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The map label for this gene is yvcT [H]

Identifier: 52787399

GI number: 52787399

Start: 3544349

End: 3545320

Strand: Direct

Name: yvcT [H]

Synonym: BLi03716

Alternate gene names: 52787399

Gene position: 3544349-3545320 (Clockwise)

Preceding gene: 52787396

Following gene: 52787401

Centisome position: 83.94

GC content: 47.63

Gene sequence:

>972_bases
ATGAAACCGTTTGTATATGTCACAAAACCGGTCCCAAAAGAAATCGAAGAGATGCTCGCTGAACATTGCGAATATGAAAT
TTGGACTTCGCGCGAGCGTATTCCCAGAACGACCCTGCTCGAGAAAATCAAGGAAGCGGACGGCCTTTTGACCTCAGGAA
CAAAAATTGACCGTGAATTATTATCCAATGCACTGAAGTTAAAAATCGTCAGCAACAATTCCGTCGGCTATGACAACTTT
GATATTGAAGCAATGAAAGAAAAATCGGTCATCGGCACCCATACGCCATATATTCTTGACGACACAGTCGCAGACCTTGC
TTTCGGTCTGATCCTTTCCTCAGCTCGGCGAATCGCCGAGCTCGACCGCTACGTCCGCGAGGGAAAATGGACCAAATCAG
AGGACGATGAAAGCTTGTTCGGATCTGATGTCCATCACCGGACGCTCGGCATCATCGGAATGGGACGAATCGGCGAACAA
GTCGCCAAACGGGCGGCCTTGGGTTTTGATATGGAAGTGCTCTATTACAGCCGCAGCCGCAAACCCGATACAGAGAAAAA
AACCGGCGCGGTTTATACGGGCTTTCATGAGCTGTTGGAGCGCTCGGATTTCATTGTTCTGGTCACACCGCTCACGGATG
AGACATACCGCCTCATCGGCGAAGCAGAATTCAAAAAAATGAAACCGTCGTCCATTTTCATCAACATCTCCCGCGGTAAA
ACAGTTGACGAACAAGCGTTGATTCAAGCGCTGAAAGAAGGATGGATTAAAGGAGCCGGACTTGATGTATTTGAAAAAGA
GCCGATTGAAAAAGACAATCCGCTCCTAAGCCTTTCCAATGTAACCCTTGTTCCCCACATTGGATCATCCACCCATGTCA
CACACGTCAACATGCTGAAAAGCGCCGTTCAAAACCTGATTGACGGTCTTCAGGGCAAACGGCCAAAAGATATAGTCAAA
GAACTGAGATAA

Upstream 100 bases:

>100_bases
TGAGCTGATAGTCCTGCGCTAGCTGGAACAATCTTTGATTTTTACAGAAACCGTTTTTCCTCTATAATGGAAGCAGATGA
TACGCGGAAGGAGAATGCAG

Downstream 100 bases:

>100_bases
CGCGCATCTTTCAGGCGCGGAACGTTTTGCCAAGCTCTCCTCCTAAGCCAAAATAGTGTCTGAAAAGATAAATCAAAGGT
TCCCATTTTTGAGGATCGAT

Product: gluconate 2-dehydrogenase

Products: NA

Alternate protein names: 2KR [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKPFVYVTKPVPKEIEEMLAEHCEYEIWTSRERIPRTTLLEKIKEADGLLTSGTKIDRELLSNALKLKIVSNNSVGYDNF
DIEAMKEKSVIGTHTPYILDDTVADLAFGLILSSARRIAELDRYVREGKWTKSEDDESLFGSDVHHRTLGIIGMGRIGEQ
VAKRAALGFDMEVLYYSRSRKPDTEKKTGAVYTGFHELLERSDFIVLVTPLTDETYRLIGEAEFKKMKPSSIFINISRGK
TVDEQALIQALKEGWIKGAGLDVFEKEPIEKDNPLLSLSNVTLVPHIGSSTHVTHVNMLKSAVQNLIDGLQGKRPKDIVK
ELR

Sequences:

>Translated_323_residues
MKPFVYVTKPVPKEIEEMLAEHCEYEIWTSRERIPRTTLLEKIKEADGLLTSGTKIDRELLSNALKLKIVSNNSVGYDNF
DIEAMKEKSVIGTHTPYILDDTVADLAFGLILSSARRIAELDRYVREGKWTKSEDDESLFGSDVHHRTLGIIGMGRIGEQ
VAKRAALGFDMEVLYYSRSRKPDTEKKTGAVYTGFHELLERSDFIVLVTPLTDETYRLIGEAEFKKMKPSSIFINISRGK
TVDEQALIQALKEGWIKGAGLDVFEKEPIEKDNPLLSLSNVTLVPHIGSSTHVTHVNMLKSAVQNLIDGLQGKRPKDIVK
ELR
>Mature_323_residues
MKPFVYVTKPVPKEIEEMLAEHCEYEIWTSRERIPRTTLLEKIKEADGLLTSGTKIDRELLSNALKLKIVSNNSVGYDNF
DIEAMKEKSVIGTHTPYILDDTVADLAFGLILSSARRIAELDRYVREGKWTKSEDDESLFGSDVHHRTLGIIGMGRIGEQ
VAKRAALGFDMEVLYYSRSRKPDTEKKTGAVYTGFHELLERSDFIVLVTPLTDETYRLIGEAEFKKMKPSSIFINISRGK
TVDEQALIQALKEGWIKGAGLDVFEKEPIEKDNPLLSLSNVTLVPHIGSSTHVTHVNMLKSAVQNLIDGLQGKRPKDIVK
ELR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=321, Percent_Identity=38.9408099688474, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=30.9278350515464, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI145580578, Length=284, Percent_Identity=32.3943661971831, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=284, Percent_Identity=32.3943661971831, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI61743967, Length=283, Percent_Identity=31.8021201413428, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4557497, Length=283, Percent_Identity=31.8021201413428, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI145580575, Length=283, Percent_Identity=32.1554770318021, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI87082289, Length=322, Percent_Identity=46.8944099378882, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1789279, Length=267, Percent_Identity=32.2097378277154, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=201, Percent_Identity=32.8358208955224, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081824, Length=150, Percent_Identity=31.3333333333333, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=269, Percent_Identity=31.5985130111524, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=279, Percent_Identity=30.1075268817204, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=273, Percent_Identity=34.7985347985348, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=281, Percent_Identity=32.3843416370107, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=281, Percent_Identity=31.6725978647687, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=325, Percent_Identity=23.0769230769231, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=257, Percent_Identity=28.0155642023346, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=146, Percent_Identity=30.8219178082192, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=215, Percent_Identity=23.2558139534884, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=38.8535031847134, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45551003, Length=314, Percent_Identity=38.8535031847134, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24585514, Length=314, Percent_Identity=38.8535031847134, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574282, Length=314, Percent_Identity=38.8535031847134, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574284, Length=314, Percent_Identity=38.8535031847134, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574286, Length=318, Percent_Identity=37.4213836477987, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI28571528, Length=313, Percent_Identity=36.741214057508, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=30.7692307692308, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19921140, Length=317, Percent_Identity=29.9684542586751, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24646446, Length=293, Percent_Identity=33.1058020477816, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646448, Length=293, Percent_Identity=33.1058020477816, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646452, Length=293, Percent_Identity=33.1058020477816, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646450, Length=293, Percent_Identity=33.1058020477816, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62472511, Length=257, Percent_Identity=36.1867704280156, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.215 [H]

Molecular weight: Translated: 36404; Mature: 36404

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFVYVTKPVPKEIEEMLAEHCEYEIWTSRERIPRTTLLEKIKEADGLLTSGTKIDREL
CCCCEEEECCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHH
LSNALKLKIVSNNSVGYDNFDIEAMKEKSVIGTHTPYILDDTVADLAFGLILSSARRIAE
HCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
LDRYVREGKWTKSEDDESLFGSDVHHRTLGIIGMGRIGEQVAKRAALGFDMEVLYYSRSR
HHHHHHCCCCCCCCCCHHHHCCCHHHHHHCEEECHHHHHHHHHHHHCCCCCEEEEEECCC
KPDTEKKTGAVYTGFHELLERSDFIVLVTPLTDETYRLIGEAEFKKMKPSSIFINISRGK
CCCCCHHCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
TVDEQALIQALKEGWIKGAGLDVFEKEPIEKDNPLLSLSNVTLVPHIGSSTHVTHVNMLK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCCHHHHHHHH
SAVQNLIDGLQGKRPKDIVKELR
HHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MKPFVYVTKPVPKEIEEMLAEHCEYEIWTSRERIPRTTLLEKIKEADGLLTSGTKIDREL
CCCCEEEECCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHH
LSNALKLKIVSNNSVGYDNFDIEAMKEKSVIGTHTPYILDDTVADLAFGLILSSARRIAE
HCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
LDRYVREGKWTKSEDDESLFGSDVHHRTLGIIGMGRIGEQVAKRAALGFDMEVLYYSRSR
HHHHHHCCCCCCCCCCHHHHCCCHHHHHHCEEECHHHHHHHHHHHHCCCCCEEEEEECCC
KPDTEKKTGAVYTGFHELLERSDFIVLVTPLTDETYRLIGEAEFKKMKPSSIFINISRGK
CCCCCHHCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
TVDEQALIQALKEGWIKGAGLDVFEKEPIEKDNPLLSLSNVTLVPHIGSSTHVTHVNMLK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCCHHHHHHHH
SAVQNLIDGLQGKRPKDIVKELR
HHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]