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The map label for this gene is proH [H]

Identifier: 52785901

GI number: 52785901

Start: 2099143

End: 2099994

Strand: Reverse

Name: proH [H]

Synonym: BLi02150

Alternate gene names: 52785901

Gene position: 2099994-2099143 (Counterclockwise)

Preceding gene: 52785902

Following gene: 52785900

Centisome position: 49.73

GC content: 46.71

Gene sequence:

>852_bases
ATGTTAAAGATCTTTAATCAAAAAAACGTAGCTTTTATAGGGGCGGGATCAATGGCAGAGGGAATGATCTCAGGCATCGT
TCAATCCAAAAAACTGCCTGCTTCGCAAATCTATGTTACAAACCACACGAACCACCGGCGTTTAGAAGAACTCCAGCAGA
AATATGGAATACAAGGCGTCAAAAAAGAACAACTTGACTATCAGAACATCGATTGCTTCATCCTGGCGATGAAGCCGAAA
GATGCAGAGGGCGCTCTTAATTCCATGAAACCGCATATCAAACCCCATCAGCTTATCGTGTCAGTTTTAGCTGGCATATC
AATATCATTTATTGAAAACACGCTGCACGACATGCAGCCGGTCATCAGAATCATGCCTAATACCTCAAGTGCAATCGGCG
CATCTGCAACCGCCATGGCCGAAGGAAGCCATGTAACGGCCGATCTGTCAAAAACCGCGAAACAACTGCTTCAATGCATG
GGAGAAGTCTATTCCATCGAAGAAAGCAAAATGGACATTTTCACTGGCATTGCCGGCAGCGGGCCTGCTTACTTTTATTA
TTTAATGGAGCACATCGAAAAAGCGGGAGCCGAGGCTGGATTAAGCCAAAAATTAACAAGGGAAATCGGCGCGCAGACAT
TGTTAGGCGCCGCCAAAATGCTGTTGGAAAGCCCTGAGGATACAGCTGTTCTCAAAGACAACATCACTTCCCCTAACGGT
ACGACTGCCGCCGGTTTAAAGGCCTTGGAAGAAAGCGGCGGAGGCGAAGCGATCGAACAGGCGGTCAAACAAGCCGCAAA
ACGATCCAAAACGATCAGTCTCGAACTGGAACAATTAGTCGCAGCAAAGTAA

Upstream 100 bases:

>100_bases
GCGCCGTCCAAGCAAAACACGCAAACTTGACATAATGATCTAAAGTGTTAATATACTAACCGTGTTCGAAAAATACGAAC
AGAAATGCGAACAAAGGGAG

Downstream 100 bases:

>100_bases
ATGCCCGTAACGAAGAAAAATACTACAGGAGTGATAAAATGACCTCTAATCAACAGAGGGTAGTTGTCAAAGTGGGAAGC
AGTTCTTTAACAAGTCTTCA

Product: ProH

Products: NA

Alternate protein names: P5C reductase 1; P5CR 1 [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLKIFNQKNVAFIGAGSMAEGMISGIVQSKKLPASQIYVTNHTNHRRLEELQQKYGIQGVKKEQLDYQNIDCFILAMKPK
DAEGALNSMKPHIKPHQLIVSVLAGISISFIENTLHDMQPVIRIMPNTSSAIGASATAMAEGSHVTADLSKTAKQLLQCM
GEVYSIEESKMDIFTGIAGSGPAYFYYLMEHIEKAGAEAGLSQKLTREIGAQTLLGAAKMLLESPEDTAVLKDNITSPNG
TTAAGLKALEESGGGEAIEQAVKQAAKRSKTISLELEQLVAAK

Sequences:

>Translated_283_residues
MLKIFNQKNVAFIGAGSMAEGMISGIVQSKKLPASQIYVTNHTNHRRLEELQQKYGIQGVKKEQLDYQNIDCFILAMKPK
DAEGALNSMKPHIKPHQLIVSVLAGISISFIENTLHDMQPVIRIMPNTSSAIGASATAMAEGSHVTADLSKTAKQLLQCM
GEVYSIEESKMDIFTGIAGSGPAYFYYLMEHIEKAGAEAGLSQKLTREIGAQTLLGAAKMLLESPEDTAVLKDNITSPNG
TTAAGLKALEESGGGEAIEQAVKQAAKRSKTISLELEQLVAAK
>Mature_283_residues
MLKIFNQKNVAFIGAGSMAEGMISGIVQSKKLPASQIYVTNHTNHRRLEELQQKYGIQGVKKEQLDYQNIDCFILAMKPK
DAEGALNSMKPHIKPHQLIVSVLAGISISFIENTLHDMQPVIRIMPNTSSAIGASATAMAEGSHVTADLSKTAKQLLQCM
GEVYSIEESKMDIFTGIAGSGPAYFYYLMEHIEKAGAEAGLSQKLTREIGAQTLLGAAKMLLESPEDTAVLKDNITSPNG
TTAAGLKALEESGGGEAIEQAVKQAAKRSKTISLELEQLVAAK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=33.5820895522388, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI24797095, Length=267, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI24797097, Length=267, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=32.2097378277154, Blast_Score=144, Evalue=9e-35,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=28.4644194756554, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17569021, Length=261, Percent_Identity=32.9501915708812, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17540664, Length=290, Percent_Identity=28.2758620689655, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320861, Length=277, Percent_Identity=26.7148014440433, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=31.0606060606061, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=31.7518248175182, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=36.6863905325444, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30405; Mature: 30405

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIFNQKNVAFIGAGSMAEGMISGIVQSKKLPASQIYVTNHTNHRRLEELQQKYGIQGV
CCEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCC
KKEQLDYQNIDCFILAMKPKDAEGALNSMKPHIKPHQLIVSVLAGISISFIENTLHDMQP
CHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
VIRIMPNTSSAIGASATAMAEGSHVTADLSKTAKQLLQCMGEVYSIEESKMDIFTGIAGS
HHEECCCCCCHHCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
GPAYFYYLMEHIEKAGAEAGLSQKLTREIGAQTLLGAAKMLLESPEDTAVLKDNITSPNG
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCC
TTAAGLKALEESGGGEAIEQAVKQAAKRSKTISLELEQLVAAK
CHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEHHHHHCCC
>Mature Secondary Structure
MLKIFNQKNVAFIGAGSMAEGMISGIVQSKKLPASQIYVTNHTNHRRLEELQQKYGIQGV
CCEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCC
KKEQLDYQNIDCFILAMKPKDAEGALNSMKPHIKPHQLIVSVLAGISISFIENTLHDMQP
CHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
VIRIMPNTSSAIGASATAMAEGSHVTADLSKTAKQLLQCMGEVYSIEESKMDIFTGIAGS
HHEECCCCCCHHCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
GPAYFYYLMEHIEKAGAEAGLSQKLTREIGAQTLLGAAKMLLESPEDTAVLKDNITSPNG
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCC
TTAAGLKALEESGGGEAIEQAVKQAAKRSKTISLELEQLVAAK
CHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1849493; 2493444 [H]