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The map label for this gene is hlyA

Identifier: 54020395

GI number: 54020395

Start: 246647

End: 247360

Strand: Reverse

Name: hlyA

Synonym: mhp218

Alternate gene names: 54020395

Gene position: 247360-246647 (Counterclockwise)

Preceding gene: 54020396

Following gene: 54020394

Centisome position: 27.71

GC content: 27.17

Gene sequence:

>714_bases
ATGACCCTACTCGAAAAGGTTTTAAAAATGGGCTTTGAAAAGGCAGAATCACTAATTCGTACAGGTTATGTAAAGCTCAA
TAATCAAACTTGTTATTTTCCAGGTCAAAAAATTTCAAATTTAGATTCCATTAATATTAAAGAAAAACAAAAATATGTCT
CTCGGGGCGCCTTAAAATTACAAGCCGCATATGATTATTTCAAACTTAATTTTCAAGATAAAATTATCCTTGATATTGGC
GCTTCTAAAGGGGGTTTTACTCAATTTTGTCTTGAAAAAGGAGCTAAAAAAGTTTATGCACTAGATTCAGGAACTAACCA
ACTTGATTATTCACTGCGAATTAACCCTAAAGTTTGTGTAAAAGAAAAGACAAATATCAAATTTGTTGATAAAAGTTTTT
TTAATGATGAAATTGATCTAATAGTTTGTGATGTTTCGTTTATTAGTCTTAAAAAAATTTTAGCGGTAGTTAAAAATTTG
TTAACACAAGGTAAAAATTTTATCACACTTTTAAAACCGCAATTCGAAGCAAATTCAAAATATGTCCAAAAGGGTGGAAT
TGTTCCAAAATTATACCATAAATTTTTAATTAATAGAATTATTGAATTTGCAAAACCAAGTTTTGAATTTCTCAATTTTT
TTGAATCACCAATTAAAGGACAAAAATCCAAAAATACAGAGTATTTTTTACATTTTATTAGAAAGAATGACTAA

Upstream 100 bases:

>100_bases
CAAACGCCGGGACGCTTTTAATGCTTTATCAATTGAATGAATTAAAGTTGATTCGGTGTTTAATCTTAAAATTATTGCGA
TTTTAAAGAGGTGAAAATAA

Downstream 100 bases:

>100_bases
CTTTAAAAATAATTTTCCTTTTCTTAACAAGGTTACTTACCTTGATTCTGCAGCAATGATGCAAAAACCACTTTCTGTAA
TTAAAAAAATTAGTGACTTT

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTLLEKVLKMGFEKAESLIRTGYVKLNNQTCYFPGQKISNLDSINIKEKQKYVSRGALKLQAAYDYFKLNFQDKIILDIG
ASKGGFTQFCLEKGAKKVYALDSGTNQLDYSLRINPKVCVKEKTNIKFVDKSFFNDEIDLIVCDVSFISLKKILAVVKNL
LTQGKNFITLLKPQFEANSKYVQKGGIVPKLYHKFLINRIIEFAKPSFEFLNFFESPIKGQKSKNTEYFLHFIRKND

Sequences:

>Translated_237_residues
MTLLEKVLKMGFEKAESLIRTGYVKLNNQTCYFPGQKISNLDSINIKEKQKYVSRGALKLQAAYDYFKLNFQDKIILDIG
ASKGGFTQFCLEKGAKKVYALDSGTNQLDYSLRINPKVCVKEKTNIKFVDKSFFNDEIDLIVCDVSFISLKKILAVVKNL
LTQGKNFITLLKPQFEANSKYVQKGGIVPKLYHKFLINRIIEFAKPSFEFLNFFESPIKGQKSKNTEYFLHFIRKND
>Mature_236_residues
TLLEKVLKMGFEKAESLIRTGYVKLNNQTCYFPGQKISNLDSINIKEKQKYVSRGALKLQAAYDYFKLNFQDKIILDIGA
SKGGFTQFCLEKGAKKVYALDSGTNQLDYSLRINPKVCVKEKTNIKFVDKSFFNDEIDLIVCDVSFISLKKILAVVKNLL
TQGKNFITLLKPQFEANSKYVQKGGIVPKLYHKFLINRIIEFAKPSFEFLNFFESPIKGQKSKNTEYFLHFIRKND

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG1189

COG function: function code J; Predicted rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004538
- InterPro:   IPR002877
- InterPro:   IPR002942 [H]

Pfam domain/function: PF01728 FtsJ; PF01479 S4 [H]

EC number: NA

Molecular weight: Translated: 27277; Mature: 27146

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLEKVLKMGFEKAESLIRTGYVKLNNQTCYFPGQKISNLDSINIKEKQKYVSRGALKL
CHHHHHHHHHCHHHHHHHHHHCEEEECCEEEECCCCHHCCCCCCCHHHHHHHHHHCCEEE
QAAYDYFKLNFQDKIILDIGASKGGFTQFCLEKGAKKVYALDSGTNQLDYSLRINPKVCV
EEECCEEEECCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEEEECCEEEE
KEKTNIKFVDKSFFNDEIDLIVCDVSFISLKKILAVVKNLLTQGKNFITLLKPQFEANSK
ECCCCEEEEEHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCH
YVQKGGIVPKLYHKFLINRIIEFAKPSFEFLNFFESPIKGQKSKNTEYFLHFIRKND
HHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHEEEEEECCC
>Mature Secondary Structure 
TLLEKVLKMGFEKAESLIRTGYVKLNNQTCYFPGQKISNLDSINIKEKQKYVSRGALKL
HHHHHHHHHCHHHHHHHHHHCEEEECCEEEECCCCHHCCCCCCCHHHHHHHHHHCCEEE
QAAYDYFKLNFQDKIILDIGASKGGFTQFCLEKGAKKVYALDSGTNQLDYSLRINPKVCV
EEECCEEEECCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEEEECCEEEE
KEKTNIKFVDKSFFNDEIDLIVCDVSFISLKKILAVVKNLLTQGKNFITLLKPQFEANSK
ECCCCEEEEEHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCH
YVQKGGIVPKLYHKFLINRIIEFAKPSFEFLNFFESPIKGQKSKNTEYFLHFIRKND
HHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1730486 [H]