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The map label for this gene is gmk

Identifier: 54020104

GI number: 54020104

Start: 255926

End: 256519

Strand: Direct

Name: gmk

Synonym: mhp229

Alternate gene names: 54020104

Gene position: 255926-256519 (Clockwise)

Preceding gene: 54020103

Following gene: 54020105

Centisome position: 28.67

GC content: 27.1

Gene sequence:

>594_bases
ATGAAGGTAAAAATGAGTAAATTAATAATTTTGTCTGGACCTTCAGGGGTTGGCAAGGGCACAATTGAATCACTTTTATT
AAAAAATAAAAATTTATTAATAAAGTTAGCAATTTCTGCAACAACTCGAGAAAAAAGGAGAGACGAAATTAACGGAGTTA
ATTATTTTTTCCTAACAGTTCAAGAGTTTAAAGAAAAAATTGAAAATGATGAATTTATTGAATGAAGTTGTCATTTTAAT
AATTATTATGGGACCCTAAAATCGCAGATTAAGTTTATTCAGTCTCAAAATTTTATCCCATTATTGGAAATTGATACAAC
AGGTGCTAAAAATATTATTGAAAATTACAAAAATAAAGGTGAATTATCCCAACTTTTAACTATTTTTATCCTCCCTCCTT
CCATTGAATCTCTTAAAAACCGGATTCAAAAACGTCTAACAGAAACAAATATTCAAATAAATCAACGACTAGAAAAAGCC
AAAGCTGAGATTAAAATTAAAAATTTGTTCAAATTTCAAGTGGTTAATGACAATTTAGAAGAATGTGTTGCCCAAATAGA
AAAAATTATAAGTAAAGAGATCCAAAAAACTTAG

Upstream 100 bases:

>100_bases
TATAAAACAAATTTAGGCTCTAAACTAATTCCGGGCATTTTTTCAATCCATCAAATAAAAAAATATGGTAAAAACAGCGT
TTTTTTCCTAAAATATTACA

Downstream 100 bases:

>100_bases
ATGAAAGGGCAAGTTGTTCGAATTATTGCCGGTTTTTATGATGTTGTCGATCTTAAAAACCGAAAATTATACCCGCTTTT
AAGAGGTTCTGGTCTTCTTC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MKVKMSKLIILSGPSGVGKGTIESLLLKNKNLLIKLAISATTREKRRDEINGVNYFFLTVQEFKEKIENDEFIEWSCHFN
NYYGTLKSQIKFIQSQNFIPLLEIDTTGAKNIIENYKNKGELSQLLTIFILPPSIESLKNRIQKRLTETNIQINQRLEKA
KAEIKIKNLFKFQVVNDNLEECVAQIEKIISKEIQKT

Sequences:

>Translated_197_residues
MKVKMSKLIILSGPSGVGKGTIESLLLKNKNLLIKLAISATTREKRRDEINGVNYFFLTVQEFKEKIENDEFIE*SCHFN
NYYGTLKSQIKFIQSQNFIPLLEIDTTGAKNIIENYKNKGELSQLLTIFILPPSIESLKNRIQKRLTETNIQINQRLEKA
KAEIKIKNLFKFQVVNDNLEECVAQIEKIISKEIQKT
>Mature_197_residues
MKVKMSKLIILSGPSGVGKGTIESLLLKNKNLLIKLAISATTREKRRDEINGVNYFFLTVQEFKEKIENDEFIE*SCHFN
NYYGTLKSQIKFIQSQNFIPLLEIDTTGAKNIIENYKNKGELSQLLTIFILPPSIESLKNRIQKRLTETNIQINQRLEKA
KAEIKIKNLFKFQVVNDNLEECVAQIEKIISKEIQKT

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=34.020618556701, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=34.020618556701, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=34.020618556701, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI186700629, Length=191, Percent_Identity=27.2251308900524, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700627, Length=191, Percent_Identity=27.2251308900524, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186972120, Length=191, Percent_Identity=27.2251308900524, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=187, Percent_Identity=34.2245989304813, Blast_Score=114, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI193203132, Length=197, Percent_Identity=34.010152284264, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17508835, Length=197, Percent_Identity=34.010152284264, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71988048, Length=189, Percent_Identity=26.4550264550265, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71988041, Length=189, Percent_Identity=26.4550264550265, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320662, Length=191, Percent_Identity=37.696335078534, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356141, Length=164, Percent_Identity=35.9756097560976, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI45551002, Length=145, Percent_Identity=32.4137931034483, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22576; Mature: 22576

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKMSKLIILSGPSGVGKGTIESLLLKNKNLLIKLAISATTREKRRDEINGVNYFFLTV
CCEEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHCCCCEEEEEEH
QEFKEKIENDEFIESCHFNNYYGTLKSQIKFIQSQNFIPLLEIDTTGAKNIIENYKNKGE
HHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCH
LSQLLTIFILPPSIESLKNRIQKRLTETNIQINQRLEKAKAEIKIKNLFKFQVVNDNLEE
HHHHHHHEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEHHHHEEEEEECCCHHH
CVAQIEKIISKEIQKT
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVKMSKLIILSGPSGVGKGTIESLLLKNKNLLIKLAISATTREKRRDEINGVNYFFLTV
CCEEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHCCCCEEEEEEH
QEFKEKIENDEFIESCHFNNYYGTLKSQIKFIQSQNFIPLLEIDTTGAKNIIENYKNKGE
HHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCH
LSQLLTIFILPPSIESLKNRIQKRLTETNIQINQRLEKAKAEIKIKNLFKFQVVNDNLEE
HHHHHHHEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEHHHHEEEEEECCCHHH
CVAQIEKIISKEIQKT
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA