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The map label for this gene is aroD

Identifier: 52784712

GI number: 52784712

Start: 941121

End: 941885

Strand: Direct

Name: aroD

Synonym: BLi00939

Alternate gene names: 52784712

Gene position: 941121-941885 (Clockwise)

Preceding gene: 52784711

Following gene: 52784713

Centisome position: 22.29

GC content: 47.58

Gene sequence:

>765_bases
TTGAAGAAACTGGTGAAGGTCAGAGGAATTACATTGGGTGAAGGCCGGCCAAAAATCTGTGTGCCGCTTGTCGGAAAAAA
CCTTGCCCAATTAAAAGAAGAAGCGGCTTATTTTCAAACGCTTGATGCCGATATTGCGGAGTGGCGTGCTGATTTTTATG
AAGATGTAGATGACGTTGATCAAGTCTGCGCGGCATTGGCGGAAATCCGCGGCCTTTTAAAGGACACTCCGCTCATTTTC
ACTTTCCGCAGCGCCGCCGAAGGCGGAGAAAAAGAGATCAGCACAGCGCGATATTTTTCTTTAAATGAAGCGGTTGTTAA
AACAGGGCTTGCCGATGTGATTGATATCGAGCTGTTCAATGACGAAGAGCAAGTGAAAGCGCTGGTGGAAACAGCACATG
GTCATGAAGTGTCCGTGATTATATCTAATCATGATTTTGAAAAGACACCAGCTGCAGAAGAAATTGTTTCCCGTTTGCGA
AAAGCACAGGAATTAGGGGCTGATCTGCCTAAAATCGCGGTGATGCCGGAAACCACGGCTGATGTCTTGCGTCTGCTTGA
AGCCACTTGTACGATGAATGAGAAGTATGCAGATCGGCCGATTATTACGATGTCAATGGCCGGCAAAGGTATCATCAGCC
GCCTGGCGGGCGAGGTATTCGGTTCAGCAATGACGTTCGGTGCCGCAAAGAAAGCTTCAGCACCGGGGCAGATTGCAGCT
GGTGAGCTCAAGGAAATCCTTCATATATTGCATCGCAATTTATAA

Upstream 100 bases:

>100_bases
GGTTCGCATAAAAAATTTTACTTGCACGAACAGTTGACATTCAGTAGTCACAGTGATTTGATAAAGGAAATTCGAATACA
GAAAGACGGGAGCTGAAACA

Downstream 100 bases:

>100_bases
CTTGATGATTGAGAGGAGCCTGGCTGACAGCCGGCTCCTTTGTCAGTTTTTTCGTAGTCCTAACGACTCATTTATCTTTC
TTTTCGGAATCGTTTTAACT

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MKKLVKVRGITLGEGRPKICVPLVGKNLAQLKEEAAYFQTLDADIAEWRADFYEDVDDVDQVCAALAEIRGLLKDTPLIF
TFRSAAEGGEKEISTARYFSLNEAVVKTGLADVIDIELFNDEEQVKALVETAHGHEVSVIISNHDFEKTPAAEEIVSRLR
KAQELGADLPKIAVMPETTADVLRLLEATCTMNEKYADRPIITMSMAGKGIISRLAGEVFGSAMTFGAAKKASAPGQIAA
GELKEILHILHRNL

Sequences:

>Translated_254_residues
MKKLVKVRGITLGEGRPKICVPLVGKNLAQLKEEAAYFQTLDADIAEWRADFYEDVDDVDQVCAALAEIRGLLKDTPLIF
TFRSAAEGGEKEISTARYFSLNEAVVKTGLADVIDIELFNDEEQVKALVETAHGHEVSVIISNHDFEKTPAAEEIVSRLR
KAQELGADLPKIAVMPETTADVLRLLEATCTMNEKYADRPIITMSMAGKGIISRLAGEVFGSAMTFGAAKKASAPGQIAA
GELKEILHILHRNL
>Mature_254_residues
MKKLVKVRGITLGEGRPKICVPLVGKNLAQLKEEAAYFQTLDADIAEWRADFYEDVDDVDQVCAALAEIRGLLKDTPLIF
TFRSAAEGGEKEISTARYFSLNEAVVKTGLADVIDIELFNDEEQVKALVETAHGHEVSVIISNHDFEKTPAAEEIVSRLR
KAQELGADLPKIAVMPETTADVLRLLEATCTMNEKYADRPIITMSMAGKGIISRLAGEVFGSAMTFGAAKKASAPGQIAA
GELKEILHILHRNL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=250, Percent_Identity=57.2, Blast_Score=300, Evalue=5e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_BACLD (Q65M66)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_078140.1
- RefSeq:   YP_090541.1
- HSSP:   P24670
- ProteinModelPortal:   Q65M66
- SMR:   Q65M66
- STRING:   Q65M66
- EnsemblBacteria:   EBBACT00000054520
- EnsemblBacteria:   EBBACT00000058723
- GeneID:   3029790
- GeneID:   3101155
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00939
- KEGG:   bli:BL00001
- NMPDR:   fig|279010.5.peg.1524
- eggNOG:   COG0710
- GeneTree:   EBGT00050000001972
- HOGENOM:   HBG732926
- OMA:   NHDFDKT
- ProtClustDB:   PRK02412
- BioCyc:   BLIC279010-1:BLI00939-MONOMER
- BioCyc:   BLIC279010:BL00001-MONOMER
- HAMAP:   MF_00214
- InterPro:   IPR018508
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 27695; Mature: 27695

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 144-144 ACT_SITE 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVKVRGITLGEGRPKICVPLVGKNLAQLKEEAAYFQTLDADIAEWRADFYEDVDDVD
CCCHHEECCEEECCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
QVCAALAEIRGLLKDTPLIFTFRSAAEGGEKEISTARYFSLNEAVVKTGLADVIDIELFN
HHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEC
DEEQVKALVETAHGHEVSVIISNHDFEKTPAAEEIVSRLRKAQELGADLPKIAVMPETTA
CHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHH
DVLRLLEATCTMNEKYADRPIITMSMAGKGIISRLAGEVFGSAMTFGAAKKASAPGQIAA
HHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCH
GELKEILHILHRNL
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKKLVKVRGITLGEGRPKICVPLVGKNLAQLKEEAAYFQTLDADIAEWRADFYEDVDDVD
CCCHHEECCEEECCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
QVCAALAEIRGLLKDTPLIFTFRSAAEGGEKEISTARYFSLNEAVVKTGLADVIDIELFN
HHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEC
DEEQVKALVETAHGHEVSVIISNHDFEKTPAAEEIVSRLRKAQELGADLPKIAVMPETTA
CHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHH
DVLRLLEATCTMNEKYADRPIITMSMAGKGIISRLAGEVFGSAMTFGAAKKASAPGQIAA
HHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCH
GELKEILHILHRNL
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA