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The map label for this gene is prsA

Identifier: 54020290

GI number: 54020290

Start: 849175

End: 850167

Strand: Direct

Name: prsA

Synonym: mhp675

Alternate gene names: 54020290

Gene position: 849175-850167 (Clockwise)

Preceding gene: 54020289

Following gene: 54020291

Centisome position: 95.12

GC content: 33.13

Gene sequence:

>993_bases
ATGAATATTGATGCAAAAAAAAATATCATCCTTTTTGGAATGGAAAATTCCCTTGATTTAGCCAAAAAAATTTCGAAAAT
CACAGGAATCCCACTTTCCGGGATTGAAAGAATTGTTTATGCTGATGGCGAAGTTTTACTAAAATCCAAAGAAACAATTA
GAAATTCAACTGTTTTTGTAGTTGCAAATACCTCCCGCCCTGTTAATGAAAATATTATGGAGCTCTTAATCTTTATTGAC
TCGCTAAAAAGAGGTTATGCCCAAGAAATTATAGTAATTCTTTCTTATTATGGTTATGCAAGGCAAGATCGAAAATCATC
AGGAAGACAGCCAATTACTGCAAAATTAGTTGCAAATTTACTTGAAAAAGCGGGACTAACCAAGCTAATTTTAGTAGATA
TTCACAATCCAAGTATTCAAGGCTTTTTTGATTTTTCAGTTGATGAAATTCATGGACAGTATATTCTTGCAAACGAACTT
GTCGGAAAAAATAAGGATTATGTTGTTGTCAGTCCCGATCATGGAGGCGCAGTTCGGGCAAGAATTCTAGCCGAAATTTT
GGGTAAACAAACAAATGTTGCTGTGATTGACAAAAGAAGGACAGGCGCTAATAAATCCGAAGTTTTAGGGCTAATTGGCG
ATGTAGATGGAAAAGACTGTATAATAATTGATGATATTATCGATACAGGTGGGACGATAATTAATGCAGCGAATGTCGTT
AGAGAAAAAGGGGCAAAATCTGTTGTTCTAGCCGCTACTCACGGCGTTTTTAGTTATGGTTTTGAAAAATTTCAGGAAAA
TCCTAATATTGACAAAGTAATAATTACCGATTCAATTGATAATAAAAAACTTGCTAAAAAGTTTCCCAAACTTTTGATAA
CCTCGCTTGCCGAATTTTTGTCAAAAAGTATTTTAGCCTGCATTTTTTCGACTTCAATTACAAGTATTTATGAAGAAACT
AAGCAAAAATTAATTAAAAAGAACCTAAATTAA

Upstream 100 bases:

>100_bases
ACATAGTTAATTTTGATAATTAATAAATAAAAATTTATTATAATTTTCTTTTATTATAATACAATTTTTAATTATAATAT
AAAAAGGAGAAAGTAATAAG

Downstream 100 bases:

>100_bases
ACATTTTTTTAAAAGATTTGAAATGTATAAGCGATTAGTTCAGGAATTTTTTCCTAAATTAGATTTTGAAAATTTAGAAA
AATACGTAAATTTAATTGAA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNIDAKKNIILFGMENSLDLAKKISKITGIPLSGIERIVYADGEVLLKSKETIRNSTVFVVANTSRPVNENIMELLIFID
SLKRGYAQEIIVILSYYGYARQDRKSSGRQPITAKLVANLLEKAGLTKLILVDIHNPSIQGFFDFSVDEIHGQYILANEL
VGKNKDYVVVSPDHGGAVRARILAEILGKQTNVAVIDKRRTGANKSEVLGLIGDVDGKDCIIIDDIIDTGGTIINAANVV
REKGAKSVVLAATHGVFSYGFEKFQENPNIDKVIITDSIDNKKLAKKFPKLLITSLAEFLSKSILACIFSTSITSIYEET
KQKLIKKNLN

Sequences:

>Translated_330_residues
MNIDAKKNIILFGMENSLDLAKKISKITGIPLSGIERIVYADGEVLLKSKETIRNSTVFVVANTSRPVNENIMELLIFID
SLKRGYAQEIIVILSYYGYARQDRKSSGRQPITAKLVANLLEKAGLTKLILVDIHNPSIQGFFDFSVDEIHGQYILANEL
VGKNKDYVVVSPDHGGAVRARILAEILGKQTNVAVIDKRRTGANKSEVLGLIGDVDGKDCIIIDDIIDTGGTIINAANVV
REKGAKSVVLAATHGVFSYGFEKFQENPNIDKVIITDSIDNKKLAKKFPKLLITSLAEFLSKSILACIFSTSITSIYEET
KQKLIKKNLN
>Mature_330_residues
MNIDAKKNIILFGMENSLDLAKKISKITGIPLSGIERIVYADGEVLLKSKETIRNSTVFVVANTSRPVNENIMELLIFID
SLKRGYAQEIIVILSYYGYARQDRKSSGRQPITAKLVANLLEKAGLTKLILVDIHNPSIQGFFDFSVDEIHGQYILANEL
VGKNKDYVVVSPDHGGAVRARILAEILGKQTNVAVIDKRRTGANKSEVLGLIGDVDGKDCIIIDDIIDTGGTIINAANVV
REKGAKSVVLAATHGVFSYGFEKFQENPNIDKVIITDSIDNKKLAKKFPKLLITSLAEFLSKSILACIFSTSITSIYEET
KQKLIKKNLN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=302, Percent_Identity=33.112582781457, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4506127, Length=300, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI84875539, Length=305, Percent_Identity=32.7868852459016, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI28557709, Length=300, Percent_Identity=32.6666666666667, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI194018537, Length=321, Percent_Identity=30.8411214953271, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI4506133, Length=341, Percent_Identity=30.2052785923754, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=31.25, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=31.25, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=31.25, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=31.25, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=40.2555910543131, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25149168, Length=302, Percent_Identity=33.112582781457, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17554702, Length=302, Percent_Identity=33.112582781457, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71989924, Length=302, Percent_Identity=33.112582781457, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17554704, Length=299, Percent_Identity=32.7759197324415, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17570245, Length=310, Percent_Identity=29.3548387096774, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319403, Length=280, Percent_Identity=36.7857142857143, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321776, Length=289, Percent_Identity=38.0622837370242, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320946, Length=264, Percent_Identity=37.8787878787879, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322667, Length=167, Percent_Identity=34.7305389221557, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324511, Length=88, Percent_Identity=40.9090909090909, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21355239, Length=300, Percent_Identity=34.3333333333333, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45551540, Length=323, Percent_Identity=31.8885448916409, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24651458, Length=328, Percent_Identity=26.5243902439024, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24651456, Length=328, Percent_Identity=26.5243902439024, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281362873, Length=328, Percent_Identity=26.5243902439024, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24651454, Length=328, Percent_Identity=26.5243902439024, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45552010, Length=347, Percent_Identity=24.4956772334294, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24651462, Length=347, Percent_Identity=24.4956772334294, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24651464, Length=347, Percent_Identity=24.4956772334294, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36297; Mature: 36297

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDAKKNIILFGMENSLDLAKKISKITGIPLSGIERIVYADGEVLLKSKETIRNSTVFV
CCCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHCEEEEECCEEEEECHHHHCCCEEEE
VANTSRPVNENIMELLIFIDSLKRGYAQEIIVILSYYGYARQDRKSSGRQPITAKLVANL
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHH
LEKAGLTKLILVDIHNPSIQGFFDFSVDEIHGQYILANELVGKNKDYVVVSPDHGGAVRA
HHHCCCEEEEEEEECCCCCCEEEECCHHHHCCCEEEEHHHHCCCCCEEEECCCCCCHHHH
RILAEILGKQTNVAVIDKRRTGANKSEVLGLIGDVDGKDCIIIDDIIDTGGTIINAANVV
HHHHHHHCCCCCEEEEECCCCCCCHHHHEEEEECCCCCCEEEEECHHCCCCCEEHHHHHH
REKGAKSVVLAATHGVFSYGFEKFQENPNIDKVIITDSIDNKKLAKKFPKLLITSLAEFL
HHCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SKSILACIFSTSITSIYEETKQKLIKKNLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIDAKKNIILFGMENSLDLAKKISKITGIPLSGIERIVYADGEVLLKSKETIRNSTVFV
CCCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHCEEEEECCEEEEECHHHHCCCEEEE
VANTSRPVNENIMELLIFIDSLKRGYAQEIIVILSYYGYARQDRKSSGRQPITAKLVANL
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHH
LEKAGLTKLILVDIHNPSIQGFFDFSVDEIHGQYILANELVGKNKDYVVVSPDHGGAVRA
HHHCCCEEEEEEEECCCCCCEEEECCHHHHCCCEEEEHHHHCCCCCEEEECCCCCCHHHH
RILAEILGKQTNVAVIDKRRTGANKSEVLGLIGDVDGKDCIIIDDIIDTGGTIINAANVV
HHHHHHHCCCCCEEEEECCCCCCCHHHHEEEEECCCCCCEEEEECHHCCCCCEEHHHHHH
REKGAKSVVLAATHGVFSYGFEKFQENPNIDKVIITDSIDNKKLAKKFPKLLITSLAEFL
HHCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SKSILACIFSTSITSIYEETKQKLIKKNLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]