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The map label for this gene is fadE [H]

Identifier: 52785859

GI number: 52785859

Start: 2048387

End: 2050102

Strand: Reverse

Name: fadE [H]

Synonym: BLi02106

Alternate gene names: 52785859

Gene position: 2050102-2048387 (Counterclockwise)

Preceding gene: 52785860

Following gene: 52785858

Centisome position: 48.55

GC content: 47.09

Gene sequence:

>1716_bases
ATGGGGAAAGCAAAACTTCGATGGAATGAACCCTTGATTTCTCAACACGAATCGGCTGCTGAAGGATTTACACCGGAAGA
TTTCACAGAGGAAGATCGACTGATTTCAAAAACGACAGAATCATTTGTCAAAAACGAAGTCATGCCCCTTCTTGAATCGA
TTGATCAGCAGGATCACGAAAGCGTGAAAAAATTGTTTCAAAAAGCAGGAGAGCTCGGTTTGCTCAGTATCGAAGTTCCG
GAGGATTGCGGCGGCCTTTCACTCAGCAAGAAGCTTTCCGGGTTGGTGGCAGAGAAAATGGGAGCCGGCGGATCGTTCAG
CGTCTCCTTTAATATTCATGCGGGAGTCGGGACACTGCCGTATATTTATTATGGAACAGAGGAACAAAAACAAAAATACC
TTCCAAAACTGGCATCGGGCGAATGGATCGGAGCATATGCTCTGACAGAGCCGGGCGCAGGATCGGATGCTTTAAACGCA
AAAACGACAGCCGTCTTGAATAGGGAAGGGACAGCCTGGATTTTAAATGGGGAAAAGCAGTGGATTACGAACGCGCAAGT
AGCTGATGTATATGTTGTCTTTGCAAAAACGGCGGAAGGCATGACAGCATTTATCGTCGAACGCTCGTTTAAAGGTGTTT
CCATCGGACCTGAAGAGAAGAAGATGGGAATCAAAGGGTCTTCGACAGCAACCTTAATCTTGGAGGAAGTCGAGGTGCCA
AGCGACAATGTTCTAGGTCATATCGGGAAAGGTCATCACGTCGCTTTGAACATTTTAAACATGGCCCGCTTAAAGCTCGC
GTTTTCGAACATTGGAACGGCAAAACAAGCATTGAACCTTGCTGTTAGCTACGCCAAACAGCGAAAGCAATTTAACAAGC
CGATCATCGGTTTTTCAATGATTCAAGAAAAGATTGCCGACATGGCGGTCTCGATTTTCGGCGCGGAAAGCGCTGCTTAC
AGAACGGCAGATTGCTTGGACAATGTTTTAGATTCGGCTCTCCCATTAGACGATAGACTGAGAAAACTCACAAACTATGC
ATCCGAATGTGCGATCAATAAAGTTTACTGCTCCGAAATCCTCGGCCGGATCGCAGACGAAGCGGTGCAGATTCATGGCG
GCTACGGATACATGCAGGAGTACGAAGTCGAACGATTGTACCGGGACGCGAGGATCAGCCGGATTTTCGAGGGGACAAAT
GAAATAAACCGCTTAACGATCGCCAAACTGCTCATGAAAGAAGTGCAGCAAAACGGCATCTCAGAGCCGGAAGCTCAACT
AGGCAGCGAGGGAAATCGAAACCGGCGATTTATTCAGCTGTCCAACAGGCTTTTCGGCAAGACACTGAAAGCGCTTATCC
GCTCTCGCGTGAACACTCAAGAAGATCAGGAATACGCACGGCTTCTCGCCGACATGAAAAAAGAAATCTATGTGATGGAA
TCCGCCGCCCGCCGAACCGAAAAAGCTAGGCAAATATACGGTGGTGAAAAAGCACGGTTGAAAGAAATGATGACGAATGT
CATTTGTGAAGAAGGCTACCGCAGAATCGAAGAGATGGCGGTGACCGCCTTATCAAGCATAGCATCTGATGAAGCCGAAA
GAAAACTCGCATTTGAAGAGGCTCGCAGCGTTTCTTTGCCTCTTTTCAGCAATCTGTTTACTCAAAAACGCGAAATCGCA
GAAAAAATAGCCGCTCATGAAAAATATACGGTGTGA

Upstream 100 bases:

>100_bases
GAAAAGGAGACGATGATTCGTATCAGCAAAAATGTAAGCGGATTCATCGTCTTTTTATCTCGGTTTATCACTCTTTTTAG
CGGAAGCGAGGAGGTAAGCA

Downstream 100 bases:

>100_bases
TCGGAGGGAAACTGTTTGAAAAAAATCGGATTTATCGGTTTGGGCAATATGGGTCTGCCAATGTCGAAGAATCTGCTTCA
GGAGAACTTTACGGTTTATG

Product: hypothetical protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MGKAKLRWNEPLISQHESAAEGFTPEDFTEEDRLISKTTESFVKNEVMPLLESIDQQDHESVKKLFQKAGELGLLSIEVP
EDCGGLSLSKKLSGLVAEKMGAGGSFSVSFNIHAGVGTLPYIYYGTEEQKQKYLPKLASGEWIGAYALTEPGAGSDALNA
KTTAVLNREGTAWILNGEKQWITNAQVADVYVVFAKTAEGMTAFIVERSFKGVSIGPEEKKMGIKGSSTATLILEEVEVP
SDNVLGHIGKGHHVALNILNMARLKLAFSNIGTAKQALNLAVSYAKQRKQFNKPIIGFSMIQEKIADMAVSIFGAESAAY
RTADCLDNVLDSALPLDDRLRKLTNYASECAINKVYCSEILGRIADEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTN
EINRLTIAKLLMKEVQQNGISEPEAQLGSEGNRNRRFIQLSNRLFGKTLKALIRSRVNTQEDQEYARLLADMKKEIYVME
SAARRTEKARQIYGGEKARLKEMMTNVICEEGYRRIEEMAVTALSSIASDEAERKLAFEEARSVSLPLFSNLFTQKREIA
EKIAAHEKYTV

Sequences:

>Translated_571_residues
MGKAKLRWNEPLISQHESAAEGFTPEDFTEEDRLISKTTESFVKNEVMPLLESIDQQDHESVKKLFQKAGELGLLSIEVP
EDCGGLSLSKKLSGLVAEKMGAGGSFSVSFNIHAGVGTLPYIYYGTEEQKQKYLPKLASGEWIGAYALTEPGAGSDALNA
KTTAVLNREGTAWILNGEKQWITNAQVADVYVVFAKTAEGMTAFIVERSFKGVSIGPEEKKMGIKGSSTATLILEEVEVP
SDNVLGHIGKGHHVALNILNMARLKLAFSNIGTAKQALNLAVSYAKQRKQFNKPIIGFSMIQEKIADMAVSIFGAESAAY
RTADCLDNVLDSALPLDDRLRKLTNYASECAINKVYCSEILGRIADEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTN
EINRLTIAKLLMKEVQQNGISEPEAQLGSEGNRNRRFIQLSNRLFGKTLKALIRSRVNTQEDQEYARLLADMKKEIYVME
SAARRTEKARQIYGGEKARLKEMMTNVICEEGYRRIEEMAVTALSSIASDEAERKLAFEEARSVSLPLFSNLFTQKREIA
EKIAAHEKYTV
>Mature_570_residues
GKAKLRWNEPLISQHESAAEGFTPEDFTEEDRLISKTTESFVKNEVMPLLESIDQQDHESVKKLFQKAGELGLLSIEVPE
DCGGLSLSKKLSGLVAEKMGAGGSFSVSFNIHAGVGTLPYIYYGTEEQKQKYLPKLASGEWIGAYALTEPGAGSDALNAK
TTAVLNREGTAWILNGEKQWITNAQVADVYVVFAKTAEGMTAFIVERSFKGVSIGPEEKKMGIKGSSTATLILEEVEVPS
DNVLGHIGKGHHVALNILNMARLKLAFSNIGTAKQALNLAVSYAKQRKQFNKPIIGFSMIQEKIADMAVSIFGAESAAYR
TADCLDNVLDSALPLDDRLRKLTNYASECAINKVYCSEILGRIADEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNE
INRLTIAKLLMKEVQQNGISEPEAQLGSEGNRNRRFIQLSNRLFGKTLKALIRSRVNTQEDQEYARLLADMKKEIYVMES
AARRTEKARQIYGGEKARLKEMMTNVICEEGYRRIEEMAVTALSSIASDEAERKLAFEEARSVSLPLFSNLFTQKREIAE
KIAAHEKYTV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=504, Percent_Identity=35.9126984126984, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI4557235, Length=525, Percent_Identity=34.4761904761905, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI76496475, Length=525, Percent_Identity=34.4761904761905, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI4557233, Length=393, Percent_Identity=37.9134860050891, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI226958412, Length=420, Percent_Identity=33.3333333333333, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI187960098, Length=421, Percent_Identity=35.1543942992874, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI4557231, Length=421, Percent_Identity=35.1543942992874, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI226958414, Length=373, Percent_Identity=34.3163538873995, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI4501859, Length=397, Percent_Identity=33.7531486146096, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI4501857, Length=391, Percent_Identity=33.2480818414322, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI7656849, Length=405, Percent_Identity=30.8641975308642, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4503943, Length=414, Percent_Identity=30.9178743961353, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI7669494, Length=390, Percent_Identity=31.5384615384615, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI38505218, Length=394, Percent_Identity=25.3807106598985, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI48976061, Length=304, Percent_Identity=27.6315789473684, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI211971008, Length=304, Percent_Identity=27.6315789473684, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI218563752, Length=248, Percent_Identity=25.4032258064516, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1786223, Length=367, Percent_Identity=28.6103542234332, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081958, Length=404, Percent_Identity=30.6930693069307, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87082384, Length=273, Percent_Identity=27.1062271062271, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI87081702, Length=356, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985184, Length=452, Percent_Identity=35.8407079646018, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17508101, Length=408, Percent_Identity=35.5392156862745, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17538396, Length=394, Percent_Identity=33.248730964467, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17506239, Length=410, Percent_Identity=34.6341463414634, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17569725, Length=404, Percent_Identity=32.9207920792079, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=33.6760925449871, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17570075, Length=386, Percent_Identity=33.6787564766839, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17533517, Length=389, Percent_Identity=31.6195372750643, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71985192, Length=303, Percent_Identity=37.953795379538, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=36.6795366795367, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=394, Percent_Identity=29.1878172588832, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=260, Percent_Identity=36.9230769230769, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=283, Percent_Identity=31.095406360424, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17551932, Length=386, Percent_Identity=26.1658031088083, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17505929, Length=390, Percent_Identity=25.8974358974359, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=259, Percent_Identity=27.7992277992278, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=377, Percent_Identity=27.3209549071618, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17540912, Length=405, Percent_Identity=22.7160493827161, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281363737, Length=376, Percent_Identity=40.1595744680851, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI21356377, Length=393, Percent_Identity=36.6412213740458, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI21355753, Length=397, Percent_Identity=36.272040302267, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24660351, Length=392, Percent_Identity=36.4795918367347, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24646207, Length=400, Percent_Identity=35.75, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24666513, Length=408, Percent_Identity=33.3333333333333, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI19920834, Length=414, Percent_Identity=28.9855072463768, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24652780, Length=296, Percent_Identity=26.3513513513513, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 63420; Mature: 63289

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKAKLRWNEPLISQHESAAEGFTPEDFTEEDRLISKTTESFVKNEVMPLLESIDQQDHE
CCCCCCCCCCCHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SVKKLFQKAGELGLLSIEVPEDCGGLSLSKKLSGLVAEKMGAGGSFSVSFNIHAGVGTLP
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCC
YIYYGTEEQKQKYLPKLASGEWIGAYALTEPGAGSDALNAKTTAVLNREGTAWILNGEKQ
EEEECCCHHHHHHCCHHCCCCEEEEEEECCCCCCCCCCCCHHHEEEECCCCEEEECCCHH
WITNAQVADVYVVFAKTAEGMTAFIVERSFKGVSIGPEEKKMGIKGSSTATLILEEVEVP
HHCCCHHHEEEEEEEECCCCCEEEEEHHCCCCCCCCCHHHHCCCCCCCCEEEEEEECCCC
SDNVLGHIGKGHHVALNILNMARLKLAFSNIGTAKQALNLAVSYAKQRKQFNKPIIGFSM
CCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IQEKIADMAVSIFGAESAAYRTADCLDNVLDSALPLDDRLRKLTNYASECAINKVYCSEI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGRIADEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEINRLTIAKLLMKEVQQNGI
HHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
SEPEAQLGSEGNRNRRFIQLSNRLFGKTLKALIRSRVNTQEDQEYARLLADMKKEIYVME
CCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
SAARRTEKARQIYGGEKARLKEMMTNVICEEGYRRIEEMAVTALSSIASDEAERKLAFEE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARSVSLPLFSNLFTQKREIAEKIAAHEKYTV
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GKAKLRWNEPLISQHESAAEGFTPEDFTEEDRLISKTTESFVKNEVMPLLESIDQQDHE
CCCCCCCCCCHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SVKKLFQKAGELGLLSIEVPEDCGGLSLSKKLSGLVAEKMGAGGSFSVSFNIHAGVGTLP
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCC
YIYYGTEEQKQKYLPKLASGEWIGAYALTEPGAGSDALNAKTTAVLNREGTAWILNGEKQ
EEEECCCHHHHHHCCHHCCCCEEEEEEECCCCCCCCCCCCHHHEEEECCCCEEEECCCHH
WITNAQVADVYVVFAKTAEGMTAFIVERSFKGVSIGPEEKKMGIKGSSTATLILEEVEVP
HHCCCHHHEEEEEEEECCCCCEEEEEHHCCCCCCCCCHHHHCCCCCCCCEEEEEEECCCC
SDNVLGHIGKGHHVALNILNMARLKLAFSNIGTAKQALNLAVSYAKQRKQFNKPIIGFSM
CCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IQEKIADMAVSIFGAESAAYRTADCLDNVLDSALPLDDRLRKLTNYASECAINKVYCSEI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGRIADEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEINRLTIAKLLMKEVQQNGI
HHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
SEPEAQLGSEGNRNRRFIQLSNRLFGKTLKALIRSRVNTQEDQEYARLLADMKKEIYVME
CCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
SAARRTEKARQIYGGEKARLKEMMTNVICEEGYRRIEEMAVTALSSIASDEAERKLAFEE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARSVSLPLFSNLFTQKREIAEKIAAHEKYTV
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]