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The map label for this gene is rnr [H]

Identifier: 54020321

GI number: 54020321

Start: 49592

End: 51676

Strand: Reverse

Name: rnr [H]

Synonym: mhp038

Alternate gene names: 54020321

Gene position: 51676-49592 (Counterclockwise)

Preceding gene: 54020322

Following gene: 54020320

Centisome position: 5.79

GC content: 28.63

Gene sequence:

>2085_bases
ATGGAAATTATATCGGAAGAGCGCTTAAAAAATTTTCTGCGTCAAGAAAAAACTTTTATTGAAATTGTTCGAAAATTTAA
CATTCCTTTCAATTTAAATCACCAGCTAACTAATCAAATTAGTAATCTAATTGAAAATTTTGTTGTTTTTAAAACCCCTG
AAGGAAAATATTATGCTCCTAAATTTCTCAAAACCACATCTGGAATTTTCAGAGCAACCAATTCTGCTTTTGGTTTTGTT
GAAGACAAAGAAAATCCAATCCAGAAAAATAACGTTTTTATCCCCGGGCGTTTTACAGCGAGCGCCCTTGAAGGTGATGA
AGTTAAAATTAATATTTATGCTGATCGTTTCAAAAGTGATCAGGTATTTGGTATAGTAACCAAAATTATTCAAAGAAATA
ACAAGTTTTTAATCGGAAAAGCTTTTAAAAATGGGAAATATTGAGATTTTGAACCTGTAAATTTTAAAGGTGGTTTTTTG
TTCCGTTGAAACACAACTGATGATTTAATTAATGATAATTATTATAAGGTAAAAATTATTGACTATCAAAAAAATACTTT
AAAAATAAGCATAATTCAGAAAATTGGTCATAAAAGCGAGCCATTTTTGTATGTAAAAATTCCAATAATTGAATCTGAAG
TTTCTAATAAATTTAGTGCTGATGTTCTTGAAGAGGCTGAAAAAATTGAAAAGGAAATTACTAATATTGAAAAAAACAGG
ACCGACCTGCGCGATGAATTAGTTATTACAATCGATGGCGAAGATACAAAAGATTTCGATGATGCAATTTCTGTTAAAAA
AACAAATGAAGGAAATTTTCTTTTGAAAGTCCATATTGCCGATGTTGCCCATTATGTCAAGCAGGATAGTCCAATTGATG
TTGAAGCCCAACGCCGAGGAACATCAATTTATCTACCTCACACCGTCATTCCAATGTTGCCCGAAGAATTATCAAATGGA
ATTTGCTCTTTAAAGCCGAATGTTGACCGATTTACAATAACAATGGAAAGTTTAATTAATAAAAGGGGTGAAAATTTATC
AATTAAAATTTATCCATCAGTAATTAACTCAAAATGGCGACTGACTTACAAAGATGTCAATAATTTTTTTAATGGAAAAT
CTAGTTTTAACGATACTAATTTAGAAAAAATGTTGAAAACAGCACAAGAATTAAACACCATTTTATCACTGTTTAAAAAA
AATCAAGGTTATATCGATTTGGCCATAGATGAGATAAAAATTATTTTGGATGAACAAGGTTTTACAGAATCTTTAAAATT
AAAAAGTAGGGGAACCTCAGAAGAATTAATTGAAAATTTTATGATTAGAGCTAATGAAAATGTCTCTGAATTCTTAACAA
AAAGGAAAATTCCAATTTTATACAGGGTTCATAACAAGCCTGATCCTGAAAAAATTATGATTTTCAATCAAATTTTGAAG
GCGTTAGGAGTTAAGAATACTTTAAAATTAAACTCAAATTCAAGGGAATTTGCAAGAAAAATTGATGAAATAAAAACAAA
AAATAACGATAATTTTTTAAAATATTCAATTTTAAGAACAATGCAAAAAGCAATTTATAGCACGGAAAACATAGGTCATT
TTGGTTTGGCAGCGAATTTTTATTCCCATTTTACAAGCCCAATTCGCCGCTACCCGGATCTAATTTTACATCGAATTATT
CGTTTTTTTATCTTTGAAAAAAACAAAAATTTTGATTTTTTCAACGAAATTTTAACTAAAAATTCCTACTTGACCACGGA
ACTAGAGCAAAAAGCCTTTAATTTAGAAAGAAAAATTGTCAATATAAAAAAAACTGAATATGTAAAAAAATTAATCGGTC
AAACTTTTAATGCCCAAATAACTTCAATTATAAAATCTGGTTTTTTTGTTGAAATTAACGGACTTTTTGATGCGATGTTA
AGTAATAAAAGTCTCCCAAACAACGAAAATGATCCATACCAATTGACAGAAGATGGGTTTTGCATTTATAATAGCAGACG
AAGATTTAAATTGGGCGAATTTATTGATATTAAAATTGAAAGTGTTAATGTTTGAGAGGGTAAAATTAGTGCTATTTTAG
CCTAA

Upstream 100 bases:

>100_bases
CAAAAGAACGCGGATTTAAAAAATTCACAAAATGAGCAATGTTTGTTGTGGGTTTTATCTTTCTCGTGCTCGCTTTAGTT
GTTAGGTTATTATAAATATT

Downstream 100 bases:

>100_bases
AATTCAGTTTTATCACTTTTTTTTTAAAAAAATTATTAATCTTCCATTTTTGTGCAAAATAAAAAATTTAGATAAGCCAA
GTATACTCGCAAAAAATTCT

Product: VACB-like ribonuclease II

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MEIISEERLKNFLRQEKTFIEIVRKFNIPFNLNHQLTNQISNLIENFVVFKTPEGKYYAPKFLKTTSGIFRATNSAFGFV
EDKENPIQKNNVFIPGRFTASALEGDEVKINIYADRFKSDQVFGIVTKIIQRNNKFLIGKAFKNGKYWDFEPVNFKGGFL
FRWNTTDDLINDNYYKVKIIDYQKNTLKISIIQKIGHKSEPFLYVKIPIIESEVSNKFSADVLEEAEKIEKEITNIEKNR
TDLRDELVITIDGEDTKDFDDAISVKKTNEGNFLLKVHIADVAHYVKQDSPIDVEAQRRGTSIYLPHTVIPMLPEELSNG
ICSLKPNVDRFTITMESLINKRGENLSIKIYPSVINSKWRLTYKDVNNFFNGKSSFNDTNLEKMLKTAQELNTILSLFKK
NQGYIDLAIDEIKIILDEQGFTESLKLKSRGTSEELIENFMIRANENVSEFLTKRKIPILYRVHNKPDPEKIMIFNQILK
ALGVKNTLKLNSNSREFARKIDEIKTKNNDNFLKYSILRTMQKAIYSTENIGHFGLAANFYSHFTSPIRRYPDLILHRII
RFFIFEKNKNFDFFNEILTKNSYLTTELEQKAFNLERKIVNIKKTEYVKKLIGQTFNAQITSIIKSGFFVEINGLFDAML
SNKSLPNNENDPYQLTEDGFCIYNSRRRFKLGEFIDIKIESVNVWEGKISAILA

Sequences:

>Translated_694_residues
MEIISEERLKNFLRQEKTFIEIVRKFNIPFNLNHQLTNQISNLIENFVVFKTPEGKYYAPKFLKTTSGIFRATNSAFGFV
EDKENPIQKNNVFIPGRFTASALEGDEVKINIYADRFKSDQVFGIVTKIIQRNNKFLIGKAFKNGKY*DFEPVNFKGGFL
FR*NTTDDLINDNYYKVKIIDYQKNTLKISIIQKIGHKSEPFLYVKIPIIESEVSNKFSADVLEEAEKIEKEITNIEKNR
TDLRDELVITIDGEDTKDFDDAISVKKTNEGNFLLKVHIADVAHYVKQDSPIDVEAQRRGTSIYLPHTVIPMLPEELSNG
ICSLKPNVDRFTITMESLINKRGENLSIKIYPSVINSKWRLTYKDVNNFFNGKSSFNDTNLEKMLKTAQELNTILSLFKK
NQGYIDLAIDEIKIILDEQGFTESLKLKSRGTSEELIENFMIRANENVSEFLTKRKIPILYRVHNKPDPEKIMIFNQILK
ALGVKNTLKLNSNSREFARKIDEIKTKNNDNFLKYSILRTMQKAIYSTENIGHFGLAANFYSHFTSPIRRYPDLILHRII
RFFIFEKNKNFDFFNEILTKNSYLTTELEQKAFNLERKIVNIKKTEYVKKLIGQTFNAQITSIIKSGFFVEINGLFDAML
SNKSLPNNENDPYQLTEDGFCIYNSRRRFKLGEFIDIKIESVNV*EGKISAILA
>Mature_694_residues
MEIISEERLKNFLRQEKTFIEIVRKFNIPFNLNHQLTNQISNLIENFVVFKTPEGKYYAPKFLKTTSGIFRATNSAFGFV
EDKENPIQKNNVFIPGRFTASALEGDEVKINIYADRFKSDQVFGIVTKIIQRNNKFLIGKAFKNGKY*DFEPVNFKGGFL
FR*NTTDDLINDNYYKVKIIDYQKNTLKISIIQKIGHKSEPFLYVKIPIIESEVSNKFSADVLEEAEKIEKEITNIEKNR
TDLRDELVITIDGEDTKDFDDAISVKKTNEGNFLLKVHIADVAHYVKQDSPIDVEAQRRGTSIYLPHTVIPMLPEELSNG
ICSLKPNVDRFTITMESLINKRGENLSIKIYPSVINSKWRLTYKDVNNFFNGKSSFNDTNLEKMLKTAQELNTILSLFKK
NQGYIDLAIDEIKIILDEQGFTESLKLKSRGTSEELIENFMIRANENVSEFLTKRKIPILYRVHNKPDPEKIMIFNQILK
ALGVKNTLKLNSNSREFARKIDEIKTKNNDNFLKYSILRTMQKAIYSTENIGHFGLAANFYSHFTSPIRRYPDLILHRII
RFFIFEKNKNFDFFNEILTKNSYLTTELEQKAFNLERKIVNIKKTEYVKKLIGQTFNAQITSIIKSGFFVEINGLFDAML
SNKSLPNNENDPYQLTEDGFCIYNSRRRFKLGEFIDIKIESVNV*EGKISAILA

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=384, Percent_Identity=30.7291666666667, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI190014623, Length=384, Percent_Identity=30.7291666666667, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI219521928, Length=393, Percent_Identity=28.498727735369, Blast_Score=140, Evalue=6e-33,
Organism=Homo sapiens, GI19115966, Length=363, Percent_Identity=29.2011019283747, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI134288890, Length=398, Percent_Identity=27.6381909547739, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI156105695, Length=392, Percent_Identity=25, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI156105693, Length=392, Percent_Identity=25, Blast_Score=100, Evalue=8e-21,
Organism=Escherichia coli, GI87082383, Length=649, Percent_Identity=30.2003081664099, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1787542, Length=656, Percent_Identity=22.5609756097561, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI212645896, Length=348, Percent_Identity=30.1724137931034, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17553506, Length=427, Percent_Identity=27.4004683840749, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324552, Length=352, Percent_Identity=32.1022727272727, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6323943, Length=444, Percent_Identity=24.5495495495495, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320499, Length=325, Percent_Identity=23.6923076923077, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24649634, Length=367, Percent_Identity=32.1525885558583, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19922976, Length=431, Percent_Identity=25.754060324826, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24654597, Length=431, Percent_Identity=25.754060324826, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24654592, Length=431, Percent_Identity=25.754060324826, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 80070; Mature: 80070

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIISEERLKNFLRQEKTFIEIVRKFNIPFNLNHQLTNQISNLIENFVVFKTPEGKYYAP
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCCCCEECC
KFLKTTSGIFRATNSAFGFVEDKENPIQKNNVFIPGRFTASALEGDEVKINIYADRFKSD
HHHHHHHHHHEECCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEECCCCCC
QVFGIVTKIIQRNNKFLIGKAFKNGKYDFEPVNFKGGFLFRNTTDDLINDNYYKVKIIDY
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCHHHHCCCEEEEEEEEE
QKNTLKISIIQKIGHKSEPFLYVKIPIIESEVSNKFSADVLEEAEKIEKEITNIEKNRTD
CCCEEEEEEEHHCCCCCCCEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LRDELVITIDGEDTKDFDDAISVKKTNEGNFLLKVHIADVAHYVKQDSPIDVEAQRRGTS
CCCEEEEEECCCCCCCHHHHEEEEECCCCCEEEEEEHHHHHHHHHCCCCCCEEHHCCCCE
IYLPHTVIPMLPEELSNGICSLKPNVDRFTITMESLINKRGENLSIKIYPSVINSKWRLT
EEECCHHHHCCHHHHCCCEEEECCCCCEEEEEHHHHHHCCCCCEEEEEEHHHHCCCEEEE
YKDVNNFFNGKSSFNDTNLEKMLKTAQELNTILSLFKKNQGYIDLAIDEIKIILDEQGFT
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCC
ESLKLKSRGTSEELIENFMIRANENVSEFLTKRKIPILYRVHNKPDPEKIMIFNQILKAL
CHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHH
GVKNTLKLNSNSREFARKIDEIKTKNNDNFLKYSILRTMQKAIYSTENIGHFGLAANFYS
CCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
HFTSPIRRYPDLILHRIIRFFIFEKNKNFDFFNEILTKNSYLTTELEQKAFNLERKIVNI
HHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCC
KKTEYVKKLIGQTFNAQITSIIKSGFFVEINGLFDAMLSNKSLPNNENDPYQLTEDGFCI
HHHHHHHHHHCCCCCHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCCEEECCCCEEE
YNSRRRFKLGEFIDIKIESVNVEGKISAILA
ECCCCCEECCCEEEEEEEEEECCCCEEEEEC
>Mature Secondary Structure
MEIISEERLKNFLRQEKTFIEIVRKFNIPFNLNHQLTNQISNLIENFVVFKTPEGKYYAP
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCCCCEECC
KFLKTTSGIFRATNSAFGFVEDKENPIQKNNVFIPGRFTASALEGDEVKINIYADRFKSD
HHHHHHHHHHEECCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEECCCCCC
QVFGIVTKIIQRNNKFLIGKAFKNGKYDFEPVNFKGGFLFRNTTDDLINDNYYKVKIIDY
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCHHHHCCCEEEEEEEEE
QKNTLKISIIQKIGHKSEPFLYVKIPIIESEVSNKFSADVLEEAEKIEKEITNIEKNRTD
CCCEEEEEEEHHCCCCCCCEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LRDELVITIDGEDTKDFDDAISVKKTNEGNFLLKVHIADVAHYVKQDSPIDVEAQRRGTS
CCCEEEEEECCCCCCCHHHHEEEEECCCCCEEEEEEHHHHHHHHHCCCCCCEEHHCCCCE
IYLPHTVIPMLPEELSNGICSLKPNVDRFTITMESLINKRGENLSIKIYPSVINSKWRLT
EEECCHHHHCCHHHHCCCEEEECCCCCEEEEEHHHHHHCCCCCEEEEEEHHHHCCCEEEE
YKDVNNFFNGKSSFNDTNLEKMLKTAQELNTILSLFKKNQGYIDLAIDEIKIILDEQGFT
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCC
ESLKLKSRGTSEELIENFMIRANENVSEFLTKRKIPILYRVHNKPDPEKIMIFNQILKAL
CHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHH
GVKNTLKLNSNSREFARKIDEIKTKNNDNFLKYSILRTMQKAIYSTENIGHFGLAANFYS
CCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
HFTSPIRRYPDLILHRIIRFFIFEKNKNFDFFNEILTKNSYLTTELEQKAFNLERKIVNI
HHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCC
KKTEYVKKLIGQTFNAQITSIIKSGFFVEINGLFDAMLSNKSLPNNENDPYQLTEDGFCI
HHHHHHHHHHCCCCCHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCCEEECCCCEEE
YNSRRRFKLGEFIDIKIESVNVEGKISAILA
ECCCCCEECCCEEEEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]