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The map label for this gene is panC

Identifier: 52786121

GI number: 52786121

Start: 2323576

End: 2324442

Strand: Reverse

Name: panC

Synonym: BLi02377

Alternate gene names: 52786121

Gene position: 2324442-2323576 (Counterclockwise)

Preceding gene: 52786122

Following gene: 52786120

Centisome position: 55.05

GC content: 48.9

Gene sequence:

>867_bases
ATGATTCAGATCTATACAGCAAAAGATATACAAAACTTAACGAAAAATTACCGCAAGGAAGGCAAAACCATCGGTTTTGT
GCCGACAATGGGCTTCCTTCATGAAGGTCATATGTCGCTAGTAGAAAAAGCGCGAAAAGACAACGATATTGTCGTGATGA
GCATTTTTGTCAATCCTATGCAGTTCGGTCCGGGAGAAGACTATGAAGCGTATCCGAGAGATATTGAAAGAGACCGTCAG
CTTGCGGCCGGCTCAGGAGTGGACGTCTTGTTCACTCCTGAGCCTGAAGAAATGTACGGCCAGGAGCCGACGGTTACCGC
AAGCGTGAAAAAGCGGACGGATGTCCTTTGCGGCCGTTCAAGAGAAGGGCATTTCGACGGTGTCGCAACAGTGCTCACAA
AGCTGTTCAATCTCACGTCTCCGACAAGGGTTTATTTCGGCATGAAGGATGCCCAGCAGGTTGCCGTCGTCGACGGGCTG
ATCAACGACTTTTTCATGGATATCGAGCTGATCCCTGTCGAAACAAAACGGGAAGAAGACGGGCTTGCCAAAAGCTCAAG
AAATGTCAATCTGCGAGCTGAAGAACGGCAGGAAGCAACCGCTCTTTACCGAGCTCTTCAGCGCGGCGCCGAGCTGATCC
GCAATGGAGAGAGAGACCCGGAGGCCGTTAAGCGGGAGATTCGGAGCATTCTGGAAAAAACGAGTGGTGTTATTGATTAT
GCCGATATTTATTCATATCCCGATCTGGAGATCAGGGATCCATTGACTGGAAAAGTCATCATAGCGGTTGCCGTTCAGTT
TTCCAAAGCCCGCTTAATTGACAATATCATCGTCGATATCCCGGCAGATCAAAAGGAGGATTTGTGA

Upstream 100 bases:

>100_bases
GATATGTTGAGGATGTCAGAAGCCGCGTGTTTCCTGAAGATGCTCATTCGTTCCGTATAGATCAGCAAGTTCTTGAAGGA
TTATACGGAGGGAAATAGGC

Downstream 100 bases:

>100_bases
TGTACCGTACGTTAATGAGCGCAAAACTTCACAGAGCGAGAGTGACGGAAGCCAATTTGAACTACGTCGGCAGCGTGACA
ATTGATGAAGATTTGCTGGA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MIQIYTAKDIQNLTKNYRKEGKTIGFVPTMGFLHEGHMSLVEKARKDNDIVVMSIFVNPMQFGPGEDYEAYPRDIERDRQ
LAAGSGVDVLFTPEPEEMYGQEPTVTASVKKRTDVLCGRSREGHFDGVATVLTKLFNLTSPTRVYFGMKDAQQVAVVDGL
INDFFMDIELIPVETKREEDGLAKSSRNVNLRAEERQEATALYRALQRGAELIRNGERDPEAVKREIRSILEKTSGVIDY
ADIYSYPDLEIRDPLTGKVIIAVAVQFSKARLIDNIIVDIPADQKEDL

Sequences:

>Translated_288_residues
MIQIYTAKDIQNLTKNYRKEGKTIGFVPTMGFLHEGHMSLVEKARKDNDIVVMSIFVNPMQFGPGEDYEAYPRDIERDRQ
LAAGSGVDVLFTPEPEEMYGQEPTVTASVKKRTDVLCGRSREGHFDGVATVLTKLFNLTSPTRVYFGMKDAQQVAVVDGL
INDFFMDIELIPVETKREEDGLAKSSRNVNLRAEERQEATALYRALQRGAELIRNGERDPEAVKREIRSILEKTSGVIDY
ADIYSYPDLEIRDPLTGKVIIAVAVQFSKARLIDNIIVDIPADQKEDL
>Mature_288_residues
MIQIYTAKDIQNLTKNYRKEGKTIGFVPTMGFLHEGHMSLVEKARKDNDIVVMSIFVNPMQFGPGEDYEAYPRDIERDRQ
LAAGSGVDVLFTPEPEEMYGQEPTVTASVKKRTDVLCGRSREGHFDGVATVLTKLFNLTSPTRVYFGMKDAQQVAVVDGL
INDFFMDIELIPVETKREEDGLAKSSRNVNLRAEERQEATALYRALQRGAELIRNGERDPEAVKREIRSILEKTSGVIDY
ADIYSYPDLEIRDPLTGKVIIAVAVQFSKARLIDNIIVDIPADQKEDL

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=290, Percent_Identity=40, Blast_Score=187, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6322046, Length=285, Percent_Identity=35.7894736842105, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_BACLD (Q65I57)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_079541.1
- RefSeq:   YP_091950.1
- ProteinModelPortal:   Q65I57
- SMR:   Q65I57
- STRING:   Q65I57
- EnsemblBacteria:   EBBACT00000056922
- EnsemblBacteria:   EBBACT00000060176
- GeneID:   3029463
- GeneID:   3100430
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02377
- KEGG:   bli:BL02751
- NMPDR:   fig|279010.5.peg.227
- eggNOG:   COG0414
- GeneTree:   EBGT00050000001451
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   BLIC279010-1:BLI02377-MONOMER
- BioCyc:   BLIC279010:BL02751-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32464; Mature: 32464

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIYTAKDIQNLTKNYRKEGKTIGFVPTMGFLHEGHMSLVEKARKDNDIVVMSIFVNPM
CEEEEEHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
QFGPGEDYEAYPRDIERDRQLAAGSGVDVLFTPEPEEMYGQEPTVTASVKKRTDVLCGRS
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCEEEHHHHHHHHHHCCC
REGHFDGVATVLTKLFNLTSPTRVYFGMKDAQQVAVVDGLINDFFMDIELIPVETKREED
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCC
GLAKSSRNVNLRAEERQEATALYRALQRGAELIRNGERDPEAVKREIRSILEKTSGVIDY
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEH
ADIYSYPDLEIRDPLTGKVIIAVAVQFSKARLIDNIIVDIPADQKEDL
HHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHEEECCCCCCCCC
>Mature Secondary Structure
MIQIYTAKDIQNLTKNYRKEGKTIGFVPTMGFLHEGHMSLVEKARKDNDIVVMSIFVNPM
CEEEEEHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
QFGPGEDYEAYPRDIERDRQLAAGSGVDVLFTPEPEEMYGQEPTVTASVKKRTDVLCGRS
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCEEEHHHHHHHHHHCCC
REGHFDGVATVLTKLFNLTSPTRVYFGMKDAQQVAVVDGLINDFFMDIELIPVETKREED
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCC
GLAKSSRNVNLRAEERQEATALYRALQRGAELIRNGERDPEAVKREIRSILEKTSGVIDY
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEH
ADIYSYPDLEIRDPLTGKVIIAVAVQFSKARLIDNIIVDIPADQKEDL
HHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA