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The map label for this gene is pncB [H]

Identifier: 54293274

GI number: 54293274

Start: 367556

End: 368959

Strand: Direct

Name: pncB [H]

Synonym: lpl0322

Alternate gene names: 54293274

Gene position: 367556-368959 (Clockwise)

Preceding gene: 54293273

Following gene: 54293275

Centisome position: 10.99

GC content: 40.88

Gene sequence:

>1404_bases
ATGATAAACATCACAGGAACCTACACTGATCAATATCAATTGGCTATGGCTCAAGTGTGTTTTTTAAAAGGGCAGCATGA
GCGCATAGCGACATTCGATTATTTTTTTCGAGCTCTTCCTTTTAAAGGAGGCTATGCGATTTTTGCGGGTTTGGAGGATT
TACTGGATGTTCTCGAACAACTTCACTTTGAACAACAAGATATAGAGTTTTTACAACATCAGAATATGCATCCTGACTTT
ATTCGCTATTTGCAGCAGTTTAAGTTCAATGGCACGGTGTATACGTCGCTCGAGGGAGATGTTGTATTTCCTACGCGGCC
AGTGGTTATTATCGAAGCCAATTTGATTGAAGCACAAATCATAGAAACGTTATTATTAAATATTCTTAATTTTCAGACAC
TTATTGCGACAAAAGCCAGACGCATCAGACAGGTTGCGGGAGAACGGATTTTAATTGATTTTGGCCTAAGGAGAGCACAG
GGTGCTGGAGGGTATTTTGCAAGCCGTGCAGCCATAGTCGGTGGCTTTGATTCGACAAGCAATGTCAGAGCAGGGCGTGA
TTATTCAATTCCTGTATCGGGTACTATGGCTCATTCCTTTATCCAAAGTTACGATAGCGAGATACAAGCTTTTTCTGATT
ATGCCGAAGCATGGCCGGAGAATTGTGTCTTGCTAGTAGATACTTATAATACCTTGCAAAGTGGTGTTCCCAATGCAATC
AAAATAGCTAAGGAAATGGAGAAGAGAGGACATAGACTCAAAGGCATTCGCCTGGATAGCGGCGATTTGGCATGGTTAGC
CAAGAGGGCTCGCCACCTGTTAGACGAGGCCGGTTTAAACTATGTGGCTATTACAGCTTCCAATCAACTCGATGAATATG
TCATCAAGAATTTGTTAGAGCAGGATGCGCCTATTGATGCTTTTGGTGTGGGGACCAATCTCGCGATTGGTGCCCCGGAT
GCGGCTCTTGATGGGGTTTATAAATTAGCGTTTATAAATGGTCAACCTAGGATTAAATTATCAGATACCCCTGCAAAGAT
CACTATTCCTTATCAAAAGCAAGTCTACAGGGTGTTCGAAAGAGATGGGACATATCGGGGTGCGGATGTTGTCTGTCTCA
AAACGGAAAAAAAAATTGATATGATGCATCATCCTTTTGAAGTTCTAAAATCACTTTCGATAAAGCACTATAAAAAAGAA
GCATTACTGCATAAAGTGATGGAAAACGGCAAACGGTTACTACCTAAAAAATCACTTGGAGAAATAGCCAGGTTTAGCCA
GCAATGTTTTGATCGATTGCCTTTGGAATACAAGCGTTTTATTAATCCTCATATCTATAAAGTGGGTTTAAGTACCGAGC
TTAAAATGAAGAGAGATCAACTGATAACTGAACACTCAAGATAA

Upstream 100 bases:

>100_bases
TCAAGAGTAAAAGGAACTAGGCCAGTTGTTGCCCATATTAAATTTTTAACTTATACCGCGCATGGTCAAAATAAAAGCAA
TATAATCGACAAGGATATAC

Downstream 100 bases:

>100_bases
TTTTATGAAGACTTTAATCATCCTCGATGTTCAAAATGATTTCATGCGAGGCGGCTCACTGGGAGTGCCGAATGGTGATG
CGATTGTTCCTGTTATTAAC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MINITGTYTDQYQLAMAQVCFLKGQHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQLHFEQQDIEFLQHQNMHPDF
IRYLQQFKFNGTVYTSLEGDVVFPTRPVVIIEANLIEAQIIETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQ
GAGGYFASRAAIVGGFDSTSNVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCVLLVDTYNTLQSGVPNAI
KIAKEMEKRGHRLKGIRLDSGDLAWLAKRARHLLDEAGLNYVAITASNQLDEYVIKNLLEQDAPIDAFGVGTNLAIGAPD
AALDGVYKLAFINGQPRIKLSDTPAKITIPYQKQVYRVFERDGTYRGADVVCLKTEKKIDMMHHPFEVLKSLSIKHYKKE
ALLHKVMENGKRLLPKKSLGEIARFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLITEHSR

Sequences:

>Translated_467_residues
MINITGTYTDQYQLAMAQVCFLKGQHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQLHFEQQDIEFLQHQNMHPDF
IRYLQQFKFNGTVYTSLEGDVVFPTRPVVIIEANLIEAQIIETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQ
GAGGYFASRAAIVGGFDSTSNVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCVLLVDTYNTLQSGVPNAI
KIAKEMEKRGHRLKGIRLDSGDLAWLAKRARHLLDEAGLNYVAITASNQLDEYVIKNLLEQDAPIDAFGVGTNLAIGAPD
AALDGVYKLAFINGQPRIKLSDTPAKITIPYQKQVYRVFERDGTYRGADVVCLKTEKKIDMMHHPFEVLKSLSIKHYKKE
ALLHKVMENGKRLLPKKSLGEIARFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLITEHSR
>Mature_467_residues
MINITGTYTDQYQLAMAQVCFLKGQHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQLHFEQQDIEFLQHQNMHPDF
IRYLQQFKFNGTVYTSLEGDVVFPTRPVVIIEANLIEAQIIETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQ
GAGGYFASRAAIVGGFDSTSNVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCVLLVDTYNTLQSGVPNAI
KIAKEMEKRGHRLKGIRLDSGDLAWLAKRARHLLDEAGLNYVAITASNQLDEYVIKNLLEQDAPIDAFGVGTNLAIGAPD
AALDGVYKLAFINGQPRIKLSDTPAKITIPYQKQVYRVFERDGTYRGADVVCLKTEKKIDMMHHPFEVLKSLSIKHYKKE
ALLHKVMENGKRLLPKKSLGEIARFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLITEHSR

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=521, Percent_Identity=31.4779270633397, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI71997947, Length=516, Percent_Identity=36.6279069767442, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI71997952, Length=516, Percent_Identity=36.6279069767442, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI71997955, Length=206, Percent_Identity=47.0873786407767, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24581587, Length=510, Percent_Identity=36.078431372549, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=45.0980392156863, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 53007; Mature: 53007

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINITGTYTDQYQLAMAQVCFLKGQHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQ
CEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LHFEQQDIEFLQHQNMHPDFIRYLQQFKFNGTVYTSLEGDVVFPTRPVVIIEANLIEAQI
HCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCEECCCCCEEEEECCHHHHHH
IETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQGAGGYFASRAAIVGGFDSTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHCCCCCCHHHHCCEEEECCCCCC
NVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCVLLVDTYNTLQSGVPNAI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHCCCHHH
KIAKEMEKRGHRLKGIRLDSGDLAWLAKRARHLLDEAGLNYVAITASNQLDEYVIKNLLE
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHH
QDAPIDAFGVGTNLAIGAPDAALDGVYKLAFINGQPRIKLSDTPAKITIPYQKQVYRVFE
CCCCCCEECCCCCEEECCCCHHHCCEEEEEEECCCCCEEECCCCCEEEECHHHHHHHHHH
RDGTYRGADVVCLKTEKKIDMMHHPFEVLKSLSIKHYKKEALLHKVMENGKRLLPKKSLG
HCCCCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHH
EIARFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLITEHSR
HHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MINITGTYTDQYQLAMAQVCFLKGQHERIATFDYFFRALPFKGGYAIFAGLEDLLDVLEQ
CEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LHFEQQDIEFLQHQNMHPDFIRYLQQFKFNGTVYTSLEGDVVFPTRPVVIIEANLIEAQI
HCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCEECCCCCEEEEECCHHHHHH
IETLLLNILNFQTLIATKARRIRQVAGERILIDFGLRRAQGAGGYFASRAAIVGGFDSTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHCCCCCCHHHHCCEEEECCCCCC
NVRAGRDYSIPVSGTMAHSFIQSYDSEIQAFSDYAEAWPENCVLLVDTYNTLQSGVPNAI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHCCCHHH
KIAKEMEKRGHRLKGIRLDSGDLAWLAKRARHLLDEAGLNYVAITASNQLDEYVIKNLLE
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHH
QDAPIDAFGVGTNLAIGAPDAALDGVYKLAFINGQPRIKLSDTPAKITIPYQKQVYRVFE
CCCCCCEECCCCCEEECCCCHHHCCEEEEEEECCCCCEEECCCCCEEEECHHHHHHHHHH
RDGTYRGADVVCLKTEKKIDMMHHPFEVLKSLSIKHYKKEALLHKVMENGKRLLPKKSLG
HCCCCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHH
EIARFSQQCFDRLPLEYKRFINPHIYKVGLSTELKMKRDQLITEHSR
HHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]