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The map label for this gene is hemZ [H]

Identifier: 52784833

GI number: 52784833

Start: 1063008

End: 1064516

Strand: Direct

Name: hemZ [H]

Synonym: BLi01061

Alternate gene names: 52784833

Gene position: 1063008-1064516 (Clockwise)

Preceding gene: 52784832

Following gene: 52784834

Centisome position: 25.17

GC content: 47.98

Gene sequence:

>1509_bases
TTGCGCATTTATATAGAAGGGCTCCAAGACGAAAGGTTCCAGAGACCGCTTGAGCATATAGCGAACTTATTCTTTGAGGA
AAGCGAAGTCGCTCTTGGCGAAGAAGCGCCGGCAGACCTTGCGATCGTTCTCGGCTATGAACGGGAAGAAAACGGCGTCA
AGGCTTCCGGTGCGATAAAGGATACGGACATTACAGCAGAATATGCGAAAAACATTGACCCCAAGCTGACGGAAAAGGAA
GCGTTTAAGCAGGTGAAGAATACCGTTTCCTACGTTTTTTTGAGCATGCTTCAGGAGCATACCGGGATCATTCAGAAATG
GGGGATTCTCACCGGTGTCCGTCCGACAAAGCTGCTTCACAAAAAGCTGGAGAGCGGCATGCCAAAGGAAGAGGCCCATG
CCGAGCTGAAGCGGGATTATTTAATTCACGACGAAAAGATCGAACTGATGCAAAACATTATTGACCGTCAGCTGAAAGCT
GTACCTGATTTGTATGAGCTGGGCCAAGAGGTCAGCATTTACATCGGCATCCCGTTCTGCCCCACGAAGTGCGCCTACTG
CACGTTCCCGGCGTATGCGATCAGAGGACAAGCCGGACGAGTCGGCTCATTTTTGTGGGGGCTTCACTATGAAATGCAAA
AAATCGGTGAATGGCTCAAGGAGAACGATGTCAGCATCACGACCGTGTATTTCGGCGGCGGAACGCCGACAAGCATTACC
GCCGAAGAAATGGATTTATTGTATGAAGAAATGCACCGTTCATTTCCCGATGTGAAAAACATCCGCGAGGTTACGGTTGA
GGCCGGGCGGCCCGATACGATTACAGAAGAAAAGCTCGCGGTCTTAAAAAAATGGAACATCGACCGCATCAGCATTAACC
CGCAGTCTTACGAAAATGAAACGCTGAAAGCGATCGGACGCCACCATACCGTGGAAGAAACGATCGAAAAGTACCATCTG
TCGCGAAATGCCGGTATGTCGAACATCAATATGGATTTGATCATCGGCCTTCCGGGCGAAGGAGTAAAAGAATTCAGACA
CTCTCTTTCCGAAACCGAAAAATTAATGCCTGAATCATTGACCGTTCATACGCTGTCATTTAAGCGCGCGTCTGAAATGA
CGAAGAACAGGCATAAGTATAAGGTGGCTGACCGCGAGGAAATTGTCGCGATGATGGATGACGCTGTCTCGTGGACGAAA
CAGCACGGTTACCATCCCTACTATTTGTACAGGCAGAAAAACATTCTCGGCAACCTGGAGAATATAGGCTATTCCCTTCC
CGGCCAGGAGAGCATCTATAACATTATGATCATGGAGGAAAAACAGACGATTATCGGGATCGGCTGCGGAGCTGCGAGCA
AATTTGTCGATCCGAGATCGGGAAAAATCACGCACTTTTCCAATCCGAAAGACCCGAAAACTTACAATGACAGATTTGAA
CATTATACAAACGAAAAAATCCGCTACTTGTCTGAGCTTTTTCAGAAGGATGGTTCTCAACAAGAATAG

Upstream 100 bases:

>100_bases
CATTTATCGGTCTCCTAAAGGAATGTATGTTTCCCGGATTGATTTTGCCCATTTATTTTTGTACACTAAAGAAAGTTTTG
AAACGAAAAAGGTGATGACA

Downstream 100 bases:

>100_bases
AAGCTGCTGCCGGGATCACCGGCAGCTTTTTTATTGCGGAATCAGGCCGGAATCGGCAACAAAAAAAGGTTTTGGAGGGC
AAAGGTGGAATAATTTAAAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MRIYIEGLQDERFQRPLEHIANLFFEESEVALGEEAPADLAIVLGYEREENGVKASGAIKDTDITAEYAKNIDPKLTEKE
AFKQVKNTVSYVFLSMLQEHTGIIQKWGILTGVRPTKLLHKKLESGMPKEEAHAELKRDYLIHDEKIELMQNIIDRQLKA
VPDLYELGQEVSIYIGIPFCPTKCAYCTFPAYAIRGQAGRVGSFLWGLHYEMQKIGEWLKENDVSITTVYFGGGTPTSIT
AEEMDLLYEEMHRSFPDVKNIREVTVEAGRPDTITEEKLAVLKKWNIDRISINPQSYENETLKAIGRHHTVEETIEKYHL
SRNAGMSNINMDLIIGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTKNRHKYKVADREEIVAMMDDAVSWTK
QHGYHPYYLYRQKNILGNLENIGYSLPGQESIYNIMIMEEKQTIIGIGCGAASKFVDPRSGKITHFSNPKDPKTYNDRFE
HYTNEKIRYLSELFQKDGSQQE

Sequences:

>Translated_502_residues
MRIYIEGLQDERFQRPLEHIANLFFEESEVALGEEAPADLAIVLGYEREENGVKASGAIKDTDITAEYAKNIDPKLTEKE
AFKQVKNTVSYVFLSMLQEHTGIIQKWGILTGVRPTKLLHKKLESGMPKEEAHAELKRDYLIHDEKIELMQNIIDRQLKA
VPDLYELGQEVSIYIGIPFCPTKCAYCTFPAYAIRGQAGRVGSFLWGLHYEMQKIGEWLKENDVSITTVYFGGGTPTSIT
AEEMDLLYEEMHRSFPDVKNIREVTVEAGRPDTITEEKLAVLKKWNIDRISINPQSYENETLKAIGRHHTVEETIEKYHL
SRNAGMSNINMDLIIGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTKNRHKYKVADREEIVAMMDDAVSWTK
QHGYHPYYLYRQKNILGNLENIGYSLPGQESIYNIMIMEEKQTIIGIGCGAASKFVDPRSGKITHFSNPKDPKTYNDRFE
HYTNEKIRYLSELFQKDGSQQE
>Mature_502_residues
MRIYIEGLQDERFQRPLEHIANLFFEESEVALGEEAPADLAIVLGYEREENGVKASGAIKDTDITAEYAKNIDPKLTEKE
AFKQVKNTVSYVFLSMLQEHTGIIQKWGILTGVRPTKLLHKKLESGMPKEEAHAELKRDYLIHDEKIELMQNIIDRQLKA
VPDLYELGQEVSIYIGIPFCPTKCAYCTFPAYAIRGQAGRVGSFLWGLHYEMQKIGEWLKENDVSITTVYFGGGTPTSIT
AEEMDLLYEEMHRSFPDVKNIREVTVEAGRPDTITEEKLAVLKKWNIDRISINPQSYENETLKAIGRHHTVEETIEKYHL
SRNAGMSNINMDLIIGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTKNRHKYKVADREEIVAMMDDAVSWTK
QHGYHPYYLYRQKNILGNLENIGYSLPGQESIYNIMIMEEKQTIIGIGCGAASKFVDPRSGKITHFSNPKDPKTYNDRFE
HYTNEKIRYLSELFQKDGSQQE

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=308, Percent_Identity=24.025974025974, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789325, Length=311, Percent_Identity=26.0450160771704, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI87082341, Length=238, Percent_Identity=23.9495798319328, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 57574; Mature: 57574

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIYIEGLQDERFQRPLEHIANLFFEESEVALGEEAPADLAIVLGYEREENGVKASGAIK
CEEEEECCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEECEECCCCCCCCCCCC
DTDITAEYAKNIDPKLTEKEAFKQVKNTVSYVFLSMLQEHTGIIQKWGILTGVRPTKLLH
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KKLESGMPKEEAHAELKRDYLIHDEKIELMQNIIDRQLKAVPDLYELGQEVSIYIGIPFC
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCC
PTKCAYCTFPAYAIRGQAGRVGSFLWGLHYEMQKIGEWLKENDVSITTVYFGGGTPTSIT
CCCCCHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
AEEMDLLYEEMHRSFPDVKNIREVTVEAGRPDTITEEKLAVLKKWNIDRISINPQSYENE
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCHH
TLKAIGRHHTVEETIEKYHLSRNAGMSNINMDLIIGLPGEGVKEFRHSLSETEKLMPESL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCE
TVHTLSFKRASEMTKNRHKYKVADREEIVAMMDDAVSWTKQHGYHPYYLYRQKNILGNLE
EEEEEHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHH
NIGYSLPGQESIYNIMIMEEKQTIIGIGCGAASKFVDPRSGKITHFSNPKDPKTYNDRFE
HCCCCCCCCCCEEEEEEEECCCEEEEEECCCHHHCCCCCCCCEEECCCCCCCCCHHHHHH
HYTNEKIRYLSELFQKDGSQQE
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIYIEGLQDERFQRPLEHIANLFFEESEVALGEEAPADLAIVLGYEREENGVKASGAIK
CEEEEECCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEECEECCCCCCCCCCCC
DTDITAEYAKNIDPKLTEKEAFKQVKNTVSYVFLSMLQEHTGIIQKWGILTGVRPTKLLH
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KKLESGMPKEEAHAELKRDYLIHDEKIELMQNIIDRQLKAVPDLYELGQEVSIYIGIPFC
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCC
PTKCAYCTFPAYAIRGQAGRVGSFLWGLHYEMQKIGEWLKENDVSITTVYFGGGTPTSIT
CCCCCHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
AEEMDLLYEEMHRSFPDVKNIREVTVEAGRPDTITEEKLAVLKKWNIDRISINPQSYENE
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCHH
TLKAIGRHHTVEETIEKYHLSRNAGMSNINMDLIIGLPGEGVKEFRHSLSETEKLMPESL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCE
TVHTLSFKRASEMTKNRHKYKVADREEIVAMMDDAVSWTKQHGYHPYYLYRQKNILGNLE
EEEEEHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHH
NIGYSLPGQESIYNIMIMEEKQTIIGIGCGAASKFVDPRSGKITHFSNPKDPKTYNDRFE
HCCCCCCCCCCEEEEEEEECCCEEEEEECCCHHHCCCCCCCCEEECCCCCCCCCHHHHHH
HYTNEKIRYLSELFQKDGSQQE
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]