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The map label for this gene is clpP

Identifier: 52787393

GI number: 52787393

Start: 3539012

End: 3539608

Strand: Direct

Name: clpP

Synonym: BLi03710

Alternate gene names: 52787393

Gene position: 3539012-3539608 (Clockwise)

Preceding gene: 52787391

Following gene: 52787395

Centisome position: 83.81

GC content: 48.74

Gene sequence:

>597_bases
ATGAATTTAATACCTACAGTCATTGAACAGACGAACCGCGGGGAAAGAGCGTATGACATTTACTCACGCTTGTTGAAAGA
CCGTATCATTATGCTGGGATCAGCAATCGATGACAATGTTGCGAACTCCATCGTATCTCAGCTTCTATTCCTTGAAGCCG
AAGATCCAGAAAAAGATATCAGCATCTATATCAACAGCCCTGGCGGCTCCATCACAGCCGGTATGGCGATTTATGACACC
ATGCAGTTTATTAAACCGCAAGTCTCCACGATTTGTACGGGAATGGCGGCATCCATGGGTGCGTTCCTTCTTGCAGCCGG
CGAGAAAGGGAAGCGCTACGCTCTTCCAAACAGTGAAGTCATGATCCACCAGCCGCTTGGCGGAGCGCAGGGTCAGGCGA
CTGAAATTGAAATTGCCGCGAAACGCATTCTTTCATTGCGCGACAAGCTGAACAAAATCCTTGCAGAGCGCACTGGGCAG
CCGCTTGAAGTAATCGAGCGCGATACAGACCGCGACAACTTCAAAACGGCTGAAGAAGCAAAAGAATACGGCCTGATTGA
TAAAGTGCTTACACGCAATATCGACGCACAGAAGTAA

Upstream 100 bases:

>100_bases
GTATGTCTTTTGGATGAAGGCGGCTTTTTGTTTGACCTTTATTGACCAAAAATGTATGATTAAACTACATACTTACCTTT
TAAGGTGAAGGAGGAGCATT

Downstream 100 bases:

>100_bases
ACAGCCAAAAAGCTGCCGGAGTCACCGGCAGCTTTTTTTTACTCCAAATGGGTTGTCCCATTCGCTATATGTAAAGCTTC
TATAAATCCTTCCACTTTTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLEAEDPEKDISIYINSPGGSITAGMAIYDT
MQFIKPQVSTICTGMAASMGAFLLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILSLRDKLNKILAERTGQ
PLEVIERDTDRDNFKTAEEAKEYGLIDKVLTRNIDAQK

Sequences:

>Translated_198_residues
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLEAEDPEKDISIYINSPGGSITAGMAIYDT
MQFIKPQVSTICTGMAASMGAFLLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILSLRDKLNKILAERTGQ
PLEVIERDTDRDNFKTAEEAKEYGLIDKVLTRNIDAQK
>Mature_198_residues
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLEAEDPEKDISIYINSPGGSITAGMAIYDT
MQFIKPQVSTICTGMAASMGAFLLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILSLRDKLNKILAERTGQ
PLEVIERDTDRDNFKTAEEAKEYGLIDKVLTRNIDAQK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti- sigma

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=56.25, Blast_Score=231, Evalue=2e-61,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=68.75, Blast_Score=284, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=53.6842105263158, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=55.7894736842105, Blast_Score=228, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_BACLD (Q65EI5)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_080797.1
- RefSeq:   YP_093222.1
- ProteinModelPortal:   Q65EI5
- SMR:   Q65EI5
- STRING:   Q65EI5
- MEROPS:   S14.001
- EnsemblBacteria:   EBBACT00000054794
- EnsemblBacteria:   EBBACT00000062127
- GeneID:   3029468
- GeneID:   3100812
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03710
- KEGG:   bli:BL03605
- NMPDR:   fig|279010.5.peg.3775
- eggNOG:   COG0740
- GeneTree:   EBGT00050000002046
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   BLIC279010-1:BLI03710-MONOMER
- BioCyc:   BLIC279010:BL03605-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21804; Mature: 21804

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLEAEDPEKDI
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCE
SIYINSPGGSITAGMAIYDTMQFIKPQVSTICTGMAASMGAFLLAAGEKGKRYALPNSEV
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCE
MIHQPLGGAQGQATEIEIAAKRILSLRDKLNKILAERTGQPLEVIERDTDRDNFKTAEEA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHH
KEYGLIDKVLTRNIDAQK
HHHCHHHHHHHCCCCCCC
>Mature Secondary Structure
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLEAEDPEKDI
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCE
SIYINSPGGSITAGMAIYDTMQFIKPQVSTICTGMAASMGAFLLAAGEKGKRYALPNSEV
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCE
MIHQPLGGAQGQATEIEIAAKRILSLRDKLNKILAERTGQPLEVIERDTDRDNFKTAEEA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHH
KEYGLIDKVLTRNIDAQK
HHHCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA