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The map label for this gene is mmuM [H]

Identifier: 52784090

GI number: 52784090

Start: 238922

End: 239869

Strand: Reverse

Name: mmuM [H]

Synonym: BLi00266

Alternate gene names: 52784090

Gene position: 239869-238922 (Counterclockwise)

Preceding gene: 52784094

Following gene: 52784089

Centisome position: 5.68

GC content: 52.11

Gene sequence:

>948_bases
ATGACAAATCCGATCCGAACTTCTTTACAACAATTTTCTGTCATTATACTTGACGGCGCGATGGCCACCGAGCTTGAACG
GTACGGCTGTGATTTGAACGATAGCCTGTGGTCTGCGAAAATTCTCATCGAAAACCCCGAGCTTATCAAACAAGTCCATC
TGGATTATTTCCGTGCGGGCGCCGATTGCGCGATTACAGCCAGCTATCAGTCGACGGTTGAGGGTTTCACAAAACGCGGC
CTTAGCGAACAAGAAGCGCTCCACCTCATCCGGGAGTCTGTCCGTCTTGCTGCAGAAGCACGCGATGAATTCTGGGCGGC
TCCGGAAAACCGCGAAGGCCGGCCTAAACCGTTTGTAGCAGCTTCAGTAGGCCCTTACGGCGCCTTTTTAGCGGATGGTT
CCGAATATCAGGGAAATTATGGCGTCACAGAAGATGAATTGGCCGATTTTCACAGGCGGAGAATGGGCGCTTTAATCGAA
GCAGGCGCCGATATTTTGGCATGTGAGACAATACCGTGCCTTTCAGAAGCAAAAGCTATCGTTCATTTATTAAAAGAGTT
CCCGGATACACATGCGTGGATCAGTTTCAGCGCTAAAGACGGACGCCATATCAGCGACGGTACGAAAGCCGGCGAATGCG
CGAAGTGGCTCGATCAGCATGACCAGGTTGCGGCAGTAGGAGTAAACTGTACGCGGCTGGAGCATGTCTCTTCGCTCATC
GGCGGCATCAAAAAGCATACAGCTAAACCGATTATCGTCTATCCAAATTCCGGTGAACAGTATGACCCGGAAACGAAAAC
ATGGCATGGCGCGGCATGTAAAGCTTCTTTCGGAGAAAGCGCCCGCAGCTGGTATAACCAAGGGGCACAGCTGATCGGCG
GCTGCTGCAGAACAACGCCTGAGGACATCAAAGCCGTCGCCGCCTGGGCGAGAAAGCTGGAGGTATAA

Upstream 100 bases:

>100_bases
TGACAAAAACCTCCCGAGTCTTTTAAACTATTTTTCATATATTTTAAAAAACTCTAAAAAAGGAGGCCGGGGTCTCGAAC
GACAGAGCCTCAACAATGAG

Downstream 100 bases:

>100_bases
TGGAACAGTCAAACACCAATCGCCAGAACTTTCAAAGAAAAATGCAAACGAGACACCTTATCATGCTTTCCTTAGGAGGC
GTTATCGGCACGGGCCTTTT

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MTNPIRTSLQQFSVIILDGAMATELERYGCDLNDSLWSAKILIENPELIKQVHLDYFRAGADCAITASYQSTVEGFTKRG
LSEQEALHLIRESVRLAAEARDEFWAAPENREGRPKPFVAASVGPYGAFLADGSEYQGNYGVTEDELADFHRRRMGALIE
AGADILACETIPCLSEAKAIVHLLKEFPDTHAWISFSAKDGRHISDGTKAGECAKWLDQHDQVAAVGVNCTRLEHVSSLI
GGIKKHTAKPIIVYPNSGEQYDPETKTWHGAACKASFGESARSWYNQGAQLIGGCCRTTPEDIKAVAAWARKLEV

Sequences:

>Translated_315_residues
MTNPIRTSLQQFSVIILDGAMATELERYGCDLNDSLWSAKILIENPELIKQVHLDYFRAGADCAITASYQSTVEGFTKRG
LSEQEALHLIRESVRLAAEARDEFWAAPENREGRPKPFVAASVGPYGAFLADGSEYQGNYGVTEDELADFHRRRMGALIE
AGADILACETIPCLSEAKAIVHLLKEFPDTHAWISFSAKDGRHISDGTKAGECAKWLDQHDQVAAVGVNCTRLEHVSSLI
GGIKKHTAKPIIVYPNSGEQYDPETKTWHGAACKASFGESARSWYNQGAQLIGGCCRTTPEDIKAVAAWARKLEV
>Mature_314_residues
TNPIRTSLQQFSVIILDGAMATELERYGCDLNDSLWSAKILIENPELIKQVHLDYFRAGADCAITASYQSTVEGFTKRGL
SEQEALHLIRESVRLAAEARDEFWAAPENREGRPKPFVAASVGPYGAFLADGSEYQGNYGVTEDELADFHRRRMGALIEA
GADILACETIPCLSEAKAIVHLLKEFPDTHAWISFSAKDGRHISDGTKAGECAKWLDQHDQVAAVGVNCTRLEHVSSLIG
GIKKHTAKPIIVYPNSGEQYDPETKTWHGAACKASFGESARSWYNQGAQLIGGCCRTTPEDIKAVAAWARKLEV

Specific function: Catalyzes Methyl Transfer From S-Methylmethionine Or S- Adenosylmethionine (Less Efficient) To Homocysteine, Selenohomocysteine And Less Efficiently Selenocysteine. [C]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=325, Percent_Identity=27.3846153846154, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786456, Length=309, Percent_Identity=51.7799352750809, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1790450, Length=337, Percent_Identity=27.5964391691395, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17535405, Length=324, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569783, Length=269, Percent_Identity=25.6505576208178, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322966, Length=327, Percent_Identity=28.1345565749235, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324982, Length=336, Percent_Identity=28.8690476190476, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323983, Length=95, Percent_Identity=34.7368421052632, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585077, Length=296, Percent_Identity=35.472972972973, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI20129603, Length=320, Percent_Identity=36.875, Blast_Score=194, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 34557; Mature: 34426

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPIRTSLQQFSVIILDGAMATELERYGCDLNDSLWSAKILIENPELIKQVHLDYFRAG
CCCHHHHHHHHCEEEEECCHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCC
ADCAITASYQSTVEGFTKRGLSEQEALHLIRESVRLAAEARDEFWAAPENREGRPKPFVA
CCEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
ASVGPYGAFLADGSEYQGNYGVTEDELADFHRRRMGALIEAGADILACETIPCLSEAKAI
ECCCCCHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
VHLLKEFPDTHAWISFSAKDGRHISDGTKAGECAKWLDQHDQVAAVGVNCTRLEHVSSLI
HHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHH
GGIKKHTAKPIIVYPNSGEQYDPETKTWHGAACKASFGESARSWYNQGAQLIGGCCRTTP
HHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCH
EDIKAVAAWARKLEV
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNPIRTSLQQFSVIILDGAMATELERYGCDLNDSLWSAKILIENPELIKQVHLDYFRAG
CCHHHHHHHHCEEEEECCHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCC
ADCAITASYQSTVEGFTKRGLSEQEALHLIRESVRLAAEARDEFWAAPENREGRPKPFVA
CCEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
ASVGPYGAFLADGSEYQGNYGVTEDELADFHRRRMGALIEAGADILACETIPCLSEAKAI
ECCCCCHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
VHLLKEFPDTHAWISFSAKDGRHISDGTKAGECAKWLDQHDQVAAVGVNCTRLEHVSSLI
HHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHH
GGIKKHTAKPIIVYPNSGEQYDPETKTWHGAACKASFGESARSWYNQGAQLIGGCCRTTP
HHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCH
EDIKAVAAWARKLEV
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]