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The map label for this gene is yrrR [H]

Identifier: 52786593

GI number: 52786593

Start: 2747497

End: 2749251

Strand: Reverse

Name: yrrR [H]

Synonym: BLi02859

Alternate gene names: 52786593

Gene position: 2749251-2747497 (Counterclockwise)

Preceding gene: 52786594

Following gene: 52786592

Centisome position: 65.11

GC content: 47.07

Gene sequence:

>1755_bases
ATGAAATGGCAAAAGCGTATGAAGTGGGTATCGATTATCATTTCGGCTGCTCTTTTATTTCTGCTGATCAGGCTGGCTGA
AATTCAACTGTTTTTTACCGAGTCCTTTTCTAAACGGAATGTGAACTTAATCCAGGAAAGCGTCAAACAGCGCACGGAGG
AAGTTCGGATTTCAGACGGGAGAGGATCTTTTTTAGATCGGAACGGCGAACATTTGTCCGTCAGCCAAAAACCGGCCATC
GTCTTGTTCCCTTTTTTAAAAAATCAGCCGTGGCCGGCCAAAGAAGCAGCCGAAATTTTAAACATGACAGAAGATGAGCT
TGGAAGCAAGCTGGACCATGCAAAAAAACCCGTGATTCTCACAAAACATGACGGAGCGTCCGTTTCAAAGACGGCTCTCG
AAAAAATCAATAAACTGAAATATCCGGGCGTTTACGGCGTATACATAGAAGAAACAGAAAAGAACAGGCTGGCTTCGCAT
ACGCTCGGTATGACCAATCAAGACCCGGACCTCCTCAGACGCAAATATCCCGATAAAGAGGGCCTCTCCATCAGCACGAA
AATCGGCACCTTCGGCATGGAGCGGACGTTTGATGAATTCCTGCTGCCTGAACAAGACACAAAACTGTTGTATCATGTGG
ACGGATTGGGAAACCCTTTGTTCGGCATGGACGTCAAATATACAGCAGACGCAAATCCGTTTTACCCGCTGCAAGTCAAA
ACAACGCTCGATAAAAAGGTTCAGCAGGCAATGGAAGATGTACTTGATGACCATCAGCTCGATAAAGGCTGGGCGGTCCT
GCTTGACATCGAGACGAACGGCGTGGTGGCGATTGCGAGCAAGCCCGACTTAAACATGGCTGCGCAAAAAACAAGGCAGA
ACTATATGCTGACTCCGGTATATCCCGGCTCGGTTTTTAAAACCGTGATTGCCGCTGCAGCGATTGAAAACGGCTTGGAT
CATCCGTCTAAAACCTTTAACTGCAATTTGAACCTGTACGGTGAGGCCGGAGAGGACAAAGGAAAGCTCAGCCTGGAAGA
CAGTTTTGCGGAAAGCTGCAACTACACGTTTACAAATCTTGCCGGACAGCTCGTAGAAAAAAACAGCTCCGTGATCGAAG
ATACTGCTGCAAAGCTTGGGCTGACCGGACGGGTCGGCTGGGAAGGAAAGCTGTATCATGAAGATGAGTTCAGACAGTTT
TATCATGAAACTGCAGGATCAATCTGGGGGGATGAAAAGGACAAAAAAGTTAAAAAAGCTGTAGCCCAGACCGCTATCGG
CCAAAAGAATGTGAAGCTGACTCCGTTGGAAATCGTCAACATGATGGCGACCATCGCAAGAGGCGGAGAGAAAAAACAAG
TCAAGATCGCAGACCAGATCGAATATAAAAACGGCACATTGATGACGGCTTTTAAAGATCACGAGCTCCCAGGAGAGAAA
ATCGACCAGTATACAGCGCAAAAGCTGCAAAAACTGCTCAGAAAAGTTGTCACATCTGAAAAGGGGACGGGCCGGCGCTT
CAGCGATCTTCCGTACGATGTAGCGGGAAAATCGGGCACAGCGCAGACAGGCAGGACGACAGATGACAAAAAAACGCTCT
ATCATAAATGGTTTGCCGGTTATTTTCCGGCGGACAAGCCGAAATATGCGCTCGTCGTCGTCCATATGGATACGCCGGAT
AGCAAGGCTGCGACAAATGCCGTATTTTATGATATTGTTAAAAAAGTATATGAAATTGAAAAGAACCAGACATAG

Upstream 100 bases:

>100_bases
AACACCTGGCGGCGAAATGCTTGTAAAAATTGTGAAAATTTCATAAAATTTGTTTAGCAAACGATGACCTCGTCCACAAT
GTGGATGAGGTGTTTTTATA

Downstream 100 bases:

>100_bases
AAGAATGCCTCAGGTGATGATAAAATAGGAAGCGAGGCAAGAGGGAAAAAGGAGTGCAATGAACTTGAGCGAAACAAGGG
AATCTCGTTTTGAAAATCGT

Product: YrrR

Products: NA

Alternate protein names: PBP-4B; PBP4b; Penicillin-binding protein I [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MKWQKRMKWVSIIISAALLFLLIRLAEIQLFFTESFSKRNVNLIQESVKQRTEEVRISDGRGSFLDRNGEHLSVSQKPAI
VLFPFLKNQPWPAKEAAEILNMTEDELGSKLDHAKKPVILTKHDGASVSKTALEKINKLKYPGVYGVYIEETEKNRLASH
TLGMTNQDPDLLRRKYPDKEGLSISTKIGTFGMERTFDEFLLPEQDTKLLYHVDGLGNPLFGMDVKYTADANPFYPLQVK
TTLDKKVQQAMEDVLDDHQLDKGWAVLLDIETNGVVAIASKPDLNMAAQKTRQNYMLTPVYPGSVFKTVIAAAAIENGLD
HPSKTFNCNLNLYGEAGEDKGKLSLEDSFAESCNYTFTNLAGQLVEKNSSVIEDTAAKLGLTGRVGWEGKLYHEDEFRQF
YHETAGSIWGDEKDKKVKKAVAQTAIGQKNVKLTPLEIVNMMATIARGGEKKQVKIADQIEYKNGTLMTAFKDHELPGEK
IDQYTAQKLQKLLRKVVTSEKGTGRRFSDLPYDVAGKSGTAQTGRTTDDKKTLYHKWFAGYFPADKPKYALVVVHMDTPD
SKAATNAVFYDIVKKVYEIEKNQT

Sequences:

>Translated_584_residues
MKWQKRMKWVSIIISAALLFLLIRLAEIQLFFTESFSKRNVNLIQESVKQRTEEVRISDGRGSFLDRNGEHLSVSQKPAI
VLFPFLKNQPWPAKEAAEILNMTEDELGSKLDHAKKPVILTKHDGASVSKTALEKINKLKYPGVYGVYIEETEKNRLASH
TLGMTNQDPDLLRRKYPDKEGLSISTKIGTFGMERTFDEFLLPEQDTKLLYHVDGLGNPLFGMDVKYTADANPFYPLQVK
TTLDKKVQQAMEDVLDDHQLDKGWAVLLDIETNGVVAIASKPDLNMAAQKTRQNYMLTPVYPGSVFKTVIAAAAIENGLD
HPSKTFNCNLNLYGEAGEDKGKLSLEDSFAESCNYTFTNLAGQLVEKNSSVIEDTAAKLGLTGRVGWEGKLYHEDEFRQF
YHETAGSIWGDEKDKKVKKAVAQTAIGQKNVKLTPLEIVNMMATIARGGEKKQVKIADQIEYKNGTLMTAFKDHELPGEK
IDQYTAQKLQKLLRKVVTSEKGTGRRFSDLPYDVAGKSGTAQTGRTTDDKKTLYHKWFAGYFPADKPKYALVVVHMDTPD
SKAATNAVFYDIVKKVYEIEKNQT
>Mature_584_residues
MKWQKRMKWVSIIISAALLFLLIRLAEIQLFFTESFSKRNVNLIQESVKQRTEEVRISDGRGSFLDRNGEHLSVSQKPAI
VLFPFLKNQPWPAKEAAEILNMTEDELGSKLDHAKKPVILTKHDGASVSKTALEKINKLKYPGVYGVYIEETEKNRLASH
TLGMTNQDPDLLRRKYPDKEGLSISTKIGTFGMERTFDEFLLPEQDTKLLYHVDGLGNPLFGMDVKYTADANPFYPLQVK
TTLDKKVQQAMEDVLDDHQLDKGWAVLLDIETNGVVAIASKPDLNMAAQKTRQNYMLTPVYPGSVFKTVIAAAAIENGLD
HPSKTFNCNLNLYGEAGEDKGKLSLEDSFAESCNYTFTNLAGQLVEKNSSVIEDTAAKLGLTGRVGWEGKLYHEDEFRQF
YHETAGSIWGDEKDKKVKKAVAQTAIGQKNVKLTPLEIVNMMATIARGGEKKQVKIADQIEYKNGTLMTAFKDHELPGEK
IDQYTAQKLQKLLRKVVTSEKGTGRRFSDLPYDVAGKSGTAQTGRTTDDKKTLYHKWFAGYFPADKPKYALVVVHMDTPD
SKAATNAVFYDIVKKVYEIEKNQT

Specific function: Penicillin-binding protein with an unknown catalytic activity. Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactamase inactivates the PBPs by acylating an essential serine residue in the active site of these p

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65616; Mature: 65616

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWQKRMKWVSIIISAALLFLLIRLAEIQLFFTESFSKRNVNLIQESVKQRTEEVRISDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHEEEECC
RGSFLDRNGEHLSVSQKPAIVLFPFLKNQPWPAKEAAEILNMTEDELGSKLDHAKKPVIL
CCCCCCCCCCEEEECCCCCEEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEE
TKHDGASVSKTALEKINKLKYPGVYGVYIEETEKNRLASHTLGMTNQDPDLLRRKYPDKE
EECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHCCCCC
GLSISTKIGTFGMERTFDEFLLPEQDTKLLYHVDGLGNPLFGMDVKYTADANPFYPLQVK
CCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEE
TTLDKKVQQAMEDVLDDHQLDKGWAVLLDIETNGVVAIASKPDLNMAAQKTRQNYMLTPV
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEECCCCCCHHHHHHCCCEEEEEC
YPGSVFKTVIAAAAIENGLDHPSKTFNCNLNLYGEAGEDKGKLSLEDSFAESCNYTFTNL
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCEEECHHHHHHCCCCHHHH
AGQLVEKNSSVIEDTAAKLGLTGRVGWEGKLYHEDEFRQFYHETAGSIWGDEKDKKVKKA
HHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCCHHHHHHHH
VAQTAIGQKNVKLTPLEIVNMMATIARGGEKKQVKIADQIEYKNGTLMTAFKDHELPGEK
HHHHHCCCCCCEECHHHHHHHHHHHHCCCCCCEEEEHHHEEECCCEEEEEECCCCCCHHH
IDQYTAQKLQKLLRKVVTSEKGTGRRFSDLPYDVAGKSGTAQTGRTTDDKKTLYHKWFAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
YFPADKPKYALVVVHMDTPDSKAATNAVFYDIVKKVYEIEKNQT
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKWQKRMKWVSIIISAALLFLLIRLAEIQLFFTESFSKRNVNLIQESVKQRTEEVRISDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHEEEECC
RGSFLDRNGEHLSVSQKPAIVLFPFLKNQPWPAKEAAEILNMTEDELGSKLDHAKKPVIL
CCCCCCCCCCEEEECCCCCEEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEE
TKHDGASVSKTALEKINKLKYPGVYGVYIEETEKNRLASHTLGMTNQDPDLLRRKYPDKE
EECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHCCCCC
GLSISTKIGTFGMERTFDEFLLPEQDTKLLYHVDGLGNPLFGMDVKYTADANPFYPLQVK
CCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEE
TTLDKKVQQAMEDVLDDHQLDKGWAVLLDIETNGVVAIASKPDLNMAAQKTRQNYMLTPV
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEECCCCCCHHHHHHCCCEEEEEC
YPGSVFKTVIAAAAIENGLDHPSKTFNCNLNLYGEAGEDKGKLSLEDSFAESCNYTFTNL
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCEEECHHHHHHCCCCHHHH
AGQLVEKNSSVIEDTAAKLGLTGRVGWEGKLYHEDEFRQFYHETAGSIWGDEKDKKVKKA
HHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCCHHHHHHHH
VAQTAIGQKNVKLTPLEIVNMMATIARGGEKKQVKIADQIEYKNGTLMTAFKDHELPGEK
HHHHHCCCCCCEECHHHHHHHHHHHHCCCCCCEEEEHHHEEECCCEEEEEECCCCCCHHH
IDQYTAQKLQKLLRKVVTSEKGTGRRFSDLPYDVAGKSGTAQTGRTTDDKKTLYHKWFAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
YFPADKPKYALVVVHMDTPDSKAATNAVFYDIVKKVYEIEKNQT
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]