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The map label for this gene is comC [H]

Identifier: 52786668

GI number: 52786668

Start: 2818475

End: 2819224

Strand: Reverse

Name: comC [H]

Synonym: BLi02936

Alternate gene names: 52786668

Gene position: 2819224-2818475 (Counterclockwise)

Preceding gene: 52786669

Following gene: 52786667

Centisome position: 66.76

GC content: 54.0

Gene sequence:

>750_bases
ATGTTCATCTTTTACCTTTTTACGGCAGGTTTAGTGCTCGGCTCTTTTTTTAATTCGGCCGGGCGCCGCATTCCTGAAAA
GATATCATTGATTGCTCCGCGTTCCCTCTGCCGCGTCTGCAAAAGGCAGCTGGGCTTCTCGGAGCTGATACCGGTTTTGT
CCTATTTGATGCAGCGGGGGAGGTGCAAAGGATGTCAAACCCCGCTCTCGATCGTGTATCCGGCAGTTGAGCTCTCCGCC
GCCATCCTGTTTGCGTTTGCCGGCATGCACGTTGGGCATGAGGGGGAGCTGGTGATTGTGCTTGCTCTTATATCTCTGCT
TTTGATCGTCTTTGTATCTGATGTGACACACATGATCATTCCGGATGCTGTTCTTTGTTTTTTCCTGCCTGTCTTTGCCG
TCGGACGATTCCTTGTTCCTCTGGAACAGTGGCACTCAAGTTTGAGCGGTGCGATGGCCGGCGGTATGCTGCCCCTCTTG
ACGCTGCTTTTGACGAAAGGGGGGATCGGCTGGGGAGACGTAAAGCTGTTTGCGGTAATCGGCATGGCGCTCGGCAGCCG
CCTCCTCGTTCTCGCTTTTTTCCTCTCGGCAGCCGCAGGAACGGTGCTTGGTCTTATTGCACTCCTGGCAGGCAAACTGA
AGAAAAATGAACCAATGCCGTTTGCTCCCGCGATTCTGGCCGGGACGCTGACGAGCTGCTTCTATGGCGAACCAATGATC
GAGTGGTACCTTCAAACGGCATGGTGGTGA

Upstream 100 bases:

>100_bases
TTATGTTTTAGGAAAAGAGGAGGCGCTTCATATTTGCTAAAATAACAGCCGCTAGGCAGCAGCTTTTTTCATGAAATTTG
ATTCTGCGAGGTTGATAACG

Downstream 100 bases:

>100_bases
AAAATTTGACGAAACCTTTTTGGGCAAGACGACAAAAGTCTTGTTCTTTTTTTTTGAGGCTGTGATAAAGTGTGGACATT
AAGAGGGACAGCCTTTAGGA

Product: hypothetical protein

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MFIFYLFTAGLVLGSFFNSAGRRIPEKISLIAPRSLCRVCKRQLGFSELIPVLSYLMQRGRCKGCQTPLSIVYPAVELSA
AILFAFAGMHVGHEGELVIVLALISLLLIVFVSDVTHMIIPDAVLCFFLPVFAVGRFLVPLEQWHSSLSGAMAGGMLPLL
TLLLTKGGIGWGDVKLFAVIGMALGSRLLVLAFFLSAAAGTVLGLIALLAGKLKKNEPMPFAPAILAGTLTSCFYGEPMI
EWYLQTAWW

Sequences:

>Translated_249_residues
MFIFYLFTAGLVLGSFFNSAGRRIPEKISLIAPRSLCRVCKRQLGFSELIPVLSYLMQRGRCKGCQTPLSIVYPAVELSA
AILFAFAGMHVGHEGELVIVLALISLLLIVFVSDVTHMIIPDAVLCFFLPVFAVGRFLVPLEQWHSSLSGAMAGGMLPLL
TLLLTKGGIGWGDVKLFAVIGMALGSRLLVLAFFLSAAAGTVLGLIALLAGKLKKNEPMPFAPAILAGTLTSCFYGEPMI
EWYLQTAWW
>Mature_249_residues
MFIFYLFTAGLVLGSFFNSAGRRIPEKISLIAPRSLCRVCKRQLGFSELIPVLSYLMQRGRCKGCQTPLSIVYPAVELSA
AILFAFAGMHVGHEGELVIVLALISLLLIVFVSDVTHMIIPDAVLCFFLPVFAVGRFLVPLEQWHSSLSGAMAGGMLPLL
TLLLTKGGIGWGDVKLFAVIGMALGSRLLVLAFFLSAAAGTVLGLIALLAGKLKKNEPMPFAPAILAGTLTSCFYGEPMI
EWYLQTAWW

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=252, Percent_Identity=28.1746031746032, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 26955; Mature: 26955

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCC
>Mature Secondary Structure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HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]