Click here to switch to the map view.

The map label for this gene is adhB [H]

Identifier: 52787511

GI number: 52787511

Start: 3657695

End: 3658828

Strand: Reverse

Name: adhB [H]

Synonym: BLi03831

Alternate gene names: 52787511

Gene position: 3658828-3657695 (Counterclockwise)

Preceding gene: 52787512

Following gene: 52787508

Centisome position: 86.65

GC content: 47.62

Gene sequence:

>1134_bases
TTGAAAGCCGTAACGTTTCAAGGGCCTCAGCATGTTGAAGTCAGCCAGGTGGAGGATGCCAAAATTGAAAAAAGCGATGA
TATCGTTGTCAGAATTACTTCTACCGCGATTTGCGGTTCGGATCTCCATCTTTATCAAGGGAATTTCCCTCTTCCAAAAG
GCTTCCAGCTCGGCCATGAACCGATGGGAATTGTAGAAGAAACAGGACCTGATGTAACAAAAGTGAAAAAAGGAGACCGG
GTTGTCATCCCGTTTACCGTTGCCTGCGGACATTGCTTTTATTGCGAAAACAAGCTGGAAAGCCAGTGCGACAATGCCAA
TCCCCATTATGATTCAGGCGGGTATTTTGGCTACTCGGAAAAATTCGGGAATCACCCTGGCGGACAGGCTGAATATTTAA
AAGTGCCGTTTGGCAATTTCACGCCGTTTGTCATTCCTGAATCATGCGAGATGGAGGACGAGTCGCTTCTGTTTTTATCA
GATGTCCTCCCAACCGCGTATTGGAGCGTGCTTCACGCAGGCGTCAAAAAAGGGGACACTGTCATTGTGCTCGGCTGCGG
GCCGGTTGGATTAATGGCGCAGAAGTTTGCCTGGATGGAAGGGGCGAAGCGGGTCATTGCAGTAGACTACTTGGACTACC
GCCTAAAGCAGGCTGAGGCATTAAACCGCGTTGAAGTATTTGACTTTACAAAATATCCTGATATGGGCGAGCATTTAAAG
GAGATTACAAAAGGCGGGGCGGATGTCGTGATCGACTGCGTAGGGATGGACGGCAAAAAATCTCCGCTTGAGTATCTGGA
GCAAAAACTGAAGCTTCAGGGCGGCACGCTCGGACCGATTCAAATTTCTACAAAGGCGGTCAGAAAGTGCGGAACCGTAC
AGATTACGGGGGTATATGGAAGCAATTACAATATGTTTCCGCTCGGCGCATTCTTTTCCAGAAATGTTACGCTAAAAATG
GGGCAGGCTCCGGTCATCCATTTGATGCCGGAGATTTACAAGAAGATCGAAGAGAATCAATTTGATCCGAAGGAAATCAT
TACGCACCAGCTTCCGCTTGAAGAAGCCGGCCGCGCTTATCATTTGTTCAACGACCATGAAGATGATTGCATTAAAGTAA
TTTTGAAGCCATAG

Upstream 100 bases:

>100_bases
TCTACATGACGGCTAATGAAACGTTTGTTTAAAAAACTGAATAAGAACCCGGGTTTATCTCACACTAAAGTCAACTGAAC
GATAATGGGAGTGTGACGAT

Downstream 100 bases:

>100_bases
CGATGATAAAGGCTGCCGAGCTACCGGCAGCCTTTTCCTCGCATTACCTTGCCAGCCATCCGCCATCGACGGCTAACACA
TGTCCATTCACATAATCGGA

Product: AdhB

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKAVTFQGPQHVEVSQVEDAKIEKSDDIVVRITSTAICGSDLHLYQGNFPLPKGFQLGHEPMGIVEETGPDVTKVKKGDR
VVIPFTVACGHCFYCENKLESQCDNANPHYDSGGYFGYSEKFGNHPGGQAEYLKVPFGNFTPFVIPESCEMEDESLLFLS
DVLPTAYWSVLHAGVKKGDTVIVLGCGPVGLMAQKFAWMEGAKRVIAVDYLDYRLKQAEALNRVEVFDFTKYPDMGEHLK
EITKGGADVVIDCVGMDGKKSPLEYLEQKLKLQGGTLGPIQISTKAVRKCGTVQITGVYGSNYNMFPLGAFFSRNVTLKM
GQAPVIHLMPEIYKKIEENQFDPKEIITHQLPLEEAGRAYHLFNDHEDDCIKVILKP

Sequences:

>Translated_377_residues
MKAVTFQGPQHVEVSQVEDAKIEKSDDIVVRITSTAICGSDLHLYQGNFPLPKGFQLGHEPMGIVEETGPDVTKVKKGDR
VVIPFTVACGHCFYCENKLESQCDNANPHYDSGGYFGYSEKFGNHPGGQAEYLKVPFGNFTPFVIPESCEMEDESLLFLS
DVLPTAYWSVLHAGVKKGDTVIVLGCGPVGLMAQKFAWMEGAKRVIAVDYLDYRLKQAEALNRVEVFDFTKYPDMGEHLK
EITKGGADVVIDCVGMDGKKSPLEYLEQKLKLQGGTLGPIQISTKAVRKCGTVQITGVYGSNYNMFPLGAFFSRNVTLKM
GQAPVIHLMPEIYKKIEENQFDPKEIITHQLPLEEAGRAYHLFNDHEDDCIKVILKP
>Mature_377_residues
MKAVTFQGPQHVEVSQVEDAKIEKSDDIVVRITSTAICGSDLHLYQGNFPLPKGFQLGHEPMGIVEETGPDVTKVKKGDR
VVIPFTVACGHCFYCENKLESQCDNANPHYDSGGYFGYSEKFGNHPGGQAEYLKVPFGNFTPFVIPESCEMEDESLLFLS
DVLPTAYWSVLHAGVKKGDTVIVLGCGPVGLMAQKFAWMEGAKRVIAVDYLDYRLKQAEALNRVEVFDFTKYPDMGEHLK
EITKGGADVVIDCVGMDGKKSPLEYLEQKLKLQGGTLGPIQISTKAVRKCGTVQITGVYGSNYNMFPLGAFFSRNVTLKM
GQAPVIHLMPEIYKKIEENQFDPKEIITHQLPLEEAGRAYHLFNDHEDDCIKVILKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=394, Percent_Identity=28.6802030456853, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI34577061, Length=380, Percent_Identity=27.8947368421053, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4501933, Length=391, Percent_Identity=27.6214833759591, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71565152, Length=390, Percent_Identity=24.1025641025641, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI71565154, Length=389, Percent_Identity=23.1362467866324, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI71743840, Length=391, Percent_Identity=25.0639386189258, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI262073058, Length=391, Percent_Identity=25.0639386189258, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI156523966, Length=376, Percent_Identity=25.2659574468085, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=390, Percent_Identity=42.8205128205128, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI87082125, Length=360, Percent_Identity=27.2222222222222, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788073, Length=363, Percent_Identity=25.8953168044077, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790045, Length=212, Percent_Identity=32.5471698113208, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787863, Length=382, Percent_Identity=24.6073298429319, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790718, Length=190, Percent_Identity=30.5263157894737, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788407, Length=293, Percent_Identity=27.3037542662116, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=219, Percent_Identity=30.1369863013699, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786552, Length=390, Percent_Identity=23.3333333333333, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI226510992, Length=195, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788075, Length=250, Percent_Identity=27.2, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562878, Length=252, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=392, Percent_Identity=23.469387755102, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=374, Percent_Identity=22.7272727272727, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=392, Percent_Identity=23.2142857142857, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=238, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=391, Percent_Identity=25.8312020460358, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=393, Percent_Identity=27.2264631043257, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=386, Percent_Identity=25.9067357512953, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=386, Percent_Identity=26.4248704663212, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=388, Percent_Identity=24.4845360824742, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=302, Percent_Identity=27.8145695364238, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=24.7058823529412, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=24.5562130177515, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=233, Percent_Identity=30.0429184549356, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=411, Percent_Identity=23.1143552311436, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737897, Length=261, Percent_Identity=27.9693486590038, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17137530, Length=261, Percent_Identity=28.735632183908, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221457811, Length=364, Percent_Identity=23.6263736263736, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550770, Length=364, Percent_Identity=23.6263736263736, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551930, Length=364, Percent_Identity=23.6263736263736, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737895, Length=389, Percent_Identity=23.1362467866324, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1; 1.2.1.1

Molecular weight: Translated: 41851; Mature: 41851

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVTFQGPQHVEVSQVEDAKIEKSDDIVVRITSTAICGSDLHLYQGNFPLPKGFQLGHE
CCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCCCC
PMGIVEETGPDVTKVKKGDRVVIPFTVACGHCFYCENKLESQCDNANPHYDSGGYFGYSE
CCCCHHCCCCCHHEECCCCEEEEEEEECCCEEEEECCHHHHHCCCCCCCCCCCCCCCCHH
KFGNHPGGQAEYLKVPFGNFTPFVIPESCEMEDESLLFLSDVLPTAYWSVLHAGVKKGDT
HHCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCE
VIVLGCGPVGLMAQKFAWMEGAKRVIAVDYLDYRLKQAEALNRVEVFDFTKYPDMGEHLK
EEEECCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
EITKGGADVVIDCVGMDGKKSPLEYLEQKLKLQGGTLGPIQISTKAVRKCGTVQITGVYG
HHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECHHHHHHCCCEEEEEEEC
SNYNMFPLGAFFSRNVTLKMGQAPVIHLMPEIYKKIEENQFDPKEIITHQLPLEEAGRAY
CCCCEEEEHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHCCCEE
HLFNDHEDDCIKVILKP
EECCCCCCCEEEEEECC
>Mature Secondary Structure
MKAVTFQGPQHVEVSQVEDAKIEKSDDIVVRITSTAICGSDLHLYQGNFPLPKGFQLGHE
CCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCCCC
PMGIVEETGPDVTKVKKGDRVVIPFTVACGHCFYCENKLESQCDNANPHYDSGGYFGYSE
CCCCHHCCCCCHHEECCCCEEEEEEEECCCEEEEECCHHHHHCCCCCCCCCCCCCCCCHH
KFGNHPGGQAEYLKVPFGNFTPFVIPESCEMEDESLLFLSDVLPTAYWSVLHAGVKKGDT
HHCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCE
VIVLGCGPVGLMAQKFAWMEGAKRVIAVDYLDYRLKQAEALNRVEVFDFTKYPDMGEHLK
EEEECCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
EITKGGADVVIDCVGMDGKKSPLEYLEQKLKLQGGTLGPIQISTKAVRKCGTVQITGVYG
HHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECHHHHHHCCCEEEEEEEC
SNYNMFPLGAFFSRNVTLKMGQAPVIHLMPEIYKKIEENQFDPKEIITHQLPLEEAGRAY
CCCCEEEEHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHCCCEE
HLFNDHEDDCIKVILKP
EECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]