Click here to switch to the map view.

The map label for this gene is garR [H]

Identifier: 52785858

GI number: 52785858

Start: 2047484

End: 2048371

Strand: Reverse

Name: garR [H]

Synonym: BLi02105

Alternate gene names: 52785858

Gene position: 2048371-2047484 (Counterclockwise)

Preceding gene: 52785859

Following gene: 52785857

Centisome position: 48.51

GC content: 46.4

Gene sequence:

>888_bases
TTGAAAAAAATCGGATTTATCGGTTTGGGCAATATGGGTCTGCCAATGTCGAAGAATCTGCTTCAGGAGAACTTTACGGT
TTATGGAATGGACCTTAACAAAGAAGCTGAATTGGCCTTGCATCATGCAGGAGGAACGATCGGGATTTCAGTTGAAAAAA
TGGTTGAAGAGTGTGACGCCATCCTCACAAGCCTTCCTTCCTCAAACGCTGCAGAGGAGGTTTTTCTGGGAAAAAAAGGG
CTCGTACACCTGGCTGAACCGGGCGTCCTCCTGATCGATACAAGCACGGTCGCTCCTGAACTGAATATCCGAATTGCGGA
GGAAGCGAAAAGCAAAGGTATCGATTTTCTTGCGGCGCCGGTCAGCGGCGGTGTGATCGGGGCGGTCAACCGGACGCTGA
CCTTTATGGTCGGGGGTCCGAAGTCCGTTTTTGATAAAGCGTTGCCTGTTTTCAATGCATTGGGCGAGAATATTTTTCAT
GTGAACGAAAACATCGACAGCGGAACGAATACAAAGCTGATCAACAACCTCTTAATCGGTTTTTATACAGCCGGCGTCAG
TGAAGCCTTGCACCTTGCCAAAAACAGCAATCTCGACCTCGACCAATTGTTTGAGATGCTGAACGTCAGCTATGGGCAGA
GCCGGATCTATGAGCGCAACTATAAAAGTTTCATAGCGGATGAAAACTATAAACCTGGCTTTTCTTTGAAGCTGCTGCTG
AAAGACCTTGGCTTTGCATTGGATTTGGCTGAGAAGAACAACGTTGAACTGCCGGTGAGCAAGATTCTCTTCGGCATTTA
CGAAGAAGCCGATCAGAACGGATACGGGGAAAAAGATATGTCTGTTTTATACAAAAAAATAAGCGAACAGAAGACAACTT
ATCAGTAA

Upstream 100 bases:

>100_bases
TTCTTTGCCTCTTTTCAGCAATCTGTTTACTCAAAAACGCGAAATCGCAGAAAAAATAGCCGCTCATGAAAAATATACGG
TGTGATCGGAGGGAAACTGT

Downstream 100 bases:

>100_bases
GGAGAGGTGAGAAATCAAATGATCACAACCAATGCAAAAAAAATGATGAACCATATCGACGGGGAATGGGTCAATTCTCT
AGGTGCGGAATCGGAAGAAG

Product: hypothetical protein

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKKIGFIGLGNMGLPMSKNLLQENFTVYGMDLNKEAELALHHAGGTIGISVEKMVEECDAILTSLPSSNAAEEVFLGKKG
LVHLAEPGVLLIDTSTVAPELNIRIAEEAKSKGIDFLAAPVSGGVIGAVNRTLTFMVGGPKSVFDKALPVFNALGENIFH
VNENIDSGTNTKLINNLLIGFYTAGVSEALHLAKNSNLDLDQLFEMLNVSYGQSRIYERNYKSFIADENYKPGFSLKLLL
KDLGFALDLAEKNNVELPVSKILFGIYEEADQNGYGEKDMSVLYKKISEQKTTYQ

Sequences:

>Translated_295_residues
MKKIGFIGLGNMGLPMSKNLLQENFTVYGMDLNKEAELALHHAGGTIGISVEKMVEECDAILTSLPSSNAAEEVFLGKKG
LVHLAEPGVLLIDTSTVAPELNIRIAEEAKSKGIDFLAAPVSGGVIGAVNRTLTFMVGGPKSVFDKALPVFNALGENIFH
VNENIDSGTNTKLINNLLIGFYTAGVSEALHLAKNSNLDLDQLFEMLNVSYGQSRIYERNYKSFIADENYKPGFSLKLLL
KDLGFALDLAEKNNVELPVSKILFGIYEEADQNGYGEKDMSVLYKKISEQKTTYQ
>Mature_295_residues
MKKIGFIGLGNMGLPMSKNLLQENFTVYGMDLNKEAELALHHAGGTIGISVEKMVEECDAILTSLPSSNAAEEVFLGKKG
LVHLAEPGVLLIDTSTVAPELNIRIAEEAKSKGIDFLAAPVSGGVIGAVNRTLTFMVGGPKSVFDKALPVFNALGENIFH
VNENIDSGTNTKLINNLLIGFYTAGVSEALHLAKNSNLDLDQLFEMLNVSYGQSRIYERNYKSFIADENYKPGFSLKLLL
KDLGFALDLAEKNNVELPVSKILFGIYEEADQNGYGEKDMSVLYKKISEQKTTYQ

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=297, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=29.4736842105263, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=37.4149659863946, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1786719, Length=286, Percent_Identity=32.8671328671329, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1789092, Length=287, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=27.8745644599303, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17557316, Length=302, Percent_Identity=30.1324503311258, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24655230, Length=300, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19922568, Length=300, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=24.5551601423488, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 32175; Mature: 32175

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIGFIGLGNMGLPMSKNLLQENFTVYGMDLNKEAELALHHAGGTIGISVEKMVEECDA
CCCEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCEEEEECCCEEEEEHHHHHHHHHH
ILTSLPSSNAAEEVFLGKKGLVHLAEPGVLLIDTSTVAPELNIRIAEEAKSKGIDFLAAP
HHHHCCCCCCHHHHHCCCCCCEEECCCCEEEEECCCCCCCEEEEEHHHHHHCCCEEEEEC
VSGGVIGAVNRTLTFMVGGPKSVFDKALPVFNALGENIFHVNENIDSGTNTKLINNLLIG
CCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHH
FYTAGVSEALHLAKNSNLDLDQLFEMLNVSYGQSRIYERNYKSFIADENYKPGFSLKLLL
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KDLGFALDLAEKNNVELPVSKILFGIYEEADQNGYGEKDMSVLYKKISEQKTTYQ
HHHCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKIGFIGLGNMGLPMSKNLLQENFTVYGMDLNKEAELALHHAGGTIGISVEKMVEECDA
CCCEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCEEEEECCCEEEEEHHHHHHHHHH
ILTSLPSSNAAEEVFLGKKGLVHLAEPGVLLIDTSTVAPELNIRIAEEAKSKGIDFLAAP
HHHHCCCCCCHHHHHCCCCCCEEECCCCEEEEECCCCCCCEEEEEHHHHHHCCCEEEEEC
VSGGVIGAVNRTLTFMVGGPKSVFDKALPVFNALGENIFHVNENIDSGTNTKLINNLLIG
CCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHH
FYTAGVSEALHLAKNSNLDLDQLFEMLNVSYGQSRIYERNYKSFIADENYKPGFSLKLLL
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KDLGFALDLAEKNNVELPVSKILFGIYEEADQNGYGEKDMSVLYKKISEQKTTYQ
HHHCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]