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The map label for this gene is mtnA

Identifier: 52785276

GI number: 52785276

Start: 1485015

End: 1486076

Strand: Reverse

Name: mtnA

Synonym: BLi01511

Alternate gene names: 52785276

Gene position: 1486076-1485015 (Counterclockwise)

Preceding gene: 52785277

Following gene: 52785273

Centisome position: 35.19

GC content: 50.38

Gene sequence:

>1062_bases
ATGCCGGAACAATTTGCGGTGCCCCGTTCTGTCGAATGGGAAGAAACATCGGTAAAAATCCTGAACCAGCAAAAGCTTCC
CGAAAAGACGGAGTACCTGCATCTCACAACTAAAGAAGACATCTATGATGCGATCCAAACGCTAAAAGTGAGGGGAGCGC
CTGCCATCGGCATAACAGCCGCCTTCGGACTCGCCCTTTGCGCACAAAGCATCGATACATCTGATGTTTCCGCTTTTCTG
CGGGAGCTCCGCAAAATCAAAGATGAACTCAATCAGGCAAGGCCGACAGCCGTCAATTTATCCTGGGCCCTCAATCGGCT
GTTAAAAAGCGCAGAGGGCGCAAAATCGGTCAATGAGGCAAAAACAAACCTCGTCCACGAAGCGATTCAGATCCAGGTTG
AAGACGAAGAAACATGCCGGCAGATCGGACAGAATGCTCTGCATTTGTTCAAATCGGGCGACAGCATCATGACCATCTGC
AACGCCGGCTCGATCGCGACAAGCAGGTACGGAACGGCCCTTTCCCCGTTTTACCTTGCCAAAACAAAGGATCTCGACCT
TCATATTTACGCCTGTGAAACAAGGCCTGTTCTTCAGGGGGCGCGCCTGACGGCGTGGGAGCTTATGCAGGGGGGGATTG
ACGTGACGCTGATTACAGACAGCATGGCTGCCCATACGATGAAGGAAAAGAACATTTCAGCCGTCATTGTCGGAGCGGAC
AGGATCGCAAGAAACGGAGATACAGCCAATAAAATCGGAACGTTCGGCTTGGCAATCCTCGCCAAAGCCTTTCAAATCCC
GTTTTTTATCGCTGCTCCCCTGTCAACTTTTGATGTCTCGATTTCATGCGGCGACGACATTCCGATTGAAGAACGCGATC
CGGATGAAGTCAGACGGATAAACGGAACGCAAATAGCGCCGCAAGAGGTGCCTGTGTTCAATCCTGCTTTTGATATCACG
CCGCACGATTTAATCTCTGGAATCATCACGGAAAAAGGGATTATCACAGATAGATTTGAAGAAGAAATCGAAGCGCTGTT
TTCCGCTGAAGCCCTTACTTAG

Upstream 100 bases:

>100_bases
CCCTTAAAATAGGCGCAGCATTCATAGAAAAACGCAGCGGTTTCCGGACGCCAAAAGACATGATTGAAGCGTTTCGAAAC
GCGCTTAAGGAGTGAATGAC

Downstream 100 bases:

>100_bases
GCCGCTTTAGCGGATTTTAATCGATTTGATGATGTCTTTCTTTTGCTCTTCGGTCAAAACGTGCAGCTTGACGAACAATT
CCGCGTATCCTGCTATTTTT

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MPEQFAVPRSVEWEETSVKILNQQKLPEKTEYLHLTTKEDIYDAIQTLKVRGAPAIGITAAFGLALCAQSIDTSDVSAFL
RELRKIKDELNQARPTAVNLSWALNRLLKSAEGAKSVNEAKTNLVHEAIQIQVEDEETCRQIGQNALHLFKSGDSIMTIC
NAGSIATSRYGTALSPFYLAKTKDLDLHIYACETRPVLQGARLTAWELMQGGIDVTLITDSMAAHTMKEKNISAVIVGAD
RIARNGDTANKIGTFGLAILAKAFQIPFFIAAPLSTFDVSISCGDDIPIEERDPDEVRRINGTQIAPQEVPVFNPAFDIT
PHDLISGIITEKGIITDRFEEEIEALFSAEALT

Sequences:

>Translated_353_residues
MPEQFAVPRSVEWEETSVKILNQQKLPEKTEYLHLTTKEDIYDAIQTLKVRGAPAIGITAAFGLALCAQSIDTSDVSAFL
RELRKIKDELNQARPTAVNLSWALNRLLKSAEGAKSVNEAKTNLVHEAIQIQVEDEETCRQIGQNALHLFKSGDSIMTIC
NAGSIATSRYGTALSPFYLAKTKDLDLHIYACETRPVLQGARLTAWELMQGGIDVTLITDSMAAHTMKEKNISAVIVGAD
RIARNGDTANKIGTFGLAILAKAFQIPFFIAAPLSTFDVSISCGDDIPIEERDPDEVRRINGTQIAPQEVPVFNPAFDIT
PHDLISGIITEKGIITDRFEEEIEALFSAEALT
>Mature_352_residues
PEQFAVPRSVEWEETSVKILNQQKLPEKTEYLHLTTKEDIYDAIQTLKVRGAPAIGITAAFGLALCAQSIDTSDVSAFLR
ELRKIKDELNQARPTAVNLSWALNRLLKSAEGAKSVNEAKTNLVHEAIQIQVEDEETCRQIGQNALHLFKSGDSIMTICN
AGSIATSRYGTALSPFYLAKTKDLDLHIYACETRPVLQGARLTAWELMQGGIDVTLITDSMAAHTMKEKNISAVIVGADR
IARNGDTANKIGTFGLAILAKAFQIPFFIAAPLSTFDVSISCGDDIPIEERDPDEVRRINGTQIAPQEVPVFNPAFDITP
HDLISGIITEKGIITDRFEEEIEALFSAEALT

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=344, Percent_Identity=40.6976744186046, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI23943880, Length=336, Percent_Identity=37.5, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI78000156, Length=268, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI78000158, Length=268, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI187607323, Length=268, Percent_Identity=25, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI7657058, Length=272, Percent_Identity=25.7352941176471, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=331, Percent_Identity=37.7643504531722, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17557123, Length=147, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325375, Length=403, Percent_Identity=40.6947890818859, Blast_Score=239, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6322878, Length=158, Percent_Identity=29.746835443038, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357667, Length=346, Percent_Identity=39.3063583815029, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24651647, Length=346, Percent_Identity=39.3063583815029, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_BACLD (Q65KK2)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_078696.1
- RefSeq:   YP_091105.1
- HSSP:   Q06489
- ProteinModelPortal:   Q65KK2
- SMR:   Q65KK2
- STRING:   Q65KK2
- EnsemblBacteria:   EBBACT00000055214
- EnsemblBacteria:   EBBACT00000060955
- GeneID:   3030591
- GeneID:   3099817
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi01511
- KEGG:   bli:BL03632
- NMPDR:   fig|279010.5.peg.1063
- eggNOG:   COG0182
- GeneTree:   EBGT00050000000839
- HOGENOM:   HBG682649
- OMA:   LNQTKLP
- ProtClustDB:   PRK05720
- BioCyc:   BLIC279010-1:BLI01511-MONOMER
- BioCyc:   BLIC279010:BL03632-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38700; Mature: 38569

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: ACT_SITE 240-240 BINDING 94-94 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEQFAVPRSVEWEETSVKILNQQKLPEKTEYLHLTTKEDIYDAIQTLKVRGAPAIGITA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHEEEEECHHHHHHHHHHHHHCCCCCHHHHH
AFGLALCAQSIDTSDVSAFLRELRKIKDELNQARPTAVNLSWALNRLLKSAEGAKSVNEA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHH
KTNLVHEAIQIQVEDEETCRQIGQNALHLFKSGDSIMTICNAGSIATSRYGTALSPFYLA
HHHHHHHHHEEEECCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEE
KTKDLDLHIYACETRPVLQGARLTAWELMQGGIDVTLITDSMAAHTMKEKNISAVIVGAD
ECCCCEEEEEEECCCCHHCCCCCHHHHHHHCCCEEEEEECHHHHHHHHHCCCCEEEEEHH
RIARNGDTANKIGTFGLAILAKAFQIPFFIAAPLSTFDVSISCGDDIPIEERDPDEVRRI
HHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHC
NGTQIAPQEVPVFNPAFDITPHDLISGIITEKGIITDRFEEEIEALFSAEALT
CCCEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEQFAVPRSVEWEETSVKILNQQKLPEKTEYLHLTTKEDIYDAIQTLKVRGAPAIGITA
CCCCCCCCCCCCCHHHHHHHHHHCCCCCHHEEEEECHHHHHHHHHHHHHCCCCCHHHHH
AFGLALCAQSIDTSDVSAFLRELRKIKDELNQARPTAVNLSWALNRLLKSAEGAKSVNEA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHH
KTNLVHEAIQIQVEDEETCRQIGQNALHLFKSGDSIMTICNAGSIATSRYGTALSPFYLA
HHHHHHHHHEEEECCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEE
KTKDLDLHIYACETRPVLQGARLTAWELMQGGIDVTLITDSMAAHTMKEKNISAVIVGAD
ECCCCEEEEEEECCCCHHCCCCCHHHHHHHCCCEEEEEECHHHHHHHHHCCCCEEEEEHH
RIARNGDTANKIGTFGLAILAKAFQIPFFIAAPLSTFDVSISCGDDIPIEERDPDEVRRI
HHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHC
NGTQIAPQEVPVFNPAFDITPHDLISGIITEKGIITDRFEEEIEALFSAEALT
CCCEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA