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The map label for this gene is hpt

Identifier: 54020347

GI number: 54020347

Start: 139503

End: 140039

Strand: Reverse

Name: hpt

Synonym: mhp117

Alternate gene names: 54020347

Gene position: 140039-139503 (Counterclockwise)

Preceding gene: 54020348

Following gene: 54020346

Centisome position: 15.69

GC content: 28.68

Gene sequence:

>537_bases
ATGATTAATAAACATATAAGTCAAATTCTCTATAACCGTGATCAAATTAAAGCGAGAATTGCTGAAATCGGGAAGTGGAT
AAATGAAACTTATAAAGATTCTAATGAAATTGTTTTTATAGGTGTGCTTAAAGGTTCGCTAATTTTTTTAACTGAATTAA
TTCAGAGTGTAGATGTGGATTCAATGGTTGATTTTGTGATTGCAAAATCATATTTTGGTGGGTCAGAATCAACTGGTGAA
TTAAAAGTTATTACAGATATTGATATTCAAATCCAAAATAAAGATGTAATTTTAATTGATGACATTCTTGATTCAGGGAT
AACATTATCAAAAATTAGGGATCATTTAAAATTAAAAAACCCAAAATCCTTGAGGGTTATTACTCTTTTTGATAAAAAGG
TAAAAAGAAAATACGATATTCAAGCAGATGTTTCTGGCTTTGTAGTTCCGGACGCTTTTCTTGTTGGATATGGTCTTGAT
TATCAGGATAAATATCGTAATTGACCTTTTGTAGCTATTTTTGATCCTAATAAATAG

Upstream 100 bases:

>100_bases
ACGAGAAGGATTTGCAGATAAAAAAAAAGAAAAATAAATATCAAAAATTTTCTAAAAATAATGTATAATTAAAAGTTAAA
AATATTTGAGGTGTTAAAAA

Downstream 100 bases:

>100_bases
TAAAAAAAAAAAAAAAAAAAGGTAATTAATGATAAAAGTTTCCGATGTTTGCTTTAGTTATACAAACAACATGGATCAGC
TTGTGCTGAAAAATATTAAT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MINKHISQILYNRDQIKARIAEIGKWINETYKDSNEIVFIGVLKGSLIFLTELIQSVDVDSMVDFVIAKSYFGGSESTGE
LKVITDIDIQIQNKDVILIDDILDSGITLSKIRDHLKLKNPKSLRVITLFDKKVKRKYDIQADVSGFVVPDAFLVGYGLD
YQDKYRNWPFVAIFDPNK

Sequences:

>Translated_178_residues
MINKHISQILYNRDQIKARIAEIGKWINETYKDSNEIVFIGVLKGSLIFLTELIQSVDVDSMVDFVIAKSYFGGSESTGE
LKVITDIDIQIQNKDVILIDDILDSGITLSKIRDHLKLKNPKSLRVITLFDKKVKRKYDIQADVSGFVVPDAFLVGYGLD
YQDKYRN*PFVAIFDPNK
>Mature_178_residues
MINKHISQILYNRDQIKARIAEIGKWINETYKDSNEIVFIGVLKGSLIFLTELIQSVDVDSMVDFVIAKSYFGGSESTGE
LKVITDIDIQIQNKDVILIDDILDSGITLSKIRDHLKLKNPKSLRVITLFDKKVKRKYDIQADVSGFVVPDAFLVGYGLD
YQDKYRN*PFVAIFDPNK

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=144, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI9910262, Length=143, Percent_Identity=28.6713286713287, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI87081689, Length=170, Percent_Identity=44.1176470588235, Blast_Score=161, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17510817, Length=171, Percent_Identity=32.1637426900585, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20143; Mature: 20143

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00962 RIBOSOMAL_S2_1 ; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKHISQILYNRDQIKARIAEIGKWINETYKDSNEIVFIGVLKGSLIFLTELIQSVDVD
CCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCHH
SMVDFVIAKSYFGGSESTGELKVITDIDIQIQNKDVILIDDILDSGITLSKIRDHLKLKN
HHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCEEEEECHHCCCCCHHHHHHHHCCCC
PKSLRVITLFDKKVKRKYDIQADVSGFVVPDAFLVGYGLDYQDKYRNPFVAIFDPNK
CCCEEEEEEECHHHHHHCCCEECCCCEECCCCEEEECCCCHHHHHCCCEEEEECCCC
>Mature Secondary Structure
MINKHISQILYNRDQIKARIAEIGKWINETYKDSNEIVFIGVLKGSLIFLTELIQSVDVD
CCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCHH
SMVDFVIAKSYFGGSESTGELKVITDIDIQIQNKDVILIDDILDSGITLSKIRDHLKLKN
HHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCEEEEECHHCCCCCHHHHHHHHCCCC
PKSLRVITLFDKKVKRKYDIQADVSGFVVPDAFLVGYGLDYQDKYRNPFVAIFDPNK
CCCEEEEEEECHHHHHHCCCEECCCCEECCCCEEEECCCCHHHHHCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]