTGTCGAAAATT
GTTGCCCGCATTATATCAACTAGAACTGGCTAATTTACTTCACGAAAAAACAAGAATTATTGGGTGTGCCCGAGAAGAGC
TCGATTTTTCTGCTTATGTTGACTTGATTAAAAATAAAATTCAGCAATTTTTATTTGATGAAATTGATGAAGCAGTATGG
TTACGTTTTGTAAAGAAACTGGCTTATTGCAAACTTGATCTAAATCAATCAGATGATTATCAAAAATTAACGGACTATGT
TAACCCTTCTGAGCGAGTGGTTATTTCTTACTTGGCAATTCCTCCAAGCCTTTATTCTCAAACTTGCCGCAGTCTTGCTC
GCCTTAATCTAACACAGAAACCATCGCGAGTTGTTTTGGAAAAACCAATTGGCCATGATTTGCCTTCTTCTGTAGCAACC
AACGAACAAGTGGCTTGTTTTTTTGCTGAAGATCAGATTTATCGAATTGATCATTACCTGGGTAAAGAAACCGTCTTGAA
TTTATTAGTGCTTCGCTTTGCTAATTCGATATTTTCAACCAATTGGGATAATCGCGTTATTGATCGAGTTGAAATTTCTG
TTGCCGAAGAAATCGGTGTTGAAGGCCGTTGGGAATATTATGATAAGTCGGGCCAAGTCAGGGACATGCTGCAAAATCAT
TTGTTACAAATATTATCTTTAGTTGCGATGGAACCCCCCTTAAGCCTTTCAGCAGAAAGCATCAGAAGCGAAAAATTAAA
AGTACTGAAATCTTTGCGTTTTATTAACAAGTCTAATGTTCATGATCATACAGTACGAGCCCAATATGTGGCTAATACTT
TAGCAAATGGTAAAAAAATACCTGGTTATTTGGAAGAGGTGGGTGCTAATCAGGCATCTACAACAGAAACTTTTGTTGCT
ATCAAAGCCTATGTAGACAATTGGCGATGGTCTGGTGTTCCATTCTATATGCTTACAGGCAAAAGATTACCCAAAAAGCA
AAGCGAAGTGGTTATTTATTTTAAACCACAGCCTTATAATATATTCCATCCCTTAAATGAAGAATTGTACCCTAATCAGT
TAATTATTCGCTTACAACCCGATGAAGGGGTGGAGGTGAGGATAATGAATAAAATCCCGGGTCTTGGTGAGCGTATGATG
TTGCATGATTCCAAGTTGGATTTAAATTTTCATCATAGTTTTAAAACGCAAAGGATTGCTGATGCCTATGAGAGATTATT
GCTAGAGGTCATGTTAGGTAATCAGTATCTTTTTGTAAGCCGAGAAGAAATTGAACAGGCTTGGCAATGGATTGACAGTA
TTGTATCGGCATGGGAAGAAGATAATATTCCGTTGTATACCTATCCAGCTTGTACATGGGGGCCAAAGGAAGTCATACGC
TTATTTAATGGGCAAGCACATGTTTGGGGTGATCACAATGCAGTTTCATAG

Upstream 100 bases:

>100_bases
CGAATGAGCGAAAAAAATCAATTTTGATTGACGCTTGATTCCAGTGATGTAAAATCGATGCAATTTCAGGGACATAGTTA
TTGTAATTTTGGGATGATAT

Downstream 100 bases:

>100_bases
TTTTAGGGATGCCAAACAGTTGATTCATGACATGGTGGAAAAATTAAGAACTATTCTATCAGATGCAATCAAACGAAGAG
GGCAAGCTTTTTTGGTGGTT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYVDLIKNKIQQFLFDEIDEAVW
LRFVKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAIPPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVAT
NEQVACFFAEDQIYRIDHYLGKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNVHDHTVRAQYVANTLANGKKIPGYLEEVGANQASTTETFVA
IKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYNIFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMM
LHDSKLDLNFHHSFKTQRIADAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
LFNGQAHVWGDHNAVS

Sequences:

>Translated_496_residues
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYVDLIKNKIQQFLFDEIDEAVW
LRFVKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAIPPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVAT
NEQVACFFAEDQIYRIDHYLGKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNVHDHTVRAQYVANTLANGKKIPGYLEEVGANQASTTETFVA
IKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYNIFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMM
LHDSKLDLNFHHSFKTQRIADAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
LFNGQAHVWGDHNAVS
>Mature_496_residues
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYVDLIKNKIQQFLFDEIDEAVW
LRFVKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAIPPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVAT
NEQVACFFAEDQIYRIDHYLGKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNVHDHTVRAQYVANTLANGKKIPGYLEEVGANQASTTETFVA
IKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYNIFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMM
LHDSKLDLNFHHSFKTQRIADAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
LFNGQAHVWGDHNAVS

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=475, Percent_Identity=37.4736842105263, Blast_Score=305, Evalue=8e-83,
Organism=Homo sapiens, GI108773793, Length=475, Percent_Identity=37.4736842105263, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI52145310, Length=505, Percent_Identity=27.5247524752475, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788158, Length=487, Percent_Identity=53.388090349076, Blast_Score=559, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=37.9876796714579, Blast_Score=309, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6324088, Length=474, Percent_Identity=33.5443037974684, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24643350, Length=489, Percent_Identity=36.1963190184049, Blast_Score=291, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24643352, Length=489, Percent_Identity=36.1963190184049, Blast_Score=291, Evalue=6e-79,
Organism=Drosophila melanogaster, GI221513548, Length=480, Percent_Identity=29.1666666666667, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57282; Mature: 57282

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYV
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
DLIKNKIQQFLFDEIDEAVWLRFVKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHCCCCCCCEEEEEEEC
PPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVATNEQVACFFAEDQIYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHH
GKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNVHDHTVRAQYVANTLANGKKI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
PGYLEEVGANQASTTETFVAIKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYN
CCHHHHHCCCCCCCHHHHHHHEEHHCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCC
IFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMMLHDSKLDLNFHHSFKTQRIA
CCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEEECCCCCEEECCCHHHHHHH
DAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
HHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHH
LFNGQAHVWGDHNAVS
HHCCCEEEECCCCCCC
>Mature Secondary Structure
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYV
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
DLIKNKIQQFLFDEIDEAVWLRFVKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHCCCCCCCEEEEEEEC
PPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVATNEQVACFFAEDQIYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHH
GKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNVHDHTVRAQYVANTLANGKKI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
PGYLEEVGANQASTTETFVAIKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYN
CCHHHHHCCCCCCCHHHHHHHEEHHCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCC
IFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMMLHDSKLDLNFHHSFKTQRIA
CCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEEECCCCCEEECCCHHHHHHH
DAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
HHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHH
LFNGQAHVWGDHNAVS
HHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]