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The map label for this gene is pr1

Identifier: 54020298

GI number: 54020298

Start: 869337

End: 870935

Strand: Direct

Name: pr1

Synonym: mhp685

Alternate gene names: 54020298

Gene position: 869337-870935 (Clockwise)

Preceding gene: 54020297

Following gene: 54020299

Centisome position: 97.38

GC content: 25.58

Gene sequence:

>1599_bases
ATGCGTTTTAACAGGCTTTTTAGTCTAGCAAAACTTAAATTTACAATTATTTTTTTAGTAATCTTTATAAAAGAGGCGGG
ATTTCTAACCCATATTTTTAGCTACAAGTTTATTTTTGAGTATTTTTCAGAGAAAAACCCTACTTTTAACCTAACTTGGT
CCCTAATTTTGTTGCTAATGCCGCTTGCCATTTTTATCATTTTTACTTTTTTGAAAGGATGAATTTTTAGTTATTTAGAA
ATGGAAGTACGCAATAAACTAAGCGATATTATAATCAAAAAAATTCAAAAAAGTAATTATTCTGACCTAAAATACAATAA
AAATGCAATGCTTTCCTGATTTAATTATGATCTCAAACTCGGTTTGAATGCAATTGAAAATCTTTTAAATATTATTTCAC
CGCTTGTTTCTATTATCACTGGAATTTCTTTGATGATAGTTTTATCACCGCAATGAGGTTGAATTTTAATTGTTACTACC
TTAATTCTAAGTTTAATTTTACTAATTTTTCAAGGGAAAATTAGTAATGCTGCTTCAAAACCAGTGATGAAACTATCAAG
TGATAGTGAAGCTTTTTCAAATTATAACCTCGGTCTTCTTAACTCTTTTAAATCATTTTTCTTTCATAACAAAAATGAAA
AATTTAAGCAACTTTTTTATAAAAGTTATGAGAATTTATCCAAAGATCAAATAAAACAATATAAGAAATTAACTAAATTA
AATGTAATTCTAACTGTCTTATTTAGTATTTCAATTGTGATTGTTTTAACTGAATTAGCAGTGTTAACTTCATTTAAATT
TTATAGTTTAGCTATTTTTTTATCCCTACTTTTATACTCAAATCGCTTTAGTACCGATATGGGAAACATTGTTCTTGGTT
TATTTGGATATAAGCAATCATCAGTTTTGCTTGATAAAATTTTGGAAAAGAAAAATTTGACTGAACAAAAAACAGTTTTA
GAAGAGCCAATAAATAAAATTGATTTTGAAAATGTTTCTTTTAGTTATAAGGATATTAAAGTACTTGAAAATTTTAATTT
TTCTTTCGAAAAAAATAAAAAATATTTAGTAAGTGCTCCAAATGGAACAGGAAAATCAACCTTAATTAAATTAATATCCG
GGGTTTATGATAATTATCTTGGAAAAATTTTAATTAATGATAGTTATGACCAAAAAGAATTGGATCAAAAATATTTAAGA
AAACAAATTGGTTTTATCGACAATCAGAATTTAATTTTTGAATCAAGTCTCAAAAATAACATCACCTTGTTTGATGAAAA
TCCTGATTATAAAAAATTAAATTCAATCCTAAAATCACTAAAAATTGAATTTGATATTGAAGAAGAGATTAGTGCTAGCA
AACTCTCAGAAGGTCAAAAACAAAAAATTGCTTTCGCCAGGCTTAAATATTCGCCGATCAAATTTTGACTAATCGATGAG
GCTTTTGATAATATTCAAAAAGAATATTCACAAATTTTAATTAGTCAGCTGCTAGAGAACCCCGAATTTACCGTTGTTTT
TATTAGTCACCATATAAACGAATGGCAAAAATTAAAATTTGATCAAATTATTGAATTAGGGGGGAAAAAATATGAATAA

Upstream 100 bases:

>100_bases
AAAAATTCCGAGTTATAACACAAAAATTTATAATTCAATATTAGAAATCTCAAAAATTTTTGCTTAAAATTTAATCAAAA
ATTTTACCTAGGAGGTTCAT

Downstream 100 bases:

>100_bases
ACTAATTAAATTACATCTTTTTAATGTTATTTACTCGTTTTTTATTTTTGGTTTAGTAACTCTTTCAGTTATGGCTAATA
AATTCTTATATCAGTCTTTG

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MRFNRLFSLAKLKFTIIFLVIFIKEAGFLTHIFSYKFIFEYFSEKNPTFNLTWSLILLLMPLAIFIIFTFLKGWIFSYLE
MEVRNKLSDIIIKKIQKSNYSDLKYNKNAMLSWFNYDLKLGLNAIENLLNIISPLVSIITGISLMIVLSPQWGWILIVTT
LILSLILLIFQGKISNAASKPVMKLSSDSEAFSNYNLGLLNSFKSFFFHNKNEKFKQLFYKSYENLSKDQIKQYKKLTKL
NVILTVLFSISIVIVLTELAVLTSFKFYSLAIFLSLLLYSNRFSTDMGNIVLGLFGYKQSSVLLDKILEKKNLTEQKTVL
EEPINKIDFENVSFSYKDIKVLENFNFSFEKNKKYLVSAPNGTGKSTLIKLISGVYDNYLGKILINDSYDQKELDQKYLR
KQIGFIDNQNLIFESSLKNNITLFDENPDYKKLNSILKSLKIEFDIEEEISASKLSEGQKQKIAFARLKYSPIKFWLIDE
AFDNIQKEYSQILISQLLENPEFTVVFISHHINEWQKLKFDQIIELGGKKYE

Sequences:

>Translated_532_residues
MRFNRLFSLAKLKFTIIFLVIFIKEAGFLTHIFSYKFIFEYFSEKNPTFNLTWSLILLLMPLAIFIIFTFLKG*IFSYLE
MEVRNKLSDIIIKKIQKSNYSDLKYNKNAMLS*FNYDLKLGLNAIENLLNIISPLVSIITGISLMIVLSPQ*G*ILIVTT
LILSLILLIFQGKISNAASKPVMKLSSDSEAFSNYNLGLLNSFKSFFFHNKNEKFKQLFYKSYENLSKDQIKQYKKLTKL
NVILTVLFSISIVIVLTELAVLTSFKFYSLAIFLSLLLYSNRFSTDMGNIVLGLFGYKQSSVLLDKILEKKNLTEQKTVL
EEPINKIDFENVSFSYKDIKVLENFNFSFEKNKKYLVSAPNGTGKSTLIKLISGVYDNYLGKILINDSYDQKELDQKYLR
KQIGFIDNQNLIFESSLKNNITLFDENPDYKKLNSILKSLKIEFDIEEEISASKLSEGQKQKIAFARLKYSPIKF*LIDE
AFDNIQKEYSQILISQLLENPEFTVVFISHHINEWQKLKFDQIIELGGKKYE
>Mature_532_residues
MRFNRLFSLAKLKFTIIFLVIFIKEAGFLTHIFSYKFIFEYFSEKNPTFNLTWSLILLLMPLAIFIIFTFLKG*IFSYLE
MEVRNKLSDIIIKKIQKSNYSDLKYNKNAMLS*FNYDLKLGLNAIENLLNIISPLVSIITGISLMIVLSPQ*G*ILIVTT
LILSLILLIFQGKISNAASKPVMKLSSDSEAFSNYNLGLLNSFKSFFFHNKNEKFKQLFYKSYENLSKDQIKQYKKLTKL
NVILTVLFSISIVIVLTELAVLTSFKFYSLAIFLSLLLYSNRFSTDMGNIVLGLFGYKQSSVLLDKILEKKNLTEQKTVL
EEPINKIDFENVSFSYKDIKVLENFNFSFEKNKKYLVSAPNGTGKSTLIKLISGVYDNYLGKILINDSYDQKELDQKYLR
KQIGFIDNQNLIFESSLKNNITLFDENPDYKKLNSILKSLKIEFDIEEEISASKLSEGQKQKIAFARLKYSPIKF*LIDE
AFDNIQKEYSQILISQLLENPEFTVVFISHHINEWQKLKFDQIIELGGKKYE

Specific function: Involved In Lipid A Export And Possibly Also In Glycerophospholipid Export And For Biogenesis Of The Outer Membrane. Transmembrane Domains (Tmd) Form A Pore In The Inner Membrane And The ATP-Binding Domain (Nbd) Is Responsible For Energy Generation. [C]

COG id: COG1132

COG function: function code V; ABC-type multidrug transport system, ATPase and permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI9665248, Length=204, Percent_Identity=28.4313725490196, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI9955966, Length=203, Percent_Identity=28.0788177339901, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI45243524, Length=203, Percent_Identity=28.0788177339901, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI9955968, Length=203, Percent_Identity=28.0788177339901, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI171184400, Length=512, Percent_Identity=23.4375, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI255708477, Length=239, Percent_Identity=27.1966527196653, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI148612844, Length=239, Percent_Identity=27.1966527196653, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI21536378, Length=220, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI42741659, Length=205, Percent_Identity=27.3170731707317, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4505771, Length=205, Percent_Identity=26.3414634146341, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI9961252, Length=205, Percent_Identity=26.3414634146341, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI9961250, Length=211, Percent_Identity=25.1184834123223, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI9955963, Length=214, Percent_Identity=27.1028037383178, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI73747915, Length=225, Percent_Identity=25.7777777777778, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI73747917, Length=203, Percent_Identity=26.6009852216749, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787143, Length=514, Percent_Identity=22.7626459143969, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1787112, Length=281, Percent_Identity=24.1992882562278, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786653, Length=266, Percent_Identity=25.9398496240602, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786698, Length=195, Percent_Identity=25.1282051282051, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1787029, Length=201, Percent_Identity=24.3781094527363, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786654, Length=200, Percent_Identity=27.5, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115534520, Length=349, Percent_Identity=27.7936962750716, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17541710, Length=499, Percent_Identity=23.6472945891784, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193208177, Length=241, Percent_Identity=31.5352697095436, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71992290, Length=283, Percent_Identity=26.5017667844523, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115535101, Length=260, Percent_Identity=26.5384615384615, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17569145, Length=569, Percent_Identity=24.0773286467487, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17569143, Length=232, Percent_Identity=28.8793103448276, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193202349, Length=202, Percent_Identity=28.2178217821782, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17567269, Length=258, Percent_Identity=24.4186046511628, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17511077, Length=203, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17543740, Length=285, Percent_Identity=27.0175438596491, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115533592, Length=205, Percent_Identity=29.2682926829268, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17558664, Length=306, Percent_Identity=25.1633986928105, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71984940, Length=306, Percent_Identity=26.4705882352941, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17567265, Length=235, Percent_Identity=26.8085106382979, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565938, Length=286, Percent_Identity=26.2237762237762, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193211015, Length=246, Percent_Identity=27.2357723577236, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71996809, Length=246, Percent_Identity=27.2357723577236, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193211017, Length=246, Percent_Identity=27.2357723577236, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988343, Length=199, Percent_Identity=29.6482412060301, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25146777, Length=247, Percent_Identity=25.1012145748988, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193209708, Length=204, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17533971, Length=210, Percent_Identity=24.2857142857143, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646699, Length=227, Percent_Identity=27.3127753303965, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324985, Length=552, Percent_Identity=23.0072463768116, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323959, Length=201, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323217, Length=220, Percent_Identity=26.3636363636364, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322980, Length=274, Percent_Identity=25.5474452554745, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322640, Length=226, Percent_Identity=26.1061946902655, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24659289, Length=239, Percent_Identity=28.4518828451883, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI85726357, Length=268, Percent_Identity=26.1194029850746, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI23397593, Length=430, Percent_Identity=22.7906976744186, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357907, Length=250, Percent_Identity=28.8, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363262, Length=227, Percent_Identity=26.431718061674, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24653245, Length=227, Percent_Identity=26.431718061674, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136662, Length=217, Percent_Identity=26.2672811059908, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650986, Length=287, Percent_Identity=27.5261324041812, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358185, Length=287, Percent_Identity=27.5261324041812, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 60986; Mature: 60986

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS50893 ABC_TRANSPORTER_2 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFNRLFSLAKLKFTIIFLVIFIKEAGFLTHIFSYKFIFEYFSEKNPTFNLTWSLILLLM
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHH
PLAIFIIFTFLKGIFSYLEMEVRNKLSDIIIKKIQKSNYSDLKYNKNAMLSFNYDLKLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEECH
NAIENLLNIISPLVSIITGISLMIVLSPQGILIVTTLILSLILLIFQGKISNAASKPVMK
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LSSDSEAFSNYNLGLLNSFKSFFFHNKNEKFKQLFYKSYENLSKDQIKQYKKLTKLNVIL
CCCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TVLFSISIVIVLTELAVLTSFKFYSLAIFLSLLLYSNRFSTDMGNIVLGLFGYKQSSVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHH
DKILEKKNLTEQKTVLEEPINKIDFENVSFSYKDIKVLENFNFSFEKNKKYLVSAPNGTG
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEECCCEEEEECCCCCC
KSTLIKLISGVYDNYLGKILINDSYDQKELDQKYLRKQIGFIDNQNLIFESSLKNNITLF
HHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEE
DENPDYKKLNSILKSLKIEFDIEEEISASKLSEGQKQKIAFARLKYSPIKFLIDEAFDNI
CCCCCHHHHHHHHHHHEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
QKEYSQILISQLLENPEFTVVFISHHINEWQKLKFDQIIELGGKKYE
HHHHHHHHHHHHHCCCCEEEEEHHHHHCHHHHCCHHHHHHCCCCCCC
>Mature Secondary Structure
MRFNRLFSLAKLKFTIIFLVIFIKEAGFLTHIFSYKFIFEYFSEKNPTFNLTWSLILLLM
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHH
PLAIFIIFTFLKGIFSYLEMEVRNKLSDIIIKKIQKSNYSDLKYNKNAMLSFNYDLKLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEECH
NAIENLLNIISPLVSIITGISLMIVLSPQGILIVTTLILSLILLIFQGKISNAASKPVMK
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LSSDSEAFSNYNLGLLNSFKSFFFHNKNEKFKQLFYKSYENLSKDQIKQYKKLTKLNVIL
CCCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TVLFSISIVIVLTELAVLTSFKFYSLAIFLSLLLYSNRFSTDMGNIVLGLFGYKQSSVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHH
DKILEKKNLTEQKTVLEEPINKIDFENVSFSYKDIKVLENFNFSFEKNKKYLVSAPNGTG
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEECCCEEEEECCCCCC
KSTLIKLISGVYDNYLGKILINDSYDQKELDQKYLRKQIGFIDNQNLIFESSLKNNITLF
HHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEE
DENPDYKKLNSILKSLKIEFDIEEEISASKLSEGQKQKIAFARLKYSPIKFLIDEAFDNI
CCCCCHHHHHHHHHHHEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
QKEYSQILISQLLENPEFTVVFISHHINEWQKLKFDQIIELGGKKYE
HHHHHHHHHHHHHCCCCEEEEEHHHHHCHHHHCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]