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The map label for this gene is pdp [H]

Identifier: 52787904

GI number: 52787904

Start: 4062055

End: 4063356

Strand: Reverse

Name: pdp [H]

Synonym: BLi04227

Alternate gene names: 52787904

Gene position: 4063356-4062055 (Counterclockwise)

Preceding gene: 52787905

Following gene: 52787903

Centisome position: 96.23

GC content: 52.07

Gene sequence:

>1302_bases
ATGAGAATGGTTGATATCATCACAAAAAAACAAAATGGAGAAGAATTGACAACAGAAGAAATTCAATTTTTCATTAAAGG
CTACACCGACGGCAGCATTCCTGACTATCAAGCGAGCGCTCTGGCGATGGCCATCTATTTTCAGGACATGACGGACAGAG
AGCGGGCCGATCTCACGATGGCGATGGTCAACTCAGGCGAAACGATCGACCTTTCCGCGATTGAAGGTATCAAGGTCGAC
AAACACTCAACAGGAGGCGTCGGCGACACGACGACGCTCGTACTTGCACCGCTTGTCGCGGCTCTCGACGTACCCGTCGC
CAAAATGTCGGGACGCGGCCTCGGACACACAGGGGGAACAATTGACAAGCTCGAAGCGATCAAAGGGTTTCACGTGGAAC
TTTCCAAAGATGAATTCATCGAGCTCGTCAACCGCGACAAGGTCGCCGTTATCGGCCAAAGCGGAAACTTGACGCCTGCT
GACAAAAAACTGTACGCCCTTCGCGATGTGACAGGCACGGTCAATTCGATCCCGCTGATTGCCAGCTCGATCATGAGCAA
GAAAATCGCCGCAGGGGCGGATGCGATTGTCCTTGACGTCAAAACGGGCGCCGGCGCATTTATGAAAACCGATGAAGATG
CAGTCAACCTTGCAAAAGCAATGGTCCGCATCGGAAACAATGTCGGCCGCCAAACGATGGCCGTCATCTCCGACATGTCC
CAGCCGCTGGGGTTTGCCATCGGAAATGCGCTTGAAGTGAAAGAGGCGATTGATACATTAAAAGGCGAAGGTCCTGAAGA
CTTGACTGAGCTTGTCTTAACATTGGGCAGCCAAATGGTCGTTCTCGCCAAAAAAGCGGAGACCCTTGACGAAGCAAGAG
AGAAACTGATCGACGTGATGAAAAACGGAAAAGCGCTGCAAAAATTCAAAGACTTCCTGCAGAATCAAGGCGGCGACAGC
TCTGTCGCGGATAACCCAGAAAAGCTGCCTCAGGCTGCCTATAAAATCGACGTTCCTGCCAAAGAAGCGGGTGTCGTGTC
TGAAATCGTCGCCGATCAAATCGGCGTTGCGGCCATGCTGCTGGGCGCCGGCCGCGCAACAAAAGAAGACAAAATCGACC
TCGCCGTCGGCATCATGCTCCGCAAAAAAGTCGGCGACGCAGTCGAAAAAGGCGAACCATTGGTTACCCTATACGCAAAC
CGCGAAAATGTCGATGACGTCATCGCAAAAGTCTACGACAACATCCAAATCGCGGAAACAGCCGAAGCACCGAAGCTTGT
GCATACGGTGATTACGGAATAG

Upstream 100 bases:

>100_bases
GTTGAAATTGCTGTACGGCGCAACGCTCGTCAGTTTCTTGACAGCGACCGTTGTAGGATTGATCTATTGATAAACATTGA
AAAAAGGACTGGTGATCACA

Downstream 100 bases:

>100_bases
AGGAACATGCAAAACAGCACATACCTTTGGGTGTGTGCTGTTTTTTTGATGTCACGGAATTTGAGAAAAGGTCATTTGAA
CTAAGTCCAGGACGCTATTT

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMVDIITKKQNGEELTTEEIQFFIKGYTDGSIPDYQASALAMAIYFQDMTDRERADLTMAMVNSGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGTIDKLEAIKGFHVELSKDEFIELVNRDKVAVIGQSGNLTPA
DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAVNLAKAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLTLGSQMVVLAKKAETLDEAREKLIDVMKNGKALQKFKDFLQNQGGDS
SVADNPEKLPQAAYKIDVPAKEAGVVSEIVADQIGVAAMLLGAGRATKEDKIDLAVGIMLRKKVGDAVEKGEPLVTLYAN
RENVDDVIAKVYDNIQIAETAEAPKLVHTVITE

Sequences:

>Translated_433_residues
MRMVDIITKKQNGEELTTEEIQFFIKGYTDGSIPDYQASALAMAIYFQDMTDRERADLTMAMVNSGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGTIDKLEAIKGFHVELSKDEFIELVNRDKVAVIGQSGNLTPA
DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAVNLAKAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLTLGSQMVVLAKKAETLDEAREKLIDVMKNGKALQKFKDFLQNQGGDS
SVADNPEKLPQAAYKIDVPAKEAGVVSEIVADQIGVAAMLLGAGRATKEDKIDLAVGIMLRKKVGDAVEKGEPLVTLYAN
RENVDDVIAKVYDNIQIAETAEAPKLVHTVITE
>Mature_433_residues
MRMVDIITKKQNGEELTTEEIQFFIKGYTDGSIPDYQASALAMAIYFQDMTDRERADLTMAMVNSGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGTIDKLEAIKGFHVELSKDEFIELVNRDKVAVIGQSGNLTPA
DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAVNLAKAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLTLGSQMVVLAKKAETLDEAREKLIDVMKNGKALQKFKDFLQNQGGDS
SVADNPEKLPQAAYKIDVPAKEAGVVSEIVADQIGVAAMLLGAGRATKEDKIDLAVGIMLRKKVGDAVEKGEPLVTLYAN
RENVDDVIAKVYDNIQIAETAEAPKLVHTVITE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=38.5749385749386, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=38.5749385749386, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=38.5749385749386, Blast_Score=262, Evalue=5e-70,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=45.7920792079208, Blast_Score=326, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46144; Mature: 46144

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDIITKKQNGEELTTEEIQFFIKGYTDGSIPDYQASALAMAIYFQDMTDRERADLTM
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCEEE
AMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGT
EEECCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAIKGFHVELSKDEFIELVNRDKVAVIGQSGNLTPADKKLYALRDVTGTVNSIPLI
HHHHHHHCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCHHHHEEHHHCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAVNLAKAMVRIGNNVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLTLGSQMVVLAKKAETLDEAREKLIDVM
CCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
KNGKALQKFKDFLQNQGGDSSVADNPEKLPQAAYKIDVPAKEAGVVSEIVADQIGVAAML
HCCHHHHHHHHHHHCCCCCCCCCCCHHHHCHHHEEECCCCHHHHHHHHHHHHHHHHHHHH
LGAGRATKEDKIDLAVGIMLRKKVGDAVEKGEPLVTLYANRENVDDVIAKVYDNIQIAET
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCEEECC
AEAPKLVHTVITE
CCCHHHHHHHHCC
>Mature Secondary Structure
MRMVDIITKKQNGEELTTEEIQFFIKGYTDGSIPDYQASALAMAIYFQDMTDRERADLTM
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCEEE
AMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGT
EEECCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAIKGFHVELSKDEFIELVNRDKVAVIGQSGNLTPADKKLYALRDVTGTVNSIPLI
HHHHHHHCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCHHHHEEHHHCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAVNLAKAMVRIGNNVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLTLGSQMVVLAKKAETLDEAREKLIDVM
CCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
KNGKALQKFKDFLQNQGGDSSVADNPEKLPQAAYKIDVPAKEAGVVSEIVADQIGVAAML
HCCHHHHHHHHHHHCCCCCCCCCCCHHHHCHHHEEECCCCHHHHHHHHHHHHHHHHHHHH
LGAGRATKEDKIDLAVGIMLRKKVGDAVEKGEPLVTLYANRENVDDVIAKVYDNIQIAET
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCEEECC
AEAPKLVHTVITE
CCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]