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The map label for this gene is yhdZ [H]

Identifier: 52784809

GI number: 52784809

Start: 1036611

End: 1037360

Strand: Direct

Name: yhdZ [H]

Synonym: BLi01037

Alternate gene names: 52784809

Gene position: 1036611-1037360 (Clockwise)

Preceding gene: 52784808

Following gene: 52784812

Centisome position: 24.55

GC content: 48.53

Gene sequence:

>750_bases
ATGGAGGAAGAAGCCCTGAGATTTGCGGATATGATCGAAAATGCCGAGCGCATTACCGTTTTGACAGGCGCCGGTATGAG
CACGGAATCAGGCATTCCTGATTTTCGTTCAGCCGGCGGCATATGGACGGAAGATCTGTCGAGAATGGAAGCGATGAGCC
GTGATTATTACGAACGATATCCAAAATTGTTTTGGCCGAAGTTTAAAGAGCTTTTTCAAATGAAAATGACGGGAACTTAT
CGGCCGAATGACGGGCACCTTTATTTAGCCGAACTCGAGAAAAGCGGTAAGGATGTCAGGGTGTTCACGCAGAATATCGA
CGGGCTGCATCTTAAGGCGGGAAGCCGCCATGTATATGAACTGCACGGTTCGATTCAAACAGCCGCTTGCCCAAAATGCG
GGGCGCGCTACGGTCTTGACCACATTCTTCAAGAAGAAGTGCCAAGGTGCAATCGCGTCAATGGCAAGGGGAGAGCATGC
GGATTTATATTAAAAACGGATGTCGTGCTGTTCGGCGACGCCGTTCAGCATTTCGACACGCTTTTTGAAGTCCTCAACGA
ATCCGACCTGCTTCTGGTGATCGGCACTTCACTCGAAGTGGCGCCTGTCAGGTTTGTTCCTGAAGAAGCGCACCTGATCC
CCGGTTTGAAGAAAGCCATGATCAATCTCGATGAAACGCCTTACGATCATTTATTCGACATTGTCATCAATCAAAAAATC
GCCGAGTTTGTTCGGAAACTCAATCATTAA

Upstream 100 bases:

>100_bases
GTTGATTTTGTTTCTCCGGGGCACAGCCTCTTTGAGTTGAAGAAAATGAAAGATCAGCAAGGAAATGCTTAGAAACAGTT
TTTGAAGGGAGACAAGCCAA

Downstream 100 bases:

>100_bases
AAAGGAAGACGCTCCAGACCGGAGCGTCTTTTTTGATCTTCATCACAGTTTTTTATAATAAAAAACGGATGCATCGAGCC
GGCCGTCTGCAGATTCCGCG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MEEEALRFADMIENAERITVLTGAGMSTESGIPDFRSAGGIWTEDLSRMEAMSRDYYERYPKLFWPKFKELFQMKMTGTY
RPNDGHLYLAELEKSGKDVRVFTQNIDGLHLKAGSRHVYELHGSIQTAACPKCGARYGLDHILQEEVPRCNRVNGKGRAC
GFILKTDVVLFGDAVQHFDTLFEVLNESDLLLVIGTSLEVAPVRFVPEEAHLIPGLKKAMINLDETPYDHLFDIVINQKI
AEFVRKLNH

Sequences:

>Translated_249_residues
MEEEALRFADMIENAERITVLTGAGMSTESGIPDFRSAGGIWTEDLSRMEAMSRDYYERYPKLFWPKFKELFQMKMTGTY
RPNDGHLYLAELEKSGKDVRVFTQNIDGLHLKAGSRHVYELHGSIQTAACPKCGARYGLDHILQEEVPRCNRVNGKGRAC
GFILKTDVVLFGDAVQHFDTLFEVLNESDLLLVIGTSLEVAPVRFVPEEAHLIPGLKKAMINLDETPYDHLFDIVINQKI
AEFVRKLNH
>Mature_249_residues
MEEEALRFADMIENAERITVLTGAGMSTESGIPDFRSAGGIWTEDLSRMEAMSRDYYERYPKLFWPKFKELFQMKMTGTY
RPNDGHLYLAELEKSGKDVRVFTQNIDGLHLKAGSRHVYELHGSIQTAACPKCGARYGLDHILQEEVPRCNRVNGKGRAC
GFILKTDVVLFGDAVQHFDTLFEVLNESDLLLVIGTSLEVAPVRFVPEEAHLIPGLKKAMINLDETPYDHLFDIVINQKI
AEFVRKLNH

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7657575, Length=251, Percent_Identity=33.8645418326693, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI300795542, Length=241, Percent_Identity=34.4398340248963, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI6912662, Length=286, Percent_Identity=32.1678321678322, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI13787215, Length=260, Percent_Identity=31.9230769230769, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI6912664, Length=259, Percent_Identity=32.046332046332, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI6912660, Length=200, Percent_Identity=37, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI63054862, Length=195, Percent_Identity=36.9230769230769, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI300797577, Length=257, Percent_Identity=29.1828793774319, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13775602, Length=206, Percent_Identity=33.0097087378641, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI13775600, Length=206, Percent_Identity=33.0097087378641, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI300797705, Length=203, Percent_Identity=32.512315270936, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI215982798, Length=200, Percent_Identity=32, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI300797597, Length=249, Percent_Identity=28.1124497991968, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI7706712, Length=254, Percent_Identity=24.8031496062992, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI308199517, Length=242, Percent_Identity=31.8181818181818, Blast_Score=95, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17541892, Length=241, Percent_Identity=34.0248962655602, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71990482, Length=295, Percent_Identity=30.1694915254237, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71990487, Length=297, Percent_Identity=29.96632996633, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17567771, Length=292, Percent_Identity=26.7123287671233, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17505510, Length=243, Percent_Identity=29.2181069958848, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324504, Length=256, Percent_Identity=30.46875, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6325242, Length=261, Percent_Identity=29.8850574712644, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6324599, Length=253, Percent_Identity=29.6442687747036, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320397, Length=259, Percent_Identity=26.2548262548263, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137536, Length=268, Percent_Identity=31.7164179104478, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24648389, Length=200, Percent_Identity=33.5, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI28571445, Length=291, Percent_Identity=31.9587628865979, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645650, Length=258, Percent_Identity=29.0697674418605, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 28266; Mature: 28266

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEEALRFADMIENAERITVLTGAGMSTESGIPDFRSAGGIWTEDLSRMEAMSRDYYERY
CCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHC
PKLFWPKFKELFQMKMTGTYRPNDGHLYLAELEKSGKDVRVFTQNIDGLHLKAGSRHVYE
HHHCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEECCCCEEEE
LHGSIQTAACPKCGARYGLDHILQEEVPRCNRVNGKGRACGFILKTDVVLFGDAVQHFDT
ECCCCCHHCCCCCHHHHCHHHHHHHHCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHH
LFEVLNESDLLLVIGTSLEVAPVRFVPEEAHLIPGLKKAMINLDETPYDHLFDIVINQKI
HHHHHCCCCEEEEEECCCEEEEEEECCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHH
AEFVRKLNH
HHHHHHHCC
>Mature Secondary Structure
MEEEALRFADMIENAERITVLTGAGMSTESGIPDFRSAGGIWTEDLSRMEAMSRDYYERY
CCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHC
PKLFWPKFKELFQMKMTGTYRPNDGHLYLAELEKSGKDVRVFTQNIDGLHLKAGSRHVYE
HHHCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEECCCCEEEE
LHGSIQTAACPKCGARYGLDHILQEEVPRCNRVNGKGRACGFILKTDVVLFGDAVQHFDT
ECCCCCHHCCCCCHHHHCHHHHHHHHCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHH
LFEVLNESDLLLVIGTSLEVAPVRFVPEEAHLIPGLKKAMINLDETPYDHLFDIVINQKI
HHHHHCCCCEEEEEECCCEEEEEEECCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHH
AEFVRKLNH
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]