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The map label for this gene is gyrA

Identifier: 54020243

GI number: 54020243

Start: 688193

End: 690754

Strand: Direct

Name: gyrA

Synonym: mhp545

Alternate gene names: 54020243

Gene position: 688193-690754 (Clockwise)

Preceding gene: 54020242

Following gene: 54020244

Centisome position: 77.09

GC content: 32.63

Gene sequence:

>2562_bases
ATGCTTGAGGAGAAAGACAAAGATAAGTCAAATTTTGACAATAGCGAGTTCGATATCGAATCAAATGATGAAATAGATGA
TGAAGATACTAACTATAAAGTCAAACCCACAATTTTAGAATCAATAACAGATAATATTTCTCCAATTAAAATTGAAGATG
AAATGAAAGCTTCATTTCTTGATTATTCAATGTCTGTTATTGTTTCGCGCGCACTTCCGGATGTCCGTGATGGGTTAAAA
CCAGTCCACCGTCGAATTCTATATACAATGGCTGAACTCGGAATTACTTCGGGAACAAGTTATAAAAAATCCGCTAGAAT
TGTTGGTGATGTTCTTGGAAAATACCATCCTCATGGCGATGCTTCTGTCTATGAATCGATGGTGCGAATGGCTCAACCTT
TTTCCTTACGTTATCCTTTAGTTGATGGTCATGGAAATTTTGGATCAATTGATGGTGATGAAGCAGCAGCAATGCGTTAT
ACAGAAGCTCGACTATCAAAAATTTCAAATAAAATGATTGAGGGGCTAAAAAAAAATACTGTTGATTTTCGGCCTAATTA
TGATGCAAGCGAAGTTGAACCAGAAGTTTTACCAGCAAAATTCCCTAATTTGTTAGTCTCTGGAGTCTCAGGAATTGCGG
TAGGAATGATGACAAAAATTCCACCGCATAATTTAGGTGAAATTATTCATTCCTTTATAATTTTTGCCAAAAATCCAAAA
ATTGAAATTAACGAGTTAATTTCAAGTCTACCGGGGCCAGATTTTCCCACTGGCGCAACAATTTATGGCAAAAAAGGAAT
AAATCAGGCTTATCTAACCGGAAAAGGTTCTTTTATAATAAGGGCAAAAGCAAAAATTGAGAACCTTAATTCCGGCAGAT
CGCGGATTATTTTCTATGAAATTCCTTATGAGGTAAAAAAACCAGCAATTATTGAAAAAGTTGCATTTTTAGTTAGAAAT
AAAAAAATTTTAGGAATAAAGGATGTCCGTGATGAAAGTAGTAGACACGGAATTCGCGTTGTTTTTGAGATTAAAAAAGG
TTTTAGTCCCGAAATTATCCTAAATAAACTTTATCATAGTACCGATTTGCAAATTAATTATTCTATAAATATGCTAGCCC
TTGTTAATGGTGTGCCAAAATTGATGAATTTAGCACAAATTTTCAACTATTATCTTGAGCATCAAAAGGAAATAAATCTA
CGTTCGCTTAATTTTGACCTCGAAAAAGCAACAGAAAAATTGAATGTCTTAGAGGGGATTAAAGTTGCAGTTGAAAATAT
TGATGAAGTAATTAAAATTATAAAATCATCAAAATCTGATCAAGCAGCCCAGGAAAAATTAGCGCATACATACAATTTAA
ATTCTGGGCAGACAAAAGCGATAATTGAAATGCGACTTGGACGGCTAACCTCACTTGCAATTGAAAAGTTAAATAATGAA
ATTGAAGAGTTAAAAGTTGAGATTAGTGAAATTAAATCAATTATTGACTCCCCAAAGAAATTAATTGATTTAATTATTGA
GCAACATAAAAATGTTGTTGCTCAATTTGGTGATCCAAGACGATCTGAAATTATTCCTGAAATTGATTGCTTAGATGAAG
AAGATTTAATAGCTGATGAGCAAGTAATTATTTCGCTAACACAAAATAATTACGTAAAAAAAATGGTGTTAGATGAATAT
CGTCTACAGAATCGTGGGGGAATTGGGACTTTAGCATCAAATCATTATAAGGATGATGAACTAAAATCATTATGCATTAC
AAATACTCTCAGTGATCTTTTAATAATTTCCTCAAGTGCTAAAATTTTTAAATTAAGGGCGCACCAAATTCCTGATGGCT
CAAAACAAGGCAAAGGAATTCCGATTCTAAATTTAATTAAATTAGAAAAAAATGAGAGTATTTCTAACTTAATTCCTTGA
AATCAAGAATATGATAATCACTGGCTAATTACAGTTTCTGCTTTCGGAAATATTAAAAAAACAGCCCTTAGTGCGTTTCG
AAACATTACAAAAAACGGAAAAATAGCACTAAAACTAGTCGAAAATGACTATTTAGTCTCAGCTTTTATAGCCCCTAACA
ATCCGGATCTTAATATTTTAATCGGCTCATCGCAAGGTTTTGTTAATCGCTGGTCGATAAAATTATTACGAGATAGTGGT
AGAACTGCAATTGGAGTTAAAGGAATCAAACTCGAAGAAGGACATAAAATAATTGGAGCTTGTTTTGCTTTCGATAACCA
TTTTATTTTTAGCCTTAGCAAAAAAGGGTTTGGGAAAAAAACTCAAGTAGGTGAGTATCGCCTTACAGGGAGAACGACAA
AAGGACTTATGAGTCTGGATGCAAAAAAAGCTGGAAATCTGGTGTTTATTTCCGCAATAAAAAATAATGAAGAAGCAATA
ATTACAACAAAAAAAGGGTTTGCAATTAGAATTGATCTTGATATGGTGCCAATAATAAGTAGAAAAACTAAGGGTGTAAA
AATAATTACTCTCAAAAAGGGAGATGAAATTACCGCAGTTAGTTTGATCAGTAAAAATGAAACTGAAAAACAGAATGAAT
AA

Upstream 100 bases:

>100_bases
AAAATACTTTAAATTTTCTGTTTGAAAATTCTTATTAAAACATAAAAAATATGGTATAATTTATACTTACCACGCGCTTT
TATATCAAAAAGGAAGAAAA

Downstream 100 bases:

>100_bases
ATAAATTATACCACAACTTTTTTGTATTTTAAAAAAATTATTTTATATCTTTATTTAAAGAACTCTAAAAGATGACCTAA
ATTATGTGATTTTAGTTCAG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 853; Mature: 853

Protein sequence:

>853_residues
MLEEKDKDKSNFDNSEFDIESNDEIDDEDTNYKVKPTILESITDNISPIKIEDEMKASFLDYSMSVIVSRALPDVRDGLK
PVHRRILYTMAELGITSGTSYKKSARIVGDVLGKYHPHGDASVYESMVRMAQPFSLRYPLVDGHGNFGSIDGDEAAAMRY
TEARLSKISNKMIEGLKKNTVDFRPNYDASEVEPEVLPAKFPNLLVSGVSGIAVGMMTKIPPHNLGEIIHSFIIFAKNPK
IEINELISSLPGPDFPTGATIYGKKGINQAYLTGKGSFIIRAKAKIENLNSGRSRIIFYEIPYEVKKPAIIEKVAFLVRN
KKILGIKDVRDESSRHGIRVVFEIKKGFSPEIILNKLYHSTDLQINYSINMLALVNGVPKLMNLAQIFNYYLEHQKEINL
RSLNFDLEKATEKLNVLEGIKVAVENIDEVIKIIKSSKSDQAAQEKLAHTYNLNSGQTKAIIEMRLGRLTSLAIEKLNNE
IEELKVEISEIKSIIDSPKKLIDLIIEQHKNVVAQFGDPRRSEIIPEIDCLDEEDLIADEQVIISLTQNNYVKKMVLDEY
RLQNRGGIGTLASNHYKDDELKSLCITNTLSDLLIISSSAKIFKLRAHQIPDGSKQGKGIPILNLIKLEKNESISNLIPW
NQEYDNHWLITVSAFGNIKKTALSAFRNITKNGKIALKLVENDYLVSAFIAPNNPDLNILIGSSQGFVNRWSIKLLRDSG
RTAIGVKGIKLEEGHKIIGACFAFDNHFIFSLSKKGFGKKTQVGEYRLTGRTTKGLMSLDAKKAGNLVFISAIKNNEEAI
ITTKKGFAIRIDLDMVPIISRKTKGVKIITLKKGDEITAVSLISKNETEKQNE

Sequences:

>Translated_853_residues
MLEEKDKDKSNFDNSEFDIESNDEIDDEDTNYKVKPTILESITDNISPIKIEDEMKASFLDYSMSVIVSRALPDVRDGLK
PVHRRILYTMAELGITSGTSYKKSARIVGDVLGKYHPHGDASVYESMVRMAQPFSLRYPLVDGHGNFGSIDGDEAAAMRY
TEARLSKISNKMIEGLKKNTVDFRPNYDASEVEPEVLPAKFPNLLVSGVSGIAVGMMTKIPPHNLGEIIHSFIIFAKNPK
IEINELISSLPGPDFPTGATIYGKKGINQAYLTGKGSFIIRAKAKIENLNSGRSRIIFYEIPYEVKKPAIIEKVAFLVRN
KKILGIKDVRDESSRHGIRVVFEIKKGFSPEIILNKLYHSTDLQINYSINMLALVNGVPKLMNLAQIFNYYLEHQKEINL
RSLNFDLEKATEKLNVLEGIKVAVENIDEVIKIIKSSKSDQAAQEKLAHTYNLNSGQTKAIIEMRLGRLTSLAIEKLNNE
IEELKVEISEIKSIIDSPKKLIDLIIEQHKNVVAQFGDPRRSEIIPEIDCLDEEDLIADEQVIISLTQNNYVKKMVLDEY
RLQNRGGIGTLASNHYKDDELKSLCITNTLSDLLIISSSAKIFKLRAHQIPDGSKQGKGIPILNLIKLEKNESISNLIP*
NQEYDNHWLITVSAFGNIKKTALSAFRNITKNGKIALKLVENDYLVSAFIAPNNPDLNILIGSSQGFVNRWSIKLLRDSG
RTAIGVKGIKLEEGHKIIGACFAFDNHFIFSLSKKGFGKKTQVGEYRLTGRTTKGLMSLDAKKAGNLVFISAIKNNEEAI
ITTKKGFAIRIDLDMVPIISRKTKGVKIITLKKGDEITAVSLISKNETEKQNE
>Mature_853_residues
MLEEKDKDKSNFDNSEFDIESNDEIDDEDTNYKVKPTILESITDNISPIKIEDEMKASFLDYSMSVIVSRALPDVRDGLK
PVHRRILYTMAELGITSGTSYKKSARIVGDVLGKYHPHGDASVYESMVRMAQPFSLRYPLVDGHGNFGSIDGDEAAAMRY
TEARLSKISNKMIEGLKKNTVDFRPNYDASEVEPEVLPAKFPNLLVSGVSGIAVGMMTKIPPHNLGEIIHSFIIFAKNPK
IEINELISSLPGPDFPTGATIYGKKGINQAYLTGKGSFIIRAKAKIENLNSGRSRIIFYEIPYEVKKPAIIEKVAFLVRN
KKILGIKDVRDESSRHGIRVVFEIKKGFSPEIILNKLYHSTDLQINYSINMLALVNGVPKLMNLAQIFNYYLEHQKEINL
RSLNFDLEKATEKLNVLEGIKVAVENIDEVIKIIKSSKSDQAAQEKLAHTYNLNSGQTKAIIEMRLGRLTSLAIEKLNNE
IEELKVEISEIKSIIDSPKKLIDLIIEQHKNVVAQFGDPRRSEIIPEIDCLDEEDLIADEQVIISLTQNNYVKKMVLDEY
RLQNRGGIGTLASNHYKDDELKSLCITNTLSDLLIISSSAKIFKLRAHQIPDGSKQGKGIPILNLIKLEKNESISNLIP*
NQEYDNHWLITVSAFGNIKKTALSAFRNITKNGKIALKLVENDYLVSAFIAPNNPDLNILIGSSQGFVNRWSIKLLRDSG
RTAIGVKGIKLEEGHKIIGACFAFDNHFIFSLSKKGFGKKTQVGEYRLTGRTTKGLMSLDAKKAGNLVFISAIKNNEEAI
ITTKKGFAIRIDLDMVPIISRKTKGVKIITLKKGDEITAVSLISKNETEKQNE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=168, Percent_Identity=29.7619047619048, Blast_Score=69, Evalue=3e-11,
Organism=Homo sapiens, GI19913406, Length=168, Percent_Identity=30.3571428571429, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788562, Length=843, Percent_Identity=40.6880189798339, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=650, Percent_Identity=35.0769230769231, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=518, Percent_Identity=23.7451737451737, Blast_Score=77, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=164, Percent_Identity=33.5365853658537, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 95220; Mature: 95220

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEEKDKDKSNFDNSEFDIESNDEIDDEDTNYKVKPTILESITDNISPIKIEDEMKASFL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCEEECHHHHHHHH
DYSMSVIVSRALPDVRDGLKPVHRRILYTMAELGITSGTSYKKSARIVGDVLGKYHPHGD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCC
ASVYESMVRMAQPFSLRYPLVDGHGNFGSIDGDEAAAMRYTEARLSKISNKMIEGLKKNT
HHHHHHHHHHCCCCEEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VDFRPNYDASEVEPEVLPAKFPNLLVSGVSGIAVGMMTKIPPHNLGEIIHSFIIFAKNPK
CCCCCCCCHHHCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHEEEECCCC
IEINELISSLPGPDFPTGATIYGKKGINQAYLTGKGSFIIRAKAKIENLNSGRSRIIFYE
EEHHHHHHHCCCCCCCCCCEEECCCCCCEEEEECCCCEEEEEEEECCCCCCCCCEEEEEE
IPYEVKKPAIIEKVAFLVRNKKILGIKDVRDESSRHGIRVVFEIKKGFSPEIILNKLYHS
CCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCC
TDLQINYSINMLALVNGVPKLMNLAQIFNYYLEHQKEINLRSLNFDLEKATEKLNVLEGI
CCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHH
KVAVENIDEVIKIIKSSKSDQAAQEKLAHTYNLNSGQTKAIIEMRLGRLTSLAIEKLNNE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IEELKVEISEIKSIIDSPKKLIDLIIEQHKNVVAQFGDPRRSEIIPEIDCLDEEDLIADE
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCC
QVIISLTQNNYVKKMVLDEYRLQNRGGIGTLASNHYKDDELKSLCITNTLSDLLIISSSA
EEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHEEEECCC
KIFKLRAHQIPDGSKQGKGIPILNLIKLEKNESISNLIPNQEYDNHWLITVSAFGNIKKT
EEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCCCEEEEEEECCCCHHHH
ALSAFRNITKNGKIALKLVENDYLVSAFIAPNNPDLNILIGSSQGFVNRWSIKLLRDSGR
HHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCCEEEEEECCCCCCEEEEEEEEECCCC
TAIGVKGIKLEEGHKIIGACFAFDNHFIFSLSKKGFGKKTQVGEYRLTGRTTKGLMSLDA
EEEEEECEEECCCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCEEECCCCCCHHHHCCC
KKAGNLVFISAIKNNEEAIITTKKGFAIRIDLDMVPIISRKTKGVKIITLKKGDEITAVS
CCCCCEEEEEEECCCCEEEEEECCCEEEEEECCEECEECCCCCCEEEEEEECCCCEEEEE
LISKNETEKQNE
EECCCCCCCCCC
>Mature Secondary Structure
MLEEKDKDKSNFDNSEFDIESNDEIDDEDTNYKVKPTILESITDNISPIKIEDEMKASFL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCEEECHHHHHHHH
DYSMSVIVSRALPDVRDGLKPVHRRILYTMAELGITSGTSYKKSARIVGDVLGKYHPHGD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCC
ASVYESMVRMAQPFSLRYPLVDGHGNFGSIDGDEAAAMRYTEARLSKISNKMIEGLKKNT
HHHHHHHHHHCCCCEEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VDFRPNYDASEVEPEVLPAKFPNLLVSGVSGIAVGMMTKIPPHNLGEIIHSFIIFAKNPK
CCCCCCCCHHHCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHEEEECCCC
IEINELISSLPGPDFPTGATIYGKKGINQAYLTGKGSFIIRAKAKIENLNSGRSRIIFYE
EEHHHHHHHCCCCCCCCCCEEECCCCCCEEEEECCCCEEEEEEEECCCCCCCCCEEEEEE
IPYEVKKPAIIEKVAFLVRNKKILGIKDVRDESSRHGIRVVFEIKKGFSPEIILNKLYHS
CCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCC
TDLQINYSINMLALVNGVPKLMNLAQIFNYYLEHQKEINLRSLNFDLEKATEKLNVLEGI
CCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHH
KVAVENIDEVIKIIKSSKSDQAAQEKLAHTYNLNSGQTKAIIEMRLGRLTSLAIEKLNNE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IEELKVEISEIKSIIDSPKKLIDLIIEQHKNVVAQFGDPRRSEIIPEIDCLDEEDLIADE
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCC
QVIISLTQNNYVKKMVLDEYRLQNRGGIGTLASNHYKDDELKSLCITNTLSDLLIISSSA
EEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHEEEECCC
KIFKLRAHQIPDGSKQGKGIPILNLIKLEKNESISNLIPNQEYDNHWLITVSAFGNIKKT
EEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCCCEEEEEEECCCCHHHH
ALSAFRNITKNGKIALKLVENDYLVSAFIAPNNPDLNILIGSSQGFVNRWSIKLLRDSGR
HHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCCEEEEEECCCCCCEEEEEEEEECCCC
TAIGVKGIKLEEGHKIIGACFAFDNHFIFSLSKKGFGKKTQVGEYRLTGRTTKGLMSLDA
EEEEEECEEECCCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCEEECCCCCCHHHHCCC
KKAGNLVFISAIKNNEEAIITTKKGFAIRIDLDMVPIISRKTKGVKIITLKKGDEITAVS
CCCCCEEEEEEECCCCEEEEEECCCEEEEEECCEECEECCCCCCEEEEEEECCCCEEEEE
LISKNETEKQNE
EECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]