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The map label for this gene is guaD [H]

Identifier: 52785186

GI number: 52785186

Start: 1413339

End: 1413809

Strand: Reverse

Name: guaD [H]

Synonym: BLi01418

Alternate gene names: 52785186

Gene position: 1413809-1413339 (Counterclockwise)

Preceding gene: 52785188

Following gene: 52785183

Centisome position: 33.48

GC content: 47.98

Gene sequence:

>471_bases
ATGAATCATGAAGCATTTTTGCAGCGCGCCATCGACCTTGCGGTGGAGAGCGTGAAAAGCGGCACAGGCGGACCTTTTGG
CGCTGTGATAGTCAAAGACGGCCAAATTATCGCCGAGGGAAAAAACAATGTCACAACAAGCAATGATCCAACCGCGCACG
CGGAAGTAACGGCTATTCGGCTCGCCTGTGAAGCACTTGGCGATTATCAGCTGAACGACTGCATTCTTTATACAAGCTGT
GAACCGTGCCCCATGTGCCTGGGAGCCATCTACTGGGCGAGACCGAAGGAAGTTTACTTCGCCGCTCAGCATTCGGATGC
CGCATCGGCCGGTTTTGACGACTCTTTTATTTATGAAGAAATCACCAAAACGAAAAGCGAACGGAAAATTCCTTTTTATA
AAATGGACCTTCAAGCAAAGCTTGAACCTTTTCTCACATGGGAAAAGACCGATCAAAAAGTGGAATATTAA

Upstream 100 bases:

>100_bases
GCGGTTTGAAATCAAATATGCTGAATATTCTGACATGTGTTTATTTTGCCGGGTCCATCAGCTATAATAAGAAGGCAAGA
CAACCAAGGAGGATACAGAA

Downstream 100 bases:

>100_bases
AAAAAGCTTCCTTCATCAGGAAGCTTTTTTTATTTTGAAGCAGACGGCTCATACCATTCAAGCTTTTGATCTTCCGATTC
CAAATCAAGGCTTTCTGCTT

Product: GuaD

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MNHEAFLQRAIDLAVESVKSGTGGPFGAVIVKDGQIIAEGKNNVTTSNDPTAHAEVTAIRLACEALGDYQLNDCILYTSC
EPCPMCLGAIYWARPKEVYFAAQHSDAASAGFDDSFIYEEITKTKSERKIPFYKMDLQAKLEPFLTWEKTDQKVEY

Sequences:

>Translated_156_residues
MNHEAFLQRAIDLAVESVKSGTGGPFGAVIVKDGQIIAEGKNNVTTSNDPTAHAEVTAIRLACEALGDYQLNDCILYTSC
EPCPMCLGAIYWARPKEVYFAAQHSDAASAGFDDSFIYEEITKTKSERKIPFYKMDLQAKLEPFLTWEKTDQKVEY
>Mature_156_residues
MNHEAFLQRAIDLAVESVKSGTGGPFGAVIVKDGQIIAEGKNNVTTSNDPTAHAEVTAIRLACEALGDYQLNDCILYTSC
EPCPMCLGAIYWARPKEVYFAAQHSDAASAGFDDSFIYEEITKTKSERKIPFYKMDLQAKLEPFLTWEKTDQKVEY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=110, Percent_Identity=37.2727272727273, Blast_Score=81, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17554608, Length=151, Percent_Identity=47.0198675496689, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17555996, Length=156, Percent_Identity=41.6666666666667, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541138, Length=163, Percent_Identity=31.9018404907975, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17324; Mature: 17324

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHEAFLQRAIDLAVESVKSGTGGPFGAVIVKDGQIIAEGKNNVTTSNDPTAHAEVTAIR
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHH
LACEALGDYQLNDCILYTSCEPCPMCLGAIYWARPKEVYFAAQHSDAASAGFDDSFIYEE
HHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHH
ITKTKSERKIPFYKMDLQAKLEPFLTWEKTDQKVEY
HHHCCCCCCCCEEEECCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MNHEAFLQRAIDLAVESVKSGTGGPFGAVIVKDGQIIAEGKNNVTTSNDPTAHAEVTAIR
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHH
LACEALGDYQLNDCILYTSCEPCPMCLGAIYWARPKEVYFAAQHSDAASAGFDDSFIYEE
HHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHH
ITKTKSERKIPFYKMDLQAKLEPFLTWEKTDQKVEY
HHHCCCCCCCCEEEECCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]