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The map label for this gene is uvrA

Identifier: 54020127

GI number: 54020127

Start: 327761

End: 330604

Strand: Direct

Name: uvrA

Synonym: mhp288

Alternate gene names: 54020127

Gene position: 327761-330604 (Clockwise)

Preceding gene: 54020126

Following gene: 54020128

Centisome position: 36.71

GC content: 32.84

Gene sequence:

>2844_bases
ATGCTTAAAAATAAAGATACTCACAATTTTATCTACATTAAAGGCGCACGCGAAAACAATTTAAAAAATATTAATCTTGT
TCTTCCAAAAAATAAACTAATAGTTTTTACGGGACTTTCAGGTTCTGGTAAATCTTCGCTCGCTTTTAACACTATTTATG
AGGAGGGAAAGCGCCGCTATATTGATTCTTTAAGTTCGTATGCTCGGCAATTTTTAGGTGGGACAAAAAAGCCAAAAGTT
GATGCAATTTATGGGCTTTTACCCACAATTTCAGTCGAACAGAAAACAAGTCATAACAATCCGCGTTCAACAGTTGGTAC
AATTACGGAAATTTATGACTATTTTCGGCTTTTATATGCAAAAATTGGGAAAGCATTCTGCCCAAACCACAAAGTTGAAA
TTATAGCTCAAAAAATTGTCACAATTTTGGATACAATTTTAGCATATCCTGAAAAAACAAAACTTATAATTATGGCGCCA
ATTATCGAAGGTGAAAAAGGGAGTCACCAAAATTTAATTAAAAATCTTAAAAATCAAGGGTTTTTGCGCATAAAAATTAA
TAAATCTTTTTATTATTTAGCTGATGATATTAAACTCGACCCAAAACAAAAGCACACAATTTGGGTAGTGATTGATCGAT
TTTTGCTTGAAAAAGAGGATAAAAATCGACTTCAGTCAGCATTAGAACTTGCCTTTGATCTTGGAAAAGGAATCGCGCTT
TGTGAATTTAATGAATCTGAAACTATCAGATTTTCAAAATTACAAGCCTGTCCTTTTGGTGATTTTGAGATGCCAAATCT
TGAAAATCGACTTTTTTCTTTTAATTCACCTTATGGAATGTGCCAGGTTTGTAAAGGTTTGGGTACAAATTTAGAGGCTG
ATTTTGACCTTATTGTTCCGGATAAAAATTTAACTATAAATCAGGGAGCGATTAAATATTTTGGAAAATCAATAAATACA
AAATCACTTGAATGACAAGAATTTAAAATTTTACTTGATTATTTTGAAATCTCGGCTGATCTAGAAATAGTAAAAATGAA
GAAAAATGAGCTTGAAATAATCAAATATGGATCAAAAGAATCTCTAAATTACTGACTAATTTCTGAAAGCGGGAAAAGAT
ATGACTATTTTCGACCAATTGAAGGAATTCTTAATAAAATTCAGAGAAAATTTTGGGAGACATCAAGCGAAGATTTACGA
CTTTGATTTAAGAAAATGATGTCAGAATTTCCTTGTAGTAGTTGCAAAGGAGCCCGGCTTAACAAGTATGCGCTTGCCGT
TTTCATTGAAAAGTATAATATCTTTCAATTATCCCAACTTTCAATTAAAGATTTAATAACTTTTTTTAGAAATTTAAAAT
TAACTGAATTTGACGGAAAAATTTCTACTTTAATTCTCGATGAAATTAAATCACGACTGTCATTTTTAGCAAATGTTGGT
CTTGAATATTTAACTTTAAATAGATCAACGGCAACCTTATCAGGAGGCGAATCCCAACGAATTAGGCTTGCAAGCCAGGT
TGGATCTCAACTAACCGGAATTCTTTATGTTCTTGATGAACCTTCAATTGGCCTACATCAAAAAGATAATGACAAATTAA
TTGCGACACTGAAAAAAATGGTTGAAATTGGTAATAGTTTAATTGTAGTCGAGCATGATTTTGAGACAATTTTAGCTGCT
GATTATATTGTTGATATCGGGCCAAAAGCTGGTGAAAACGGTGGTTTTTTGGTTGCTGCAGGATCAATTAAGGATATTGA
AAATGAACCAAAATCACTTACCGGCCAATTTTTAACTGGAAAATTGGAAATTCCAGTACCAAAAAAACGACGGGCTGGCA
ATGGCAAATTTATAATTATTGAAAAAGCTGCTGAAAATAATTTAAAAAAAATTAATGTCAACATTCCTCTAGGCAAATTT
GTTGTTGTCACTGGTGTTTCTGGATCTGGAAAGTCGACATTAGTTAATCAAATTATCGTAAATGCGATTGCCAAAAATCT
TGGAACAACTAATATTCGCATTGGAAAATGCGAGGAAATTAGAGGGCTTTTTAATATTGATAAGTTGATTGCAATCAATC
AAAGTCCAATCGGACGAACGCCTAGATCAAATCCCGCAACTTATACCTCTGTTTTTGATGATATCCGTGAGGTTTTTGCC
AATACTGAGCAGGCAAGAGCGCTTGGTTTTTCAAAGTCAAAATTTTCCTTTAATCTGCAAACTGGGCGGTGTGATAAATG
CCAAGGAGACGGGCAAATTAAAATTGAAATGTATTTTATGCCTGATATTTATGTTTTATGTGATCACTGCCAAGGAAAAA
GATACAAGCCGGATGTCCTACAAATTCGTTTTTATGGAAAAACAATCGCGGATATTCTTGATTTAACAGTTTCAGAAGCA
CTTGAATTTTTCCATAATTGGCCTAAAATAATCGCAAAATTACAAACCCTAGCTGATGTTGGTCTTGGTTATATAAAACT
TGGCCAATCAGCAATAACTTTATCAGGAGGAGAAGCTCAACGAATTAAATTAGCCACTTTTTTACAAAAAAAACCTACAG
GAAAATCACTTTTTGTACTTGACGAGCCAACAACTGGACTCCATAATTATGATGTTGCTAATTTAATTAAAGTGCTAAAT
CGAATAGTCGATAACGGTGATAGCATAATTGTAATCGAGCATAATTTAGAGGTAATTAAAGTTGCTGACTATATTATTGA
TTTAGGCCCAAACGGCGGGGATAACGGGGGCCAAATAGTTGCAAAAGGAACACCAGAAGCTGTAGCAAAAGTTAGCGAAT
CATATACTGGTGTTTATTTAAAGACAATTTTAAATATAAAATAA

Upstream 100 bases:

>100_bases
AAAAATTTAAAAAATCTAATTTTATTACTGCTATAAATACTAAAATTAATAAAGAAAATAATAAAAAAAACTCACAAAAA
AAGTAATAAAATACCGAAAA

Downstream 100 bases:

>100_bases
TTGTTTTTAAATAAAAACCACCAAATAAATTTGGTGGTGCAGTTTTTTTGCTTTAACTACAACTGCAAAGTCAAAGATGT
TCATCTGAGCGGTTTGAACT

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 947; Mature: 947

Protein sequence:

>947_residues
MLKNKDTHNFIYIKGARENNLKNINLVLPKNKLIVFTGLSGSGKSSLAFNTIYEEGKRRYIDSLSSYARQFLGGTKKPKV
DAIYGLLPTISVEQKTSHNNPRSTVGTITEIYDYFRLLYAKIGKAFCPNHKVEIIAQKIVTILDTILAYPEKTKLIIMAP
IIEGEKGSHQNLIKNLKNQGFLRIKINKSFYYLADDIKLDPKQKHTIWVVIDRFLLEKEDKNRLQSALELAFDLGKGIAL
CEFNESETIRFSKLQACPFGDFEMPNLENRLFSFNSPYGMCQVCKGLGTNLEADFDLIVPDKNLTINQGAIKYFGKSINT
KSLEWQEFKILLDYFEISADLEIVKMKKNELEIIKYGSKESLNYWLISESGKRYDYFRPIEGILNKIQRKFWETSSEDLR
LWFKKMMSEFPCSSCKGARLNKYALAVFIEKYNIFQLSQLSIKDLITFFRNLKLTEFDGKISTLILDEIKSRLSFLANVG
LEYLTLNRSTATLSGGESQRIRLASQVGSQLTGILYVLDEPSIGLHQKDNDKLIATLKKMVEIGNSLIVVEHDFETILAA
DYIVDIGPKAGENGGFLVAAGSIKDIENEPKSLTGQFLTGKLEIPVPKKRRAGNGKFIIIEKAAENNLKKINVNIPLGKF
VVVTGVSGSGKSTLVNQIIVNAIAKNLGTTNIRIGKCEEIRGLFNIDKLIAINQSPIGRTPRSNPATYTSVFDDIREVFA
NTEQARALGFSKSKFSFNLQTGRCDKCQGDGQIKIEMYFMPDIYVLCDHCQGKRYKPDVLQIRFYGKTIADILDLTVSEA
LEFFHNWPKIIAKLQTLADVGLGYIKLGQSAITLSGGEAQRIKLATFLQKKPTGKSLFVLDEPTTGLHNYDVANLIKVLN
RIVDNGDSIIVIEHNLEVIKVADYIIDLGPNGGDNGGQIVAKGTPEAVAKVSESYTGVYLKTILNIK

Sequences:

>Translated_947_residues
MLKNKDTHNFIYIKGARENNLKNINLVLPKNKLIVFTGLSGSGKSSLAFNTIYEEGKRRYIDSLSSYARQFLGGTKKPKV
DAIYGLLPTISVEQKTSHNNPRSTVGTITEIYDYFRLLYAKIGKAFCPNHKVEIIAQKIVTILDTILAYPEKTKLIIMAP
IIEGEKGSHQNLIKNLKNQGFLRIKINKSFYYLADDIKLDPKQKHTIWVVIDRFLLEKEDKNRLQSALELAFDLGKGIAL
CEFNESETIRFSKLQACPFGDFEMPNLENRLFSFNSPYGMCQVCKGLGTNLEADFDLIVPDKNLTINQGAIKYFGKSINT
KSLE*QEFKILLDYFEISADLEIVKMKKNELEIIKYGSKESLNY*LISESGKRYDYFRPIEGILNKIQRKFWETSSEDLR
L*FKKMMSEFPCSSCKGARLNKYALAVFIEKYNIFQLSQLSIKDLITFFRNLKLTEFDGKISTLILDEIKSRLSFLANVG
LEYLTLNRSTATLSGGESQRIRLASQVGSQLTGILYVLDEPSIGLHQKDNDKLIATLKKMVEIGNSLIVVEHDFETILAA
DYIVDIGPKAGENGGFLVAAGSIKDIENEPKSLTGQFLTGKLEIPVPKKRRAGNGKFIIIEKAAENNLKKINVNIPLGKF
VVVTGVSGSGKSTLVNQIIVNAIAKNLGTTNIRIGKCEEIRGLFNIDKLIAINQSPIGRTPRSNPATYTSVFDDIREVFA
NTEQARALGFSKSKFSFNLQTGRCDKCQGDGQIKIEMYFMPDIYVLCDHCQGKRYKPDVLQIRFYGKTIADILDLTVSEA
LEFFHNWPKIIAKLQTLADVGLGYIKLGQSAITLSGGEAQRIKLATFLQKKPTGKSLFVLDEPTTGLHNYDVANLIKVLN
RIVDNGDSIIVIEHNLEVIKVADYIIDLGPNGGDNGGQIVAKGTPEAVAKVSESYTGVYLKTILNIK
>Mature_947_residues
MLKNKDTHNFIYIKGARENNLKNINLVLPKNKLIVFTGLSGSGKSSLAFNTIYEEGKRRYIDSLSSYARQFLGGTKKPKV
DAIYGLLPTISVEQKTSHNNPRSTVGTITEIYDYFRLLYAKIGKAFCPNHKVEIIAQKIVTILDTILAYPEKTKLIIMAP
IIEGEKGSHQNLIKNLKNQGFLRIKINKSFYYLADDIKLDPKQKHTIWVVIDRFLLEKEDKNRLQSALELAFDLGKGIAL
CEFNESETIRFSKLQACPFGDFEMPNLENRLFSFNSPYGMCQVCKGLGTNLEADFDLIVPDKNLTINQGAIKYFGKSINT
KSLE*QEFKILLDYFEISADLEIVKMKKNELEIIKYGSKESLNY*LISESGKRYDYFRPIEGILNKIQRKFWETSSEDLR
L*FKKMMSEFPCSSCKGARLNKYALAVFIEKYNIFQLSQLSIKDLITFFRNLKLTEFDGKISTLILDEIKSRLSFLANVG
LEYLTLNRSTATLSGGESQRIRLASQVGSQLTGILYVLDEPSIGLHQKDNDKLIATLKKMVEIGNSLIVVEHDFETILAA
DYIVDIGPKAGENGGFLVAAGSIKDIENEPKSLTGQFLTGKLEIPVPKKRRAGNGKFIIIEKAAENNLKKINVNIPLGKF
VVVTGVSGSGKSTLVNQIIVNAIAKNLGTTNIRIGKCEEIRGLFNIDKLIAINQSPIGRTPRSNPATYTSVFDDIREVFA
NTEQARALGFSKSKFSFNLQTGRCDKCQGDGQIKIEMYFMPDIYVLCDHCQGKRYKPDVLQIRFYGKTIADILDLTVSEA
LEFFHNWPKIIAKLQTLADVGLGYIKLGQSAITLSGGEAQRIKLATFLQKKPTGKSLFVLDEPTTGLHNYDVANLIKVLN
RIVDNGDSIIVIEHNLEVIKVADYIIDLGPNGGDNGGQIVAKGTPEAVAKVSESYTGVYLKTILNIK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=939, Percent_Identity=49.5207667731629, Blast_Score=914, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 105590; Mature: 105590

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2 ; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNKDTHNFIYIKGARENNLKNINLVLPKNKLIVFTGLSGSGKSSLAFNTIYEEGKRRY
CCCCCCCCCEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEHHHHHHHHHHHH
IDSLSSYARQFLGGTKKPKVDAIYGLLPTISVEQKTSHNNPRSTVGTITEIYDYFRLLYA
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
KIGKAFCPNHKVEIIAQKIVTILDTILAYPEKTKLIIMAPIIEGEKGSHQNLIKNLKNQG
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCC
FLRIKINKSFYYLADDIKLDPKQKHTIWVVIDRFLLEKEDKNRLQSALELAFDLGKGIAL
EEEEEECCCEEEEEECCEECCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEE
CEFNESETIRFSKLQACPFGDFEMPNLENRLFSFNSPYGMCQVCKGLGTNLEADFDLIVP
EECCCCCCEEEEEECCCCCCCCCCCCHHHHHEECCCCCCHHHHHHHCCCCCCCCEEEEEC
DKNLTINQGAIKYFGKSINTKSLEQEFKILLDYFEISADLEIVKMKKNELEIIKYGSKES
CCCCEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHH
LNYLISESGKRYDYFRPIEGILNKIQRKFWETSSEDLRLFKKMMSEFPCSSCKGARLNKY
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCE
ALAVFIEKYNIFQLSQLSIKDLITFFRNLKLTEFDGKISTLILDEIKSRLSFLANVGLEY
EEEEEEECCCEEEEHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEEE
LTLNRSTATLSGGESQRIRLASQVGSQLTGILYVLDEPSIGLHQKDNDKLIATLKKMVEI
EEECCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHC
GNSLIVVEHDFETILAADYIVDIGPKAGENGGFLVAAGSIKDIENEPKSLTGQFLTGKLE
CCCEEEEECCHHHHHHHHHEEECCCCCCCCCCEEEEECCCHHCCCCCCCCCCCEEEEEEE
IPVPKKRRAGNGKFIIIEKAAENNLKKINVNIPLGKFVVVTGVSGSGKSTLVNQIIVNAI
CCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHH
AKNLGTTNIRIGKCEEIRGLFNIDKLIAINQSPIGRTPRSNPATYTSVFDDIREVFANTE
HHHCCCCCEEECCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCH
QARALGFSKSKFSFNLQTGRCDKCQGDGQIKIEMYFMPDIYVLCDHCQGKRYKPDVLQIR
HHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCCEEEEE
FYGKTIADILDLTVSEALEFFHNWPKIIAKLQTLADVGLGYIKLGQSAITLSGGEAQRIK
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCEEE
LATFLQKKPTGKSLFVLDEPTTGLHNYDVANLIKVLNRIVDNGDSIIVIEHNLEVIKVAD
HHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEE
YIIDLGPNGGDNGGQIVAKGTPEAVAKVSESYTGVYLKTILNIK
EHEECCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MLKNKDTHNFIYIKGARENNLKNINLVLPKNKLIVFTGLSGSGKSSLAFNTIYEEGKRRY
CCCCCCCCCEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEHHHHHHHHHHHH
IDSLSSYARQFLGGTKKPKVDAIYGLLPTISVEQKTSHNNPRSTVGTITEIYDYFRLLYA
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
KIGKAFCPNHKVEIIAQKIVTILDTILAYPEKTKLIIMAPIIEGEKGSHQNLIKNLKNQG
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCC
FLRIKINKSFYYLADDIKLDPKQKHTIWVVIDRFLLEKEDKNRLQSALELAFDLGKGIAL
EEEEEECCCEEEEEECCEECCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEE
CEFNESETIRFSKLQACPFGDFEMPNLENRLFSFNSPYGMCQVCKGLGTNLEADFDLIVP
EECCCCCCEEEEEECCCCCCCCCCCCHHHHHEECCCCCCHHHHHHHCCCCCCCCEEEEEC
DKNLTINQGAIKYFGKSINTKSLEQEFKILLDYFEISADLEIVKMKKNELEIIKYGSKES
CCCCEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHH
LNYLISESGKRYDYFRPIEGILNKIQRKFWETSSEDLRLFKKMMSEFPCSSCKGARLNKY
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCE
ALAVFIEKYNIFQLSQLSIKDLITFFRNLKLTEFDGKISTLILDEIKSRLSFLANVGLEY
EEEEEEECCCEEEEHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEEE
LTLNRSTATLSGGESQRIRLASQVGSQLTGILYVLDEPSIGLHQKDNDKLIATLKKMVEI
EEECCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHC
GNSLIVVEHDFETILAADYIVDIGPKAGENGGFLVAAGSIKDIENEPKSLTGQFLTGKLE
CCCEEEEECCHHHHHHHHHEEECCCCCCCCCCEEEEECCCHHCCCCCCCCCCCEEEEEEE
IPVPKKRRAGNGKFIIIEKAAENNLKKINVNIPLGKFVVVTGVSGSGKSTLVNQIIVNAI
CCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHH
AKNLGTTNIRIGKCEEIRGLFNIDKLIAINQSPIGRTPRSNPATYTSVFDDIREVFANTE
HHHCCCCCEEECCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCH
QARALGFSKSKFSFNLQTGRCDKCQGDGQIKIEMYFMPDIYVLCDHCQGKRYKPDVLQIR
HHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCCEEEEE
FYGKTIADILDLTVSEALEFFHNWPKIIAKLQTLADVGLGYIKLGQSAITLSGGEAQRIK
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCEEE
LATFLQKKPTGKSLFVLDEPTTGLHNYDVANLIKVLNRIVDNGDSIIVIEHNLEVIKVAD
HHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEE
YIIDLGPNGGDNGGQIVAKGTPEAVAKVSESYTGVYLKTILNIK
EHEECCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]