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The map label for this gene is folE [H]

Identifier: 52786157

GI number: 52786157

Start: 2355423

End: 2355992

Strand: Reverse

Name: folE [H]

Synonym: BLi02413

Alternate gene names: 52786157

Gene position: 2355992-2355423 (Counterclockwise)

Preceding gene: 52786158

Following gene: 52786156

Centisome position: 55.79

GC content: 47.54

Gene sequence:

>570_bases
ATGAGAGAAATCAACAAAGACCAAATTGAACAAGCCGTCCGGCAAATATTGGAGGCGATCGGAGAAGATCCGAACCGCGA
GGGCCTTCTTGATACACCGAAAAGAGTCGCAAAGATGTACGCTGAAGTATTTGCGGGTTTAAACGAAGATCCGAAAGAGC
ATTTCAAAACGATTTTCGGCGAGGATCACGAAGAGCTTGTTCTTGTTAAAGATATTCCTTTTTATTCAATGTGTGAGCAC
CATTTAGTTCCTTTCTACGGGAAAGCCCATGTAGCCTATATCCCTAAAGGCGGAAAAGTGACAGGACTCAGCAAGTTGGC
GAGAGCCGTTGAAGCGGTGGCAAAACGTCCGCAGCTTCAGGAGCGGATTACGTCAACAATTGCCGACAGCATTGTTGAAA
CGCTGACTCCGCACGGTGTAATGGTGGTTGTTGAAGCCGAGCATATGTGCATGACGATGCGCGGCGTGAAAAAGCCGGGT
TCAAAAACTGTCACTTCAGCTGTAAGGGGAACGTTTAGACAGGATGTGGCTGCTCGCTCTGAGGTGTTGGAGCTTATCAA
AACATCATGA

Upstream 100 bases:

>100_bases
GATAACATTTTGCCGGCAAAAAACCTTTCATTTTGCTTTTATAAGCTGAAGTGTGCTAGAATCTGAATTAAATGTATGCG
TTTCTGGAGGATATAAAACA

Downstream 100 bases:

>100_bases
TTAAAAATGAGAAGGTGTGCGATGAACATGACCAATAATCAATCGAATGATTTTGTCGTTATCAAAGCCGTTGAAGACGG
CGTCAATGTGATCGGACTGA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MREINKDQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVFAGLNEDPKEHFKTIFGEDHEELVLVKDIPFYSMCEH
HLVPFYGKAHVAYIPKGGKVTGLSKLARAVEAVAKRPQLQERITSTIADSIVETLTPHGVMVVVEAEHMCMTMRGVKKPG
SKTVTSAVRGTFRQDVAARSEVLELIKTS

Sequences:

>Translated_189_residues
MREINKDQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVFAGLNEDPKEHFKTIFGEDHEELVLVKDIPFYSMCEH
HLVPFYGKAHVAYIPKGGKVTGLSKLARAVEAVAKRPQLQERITSTIADSIVETLTPHGVMVVVEAEHMCMTMRGVKKPG
SKTVTSAVRGTFRQDVAARSEVLELIKTS
>Mature_189_residues
MREINKDQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVFAGLNEDPKEHFKTIFGEDHEELVLVKDIPFYSMCEH
HLVPFYGKAHVAYIPKGGKVTGLSKLARAVEAVAKRPQLQERITSTIADSIVETLTPHGVMVVVEAEHMCMTMRGVKKPG
SKTVTSAVRGTFRQDVAARSEVLELIKTS

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=193, Percent_Identity=51.2953367875648, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI4503949, Length=193, Percent_Identity=51.2953367875648, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI66932970, Length=151, Percent_Identity=49.6688741721854, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI66932972, Length=151, Percent_Identity=49.6688741721854, Blast_Score=136, Evalue=9e-33,
Organism=Escherichia coli, GI1788476, Length=189, Percent_Identity=38.0952380952381, Blast_Score=113, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=50.561797752809, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321706, Length=181, Percent_Identity=50.828729281768, Blast_Score=177, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24656782, Length=188, Percent_Identity=47.3404255319149, Blast_Score=166, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24656796, Length=188, Percent_Identity=47.3404255319149, Blast_Score=166, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24656791, Length=188, Percent_Identity=47.3404255319149, Blast_Score=165, Evalue=1e-41,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21069; Mature: 21069

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2 ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREINKDQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVFAGLNEDPKEHFKTIFG
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHC
EDHEELVLVKDIPFYSMCEHHLVPFYGKAHVAYIPKGGKVTGLSKLARAVEAVAKRPQLQ
CCCCCEEEEECCCHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHH
ERITSTIADSIVETLTPHGVMVVVEAEHMCMTMRGVKKPGSKTVTSAVRGTFRQDVAARS
HHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EVLELIKTS
HHHHHHHCC
>Mature Secondary Structure
MREINKDQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVFAGLNEDPKEHFKTIFG
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHC
EDHEELVLVKDIPFYSMCEHHLVPFYGKAHVAYIPKGGKVTGLSKLARAVEAVAKRPQLQ
CCCCCEEEEECCCHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHH
ERITSTIADSIVETLTPHGVMVVVEAEHMCMTMRGVKKPGSKTVTSAVRGTFRQDVAARS
HHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EVLELIKTS
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA