Click here to switch to the map view.

The map label for this gene is sqhC [H]

Identifier: 52785998

GI number: 52785998

Start: 2209502

End: 2211280

Strand: Direct

Name: sqhC [H]

Synonym: BLi02253

Alternate gene names: 52785998

Gene position: 2209502-2211280 (Clockwise)

Preceding gene: 52785995

Following gene: 52785999

Centisome position: 52.33

GC content: 50.59

Gene sequence:

>1779_bases
ATGACGGACAGTTTTTTCATTCTGATGCTGACATCACTCGGCGATCAGGACTCTTCTCTCATCGCAAGTCTTGCTGAACG
AATCCGTTCAAGGCAGAGCGAAGACGGCGCGTTTCGCAATCACCCGGATGAAAGAGCAGGCAATCTGACCGCGACAGTCC
AGGGCTATACCGGAATGCTGGCTTCGGGGCTCTATGACCGGAAAGCTCCGCATATGCAGAAAGCCGAAGCTTTTATTAAG
GACGCAGGCGGATTGAAGGGCGTCCACTTTATGACGAAGTGGATGCTCGCCGCCAACGGTCTGTATCCATGGCCGAGAGC
CTATATTCCGCTCTCGTTTTTGCTGATCCCGTCCTATTTCCCGCTGCATTTTTACCATTTCAGCACATACGCAAGAATTC
ATTTTGTCCCCATGGCCATTACGTTTAATCGGCGATTCTCTTTAAAAAACAACCAAATCGGCTCGCTTCGGCACCTGGAT
GAAGCCATGTCAAAAAACCCTCTCGAATGGCTGAACATCCGCGCCTTTGACGAAAGAACCTTCTATTCTTTCAATCTGCA
ATGGAAACAGCTCTTTCAATGGCCGGCTTACGTCCATCAGCTCGGATTTGAGGCCGGCAAAAAATATATGCTGGACAGAA
TCGAAGAAGACGGAACGCTATACAGCTATGCGAGCGCGACCATGTTCATGATTTACAGCCTGCTTGCGATGGGAATATCT
AAAAACGCCCCCGTTGTCAAAAAAGCAGTCAGCGGAATCAAAAGTCTTATTTCATCATGCGGAAAGGAAGGGGCCCATTT
GGAAAACTCAACTTCCACCGTCTGGGATACGGCCCTCATCAGCTATGCCATGCAGGAATCCGGAGTGCCTGAACAACATT
CTTCCACCTCATCGGCAGCCGACTACCTTCTCAAAAGACAGCATGTGAAAAAAGCGGACTGGGCTGTCTCAAATCCTCAA
GCGGTCCCTGGCGGGTGGGGTTTTTCACACATCAATACAAACAATCCCGATTTGGACGATACCGCTGCGGCATTAAAAGC
TATTCCGTTTCAACGGCGTCCGGATGCATGGAACCGGGGGCTCGCCTGGCTTTTATCCATGCAAAACAAGGACGGAGGGT
TTGCGGCATTTGAAAAAGATGTTGACCATCCGCTTATTCGAAATCTGCCGCTCGAATCTGCCGCTGAGGCAGCAGTCGAT
CCGTCAACGGCAGACTTGACCGGACGCGTTCTTCATCTGCTCGGGCTTAAAGGGCGGTTCACAGATAACCATCCTGCGGT
CCGGCGCGCCCTCAGGTGGCTTGATCATCATCAGAAAGCGGACGGCTCTTGGTATGGCAGATGGGGCGTCTGCTTTATTT
ACGGTACATGGGCCGCACTCACCGGTATGAAAGCTGTCGGGGTTTCCGCCAACCAGACGTCTGTCAAAAAAGCGATCTCC
TGGCTAAAATCGATCCAGCGTGAAGACGGAAGCTGGGGAGAATCTTGCAAAAGCTGTGAAGCGAAGCGTTTTGTCCCTCT
TCACTTTGGAACAGTTGTTCAATCTTCATGGGCGCTGGAGGCGCTTTTGCAATATGAGCGTCCGGATGACCCACAGATCA
TAAAAGGGATCCGTTTTCTCATCGATGAACACGAAAGCTCGCGTGAGCGACTCGAATACCCGACGGGAATCGGGCTGCCG
AACCAATTCTACATCCGCTATCACAGTTATCCTTTTGTGTTTTCATTGCTCGCTTCAAGCGCATTTATTAAAAAAGCGGA
AATGAGGGAGACATATTGA

Upstream 100 bases:

>100_bases
ACTAGAAGACGTGAAAGCTTTCAGGCAAAAGACGCTCGCAGAGCTTCAAAACAGACAAAGATCTGATGGTTCGTGGCGGT
TTTGTTTTGAAGGGCCCGTG

Downstream 100 bases:

>100_bases
ACAGAGATGCTTACAAAGAAAAAATATCGTCATGGGCCAAAGACCTGAAAGACCAGATGAAAGATGATCCTTCTTTAGAA
AGCCATTTAGAAAAACTTTT

Product: SqhC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MTDSFFILMLTSLGDQDSSLIASLAERIRSRQSEDGAFRNHPDERAGNLTATVQGYTGMLASGLYDRKAPHMQKAEAFIK
DAGGLKGVHFMTKWMLAANGLYPWPRAYIPLSFLLIPSYFPLHFYHFSTYARIHFVPMAITFNRRFSLKNNQIGSLRHLD
EAMSKNPLEWLNIRAFDERTFYSFNLQWKQLFQWPAYVHQLGFEAGKKYMLDRIEEDGTLYSYASATMFMIYSLLAMGIS
KNAPVVKKAVSGIKSLISSCGKEGAHLENSTSTVWDTALISYAMQESGVPEQHSSTSSAADYLLKRQHVKKADWAVSNPQ
AVPGGWGFSHINTNNPDLDDTAAALKAIPFQRRPDAWNRGLAWLLSMQNKDGGFAAFEKDVDHPLIRNLPLESAAEAAVD
PSTADLTGRVLHLLGLKGRFTDNHPAVRRALRWLDHHQKADGSWYGRWGVCFIYGTWAALTGMKAVGVSANQTSVKKAIS
WLKSIQREDGSWGESCKSCEAKRFVPLHFGTVVQSSWALEALLQYERPDDPQIIKGIRFLIDEHESSRERLEYPTGIGLP
NQFYIRYHSYPFVFSLLASSAFIKKAEMRETY

Sequences:

>Translated_592_residues
MTDSFFILMLTSLGDQDSSLIASLAERIRSRQSEDGAFRNHPDERAGNLTATVQGYTGMLASGLYDRKAPHMQKAEAFIK
DAGGLKGVHFMTKWMLAANGLYPWPRAYIPLSFLLIPSYFPLHFYHFSTYARIHFVPMAITFNRRFSLKNNQIGSLRHLD
EAMSKNPLEWLNIRAFDERTFYSFNLQWKQLFQWPAYVHQLGFEAGKKYMLDRIEEDGTLYSYASATMFMIYSLLAMGIS
KNAPVVKKAVSGIKSLISSCGKEGAHLENSTSTVWDTALISYAMQESGVPEQHSSTSSAADYLLKRQHVKKADWAVSNPQ
AVPGGWGFSHINTNNPDLDDTAAALKAIPFQRRPDAWNRGLAWLLSMQNKDGGFAAFEKDVDHPLIRNLPLESAAEAAVD
PSTADLTGRVLHLLGLKGRFTDNHPAVRRALRWLDHHQKADGSWYGRWGVCFIYGTWAALTGMKAVGVSANQTSVKKAIS
WLKSIQREDGSWGESCKSCEAKRFVPLHFGTVVQSSWALEALLQYERPDDPQIIKGIRFLIDEHESSRERLEYPTGIGLP
NQFYIRYHSYPFVFSLLASSAFIKKAEMRETY
>Mature_591_residues
TDSFFILMLTSLGDQDSSLIASLAERIRSRQSEDGAFRNHPDERAGNLTATVQGYTGMLASGLYDRKAPHMQKAEAFIKD
AGGLKGVHFMTKWMLAANGLYPWPRAYIPLSFLLIPSYFPLHFYHFSTYARIHFVPMAITFNRRFSLKNNQIGSLRHLDE
AMSKNPLEWLNIRAFDERTFYSFNLQWKQLFQWPAYVHQLGFEAGKKYMLDRIEEDGTLYSYASATMFMIYSLLAMGISK
NAPVVKKAVSGIKSLISSCGKEGAHLENSTSTVWDTALISYAMQESGVPEQHSSTSSAADYLLKRQHVKKADWAVSNPQA
VPGGWGFSHINTNNPDLDDTAAALKAIPFQRRPDAWNRGLAWLLSMQNKDGGFAAFEKDVDHPLIRNLPLESAAEAAVDP
STADLTGRVLHLLGLKGRFTDNHPAVRRALRWLDHHQKADGSWYGRWGVCFIYGTWAALTGMKAVGVSANQTSVKKAISW
LKSIQREDGSWGESCKSCEAKRFVPLHFGTVVQSSWALEALLQYERPDDPQIIKGIRFLIDEHESSRERLEYPTGIGLPN
QFYIRYHSYPFVFSLLASSAFIKKAEMRETY

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=606, Percent_Identity=25.5775577557756, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI47933395, Length=602, Percent_Identity=25.7475083056478, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI47933397, Length=602, Percent_Identity=25.7475083056478, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI224177556, Length=560, Percent_Identity=26.0714285714286, Blast_Score=134, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321863, Length=614, Percent_Identity=24.5928338762215, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 66772; Mature: 66640

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS01074 TERPENE_SYNTHASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSFFILMLTSLGDQDSSLIASLAERIRSRQSEDGAFRNHPDERAGNLTATVQGYTGML
CCCCEEEEEEHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCEEEEECCHHHHH
ASGLYDRKAPHMQKAEAFIKDAGGLKGVHFMTKWMLAANGLYPWPRAYIPLSFLLIPSYF
HHCCHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHCCCC
PLHFYHFSTYARIHFVPMAITFNRRFSLKNNQIGSLRHLDEAMSKNPLEWLNIRAFDERT
HHHHHHHHHEEEEEEEEEEEEECCEEECCCCCCCHHHHHHHHHCCCCCHHEEEEEECCCE
FYSFNLQWKQLFQWPAYVHQLGFEAGKKYMLDRIEEDGTLYSYASATMFMIYSLLAMGIS
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCC
KNAPVVKKAVSGIKSLISSCGKEGAHLENSTSTVWDTALISYAMQESGVPEQHSSTSSAA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHH
DYLLKRQHVKKADWAVSNPQAVPGGWGFSHINTNNPDLDDTAAALKAIPFQRRPDAWNRG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHCC
LAWLLSMQNKDGGFAAFEKDVDHPLIRNLPLESAAEAAVDPSTADLTGRVLHLLGLKGRF
CEEEEEECCCCCCCCHHHHCCCCHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
TDNHPAVRRALRWLDHHQKADGSWYGRWGVCFIYGTWAALTGMKAVGVSANQTSVKKAIS
CCCCHHHHHHHHHHHHHCCCCCCEECCCEEEEEEEHHHHHHCCHHCCCCCCHHHHHHHHH
WLKSIQREDGSWGESCKSCEAKRFVPLHFGTVVQSSWALEALLQYERPDDPQIIKGIRFL
HHHHHHHCCCCHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IDEHESSRERLEYPTGIGLPNQFYIRYHSYPFVFSLLASSAFIKKAEMRETY
HHCCCCHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDSFFILMLTSLGDQDSSLIASLAERIRSRQSEDGAFRNHPDERAGNLTATVQGYTGML
CCCEEEEEEHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCEEEEECCHHHHH
ASGLYDRKAPHMQKAEAFIKDAGGLKGVHFMTKWMLAANGLYPWPRAYIPLSFLLIPSYF
HHCCHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHCCCC
PLHFYHFSTYARIHFVPMAITFNRRFSLKNNQIGSLRHLDEAMSKNPLEWLNIRAFDERT
HHHHHHHHHEEEEEEEEEEEEECCEEECCCCCCCHHHHHHHHHCCCCCHHEEEEEECCCE
FYSFNLQWKQLFQWPAYVHQLGFEAGKKYMLDRIEEDGTLYSYASATMFMIYSLLAMGIS
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCC
KNAPVVKKAVSGIKSLISSCGKEGAHLENSTSTVWDTALISYAMQESGVPEQHSSTSSAA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHH
DYLLKRQHVKKADWAVSNPQAVPGGWGFSHINTNNPDLDDTAAALKAIPFQRRPDAWNRG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHCC
LAWLLSMQNKDGGFAAFEKDVDHPLIRNLPLESAAEAAVDPSTADLTGRVLHLLGLKGRF
CEEEEEECCCCCCCCHHHHCCCCHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
TDNHPAVRRALRWLDHHQKADGSWYGRWGVCFIYGTWAALTGMKAVGVSANQTSVKKAIS
CCCCHHHHHHHHHHHHHCCCCCCEECCCEEEEEEEHHHHHHCCHHCCCCCCHHHHHHHHH
WLKSIQREDGSWGESCKSCEAKRFVPLHFGTVVQSSWALEALLQYERPDDPQIIKGIRFL
HHHHHHHCCCCHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IDEHESSRERLEYPTGIGLPNQFYIRYHSYPFVFSLLASSAFIKKAEMRETY
HHCCCCHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]