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The map label for this gene is yhcL

Identifier: 52784747

GI number: 52784747

Start: 972561

End: 973946

Strand: Direct

Name: yhcL

Synonym: BLi00975

Alternate gene names: 52784747

Gene position: 972561-973946 (Clockwise)

Preceding gene: 52784746

Following gene: 52784750

Centisome position: 23.03

GC content: 48.27

Gene sequence:

>1386_bases
ATGACATTATTTGTTGTTATTAATATTATCGTCATGCTCGGCCTGATGGCGCTCCTTTATATGATGCAAAAAAAGCATGT
TTCTTTTTCTAAGCGGGTATTTACCGCTCTGGGAATCGGAATTGTTTTTGGATTCGCTTTGCATTTTATATATGGTTCGT
CTTCAGAAACGATTACGCAGACTTCTGATTGGTTTAATATCGCAGGCGGCGGCTATGTCAAGCTTTTGCAGATGATCGTT
ATGCCGCTTGTATTCATCTCGATTTTGGGTGCTTTTACAAAGCTTAAGCTGACGCACAATATCGGAAAAATCAGCGGATT
GATCATCGGGCTCTTAATCGCGACGACAGCCGTCGCTGCTGCGGTGGGTATCGCGTCCGCGCTTGCTTTCGACCTGCAGG
CCGTCCATGTGGACCAAGGCCAGGCGGAGACAATGAGAGGGGCGGAACTCGAACAGAAATCGCAGGACATGGAAGCCAAA
ACGCTTCCGCAGCAAATTGTCGAGCTTCTTCCTGGAAATCCGTTTTTAGACTTTACTGGAGCAAGACCGACATCAACGAT
CGCAGTTGTTATTTTTGCGGCTTTCCTTGGGATCGCTTATCTCGGGGTCAACCGAAAACAGCCTGAACAAGCTGAACTTT
TCAAAAAAATGGTTGATGCCGTGTATGCGATCATTATGCGTGTGGTCACCTTAATTCTGAGGTTGACGCCTTACGGTGTA
TTGGCGATCATGACAAAAACGATTGCAACGAGCGACCTCGACAGCATTGCCAAACTCGGCAAATTTGTCATCGCTTCATA
TGCGGCGCTGATCGTCATGTTCATCATTCACCTGCTGCTCATTACATTCAGCGGTTTAAATCCTGTCACATACTTGAAAA
AGGCGTTTCCAGTTCTTGTATTCGCGTTTACATCAAGATCAAGCGCAGGCGCTTTGCCGCTGAACATTAAAACGCAGCGA
AGCCTTGGTGTTCCAGAAGGCATTGCGAACTTTGCCGGATCCTTCGGACTGTCCATCGGTCAAAACGGATGTGCCGGCAT
TTACCCTGCAATGCTCGCGATTATGATCGCGCCGACTGTCGGCCAAAATCCGCTTGATCCGTCATTCTTGTTCACGGTTA
TCGCAGTTGTTGCGATCAGCTCTTTCGGAGTGGCAGGCGTCGGCGGAGGTGCGACCTTTGCAGCGCTTCTCGTCCTTTCG
GCATTAAACATGCCTGTAGCGCTTGCCGGACTTCTGATTTCTGTTGAGCCGCTGATCGACATGGGGCGTACGGCTCTCAA
TGTCAGCGGCAGCATGACGTCAGGACTTGTCACGAGCAAAGTGACAAATGAGCTTGAAAAAGACACGTACCAAGACCGTA
CAAATATCATTGAAGCAGAAGTGTAA

Upstream 100 bases:

>100_bases
GGTCATATATTGAAATACATCGATAATTCCTACTTGACCAATCAGGTTTGTTGTACTATAGTTTTTAAATGTAAAAAATT
CTGGGGGTGCTTTTGTTATC

Downstream 100 bases:

>100_bases
AAGAAAAACGGCCCGCACAGCTTGAGAGCTCGTGCGGGCCGTTTTTTATGAATAGCTTTGATCGTCATCGAACATCGTCT
GAGCTGCAGCCTGATCGTTC

Product: YhcL

Products: NA

Alternate protein names: Transporter of cystine tcyP

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTLFVVINIIVMLGLMALLYMMQKKHVSFSKRVFTALGIGIVFGFALHFIYGSSSETITQTSDWFNIAGGGYVKLLQMIV
MPLVFISILGAFTKLKLTHNIGKISGLIIGLLIATTAVAAAVGIASALAFDLQAVHVDQGQAETMRGAELEQKSQDMEAK
TLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGIAYLGVNRKQPEQAELFKKMVDAVYAIIMRVVTLILRLTPYGV
LAIMTKTIATSDLDSIAKLGKFVIASYAALIVMFIIHLLLITFSGLNPVTYLKKAFPVLVFAFTSRSSAGALPLNIKTQR
SLGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAIMIAPTVGQNPLDPSFLFTVIAVVAISSFGVAGVGGGATFAALLVLS
ALNMPVALAGLLISVEPLIDMGRTALNVSGSMTSGLVTSKVTNELEKDTYQDRTNIIEAEV

Sequences:

>Translated_461_residues
MTLFVVINIIVMLGLMALLYMMQKKHVSFSKRVFTALGIGIVFGFALHFIYGSSSETITQTSDWFNIAGGGYVKLLQMIV
MPLVFISILGAFTKLKLTHNIGKISGLIIGLLIATTAVAAAVGIASALAFDLQAVHVDQGQAETMRGAELEQKSQDMEAK
TLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGIAYLGVNRKQPEQAELFKKMVDAVYAIIMRVVTLILRLTPYGV
LAIMTKTIATSDLDSIAKLGKFVIASYAALIVMFIIHLLLITFSGLNPVTYLKKAFPVLVFAFTSRSSAGALPLNIKTQR
SLGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAIMIAPTVGQNPLDPSFLFTVIAVVAISSFGVAGVGGGATFAALLVLS
ALNMPVALAGLLISVEPLIDMGRTALNVSGSMTSGLVTSKVTNELEKDTYQDRTNIIEAEV
>Mature_460_residues
TLFVVINIIVMLGLMALLYMMQKKHVSFSKRVFTALGIGIVFGFALHFIYGSSSETITQTSDWFNIAGGGYVKLLQMIVM
PLVFISILGAFTKLKLTHNIGKISGLIIGLLIATTAVAAAVGIASALAFDLQAVHVDQGQAETMRGAELEQKSQDMEAKT
LPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGIAYLGVNRKQPEQAELFKKMVDAVYAIIMRVVTLILRLTPYGVL
AIMTKTIATSDLDSIAKLGKFVIASYAALIVMFIIHLLLITFSGLNPVTYLKKAFPVLVFAFTSRSSAGALPLNIKTQRS
LGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAIMIAPTVGQNPLDPSFLFTVIAVVAISSFGVAGVGGGATFAALLVLSA
LNMPVALAGLLISVEPLIDMGRTALNVSGSMTSGLVTSKVTNELEKDTYQDRTNIIEAEV

Specific function: Mediates uptake of L-cystine, the oxidized form of L- cysteine

COG id: COG1823

COG function: function code R; Predicted Na+/dicarboxylate symporter

Gene ontology:

Cell location: Membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family

Homologues:

Organism=Homo sapiens, GI40254478, Length=256, Percent_Identity=30.46875, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI223468566, Length=272, Percent_Identity=26.8382352941176, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=26.8382352941176, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI5032093, Length=403, Percent_Identity=25.0620347394541, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI169790839, Length=322, Percent_Identity=26.3975155279503, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI21314632, Length=271, Percent_Identity=23.9852398523985, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI66773030, Length=259, Percent_Identity=27.7992277992278, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4827012, Length=268, Percent_Identity=25.7462686567164, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI194239697, Length=235, Percent_Identity=25.9574468085106, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788024, Length=460, Percent_Identity=52.6086956521739, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1790514, Length=438, Percent_Identity=24.6575342465753, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789947, Length=442, Percent_Identity=24.4343891402715, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983106, Length=425, Percent_Identity=25.4117647058824, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71983099, Length=434, Percent_Identity=25.1152073732719, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537407, Length=429, Percent_Identity=24.2424242424242, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193206505, Length=469, Percent_Identity=23.0277185501066, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193206654, Length=462, Percent_Identity=22.5108225108225, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71996953, Length=311, Percent_Identity=24.7588424437299, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583025, Length=453, Percent_Identity=24.7240618101545, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137668, Length=453, Percent_Identity=24.7240618101545, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583023, Length=453, Percent_Identity=24.7240618101545, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TCYP_BACLD (Q65M31)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_078178.1
- RefSeq:   YP_090576.1
- ProteinModelPortal:   Q65M31
- STRING:   Q65M31
- EnsemblBacteria:   EBBACT00000056210
- EnsemblBacteria:   EBBACT00000061161
- GeneID:   3029851
- GeneID:   3098224
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00975
- KEGG:   bli:BL03177
- NMPDR:   fig|279010.5.peg.1650
- eggNOG:   COG1823
- GeneTree:   EBGT00070000032022
- HOGENOM:   HBG739804
- OMA:   AWVMRLV
- ProtClustDB:   CLSK2518215
- BioCyc:   BLIC279010-1:BLI00975-MONOMER
- BioCyc:   BLIC279010:BL03177-MONOMER
- InterPro:   IPR001991
- PANTHER:   PTHR11958
- PRINTS:   PR00173

Pfam domain/function: PF00375 SDF

EC number: NA

Molecular weight: Translated: 48893; Mature: 48762

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xcd9f4a0)-; HASH(0xd6755ac)-; HASH(0xb1e1410)-; HASH(0xdcaa1a0)-; HASH(0xdec77fc)-; HASH(0xdcaa218)-; HASH(0xdf3f5dc)-; HASH(0xdf6fe28)-; HASH(0xd91939c)-; HASH(0xdd0d998)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFVVINIIVMLGLMALLYMMQKKHVSFSKRVFTALGIGIVFGFALHFIYGSSSETITQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEC
TSDWFNIAGGGYVKLLQMIVMPLVFISILGAFTKLKLTHNIGKISGLIIGLLIATTAVAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGIASALAFDLQAVHVDQGQAETMRGAELEQKSQDMEAKTLPQQIVELLPGNPFLDFTG
HHHHHHHHHHHHHHEECCCCCHHHHCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCEECCC
ARPTSTIAVVIFAAFLGIAYLGVNRKQPEQAELFKKMVDAVYAIIMRVVTLILRLTPYGV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LAIMTKTIATSDLDSIAKLGKFVIASYAALIVMFIIHLLLITFSGLNPVTYLKKAFPVLV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FAFTSRSSAGALPLNIKTQRSLGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAIMIAPTV
HEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
GQNPLDPSFLFTVIAVVAISSFGVAGVGGGATFAALLVLSALNMPVALAGLLISVEPLID
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
MGRTALNVSGSMTSGLVTSKVTNELEKDTYQDRTNIIEAEV
CCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
TLFVVINIIVMLGLMALLYMMQKKHVSFSKRVFTALGIGIVFGFALHFIYGSSSETITQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEC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CCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA